Tumor-Promoting Desmoplasia Is Disrupted by Depleting FAP-Expressing Stromal Cells von Lo, Albert, Wang, Liang-Chuan S, Scholler, John, Monslow, James, Avery, Diana, Newick, Kheng, O'Brien, Shaun, Evans, Rebecca A, Bajor, David J, Clendenin, Cynthia, Durham, Amy C, Buza, Elizabeth L, Vonderheide, Robert H, June, Carl H, Albelda, Steven M, Puré, Ellen

Volltext

HDAC5 controls the functions of Foxp3+ T‐regulatory and CD8+ T cells von Xiao, Haiyan, Jiao, Jing, Wang, Liqing, O'Brien, Shaun, Newick, Kheng, Wang, Liang‐Chuan S., Falkensammer, Eva, Liu, Yujie, Han, Rongxiang, Kapoor, Veena, Hansen, Finn K., Kurz, Thomas, Hancock, Wayne W., Beier, Ulf H.

Volltext

Intra-tumoral delivery of CXCL11 via a vaccinia virus, but not by modified T cells, enhances the efficacy of adoptive T cell therapy and vaccines von Moon, Edmund K., Wang, Liang-Chuan S., Bekdache, Kheng, Lynn, Rachel C., Lo, Albert, Thorne, Stephen H., Albelda, Steven M.

Volltext

Expression of a Functional CCR2 Receptor Enhances Tumor Localization and Tumor Eradication by Retargeted Human T cells Expressing a Mesothelin-Specific Chimeric Antibody Receptor von MOON, Edmund K, CARPENITO, Carmine, JING SUN, WANG, Liang-Chuan S, KAPOOR, Veena, PREDINA, Jarrod, POWELL, Daniel J, RILEY, James L, JUNE, Carl H, ALBELDA, Steven M

Volltext

Characterization of INCB086550: A Potent and Novel Small-Molecule PD-L1 Inhibitor von Koblish, Holly K, Wu, Liangxing, Wang, Liang-Chuan S, Liu, Phillip C C, Wynn, Richard, Rios-Doria, Jonathan, Spitz, Susan, Liu, Hao, Volgina, Alla, Zolotarjova, Nina, Kapilashrami, Kanishk, Behshad, Elham, Covington, Maryanne, Yang, Yan-Ou, Li, Jingwei, Diamond, Sharon, Soloviev, Maxim, O'Hayer, Kevin, Rubin, Stephen, Kanellopoulou, Chrysi, Yang, Gengjie, Rupar, Mark, DiMatteo, Darlise, Lin, Luping, Stevens, Christina, Zhang, Yue, Thekkat, Pramod, Geschwindt, Ryan, Marando, Cindy, Yeleswaram, Swamy, Jackson, Jeff, Scherle, Peggy, Huber, Reid, Yao, Wenqing, Hollis, Gregory

Volltext

Targeting Fibroblast Activation Protein in Tumor Stroma with Chimeric Antigen Receptor T Cells Can Inhibit Tumor Growth and Augment Host Immunity without Severe Toxicity von WANG, Liang-Chuan S, LO, Albert, SOLOMIDES, Charalambos C, JUNE, Carl H, PURE, Ellen, ALBELDA, Steven M, SCHOLLER, John, JING SUN, MAJUMDAR, Rajrupa S, KAPOOR, Veena, ANTZIS, Michael, COTNER, Cody E, JOHNSON, Laura A, DURHAM, Amy C

Volltext

Changes in the local tumor microenvironment in recurrent cancers may explain the failure of vaccines after surgery von Predina, Jarrod, Eruslanov, Evgeniy, Judy, Brendan, Kapoor, Veena, Cheng, Guanjun, Wang, Liang-Chuan, Sun, Jing, Moon, Edmund K., Fridlender, Gregorio, Albelda, Steven, Singhal, Sunil

Volltext

CCL2 Blockade Augments Cancer Immunotherapy von FRIDLENDER, Zvi G, BUCHLIS, George, ALBELDA, Steven M, KAPOOR, Veena, GUANJUN CHENG, JING SUN, SINGHAL, Sunil, CRISANTI, Cecilia, WANG, Liang-Chuan S, HEITJAN, Daniel, SNYDER, Linda A

Volltext

Enhanced Effector Responses in Activated CD8+ T Cells Deficient in Diacylglycerol Kinases von RIESE, Matthew J, WANG, Liang-Chuan S, MOON, Edmund K, JOSHI, Rohan P, RANGANATHAN, Anjana, JUNE, Carl H, KORETZKY, Gary A, ALBELDA, Steven M

Volltext

Treating Tumors With a Vaccinia Virus Expressing IFNβ Illustrates the Complex Relationships Between Oncolytic Ability and Immunogenicity von Wang, Liang-Chuan S, Lynn, Rachel C, Cheng, Guanjun, Alexander, Edward, Kapoor, Veena, Moon, Edmund K, Sun, Jing, Fridlender, Zvi G, Isaacs, Stuart N, Thorne, Stephen H, Albelda, Steven M

Volltext

CD11b+Ly6G+ cells inhibit tumor growth by suppressing IL-17 production at early stages of tumorigenesis von Liu, Yuhong, O'Leary, Claire E., Wang, Liang-Chuan S., Bhatti, Tricia R., Dai, Ning, Kapoor, Veena, Liu, Peihui, Mei, Junjie, Guo, Lei, Oliver, Paula M., Albelda, Steven M., Worthen, G. Scott

Volltext

Ligand-Induced Degradation of a CAR Permits Reversible Remote Control of CAR T Cell Activity In Vitro and In Vivo von Richman, Sarah A., Wang, Liang-Chuan, Moon, Edmund K., Khire, Uday R., Albelda, Steven M., Milone, Michael C.

