Anti‐tumour efficacy on glioma models of PHA‐848125, a multi‐kinase inhibitor able to cross the blood–brain barrier von Albanese, C, Alzani, R, Amboldi, N, Degrassi, A, Festuccia, C, Fiorentini, F, Gravina, GL, Mercurio, C, Pastori, W, Brasca, MG, Pesenti, E, Galvani, A, Ciomei, M

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NMS-P088, a CSF-1R, FLT3 and KIT inhibitor with outstanding activity on gatekeeper resistance mutations, high tolerability, and potential for combination therapies von Ardini, E, Lombardi Borgia, A, Texido, G, Alzani, R, Avanzi, N, Amboldi, N, Cribioli, S, Mancini, L, Casero, D, Pastori, W, Montemartini, M, Montagnoli, A, Donati, D, Galvani, A, Isacchi, A, Ciomei, M

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31 N-Myc amplification sensitizes tumor cells to inhibition by Danusertib, an Aurora kinase inhibitor von Carpinelli, P, Ceruti, R, Alzani, R, Re, C, Ballinari, D, Cribioli, S, Russo, M, Degrassi, A, Texido, G, Ciomei, M, Pesenti, E, Montagnoli, A, Galvani, A

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544 Characterization of Potent and Well Tolerated Second Generation FLT3 Inhibitors von Ciomei, M, Amboldi, N, Cribioli, S, Donati, D, Fraietta, I, Galvani, A, Nuccio, C, Pesenti, E, Romero, G. Texido, Borgia, A. Lombardi

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310 Inhibition of Trk-driven tumors by the pan-Trk inhibitor RXDX-101 von Anderson, D, Ciomei, M, Banfi, P, Cribioli, S, Ardini, E, Galvani, A, Li, G

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The Basic Domain in HIV-1 Tat Protein as a Target for Polysulfonated Heparin-mimicking Extracellular Tat Antagonists von Rusnati, M, Tulipano, G, Urbinati, C, Tanghetti, E, Giuliani, R, Giacca, M, Ciomei, M, Corallini, A, Presta, M

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3-Aminopyrazole Inhibitors of CDK2/Cyclin A as Antitumor Agents. 1. Lead Finding von Pevarello, Paolo, Brasca, Maria Gabriella, Amici, Raffaella, Orsini, Paolo, Traquandi, Gabriella, Corti, Luca, Piutti, Claudia, Sansonna, Pietro, Villa, Manuela, Pierce, Betsy S, Pulici, Maurizio, Giordano, Patrizia, Martina, Katia, Fritzen, Edward L, Nugent, Richard A, Casale, Elena, Cameron, Alexander, Ciomei, Marina, Roletto, Fulvia, Isacchi, Antonella, Fogliatto, GianPaolo, Pesenti, Enrico, Pastori, Wilma, Marsiglio, Aurelio, Leach, Karen L, Clare, Paula M, Fiorentini, Francesco, Varasi, Mario, Vulpetti, Anna, Warpehoski, Martha A

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3-Aminopyrazole Inhibitors of CDK2/Cyclin A as Antitumor Agents. 2. Lead Optimization von Pevarello, Paolo, Brasca, Maria Gabriella, Orsini, Paolo, Traquandi, Gabriella, Longo, Antonio, Nesi, Marcella, Orzi, Fabrizio, Piutti, Claudia, Sansonna, Pietro, Varasi, Mario, Cameron, Alexander, Vulpetti, Anna, Roletto, Fulvia, Alzani, Rachele, Ciomei, Marina, Albanese, Clara, Pastori, Wilma, Marsiglio, Aurelio, Pesenti, Enrico, Fiorentini, Francesco, Bischoff, Jim R, Mercurio, Ciro

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388 - NMS-P088, a CSF-1R, FLT3 and KIT inhibitor with outstanding activity on gatekeeper resistance mutations, high tolerability, and potential for combination therapies von Ardini, E., Lombardi Borgia, A., Texido, G., Alzani, R., Avanzi, N., Amboldi, N., Cribioli, S., Mancini, L., Casero, D., Pastori, W., Montemartini, M., Montagnoli, A., Donati, D., Galvani, A., Isacchi, A., Ciomei, M.

