Evidence for the critical role of transmembrane helices 1 and 7 in substrate transport by human P-glycoprotein (ABCB1) von Sajid, Andaleeb, Lusvarghi, Sabrina, Chufan, Eduardo E, Ambudkar, Suresh V

Volltext

Multiple transport-active binding sites are available for a single substrate on human P-glycoprotein (ABCB1) von Chufan, Eduardo E, Kapoor, Khyati, Sim, Hong-May, Singh, Satyakam, Talele, Tanaji T, Durell, Stewart R, Ambudkar, Suresh V

Volltext

Drug–protein hydrogen bonds govern the inhibition of the ATP hydrolysis of the multidrug transporter P-glycoprotein von Chufan, Eduardo E., Kapoor, Khyati, Ambudkar, Suresh V.

Volltext

Effects of a detergent micelle environment on P-glycoprotein (ABCB1)-ligand interactions von Shukla, Suneet, Abel, Biebele, Chufan, Eduardo E., Ambudkar, Suresh V.

Volltext

Reversing the direction of drug transport mediated by the human multidrug transporter P-glycoprotein von Sajid, Andaleeb, Lusvarghi, Sabrina, Murakami, Megumi, Chufan, Eduardo E., Abel, Biebele, Gottesman, Michael M., Durell, Stewart R., Ambudkar, Suresh V.

Volltext

Molecular Basis of the Polyspecificity of P-Glycoprotein (ABCB1): Recent Biochemical and Structural Studies von Chufan, Eduardo E, Sim, Hong-May, Ambudkar, Suresh V

Volltext

Global alteration of the drug-binding pocket of human P-glycoprotein (ABCB1) by substitution of fifteen conserved residues reveals a negative correlation between substrate size and... von Vahedi, Shahrooz, Chufan, Eduardo E., Ambudkar, Suresh V.

Volltext

Synthetic Analogs of Curcumin Modulate the Function of Multidrug Resistance–Linked ATP-Binding Cassette Transporter ABCG2 von Murakami, Megumi, Ohnuma, Shinobu, Fukuda, Michihiro, Chufan, Eduardo E., Kudoh, Katsuyoshi, Kanehara, Keigo, Sugisawa, Norihiko, Ishida, Masaharu, Naitoh, Takeshi, Shibata, Hiroyuki, Iwabuchi, Yoshiharu, Ambudkar, Suresh V., Unno, Michiaki

Volltext

Design and Synthesis of Human ABCB1 (P-Glycoprotein) Inhibitors by Peptide Coupling of Diverse Chemical Scaffolds on Carboxyl and Amino Termini of (S)‑Valine-Derived Thiazole Amino... von Singh, Satyakam, Prasad, Nagarajan Rajendra, Chufan, Eduardo E, Patel, Bhargav A, Wang, Yi-Jun, Chen, Zhe-Sheng, Ambudkar, Suresh V, Talele, Tanaji T

Volltext

Mutations in Intracellular Loops 1 and 3 Lead to Misfolding of Human P-glycoprotein (ABCB1) That Can Be Rescued by Cyclosporine A, Which Reduces Its Association with Chaperone Hsp7... von Kapoor, Khyati, Bhatnagar, Jaya, Chufan, Eduardo E., Ambudkar, Suresh V.

Volltext

Amidation of Bioactive Peptides: The Structure of the Lyase Domain of the Amidating Enzyme von Chufán, Eduardo E., De, Mithu, Eipper, Betty A., Mains, Richard E., Amzel, L. Mario

Volltext

PD173074, a selective FGFR inhibitor, reverses ABCB1-mediated drug resistance in cancer cells von Patel, Atish, Tiwari, Amit K., Chufan, Eduardo E., Sodani, Kamlesh, Anreddy, Nagaraju, Singh, Satyakam, Ambudkar, Suresh V., Stephani, Ralph, Chen, Zhe-Sheng

Volltext

Human–Mouse Chimeras with Normal Expression and Function Reveal That Major Domain Swapping Is Tolerated by P‑Glycoprotein (ABCB1) von Pluchino, Kristen M, Hall, Matthew D, Moen, Janna K, Chufan, Eduardo E, Fetsch, Patricia A, Shukla, Suneet, Gill, Deborah R, Hyde, Stephen C, Xia, Di, Ambudkar, Suresh V, Gottesman, Michael M

Volltext

Design, Synthesis, and Biological Evaluation of (S)-Valine Thiazole-Derived Cyclic and Noncyclic Peptidomimetic Oligomers as Modulators of Human P-Glycoprotein (ABCB1) von Singh, Satyakam, Prasad, Nagarajan Rajendra, Kapoor, Khyati, Chufan, Eduardo E., Patel, Bhargav A., Ambudkar, Suresh V., Talele, Tanaji T.

Volltext

Conserved Walker A Cysteines 431 and 1074 in Human P‑Glycoprotein Are Accessible to Thiol-Specific Agents in the Apo and ADP-Vanadate Trapped Conformations von Sim, Hong-May, Bhatnagar, Jaya, Chufan, Eduardo E, Kapoor, Khyati, Ambudkar, Suresh V

Volltext

How Much Binding Affinity Can be Gained by Filling a Cavity von Kawasaki, Yuko, Chufan, Eduardo E, Lafont, Virginie, Hidaka, Koushi, Kiso, Yoshiaki, Mario Amzel, L, Freire, Ernesto

Volltext

Synthetic Models for Heme−Copper Oxidases von Kim, Eunsuk, Chufán, Eduardo E, Kamaraj, Kaliappan, Karlin, Kenneth D

Volltext

Heme–Copper/Dioxygen Adduct Formation, Properties, and Reactivity von Chufán, Eduardo E, Puiu, Simona C, Karlin, Kenneth D

Volltext

Abstract 5217: Mechanism of polyspecificity of P-glycoprotein: Substitution of fifteen residues in the drug-binding pocket with tyrosine reveals a negative correlation between subs... von Vahedi, Shahrooz, Chufan, Eduardo, Ambudkar, Suresh V.

Volltext

Abstract 1270: Human P-glycoprotein-mediated drug transport: Two aromatic residues in the drug-binding pocket are critical for function von Murakami, Megumi, Chufan, Eduardo E., Lusvarghi, Sabrina, Ambudkar, Suresh V.

Volltext