Trifluoroethylamines as amide isosteres in inhibitors of cathepsin K von Black, W. Cameron, Bayly, Christopher I., Davis, Dana E., Desmarais, Sylvie, Falgueyret, Jean-Pierre, Léger, Serge, Li, Chun Sing, Massé, Frédéric, McKay, Daniel J., Palmer, James T., Percival, M. David, Robichaud, Joël, Tsou, Nancy, Zamboni, Robert

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Antibody Conjugation of a Chimeric BET Degrader Enables in vivo Activity von Pillow, Thomas H., Adhikari, Pragya, Blake, Robert A., Chen, Jinhua, Del Rosario, Geoffrey, Deshmukh, Gauri, Figueroa, Isabel, Gascoigne, Karen E., Kamath, Amrita V., Kaufman, Susan, Kleinheinz, Tracy, Kozak, Katherine R., Latifi, Brandon, Leipold, Douglas D., Sing Li, Chun, Li, Ruina, Mulvihill, Melinda M., O'Donohue, Aimee, Rowntree, Rebecca K., Sadowsky, Jack D., Wai, John, Wang, Xinxin, Wu, Cong, Xu, Zijin, Yao, Hui, Yu, Shang‐Fan, Zhang, Donglu, Zang, Richard, Zhang, Hongyan, Zhou, Hao, Zhu, Xiaoyu, Dragovich, Peter S.

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Discovery of GuaB inhibitors with efficacy against Acinetobacter baumannii infection von Kofoed, Eric M, Aliagas, Ignacio, Crawford, Terry, Mao, Jialin, Harris, Seth F, Xu, Min, Wang, Shumei, Wu, Ping, Ma, Fang, Clark, Kevin, Sims, Jessica, Xu, Yiming, Peng, Yutian, Skippington, Elizabeth, Yang, Ying, Reeder, Janina, Ubhayakar, Savita, Baumgardner, Matt, Yan, Zhengyin, Chen, Jacob, Park, Summer, Zhang, Hua, Yen, Chun-Wan, Lorenzo, Maria, Skelton, Nicholas, Liang, Xiaorong, Chen, Liuxi, Hoag, Bridget, Li, Chun Sing, Liu, Zhiguo, Wai, John, Liu, Xingrong, Liang, Jun, Tan, Man Wah

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Rapid measurement of deuterium-labeled long-chain fatty acids in plasma by HPLC-ESI-MS von Gagné, Sébastien, Crane, Sheldon, Huang, Zheng, Li, Chun Sing, Bateman, Kevin P., Lévesque, Jean-François

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Development of a Liver-Targeted Stearoyl-CoA Desaturase (SCD) Inhibitor (MK-8245) to Establish a Therapeutic Window for the Treatment of Diabetes and Dyslipidemia von Oballa, Renata M, Belair, Liette, Black, W. Cameron, Bleasby, Kelly, Chan, Chi Chung, Desroches, Carole, Du, Xiaobing, Gordon, Robert, Guay, Jocelyne, Guiral, Sebastien, Hafey, Michael J, Hamelin, Emelie, Huang, Zheng, Kennedy, Brian, Lachance, Nicolas, Landry, France, Li, Chun Sing, Mancini, Joseph, Normandin, Denis, Pocai, Alessandro, Powell, David A, Ramtohul, Yeeman K, Skorey, Kathryn, Sørensen, Dan, Sturkenboom, Wayne, Styhler, Angela, Waddleton, Deena M, Wang, Hao, Wong, Simon, Xu, Lijing, Zhang, Lei

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Synthesis and biological activity of a potent and orally bioavailable SCD inhibitor (MF-438) von Léger, Serge, Black, W. Cameron, Deschenes, Denis, Dolman, Sarah, Falgueyret, Jean-Pierre, Gagnon, Marc, Guiral, Sébastien, Huang, Zheng, Guay, Jocelyne, Leblanc, Yves, Li, Chun-Sing, Massé, Frédéric, Oballa, Renata, Zhang, Lei

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Thiazole analog as stearoyl-CoA desaturase 1 inhibitor von Li, Chun Sing, Belair, Liette, Guay, Jocelyne, Murgasva, Renata, Sturkenboom, Wayne, Ramtohul, Yeeman K., Zhang, Lei, Huang, Zheng

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SAR and optimization of thiazole analogs as potent stearoyl-CoA desaturase inhibitors von Ramtohul, Yeeman K., Black, Cameron, Chan, Chi-Chung, Crane, Sheldon, Guay, Jocelyne, Guiral, Sébastien, Huang, Zheng, Oballa, Renata, Xu, Li-Jing, Zhang, Lei, Li, Chun Sing

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The identification of potent, selective, and bioavailable cathepsin S inhibitors von Gauthier, Jacques Yves, Black, W. Cameron, Courchesne, Isabelle, Cromlish, Wanda, Desmarais, Sylvie, Houle, Robert, Lamontagne, Sonia, Li, Chun Sing, Massé, Frédéric, McKay, Daniel J., Ouellet, Marc, Robichaud, Joël, Truchon, Jean-François, Truong, Vouy-Linh, Wang, Qingping, Percival, M. David

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Plasma-based approach to measure target engagement for liver-targeting stearoyl-CoA desaturase 1 inhibitors von Landry, France, Chan, Chi-Chung, Huang, Zheng, Leclair, Gregoire, Li, Chun Sing, Oballa, Renata, Zhang, Lei, Bateman, Kevin

