Synthesis of Vibegron Enabled by a Ketoreductase Rationally Designed for High pH Dynamic Kinetic Reduction von Xu, Feng, Kosjek, Birgit, Cabirol, Fabien L., Chen, Haibin, Desmond, Richard, Park, Jeonghan, Gohel, Anupam P., Collier, Steven J., Smith, Derek J., Liu, Zhuqing, Janey, Jacob M., Chung, John Y. L., Alvizo, Oscar

Volltext

Enantiospecific and regioselective opening of 2-alkyl nosylaziridines by indoles mediated by boron trifluoride. Application to a practical synthesis of a GnRH antagonist von Farr, Roger N, Alabaster, Ramon J, Chung, John Y.L, Craig, Bridgette, Edwards, John S, Gibson, Andrew W, Ho, Guo-Jie, Humphrey, Guy R, Johnson, Simon A, Grabowski, E.J.J

Volltext

Asymmetric Synthesis of N‑Boc‑(R)‑Silaproline via Rh-Catalyzed Intramolecular Hydrosilylation of Dehydroalanine and Continuous Flow N‑Alkylation von Chung, John Y. L, Shevlin, Michael, Klapars, Artis, Journet, Michel

Volltext

Diastereoselective FeCl3·6H2O/NaBH4 Reduction of Oxime Ether for the Synthesis of β‑Lactamase Inhibitor Relebactam von Chung, John Y. L, Meng, Dongfang, Shevlin, Michael, Gudipati, Venugopal, Chen, Qinghao, Liu, Yizhou, Lam, Yu-hong, Dumas, Aaron, Scott, Jeremy, Tu, Qiang, Xu, Feng

Volltext

Efficient synthesis of antiviral agent uprifosbuvir enabled by new synthetic methods von Klapars, Artis, Chung, John Y. L, Limanto, John, Calabria, Ralph, Campeau, Louis-Charles, Campos, Kevin R, Chen, Wenyong, Dalby, Stephen M, Davis, Tyler A, DiRocco, Daniel A, Hyde, Alan M, Kassim, Amude M, Larsen, Mona Utne, Liu, Guiquan, Maligres, Peter E, Moment, Aaron, Peng, Feng, Ruck, Rebecca T, Shevlin, Michael, Simmons, Bryon L, Song, Zhiguo Jake, Tan, Lushi, Wright, Timothy J, Zultanski, Susan L

Volltext

Kilogram-Scale Synthesis of 2′‑C‑Methyl-arabino-Uridine from Uridine via Dynamic Selective Dipivaloylation von Chung, John Y. L, Kassim, Amude M, Simmons, Bryon, Davis, Tyler A, Song, Zhiguo J, Limanto, John, Dalby, Stephen M, He, Cyndi Q, Calabria, Ralph, Wright, Timothy J, Campeau, Louis-Charles

Volltext

Evolution of a Manufacturing Route to Omarigliptin, A Long-Acting DPP‑4 Inhibitor for the Treatment of Type 2 Diabetes von Chung, John Y. L, Scott, Jeremy P, Anderson, Camille, Bishop, Brian, Bremeyer, Nadine, Cao, Yang, Chen, Qinghao, Dunn, Robert, Kassim, Amude, Lieberman, David, Moment, Aaron J, Sheen, Faye, Zacuto, Michael

Volltext

Development of a Commercial Manufacturing Route to 2‑Fluoroadenine, The Key Unnatural Nucleobase of Islatravir von Hong, Cynthia M, Xu, Yingju, Chung, John Y. L, Schultz, Danielle M, Weisel, Mark, Varsolona, Richard J, Zhong, Yong-Li, Purohit, Akasha K, He, Cyndi Q, Gauthier, Donald R, Humphrey, Guy R, Maloney, Kevin M, Lévesque, François, Wang, Zhixun, Whittaker, Aaron M, Sirota, Eric, McMullen, Jonathan P

Volltext

Asymmetric Formal Synthesis of the Long-Acting DPP-4 Inhibitor Omarigliptin von Peng, Feng, Chen, Yonggang, Chen, Cheng-yi, Dormer, Peter G, Kassim, Amude, McLaughlin, Mark, Reamer, Robert A, Sherer, Edward C, Song, Zhiguo J, Tan, Lushi, Tudge, Matthew T, Wan, Baoqiang, Chung, John Y. L

Volltext

A General Procedure for the Preparation of β-Ketophosphonates von Maloney, Kevin M, Chung, John Y. L

