A Clinical Perspective of the Multifaceted Mechanism of Metformin in Diabetes, Infections, Cognitive Dysfunction, and Cancer von Chow, Elaine, Yang, Aimin, Chung, Colin H L, Chan, Juliana C N

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Discovery of a Novel Bromodomain and Extra Terminal Domain (BET) Protein Inhibitor, I-BET282E, Suitable for Clinical Progression von Jones, Katherine L, Beaumont, Dominic M, Bernard, Sharon G, Bit, Rino A, Campbell, Simon P, Chung, Chun-Wa, Cutler, Leanne, Demont, Emmanuel H, Dennis, Kate, Gordon, Laurie, Gray, James R, Haase, Michael V, Lewis, Antonia J, McCleary, Scott, Mitchell, Darren J, Moore, Susanne M, Parr, Nigel, Robb, Olivia J, Smithers, Nicholas, Soden, Peter E, Suckling, Colin J, Taylor, Simon, Walker, Ann L, Watson, Robert J, Prinjha, Rab K

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Efficacy and safety of oral semaglutide with flexible dose adjustment versus sitagliptin in type 2 diabetes (PIONEER 7): a multicentre, open-label, randomised, phase 3a trial von Pieber, Thomas R, Bode, Bruce, Mertens, Ann, Cho, Young Min, Christiansen, Erik, Hertz, Christin L, Wallenstein, Signe O R, Buse, John B, Akın, S, Aladağ, N, Arif, A A, Aronne, L J, Aronoff, S, Ataoglu, E, Baik, S H, Bays, H, Beckett, P L, Berker, D, Bilz, S, Bode, B, Braun, E W, Buse, J B, Canani, L H S, Cho, Y M, Chung, C H, Colin, I, Condit, J, Cooper, J, Delgado, B, Eagerton, D C, El Ebrashy, I N, El Hefnawy, M H M F, Eliaschewitz, F G, Finneran, M P, Fischli, S, Fließer-Görzer, E, Geohas, J, Godbole, N A, Golay, A, Gorban de Lapertosa, S, Gross, J L, Gulseth, H L, Helland, F, Høivik, H O, Issa, C, Kang, E S, Keller, C, Khalil, S H A, Kim, N H, Kim, I J, Klaff, L J, Laimer, M, LaRocque, J C, Lederman, S N, Lee, K-W, Litchfield, W R, Manning, M B, Mertens, A, Morawski, E J, Murray, A V, Nicol, P R, O'Connor, T M, Oğuz, A, Ong, S, Özdemir, A, Palace, E M, Palchick, B A, Pereles-Ortiz, J, Pieber, T, Prager, R, Preumont, V, Riffer, E, Rista, L, Rudofsky, G, Sarı, R, Scheen, A, Schultes, B, Seo, J A, Shelbaya, S A, Sivalingam, K, Sorli, C H, Stäuble, S, Streja, D A, T'Sjoen, G, Tetiker, T, Van Gaal, L, Vercammen, C, Warren, M L, Weinstein, D L, Weiss, D, White, A, Winnie, M, Wium, C, Yavuz, D

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Supportive care in the acute phase of Stevens–Johnson syndrome and toxic epidermal necrolysis: an international, multidisciplinary Delphi‐based consensus von Brüggen, M.‐C., Le, S.T., Walsh, S., Toussi, A., Prost, N., Ranki, A., Didona, B., Colin, A., Horváth, B., Brezinova, E., Milpied, B., Moss, C., Bodemer, C., Meyersburg, D., Salavastru, C., Tiplica, G.‐S., Howard, E., Bequignon, E., Bouwes Bavinck, J.N., Newman, J., Gueudry, J., Nägeli, M., Zaghbib, K., Pallesen, K., Bygum, A., Joly, P., Wolkenstein, P., Chua, S.‐L., Le Floch, R., Shear, N.H., Chu, C.‐Y., Hama, N., Abe, R., Chung, W.‐H., Shiohara, T., Ardern‐Jones, M., Romanelli, P., Phillips, E.J., Stern, R.S., Cotliar, J., Micheletti, R.G., Brassard, A., Schulz, J.T., Dodiuk‐Gad, R.P., Dominguez, A.R., Paller, A.S., Seminario‐Vidal, L., Mostaghimi, A., Noe, M.H., Worswick, S., Tartar, D., Sheridan, R., Kaffenberger, B.H., Shinkai, K., Maverakis, E., French, L.E., Ingen‐Housz‐Oro, S.