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Bicyclic heteroaryl inhibitors of stearoyl-CoA desaturase: From systemic to liver-targeting inhibitors von Ramtohul, Yeeman K., Powell, David, Leclerc, Jean-Philippe, Leger, Serge, Oballa, Renata, Black, Cameron, Isabel, Elise, Li, Chun Sing, Crane, Sheldon, Robichaud, Joel, Guay, Jocelyne, Guiral, Sébastien, Zhang, Lei, Huang, Zheng

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Discovery of potent and liver-selective stearoyl-CoA desaturase (SCD) inhibitors in an acyclic linker series von Lachance, Nicolas, Guiral, Sébastien, Huang, Zheng, Leclerc, Jean-Philippe, Li, Chun Sing, Oballa, Renata M., Ramtohul, Yeeman K., Wang, Hao, Wu, Jin, Zhang, Lei

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Identification of a potent and selective non-basic cathepsin K inhibitor von Li, Chun Sing, Deschenes, Denis, Desmarais, Sylvie, Falgueyret, Jean-Pierre, Gauthier, Jacques Yves, Kimmel, Donald. B., Léger, Serge, Massé, Frédéric, McGrath, Mary E., McKay, Daniel J., Percival, M. David, Riendeau, Denis, Rodan, Sevgi B., Thérien, Michel, Truong, Vouy-Linh, Wesolowski, Gregg, Zamboni, Robert, Black, W. Cameron

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Conversion of systemically-distributed triazole-based stearoyl-CoA desaturase (SCD) uHTS hits into liver-targeted SCD inhibitors von Leclerc, Jean-Philippe, Falgueyret, Jean-Pierre, Girardin, Mélina, Guay, Jocelyne, Guiral, Sébastien, Huang, Zheng, Li, Chun Sing, Oballa, Renata, Ramtohul, Yeeman K., Skorey, Kathryn, Tawa, Paul, Wang, Hao, Zhang, Lei

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Cyclooxygenase-2 Inhibitors. Synthesis and Pharmacological Activities of 5-Methanesulfonamido-1-indanone Derivatives von Li, Chun-Sing, Black, W. Cameron, Chan, Chi-Chung, Ford-Hutchinson, Anthony W, Gauthier, Jacques-Yves, Gordon, Robert, Guay, Daniel, Kargman, Stacia, Lau, Cheuk K

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Synthesis of pyran-4-ones from isoxazoles von Li, Chun-Sing, Lacasse, Edith

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Difluoroethylamines as an amide isostere in inhibitors of cathepsin K von Isabel, Elise, Mellon, Christophe, Boyd, Michael J., Chauret, Nathalie, Deschênes, Denis, Desmarais, Sylvie, Falgueyret, Jean-Pierre, Gauthier, Jacques Yves, Khougaz, Karine, Lau, Cheuk K., Léger, Serge, Levorse, Dorothy A., Li, Chun Sing, Massé, Frédéric, David Percival, M., Roy, Bruno, Scheigetz, John, Thérien, Michel, Truong, Vouy Linh, Wesolowski, Gregg, Young, Robert N., Zamboni, Robert, Cameron Black, W.

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Structure based design of a series of potent and selective non peptidic PTP-1B inhibitors von LOU, Cheuk K, BAYLY, Christopher I, QINGPING WANG, SKOREY, Kathryn, WADDLETON, Deena, PAYETTE, Paul, RAMACHANDRAN, Chidambaram, KENNEDY, Brian P, SCAPIN, Giovana, GAUTHIER, Jacques Yves, CHUN SING LI, THERIEN, Michel, ASANTE-APPIAH, Ernest, CROMLISH, Wanda, BOIE, Yves, FORGHANI, Farnaz, DESMARAIS, Sylvie

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Pyridazinones as selective cyclooxygenase-2 inhibitors von Li, Chun Sing, Brideau, Christine, Chan, Chi Chung, Savoie, Chantal, Claveau, David, Charleson, Stella, Gordon, Robert, Greig, Gillian, Gauthier, Jacques Yves, Lau, Cheuk K, Riendeau, Denis, Thérien, Michel, Wong, Elizabeth, Prasit, Petpiboon

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Antibody-mediated delivery of chimeric protein degraders which target estrogen receptor alpha (ERα) von Dragovich, Peter S., Adhikari, Pragya, Blake, Robert A., Blaquiere, Nicole, Chen, Jinhua, Cheng, Yun-Xing, den Besten, Willem, Han, Jinping, Hartman, Steven J., He, Jintang, He, Mingtao, Rei Ingalla, Ellen, Kamath, Amrita V., Kleinheinz, Tracy, Lai, Tommy, Leipold, Douglas D., Li, Chun Sing, Liu, Qi, Lu, Jiawei, Lu, Ying, Meng, Fanwei, Meng, Lingyao, Ng, Carl, Peng, Kaishan, Lewis Phillips, Gail, Pillow, Thomas H., Rowntree, Rebecca K., Sadowsky, Jack D., Sampath, Deepak, Staben, Leanna, Staben, Steven T., Wai, John, Wan, Kunpeng, Wang, Xinxin, Wei, BinQing, Wertz, Ingrid E., Xin, Jianfeng, Xu, Keyang, Yao, Hui, Zang, Richard, Zhang, Donglu, Zhou, Hao, Zhao, Yongxin

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