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Optimization of Diarylthiazole B-Raf Inhibitors: Identification of a Compound Endowed with High Oral Antitumor Activity, Mitigated hERG Inhibition, and Low Paradoxical Effect von Pulici, Maurizio, Traquandi, Gabriella, Marchionni, Chiara, Modugno, Michele, Lupi, Rosita, Amboldi, Nadia, Casale, Elena, Colombo, Nicoletta, Corti, Luca, Fasolini, Marina, Gasparri, Fabio, Pastori, Wilma, Scolaro, Alessandra, Donati, Daniele, Felder, Eduard, Galvani, Arturo, Isacchi, Antonella, Pesenti, Enrico, Ciomei, Marina

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3-Amino-1,4,5,6-tetrahydropyrrolo[3,4- c]pyrazoles: A new class of CDK2 inhibitors von Pevarello, Paolo, Fancelli, Daniele, Vulpetti, Anna, Amici, Raffaella, Villa, Manuela, Pittalà, Valeria, Vianello, Paola, Cameron, Alexander, Ciomei, Marina, Mercurio, Ciro, Bischoff, James R., Roletto, Fulvia, Varasi, Mario, Brasca, Maria Gabriella

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Antitumor Efficacy of Edotecarin as a Single Agent and in Combination with Chemotherapy Agents in a Xenograft Model von CIOMEI, Marina, CROCI, Valter, CIAVOLELLA, Antonella, BALLINARI, Dario, PESENTI, Enrico

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Decreased tyrosine phosphorylation in tumour cells resistant to FCE 24517 (tallimustine) von CIOMEI, M, PASTORI, W, CAPOLONGO, L, GERONI, C, MELEGARO, G, PENNELLA, G, GRANDI, M

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Multiple effects of paclitaxel are modulated by a high c- myc amplification level von Bottone, Maria Grazia, Soldani, Cristiana, Tognon, Gianluca, Gorrini, Chiara, Lazzè, M.Claudia, Brison, Olivier, Ciomei, Marina, Pellicciari, Carlo, Scovassi, A.Ivana

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Phase I/II trial of nemorubicin hydrochloride in combination with cisplatin is supported by new preclinical evidences of its mechanism of action von Pacciarini, M. A., Geroni, C., Sabatino, M. A., Ciomei, M., Valota, O., Ballinari, D., Capolongo, L., Broggini, M.

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Bombesin stimulates growth of human prostatic cancer cells in vitro von Bologna, Mauro, Festuccia, Claudio, Muzi, Paola, Biordi, Leda, Ciomei, Marina

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3-Aminopyrazole Inhibitors of CDK2/Cyclin A as Antitumor Agents. 2. Lead Optimization von Pevarello, Paolo, Brasca, Maria Gabriella, Orsini, Paolo, Traquandi, Gabriella, Longo, Antonio, Nesi, Marcella, Orzi, Fabrizio, Piutti, Claudia, Sansonna, Pietro, Varasi, Mario, Cameron, Alexander, Vulpetti, Anna, Roletto, Fulvia, Alzani, Rachele, Ciomei, Marina, Albanese, Clara, Pastori, Wilma, Marsiglio, Aurelio, Pesenti, Enrico, Fiorentini, Francesco, Bischoff, Jim R, Mercurio, Ciro

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Pharmacological and toxicological aspects of 4-demethoxy-3'-deamino-3'-aziridinyl-4'-methylsulphonyl-daunorubicin (PNU-159548) : A novel antineoplastic agent von GERONI, Cristina, RIPAMONTI, Marina, CIOMEI, Marina, ROSSI, Rosaria, CARUSO, Michele, ARRIGONI, Claudio, FIORENTINI, Francesco, CAPOLONGO, Laura, MONETA, Donatella, MARCHINI, Sergio, DELLA TORRE, Paola, ALBANESE, Clara, LAMPARELLI, Maria Grazia

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304 POSTER Combination treatment of new molecular-targeted therapies and the DNA minor groove binder brostallicin von Geroni, C., Pesenti, E., Ballinari, D., Ciomei, M., Croci, V., Marsiglio, A.

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New sulfonated distamycin a derivatives with bFGF complexing activity von Ciomei, Marina, Pastori, Wilma, Mariani, Mariangela, Sola, Francesco, Grandi, Maria, Mongelli, Nicola

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