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The MIF Antagonist ISO-1 Attenuates Corticosteroid-Insensitive Inflammation and Airways Hyperresponsiveness in an Ozone-Induced Model of COPD von Russell, Kirsty E, Chung, Kian Fan, Clarke, Colin J, Durham, Andrew L, Mallia, Patrick, Footitt, Joseph, Johnston, Sebastian L, Barnes, Peter J, Hall, Simon R, Simpson, Karen D, Starkey, Malcolm R, Hansbro, Philip M, Adcock, Ian M, Wiegman, Coen H

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Many Labs 3: Evaluating participant pool quality across the academic semester via replication von Ebersole, Charles R., Atherton, Olivia E., Belanger, Aimee L., Skulborstad, Hayley M., Allen, Jill M., Banks, Jonathan B., Baranski, Erica, Bernstein, Michael J., Bonfiglio, Diane B.V., Boucher, Leanne, Brown, Elizabeth R., Budiman, Nancy I., Cairo, Athena H., Capaldi, Colin A., Chartier, Christopher R., Chung, Joanne M., Cicero, David C., Coleman, Jennifer A., Conway, John G., Davis, William E., Devos, Thierry, Fletcher, Melody M., German, Komi, Grahe, Jon E., Hermann, Anthony D., Hicks, Joshua A., Honeycutt, Nathan, Humphrey, Brandon, Janus, Matthew, Johnson, David J., Joy-Gaba, Jennifer A., Juzeler, Hannah, Keres, Ashley, Kinney, Diana, Kirshenbaum, Jacqeline, Klein, Richard A., Lucas, Richard E., Lustgraaf, Christopher J.N., Martin, Daniel, Menon, Madhavi, Metzger, Mitchell, Moloney, Jaclyn M., Morse, Patrick J., Prislin, Radmila, Razza, Timothy, Re, Daniel E., Rule, Nicholas O., Sacco, Donald F., Sauerberger, Kyle, Shrider, Emily, Shultz, Megan, Siemsen, Courtney, Sobocko, Karin, Weylin Sternglanz, R., Summerville, Amy, Tskhay, Konstantin O., van Allen, Zack, Vaughn, Leigh Ann, Walker, Ryan J., Weinberg, Ashley, Wilson, John Paul, Wirth, James H., Wortman, Jessica, Nosek, Brian A.

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A Controlled Trial of Renal Denervation for Resistant Hypertension von Bhatt, Deepak L, Kandzari, David E, O'Neill, William W, D'Agostino, Ralph, Flack, John M, Katzen, Barry T, Leon, Martin B, Liu, Minglei, Mauri, Laura, Negoita, Manuela, Cohen, Sidney A, Oparil, Suzanne, Rocha-Singh, Krishna, Townsend, Raymond R, Bakris, George L

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Mutations in Spliceosomal Genes PPIL1 and PRP17 Cause Neurodegenerative Pontocerebellar Hypoplasia with Microcephaly von Chai, Guoliang, Webb, Alice, Li, Chen, Antaki, Danny, Lee, Sangmoon, Breuss, Martin W., Lang, Nhi, Stanley, Valentina, Anzenberg, Paula, Yang, Xiaoxu, Marshall, Trevor, Gaffney, Patrick, Wierenga, Klaas J., Chung, Brian Hon-Yin, Tsang, Mandy Ho-Yin, Pais, Lynn S., Lovgren, Alysia Kern, VanNoy, Grace E., Rehm, Heidi L., Mirzaa, Ghayda, Leon, Eyby, Diaz, Jullianne, Neumann, Alexander, Kalverda, Arnout P., Manfield, Iain W., Parry, David A., Logan, Clare V., Johnson, Colin A., Bonthron, David T., Valleley, Elizabeth M.A., Issa, Mahmoud Y., Abdel-Ghafar, Sherif F., Abdel-Hamid, Mohamed S., Jennings, Patricia, Zaki, Maha S., Sheridan, Eamonn, Gleeson, Joseph G.