Volltext

Development of a Green and Sustainable Manufacturing Process for Gefapixant Citrate (MK-7264) Part 3: Development of a One-Pot Formylation–Cyclization Sequence to the Diaminopyrimi... von Basu, Kallol, Lehnherr, Dan, Martin, Gary E, Desmond, Richard A, Lam, Yu-hong, Peng, Feng, Chung, John Y. L, Arvary, Rebecca A, Zompa, Michael A, Zhang, Si-Wei, Liu, Jinchu, Dance, Zachary E. X, Larpent, Patrick, Cohen, Ryan D, Guzman, Francisco J, Rogus, Nicholas J, Di Maso, Michael J, Ren, Hong, Maloney, Kevin M

Volltext

Asymmetric Synthesis of Cyclic Indole Aminals via 1,3-Stereoinduction von Li, Hongmei, Chen, Cheng-yi, Nguyen, Hoa, Cohen, Ryan, Maligres, Peter E, Yasuda, Nobuyoshi, Mangion, Ian, Zavialov, Ilia, Reibarkh, Mikhail, Chung, John Y. L

Volltext

Asymmetric Synthesis of cis-2,5-Disubstituted Pyrrolidine, the Core Scaffold of β3‑AR Agonists von Xu, Feng, Chung, John Y. L, Moore, Jeffery C, Liu, Zhuqing, Yoshikawa, Naoki, Hoerrner, R. Scott, Lee, Jaemoon, Royzen, Maksim, Cleator, Ed, Gibson, Andrew G, Dunn, Robert, Maloney, Kevin M, Alam, Mahbub, Goodyear, Adrian, Lynch, Joseph, Yasuda, Nobuyashi, Devine, Paul N

Volltext

Unusual Pyrimidine Participation: Efficient Stereoselective Synthesis of Potent Dual Orexin Receptor Antagonist MK-6096 von Chung, John Y. L, Zhong, Yong-Li, Maloney, Kevin M, Reamer, Robert A, Moore, Jeffrey C, Strotman, Hallena, Kalinin, Alexei, Feng, Ronnie, Strotman, Neil A, Xiang, Bangping, Yasuda, Nobuyoshi

Volltext

Practical chemoenzymatic synthesis of a 3-pyridylethanolamino β3 adrenergic receptor agonist von Chung, John Y.L, Ho, Guo-Jie, Chartrain, Michel, Roberge, Chris, Zhao, Dalian, Leazer, John, Farr, Roger, Robbins, Michael, Emerson, Kateeta, Mathre, David J, McNamara, James M, Hughes, David L, Grabowski, Edward J.J, Reider, Paul J

Volltext

Synthesis of ((3R,6R)‑6-Methylpiperidin-3-yl)methanol via Biocatalytic Transamination and Crystallization-Induced Dynamic Resolution von Chung, John Y. L, Marcune, Benjamin, Strotman, Hallena R, Petrova, Rositza I, Moore, Jeffrey C, Dormer, Peter G

Volltext

Diastereoselective Friedel−Crafts Alkylation of Indoles with Chiral α-Phenyl Benzylic Cations. Asymmetric Synthesis of Anti-1,1,2-Triarylalkanes von Chung, John Y. L, Mancheno, Danny, Dormer, Peter G, Variankaval, Narayan, Ball, Richard G, Tsou, Nancy N

Volltext

Asymmetric Synthesis of a Glucagon Receptor Antagonist via Friedel–Crafts Alkylation of Indole with Chiral α‑Phenyl Benzyl Cation von Chung, John Y. L, Steinhuebel, Dietrich, Krska, Shane W, Hartner, Fred W, Cai, Chaoxian, Rosen, Jonathan, Mancheno, Danny E, Pei, Tao, DiMichele, Lisa, Ball, Richard G, Chen, Cheng-yi, Tan, Lushi, Alorati, Antony D, Brewer, Sarah E, Scott, Jeremy P

Volltext

Synthesis of Antifungal Glucan Synthase Inhibitors from Enfumafungin von Zhong, Yong-Li, Gauthier, Donald R, Shi, Yao-Jun, McLaughlin, Mark, Chung, John Y. L, Dagneau, Philippe, Marcune, Benjamin, Krska, Shane W, Ball, Richard G, Reamer, Robert A, Yasuda, Nobuyoshi

Volltext

Synthesis development of an aminomethylcycline antibiotic via an electronically tuned acyliminium Friedel–Crafts reaction von Chung, John Y.L., Hartner, Frederick W., Cvetovich, Raymond J.

Volltext