Structure-Guided Discovery of Aminoquinazolines as Brain-Penetrant and Selective LRRK2 Inhibitors von Keylor, Mitchell H, Gulati, Anmol, Kattar, Solomon D, Johnson, Rebecca E, Chau, Ryan W, Margrey, Kaila A, Ardolino, Michael J, Zarate, Cayetana, Poremba, Kelsey E, Simov, Vladimir, Morriello, Gregori J, Acton, John J, Pio, Barbara, Yan, Xin, Palte, Rachel L, McMinn, Spencer E, Nogle, Lisa, Lesburg, Charles A, Adpressa, Donovon, Lin, Shishi, Neelamkavil, Santhosh, Liu, Ping, Su, Jing, Hegde, Laxminarayan G, Woodhouse, Janice D, Faltus, Robert, Xiong, Tina, Ciaccio, Paul J, Piesvaux, Jennifer, Otte, Karin M, Wood, Harold B, Kennedy, Matthew E, Bennett, David Jonathan, DiMauro, Erin F, Fell, Matthew J, Fuller, Peter H

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Characterization of the Onset, Progression, and Reversibility of Morphological Changes in Mouse Lung after Pharmacological Inhibition of Leucine-Rich Kinase 2 Kinase Activity von Bryce, Dianne K, Ware, Chris M, Woodhouse, Janice D, Ciaccio, Paul J, Ellis, J Michael, Hegde, Laxminarayan G, Kuruvilla, Sabu, Maddess, Matthew L, Markgraf, Carrie G, Otte, Karin M, Poulet, Frederique M, Timmins, Lauren M, Kennedy, Matthew E, Fell, Matthew J

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Discovery and Optimization of N‑Heteroaryl Indazole LRRK2 Inhibitors von Logan, Kaitlyn M., Kaplan, Will, Simov, Vladimir, Zhou, Hua, Li, Derun, Torres, Luis, Morriello, Gregori J., Acton, John J., Pio, Barbara, Chen, Yi-Heng, Keylor, Mitchell H., Johnson, Rebecca, Kattar, Solomon D., Chau, Ryan, Yan, Xin, Ardolino, Michael, Zarate, Cayetana, Otte, Karin M., Palte, Rachel L., Xiong, Tina, McMinn, Spencer E., Lin, Shishi, Neelamkavil, Santhosh F., Liu, Ping, Su, Jing, Hegde, Laxminarayan G., Woodhouse, Janice D., Moy, Lily Y., Ciaccio, Paul J., Piesvaux, Jennifer, Zebisch, Matthias, Henry, Clare, Barker, John, Wood, Harold B., Kennedy, Matthew E., DiMauro, Erin F., Fell, Matthew J., Fuller, Peter H.

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Modulation of Notch Processing by γ-Secretase Inhibitors Causes Intestinal Goblet Cell Metaplasia and Induction of Genes Known to Specify Gut Secretory Lineage Differentiation von Milano, Joseph, McKay, Jenny, Dagenais, Claude, Foster-Brown, Linda, Pognan, Francois, Gadient, Reto, Jacobs, Robert T., Zacco, Anna, Greenberg, Barry, Ciaccio, Paul J.

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Effects of LRRK2 Inhibitors in Nonhuman Primates von Miller, Glen K., Kuruvilla, Sabu, Jacob, Binod, LaFranco-Scheuch, Lisa, Bakthavatchalu, Vasudevan, Flor, Jason, Flor, Kristin, Ziegler, Julie, Reichard, Christine, Manfre, Phil, Firner, Suzanne, McNutt, Tara, Quay, Diane, Bellum, Sairam, Doto, Greg, Ciaccio, Paul J., Pearson, Kara, Valentine, Jack, Fuller, Pete, Fell, Matt, Tsuchiya, Takayuki, Williamson, Toni, Wollenberg, Gordon

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Discovery of MK-1468: A Potent, Kinome-Selective, Brain-Penetrant Amidoisoquinoline LRRK2 Inhibitor for the Potential Treatment of Parkinson’s Disease von Kattar, Solomon D., Gulati, Anmol, Margrey, Kaila A., Keylor, Mitchell H., Ardolino, Michael, Yan, Xin, Johnson, Rebecca, Palte, Rachel L., McMinn, Spencer E., Nogle, Lisa, Su, Jing, Xiao, Dong, Piesvaux, Jennifer, Lee, Susi, Hegde, Laxminarayan G., Woodhouse, Janice D., Faltus, Robert, Moy, Lily Y., Xiong, Tina, Ciaccio, Paul J., Pearson, Kara, Patel, Mayankbhai, Otte, Karin M., Leyns, Cheryl E.G., Kennedy, Matthew E., Bennett, David Jonathan, DiMauro, Erin F., Fell, Matthew J., Fuller, Peter H.