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Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure von Henry, Albert, Roselli, Carolina, Sveinbjörnsson, Garðar, Fatemifar, Ghazaleh, Hedman, Åsa K., Morley, Michael P., Helgadottir, Anna, Verweij, Niek, Dehghan, Abbas, Almgren, Peter, Andersson, Charlotte, Backman, Joshua D., Biggs, Mary L., Brandimarto, Jeffrey, Buckbinder, Leonard, Carey, David J., Chasman, Daniel I., Chen, Xu, Chung, Jonathan, Cook, James P., Delgado, Graciela E., Denaxas, Spiros, Dörr, Marcus, Dudley, Samuel C., Esko, Tõnu, Finan, Chris, Gottdiener, John S., Gross, Stefan, Guðbjartsson, Daníel F., Gutmann, Rebecca, Haggerty, Christopher M., Hyde, Craig L., Ingelsson, Erik, Jukema, J. Wouter, Kavousi, Maryam, Khaw, Kay-Tee, Kleber, Marcus E., Køber, Lars, Koekemoer, Andrea, Langenberg, Claudia, Lind, Lars, Lotta, Luca A., Luan, Jian’an, März, Winfried, Melander, Olle, Mordi, Ify R., Morgan, Thomas, Morris, Andrew D., Morris, Andrew P., Morrison, Alanna C., Nelson, Christopher P., Niessner, Alexander, Niiranen, Teemu, O’Donoghue, Michelle L., Owens, Anjali T., Parry, Helen M., Perola, Markus, Rice, Kenneth M., Ridker, Paul M., Rotter, Jerome I., Salo, Perttu, Salomaa, Veikko, Smelser, Diane T., Stender, Steen, Stott, David J., Tammesoo, Mari-Liis, Taylor, Kent D., Teder-Laving, Maris, Thorsteinsdottir, Unnur, Torp-Pedersen, Christian, Trompet, Stella, Tyl, Benoit, Uitterlinden, Andre G., Veluchamy, Abirami, Völker, Uwe, Voors, Adriaan A., Wareham, Nicholas J., Waterworth, Dawn, Weiss, Raul, Wiggins, Kerri L., Yerges-Armstrong, Laura M., Yu, Bing, Zannad, Faiez, Zhao, Jing Hua, Hemingway, Harry, McMurray, John J. V., Yang, Jian, Visscher, Peter M., Malarstig, Anders, Holm, Hilma, Sattar, Naveed, Holmes, Michael V., Cappola, Thomas P., Hingorani, Aroon D., Kuchenbaecker, Karoline, Ellinor, Patrick T., Smith, J. Gustav, Vasan, Ramachandran S., Swerdlow, Daniel I., Lumbers, R. Thomas