Volltext

Pharmacologic activation of the innate immune system to prevent respiratory viral infections von Cheng, Guanjun, Wang, Liang-Chuan S, Fridlender, Zvi G, Cheng, Guang-Shing, Chen, Bei, Mangalmurti, Nilam S, Saloura, Vassiliki, Yu, Zaifang, Kapoor, Veena, Mozdzanowska, Krystyna, Moon, Edmund, Sun, Jing, Kreindler, James L, Cohen, Noam A, Caton, Andrew J, Erikson, Jan, Albelda, Steven M

Volltext

Evaluation of an Attenuated Vesicular Stomatitis Virus Vector Expressing Interferon-β for Use in Malignant Pleural Mesothelioma: Heterogeneity in Interferon Responsiveness Defines... von SALOURA, Vassiliki, WANG, Liang-Chuan S, VILE, Richard G, FEDERSPIEL, Mark J, RUSSELL, Stephen J, LITZKY, Leslie, ALBELDA, Steven M, FRIDLENDER, Zvi G, JING SUN, GUANJUN CHENG, KAPOOR, Veena, STERMAN, Daniel H, HARTY, Ronald N, OKUMURA, Atsushi, BARBER, Glen N

Volltext

A human CD137×PD-L1 bispecific antibody promotes anti-tumor immunity via context-dependent T cell costimulation and checkpoint blockade von Geuijen, Cecile, Tacken, Paul, Wang, Liang-Chuan, Klooster, Rinse, van Loo, Pieter Fokko, Zhou, Jing, Mondal, Arpita, Liu, Yao-bin, Kramer, Arjen, Condamine, Thomas, Volgina, Alla, Hendriks, Linda J. A., van der Maaden, Hans, Rovers, Eric, Engels, Steef, Fransen, Floris, den Blanken-Smit, Renate, Zondag-van der Zande, Vanessa, Basmeleh, Abdul, Bartelink, Willem, Kulkarni, Ashwini, Marissen, Wilfred, Huang, Cheng-Yen, Hall, Leslie, Harvey, Shane, Kim, Soyeon, Martinez, Marina, O’Brien, Shaun, Moon, Edmund, Albelda, Steven, Kanellopoulou, Chrysi, Stewart, Shaun, Nastri, Horacio, Bakker, Alexander B. H., Scherle, Peggy, Logtenberg, Ton, Hollis, Gregory, de Kruif, John, Huber, Reid, Mayes, Patrick A., Throsby, Mark

Volltext

Activation of mitogen-activated protein kinases by 5,6-dimethylxanthenone-4-acetic acid (DMXAA) plays an important role in macrophage stimulation von Sun, Jing, Wang, Liang-Chuan S., Fridlender, Zvi G., Kapoor, Veena, Cheng, Guanjun, Ching, Lai-Ming, Albelda, Steven M.

Volltext

814 MCLA-145 (CD137xPD-L1): a potent CD137 agonist and immune checkpoint inhibitor that that does not show signs of peripheral toxicity von Bol, Kees, Marissen, Wilfred, Elaissais-Schaap, Jeroen, Tacken, Paul, Engels, Steef, Wang, Liang-Chuan, Mondal, Arpita, Throsby, Mark, Roberts, Alan, Mayes, Patrick, Geuijen, Cecile

Volltext

Overcoming intrinsic inhibitory pathways to augment the antineoplastic activity of adoptively transferred T cells: Re-tuning your CAR before hitting a rocky road von Wang, Liang-Chuan, Riese, Matthew, Moon, Edmund, Albelda, Steven M.

Volltext

820 MCLA-145 is a bispecific IgG1 antibody that inhibits PD-1/PD-L1 signaling while simultaneously activating CD137 signaling on T cells von Tacken, Paul, Wang, Liang-chuan, Klooster, Rinse, Loo, Pieter Fokko Van, Zhou, Jing, Mondal, Arpita, Liu, Yao-Bin, Kramer, Arjen, Condamine, Thomas, Volgina, Alla, Hendriks, Linda, Maaden, Hans van der, Rovers, Eric, Engels, Steef, Fransen, Floris, Blanken-Smit, Renate den, Zande, Vanessa Zondag-van der, Basmeleh, Abdul, Bartelink, Willem, Kulkarni, Ashwini, Marissen, Wilfred, Huang, Cheng-Yen, Hall, Leslie, Harvey, Shane, Kanellopoulou, Chrysi, Stewart, Shaun, Nastri, Horacio, Bakker, Lex, Logtenberg, Ton, Plyte, Simon, Mayes, Patrick, Throsby, Mark, Geuijen, Cecile

Volltext

Synthesis and Biological Activity of Azido Analogues of 5,6-Dimethylxanthenone-4-acetic Acid for Use in Photoaffinity Labeling von Palmer, Brian D, Henare, Kimiora, Woon, See-Tarn, Sutherland, Rachel, Reddy, Charu, Wang, Liang-Chuan S, Kieda, Claudine, Ching, Lai-Ming

Volltext