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Early-Onset albuminuria and Associated Renal Pathology in Leucine-Rich Repeat Kinase 2 Knockout Rats von Gu, Yi-Zhong, Vlasakova, Katerina, Miller, Glen, Gatto, Nicholas T., Ciaccio, Paul J., Kuruvilla, Sabu, Besteman, Elizabeth G., Smith, Roger, Reynolds, Spencer J., Amin, Rupesh P., Glaab, Warren E., Wollenberg, Gordon, Lebron, Jose, Sistare, Frank D.

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Differential Cytotoxicity Responses by Dog and Rat Hepatocytes to Phospholipogenic Treatments von Morelli, James K., Ciaccio, Paul J.

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Phospholipogenic Pharmaceuticals Are Associated with a Higher Incidence of Histological Findings than Nonphospholipogenic Pharmaceuticals in Preclinical Toxicology Studies von Barone, Linda R., Boyer, Scott, Damewood, James R., Fikes, James, Ciaccio, Paul J.

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2,6-Disubstituted pyrazines and related analogs as NR2B site antagonists of the NMDA receptor with anti-depressant activity von Brown, Dean G., Maier, Donna L., Sylvester, Mark A., Hoerter, Tiffany N., Menhaji-Klotz, Elnaz, Lasota, Celina C., Hirata, Lee T., Wilkins, Deidre E., Scott, Clay W., Trivedi, Shephali, Chen, Tongming, McCarthy, Dennis J., Maciag, Carla M., Sutton, Evelynjeane J., Cumberledge, Jerry, Mathisen, Don, Roberts, John, Gupta, Anshul, Liu, Frank, Elmore, Charles S., Alhambra, Cristobal, Krumrine, Jennifer R., Wang, Xia, Ciaccio, Paul J., Wood, Michael W., Campbell, James B., Johansson, Magnus J., Xia, Jian, Wen, Xiaotian, Jiang, Ji, Wang, Xiaoping, Peng, Zuozhong, Hu, Tao, Wang, Jian

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Development of a phospholipidosis screen: Comparison of a rat hepatoma cell line with rat isolated hepatocytes von Gustafsson, Frida, Bowes, Joanne, Brown, Martin, Ciaccio, Paul J., Goodall, Tony, Pilling, James, Ainscow, Edward, Valentin, Jean- Pierre

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Genomic sequence of human glyoxalase-I: analysis of promoter activity and its regulation von Ranganathan, Sulabha, Ciaccio, Paul J., Walsh, Eileen S., Tew, Kenneth D.

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Characterization of the Onset, Progression, and Reversibility of Morphological Changes in Mouse Lung after Pharmacological Inhibition of Leucine-Rich Kinase 2 Kinase Activitys von Bryce, Dianne K., Ware, Chris M., Woodhouse, Janice D., Ciaccio, Paul J., Ellis, J. Michael, Hegde, Laxminarayan G., Kuruvilla, Sabu, Maddess, Matthew L., Markgraf, Carrie G., Otte, Karin M., Poulet, Frederique M., Timmins, Lauren M., Kennedy, Matthew E., Fell, Matthew J.

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Cellular and in Vitro Transport of Glutathione Conjugates by MRP von Shen, Hongxie, Paul, Saptarshi, Breuninger, Lisa M, Ciaccio, Paul J, Laing, Naomi M, Helt, Marija, Tew, Kenneth D, Kruh, Gary D

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Promoter Analysis of a Human Dihydrodiol Dehydrogenase von Ciaccio, Paul J., Walsh, Eileen S., Tew, Kenneth D.

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Cellular and in Vitro Transport of Glutathione Conjugates by MRP von Shen, Hongxie, Paul, Saptarshi, Breuninger, Lisa M, Ciaccio, Paul J, Laing, Naomi M, Helt, Marija, Tew, Kenneth D, Kruh, Gary D

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Isozyme-specific glutathione S-transferase inhibitors potentiate drug sensitivity in cultured human tumor cell lines von MORGAN, A. S, CIACCIO, P. J, TEW, K. D, KAUVAR, L. M

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The metabolism of xenobiotics and endogenous compounds by the constitutive dog liver cytochrome P450 PBD-2 von Duignan, David B., Sipes, I.Glenn, Ciaccio, Paul J., Halpert, James R.

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Enzymatic conjugation of chlorambucil with glutathione by human glutathione S-transferases and inhibition by ethacrynic acid von Ciaccio, Paul J., Tew, Kenneth D., LaCreta, Frank P.

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