Breaking bad: R-loops and genome integrity von Sollier, Julie, Cimprich, Karlene A

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Conflict Resolution in the Genome: How Transcription and Replication Make It Work von Hamperl, Stephan, Cimprich, Karlene A.

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R-Loops as Cellular Regulators and Genomic Threats von Crossley, Madzia P., Bocek, Michael, Cimprich, Karlene A.

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The essential kinase ATR: ensuring faithful duplication of a challenging genome von Saldivar, Joshua C., Cortez, David, Cimprich, Karlene A.

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Causes and consequences of replication stress von Zeman, Michelle K., Cimprich, Karlene A.

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Transcription-Coupled Nucleotide Excision Repair Factors Promote R-Loop-Induced Genome Instability von Sollier, Julie, Stork, Caroline Townsend, García-Rubio, María L., Paulsen, Renee D., Aguilera, Andrés, Cimprich, Karlene A.

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ATR: an essential regulator of genome integrity von Cimprich, Karlene A, Cortez, David

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Transcription-Replication Conflict Orientation Modulates R-Loop Levels and Activates Distinct DNA Damage Responses von Hamperl, Stephan, Bocek, Michael J., Saldivar, Joshua C., Swigut, Tomek, Cimprich, Karlene A.

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The contribution of co-transcriptional RNA:DNA hybrid structures to DNA damage and genome instability von Hamperl, Stephan, Cimprich, Karlene A.

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Walking a tightrope: The complex balancing act of R-loops in genome stability von Brickner, Joshua R., Garzon, Jada L., Cimprich, Karlene A.

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qDRIP: a method to quantitatively assess RNA–DNA hybrid formation genome-wide von Crossley, Magdalena P, Bocek, Michael J, Hamperl, Stephan, Swigut, Tomek, Cimprich, Karlene A

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A Role for the MRN Complex in ATR Activation via TOPBP1 Recruitment von Duursma, Anja M., Driscoll, Robert, Elias, Josh E., Cimprich, Karlene A.

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A Two-Dimensional ERK-AKT Signaling Code for an NGF-Triggered Cell-Fate Decision von Chen, Jia-Yun, Lin, Jia-Ren, Cimprich, Karlene A., Meyer, Tobias

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Directed evolution using dCas9-targeted somatic hypermutation in mammalian cells von Hess, Gaelen T, Frésard, Laure, Han, Kyuho, Lee, Cameron H, Li, Amy, Cimprich, Karlene A, Montgomery, Stephen B, Bassik, Michael C

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SHPRH and HLTF Act in a Damage-Specific Manner to Coordinate Different Forms of Postreplication Repair and Prevent Mutagenesis von Lin, Jia-Ren, Zeman, Michelle K., Chen, Jia-Yun, Yee, Muh-Ching, Cimprich, Karlene A.

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HLTF’s Ancient HIRAN Domain Binds 3′ DNA Ends to Drive Replication Fork Reversal von Kile, Andrew C., Chavez, Diana A., Bacal, Julien, Eldirany, Sherif, Korzhnev, Dmitry M., Bezsonova, Irina, Eichman, Brandt F., Cimprich, Karlene A.

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ATR phosphorylates SMARCAL1 to prevent replication fork collapse von Couch, Frank B, Bansbach, Carol E, Driscoll, Robert, Luzwick, Jessica W, Glick, Gloria G, Bétous, Rémy, Carroll, Clinton M, Jung, Sung Yun, Qin, Jun, Cimprich, Karlene A, Cortez, David

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HLTF Promotes Fork Reversal, Limiting Replication Stress Resistance and Preventing Multiple Mechanisms of Unrestrained DNA Synthesis von Bai, Gongshi, Kermi, Chames, Stoy, Henriette, Schiltz, Carl J., Bacal, Julien, Zaino, Angela M., Hadden, M. Kyle, Eichman, Brandt F., Lopes, Massimo, Cimprich, Karlene A.

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R-loop-derived cytoplasmic RNA–DNA hybrids activate an immune response von Crossley, Magdalena P., Song, Chenlin, Bocek, Michael J., Choi, Jun-Hyuk, Kousouros, Joseph N., Sathirachinda, Ataya, Lin, Cindy, Brickner, Joshua R., Bai, Gongshi, Lans, Hannes, Vermeulen, Wim, Abu-Remaileh, Monther, Cimprich, Karlene A.

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Co-transcriptional R-loops are the main cause of estrogen-induced DNA damage von Stork, Caroline Townsend, Bocek, Michael, Crossley, Madzia P, Sollier, Julie, Sanz, Lionel A, Chédin, Frédéric, Swigut, Tomek, Cimprich, Karlene A

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