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Expanded encyclopaedias of DNA elements in the human and mouse genomes von Moore, Jill E., Purcaro, Michael J., Pratt, Henry E., Epstein, Charles B., Shoresh, Noam, Adrian, Jessika, Kawli, Trupti, Davis, Carrie A., Dobin, Alexander, Kaul, Rajinder, Halow, Jessica, Van Nostrand, Eric L., Freese, Peter, Gorkin, David U., Shen, Yin, He, Yupeng, Mackiewicz, Mark, Pauli-Behn, Florencia, Williams, Brian A., Mortazavi, Ali, Keller, Cheryl A., Zhang, Xiao-Ou, Elhajjajy, Shaimae I., Huey, Jack, Dickel, Diane E., Snetkova, Valentina, Wei, Xintao, Wang, Xiaofeng, Rivera-Mulia, Juan Carlos, Rozowsky, Joel, Zhang, Jing, Chhetri, Surya B., Zhang, Jialing, Victorsen, Alec, White, Kevin P., Visel, Axel, Yeo, Gene W., Burge, Christopher B., Lécuyer, Eric, Gilbert, David M., Dekker, Job, Rinn, John, Mendenhall, Eric M., Ecker, Joseph R., Kellis, Manolis, Klein, Robert J., Noble, William S., Kundaje, Anshul, Guigó, Roderic, Farnham, Peggy J., Cherry, J. Michael, Myers, Richard M., Ren, Bing, Graveley, Brenton R., Gerstein, Mark B., Pennacchio, Len A., Snyder, Michael P., Bernstein, Bradley E., Wold, Barbara, Hardison, Ross C., Gingeras, Thomas R., Stamatoyannopoulos, John A., Weng, Zhiping

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Understanding the Operative Experience of the Practicing Pediatric Surgeon: Implications for Training and Maintaining Competency von Abdullah, Fizan, Salazar, Jose H, Gause, Colin D, Gadepalli, Samir, Biester, Thomas W, Azarow, Kenneth S, Brandt, Mary L, Chung, Dai H, Lund, Dennis P, Rescorla, Frederick J, Waldhausen, John H. T, Tracy, Thomas F, Fallat, Mary E, Klein, Michael D, Lewis, Frank R, Hirschl, Ronald B

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Single nucleotide polymorphisms in the human interleukin-1B gene affect transcription according to haplotype context von Chen, Hongmin, Wilkins, Leon M., Aziz, Nazneen, Cannings, Christopher, Wyllie, David H., Bingle, Colin, Rogus, John, Beck, James D., Offenbacher, Steven, Cork, Michael J., Rafie-Kolpin, Maryam, Hsieh, Chung-Ming, Kornman, Kenneth S., Duff, Gordon W.

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Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis von Weinstock, Joshua S., Gopakumar, Jayakrishnan, Burugula, Bala Bharathi, Jahn, Nikolaus, Belk, Julia A., Bouzid, Hind, Daniel, Bence, Miao, Zhuang, Ly, Nghi, Mack, Taralynn M., Luna, Sofia E., Prothro, Katherine P., Mitchell, Shaneice R., Laurie, Cecelia A., Broome, Jai G., Taylor, Kent D., Guo, Xiuqing, Sinner, Moritz F., von Falkenhausen, Aenne S., Shuldiner, Alan R., O’Connell, Jeffrey R., Lewis, Joshua P., Boerwinkle, Eric, Chami, Nathalie, Kenny, Eimear E., Loos, Ruth J. F., Fornage, Myriam, Hou, Lifang, Lloyd-Jones, Donald M., Redline, Susan, Cade, Brian E., Psaty, Bruce M., Bis, Joshua C., Brody, Jennifer A., Yun, Jeong H., Qiao, Dandi, Palmer, Nicholette D., Freedman, Barry I., Bowden, Donald W., Cho, Michael H., Vasan, Ramachandran S., Yanek, Lisa R., Becker, Lewis C., Kardia, Sharon L. R., Peyser, Patricia A., He, Jiang, Rienstra, Michiel, Van der Harst, Pim, Kaplan, Robert, Heckbert, Susan R., Smith, Nicholas L., Wiggins, Kerri L., Arnett, Donna K., Irvin, Marguerite R., Tiwari, Hemant, Cutler, Michael J., Knight, Stacey, Muhlestein, J. Brent, Correa, Adolfo, Raffield, Laura M., Gao, Yan, de Andrade, Mariza, Rotter, Jerome I., Rich, Stephen S., Konkle, Barbara A., Johnsen, Jill M., Wheeler, Marsha M., Smith, J. Gustav, Melander, Olle, Nilsson, Peter M., Custer, Brian S., Duggirala, Ravindranath, Curran, Joanne E., Blangero, John, Xiao, Shujie, Yang, Mao, Gu, C. Charles, Chen, Yii-Der Ida, Lee, Wen-Jane, Marcus, Gregory M., Kane, John P., Pullinger, Clive R., Shoemaker, M. Benjamin, Darbar, Dawood, Roden, Dan M., Kooperberg, Charles, Zhou, Ying, Manson, JoAnn E., Desai, Pinkal, Johnson, Andrew D., Mathias, Rasika A., Abecasis, Goncalo R., Kang, Hyun M., Satpathy, Ansuman T., Natarajan, Pradeep, Kitzman, Jacob O., Whitsel, Eric A., Reiner, Alexander P., Bick, Alexander G., Jaiswal, Siddhartha

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Perspectives on ENCODE von Snyder, Michael P., Gingeras, Thomas R., Moore, Jill E., Weng, Zhiping, Gerstein, Mark B., Ren, Bing, Hardison, Ross C., Stamatoyannopoulos, John A., Graveley, Brenton R., Feingold, Elise A., Pazin, Michael J., Pagan, Michael, Gilchrist, Daniel A., Hitz, Benjamin C., Cherry, J. Michael, Bernstein, Bradley E., Mendenhall, Eric M., Zerbino, Daniel R., Frankish, Adam, Flicek, Paul, Myers, Richard M.

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STATE OF THE CLIMATE IN 2016 von Blunden, Jessica, Arndt, Derek S

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Immune imbalance and activation are associated with lower lung function in youth with perinatally acquired HIV von Attia, Engi F., Jacobson, Denise, Yu, Wendy, Crowell, Claudia S., Maleche-Obimbo, Elizabeth, Williams, Paige L., West, T. Eoin, Burchett, Sandra K., Kattan, Meyer, Colin, Andrew A., Eskander, Sherry, Chung, Michael H., Crothers, Kristina, Shearer, William T.

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Pathophysiological mechanisms of dominant and recessive GLRA1 mutations in hyperekplexia von Chung, Seo-Kyung, Vanbellinghen, Jean-François, Mullins, Jonathan G L, Robinson, Angela, Hantke, Janina, Hammond, Carrie L, Gilbert, Daniel F, Freilinger, Michael, Ryan, Monique, Kruer, Michael C, Masri, Amira, Gurses, Candan, Ferrie, Colin, Harvey, Kirsten, Shiang, Rita, Christodoulou, John, Andermann, Frederick, Andermann, Eva, Thomas, Rhys H, Harvey, Robert J, Lynch, Joseph W, Rees, Mark I

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The persistent shadow of the supermassive black hole of M 87: I. Observations, calibration, imaging, and analysis von Akiyama, Kazunori, Alberdi, Antxon, Alef, Walter, Algaba, Juan Carlos, Anantua, Richard, Asada, Keiichi, Azulay, Rebecca, Bach, Uwe, Baczko, Anne-Kathrin, Ball, David, Baloković, Mislav, Bandyopadhyay, Bidisha, Barrett, John, Bauböck, Michi, Benson, Bradford A., Bintley, Dan, Blackburn, Lindy, Blundell, Raymond, Bouman, Katherine L., Bower, Geoffrey C., Boyce, Hope, Bremer, Michael, Brissenden, Roger, Britzen, Silke, Broderick, Avery E., Broguiere, Dominique, Bronzwaer, Thomas, Bustamante, Sandra, Carlstrom, John E., Chael, Andrew, Chan, Chi-kwan, Chang, Dominic O., Chatterjee, Koushik, Chatterjee, Shami, Chen, Ming-Tang, Chen, Yongjun, Cheng, Xiaopeng, Cho, Ilje, Christian, Pierre, Conroy, Nicholas S., Conway, John E., Crawford, Thomas M., Crew, Geoffrey B., Cruz-Osorio, Alejandro, Cui, Yuzhu, Dahale, Rohan, Davelaar, Jordy, De Laurentis, Mariafelicia, Deane, Roger, Dempsey, Jessica, Desvignes, Gregory, Dexter, Jason, Dhruv, Vedant, Dihingia, Indu K., Doeleman, Sheperd S., Dzib, Sergio A., Eatough, Ralph P., Emami, Razieh, Falcke, Heino, Farah, Joseph, Fish, Vincent L., Fomalont, Edward, Ford, H. Alyson, Foschi, Marianna, Fraga-Encinas, Raquel, Freeman, William T., Friberg, Per, Fromm, Christian M., Fuentes, Antonio, Galison, Peter, Gammie, Charles F., García, Roberto, Gentaz, Olivier, Georgiev, Boris, Goddi, Ciriaco, Gold, Roman, Gómez-Ruiz, Arturo I., Gómez, José L., Gu, Minfeng, Gurwell, Mark, Hada, Kazuhiro, Haggard, Daryl, Hesper, Ronald, Heumann, Dirk, Ho, Luis C., Ho, Paul, Honma, Mareki, Huang, Chih-Wei L., Huang, Lei, Hughes, David H., Ikeda, Shiro, Violette Impellizzeri, C. M., Inoue, Makoto, Issaoun, Sara, James, David J., Jannuzi, Buell T., Janssen, Michael, Jeter, Britton, Jiang, Wu, Jiménez-Rosales, Alejandra

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Genome sequencing unveils a regulatory landscape of platelet reactivity von Keramati, Ali R., Chen, Ming-Huei, Rodriguez, Benjamin A. T., Yanek, Lisa R., Bhan, Arunoday, Gaynor, Brady J., Ryan, Kathleen, Brody, Jennifer A., Zhong, Xue, Wei, Qiang, Kammers, Kai, Kanchan, Kanika, Iyer, Kruthika, Kowalski, Madeline H., Pitsillides, Achilleas N., Cupples, L. Adrienne, Li, Bingshan, Schlaeger, Thorsten M., Shuldiner, Alan R., O’Connell, Jeffrey R., Ruczinski, Ingo, Mitchell, Braxton D., Faraday, Nauder, Taub, Margaret A., Becker, Lewis C., Lewis, Joshua P., Mathias, Rasika A., Johnson, Andrew D.

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STATE OF THE CLIMATE IN 2017 von BLUNDEN, J., HARTFIELD, G., ARNDT, D. S., DUNN, R. J. H., TYE, M. R., BLENKINSOP, S., DONAT, M., DURRE, I., ZIESE, M., COOPER, O. R., HEMMING, D. L., ABERNETHY, R., ARMITAGE, C., BOLMGREN, K., MYNENI, R., PARK, T., RICHARDSON, A. D., RUTISHÄUSER, T., SPARKS, T. H., THACKERAY, S. J., EAKIN, C. M., LIU, G., GOMEZ, A. M., DE LA COUR, J. L., HERON, S. F., SKIRVING, W. J., GEIGER, E. F., MARSH, B. L., TIRAK, K. V., STRONG, A. E., YOON, H., WIDLANSKY, M. J., THOMPSON, P. R., KLOTZBACH, P. J., VELDEN, C. S., ROTH, D. M., NIELSEN-GAMMON, J. W., OSBORNE, E., CRONIN, T., FARMER, J., BEHE, C., DANIEL, R., YORK, A., BHATT, U., THOMAN, R., ZIEL, R., SWART, S., CAMPBELL, E. C., HEUZÉ, C. H., JOHNSON, K., LIESER, J. L., MASSOM, R., MAZLOFF, M., MEREDITH, M., REID, P., SALLÉE, J.-B., STAMMERJOHN, S., MARTINEZ-SÁNCHEZ, O., TAKAHASHI, K., ALIAGA-NESTARES, V., AVALOS, G., BOUCHON, M., CASTRO, A., CRUZADO, L., DEWITTE, B., GUTIÉRREZ, D., LAVADO-CASIMIRO, W., MARENGO, J., MARTÍNEZ, A. G., MOSQUERA-VÁSQUEZ, K., QUISPE, N., ZHU, Z., LI, T., TOGAWA, H., TOBIN, S., JACOBS, S. J.

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