The Nrf2 cell defence pathway: Keap1-dependent and -independent mechanisms of regulation von Bryan, Holly K., Olayanju, Adedamola, Goldring, Christopher E., Park, B. Kevin

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ERK5: Structure, regulation and function von Nithianandarajah-Jones, Gopika N., Wilm, Bettina, Goldring, Christopher E.P., Müller, Jürgen, Cross, Michael J.

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Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models von Weaver, Richard J., Blomme, Eric A., Chadwick, Amy E., Copple, Ian M., Gerets, Helga H. J., Goldring, Christopher E., Guillouzo, Andre, Hewitt, Philip G., Ingelman-Sundberg, Magnus, Jensen, Klaus Gjervig, Juhila, Satu, Klingmüller, Ursula, Labbe, Gilles, Liguori, Michael J., Lovatt, Cerys A., Morgan, Paul, Naisbitt, Dean J., Pieters, Raymond H. H., Snoeys, Jan, van de Water, Bob, Williams, Dominic P., Park, B. Kevin

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Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defence and lipid metabolism as primary Nrf2-dependent pathways in the liver von Kitteringham, Neil R., Abdullah, Azman, Walsh, Joanne, Randle, Laura, Jenkins, Rosalind E., Sison, Rowena, Goldring, Christopher E.P., Powell, Helen, Sanderson, Christopher, Williams, Samantha, Higgins, Larry, Yamamoto, Masayuki, Hayes, John, Park, B. Kevin

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Mechanistic biomarkers provide early and sensitive detection of acetaminophen‐induced acute liver injury at first presentation to hospital von Antoine, Daniel J., Dear, James W., Lewis, Philip Starkey, Platt, Vivien, Coyle, Judy, Masson, Moyra, Thanacoody, Ruben H., Gray, Alasdair J., Webb, David J., Moggs, Jonathan G., Bateman, D. Nicholas, Goldring, Christopher E., Park, B. Kevin

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Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease von Bell, Catherine C., Hendriks, Delilah F. G., Moro, Sabrina M. L., Ellis, Ewa, Walsh, Joanne, Renblom, Anna, Fredriksson Puigvert, Lisa, Dankers, Anita C. A., Jacobs, Frank, Snoeys, Jan, Sison-Young, Rowena L., Jenkins, Rosalind E., Nordling, Åsa, Mkrtchian, Souren, Park, B. Kevin, Kitteringham, Neil R., Goldring, Christopher E. P., Lauschke, Volker M., Ingelman-Sundberg, Magnus

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Massive rearrangements of cellular MicroRNA signatures are key drivers of hepatocyte dedifferentiation von Lauschke, Volker M., Vorrink, Sabine U., Moro, Sabrina M.L., Rezayee, Fatemah, Nordling, Åsa, Hendriks, Delilah F.G., Bell, Catherine C., Sison‐Young, Rowena, Park, B. Kevin, Goldring, Christopher E., Ellis, Ewa, Johansson, Inger, Mkrtchian, Souren, Andersson, Tommy B., Ingelman‐Sundberg, Magnus

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Comparative Proteomic Characterization of 4 Human Liver-Derived Single Cell Culture Models Reveals Significant Variation in the Capacity for Drug Disposition, Bioactivation, and De... von Sison-Young, Rowena L C, Mitsa, Dimitra, Jenkins, Rosalind E, Mottram, David, Alexandre, Eliane, Richert, Lysiane, Aerts, Hélène, Weaver, Richard J, Jones, Robert P, Johann, Esther, Hewitt, Philip G, Ingelman-Sundberg, Magnus, Goldring, Christopher E P, Kitteringham, Neil R, Park, B Kevin

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Brusatol provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicity—implications for therapeutic targeting of Nrf2 von Olayanju, Adedamola, Copple, Ian M., Bryan, Holly K., Edge, George T., Sison, Rowena L., Wong, Min Wei, Lai, Zheng-Quan, Lin, Zhi-Xiu, Dunn, Karen, Sanderson, Christopher M., Alghanem, Ahmad F., Cross, Michael J., Ellis, Ewa C., Ingelman-Sundberg, Magnus, Malik, Hassan Z., Kitteringham, Neil R., Goldring, Christopher E., Park, B. Kevin

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Pharmacological Activation of Nrf2 Enhances Functional Liver Regeneration von Chan, Benjamin K.Y., Elmasry, Mohamed, Forootan, Shiva S., Russomanno, Giusy, Bunday, Tobias M., Zhang, Fang, Brillant, Nathalie, Starkey Lewis, Philip J., Aird, Rhona, Ricci, Emanuele, Andrews, Timothy D., Sison‐Young, Rowena L., Schofield, Amy L., Fang, Yongxiang, Lister, Adam, Sharkey, Jack W., Poptani, Harish, Kitteringham, Neil R., Forbes, Stuart J., Malik, Hassan Z., Fenwick, Stephen W., Park, B. Kevin, Goldring, Christopher E., Copple, Ian M.

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Limitations of acetaminophen as a reference hepatotoxin for the evaluation of in vitro liver models von Livoti, Lucia A, Sison-Young, Rowena, Reddyhoff, Dennis, Fisher, Ciarán P, Gardner, Iain, Diaz-Nieto, Rafael, Goldring, Christopher E, Copple, Ian M

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Identification and quantification of the basal and inducible Nrf2-dependent proteomes in mouse liver: Biochemical, pharmacological and toxicological implications von Walsh, Joanne, Jenkins, Rosalind E., Wong, Michael, Olayanju, Adedamola, Powell, Helen, Copple, Ian, O’Neill, Paul M., Goldring, Christopher E.P., Kitteringham, Neil R., Park, B. Kevin

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A novel chemically directed route for the generation of definitive endoderm from human embryonic stem cells based on inhibition of GSK-3 von Bone, Heather K, Nelson, Adam S, Goldring, Christopher E, Tosh, David, Welham, Melanie J

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Application of porcine gastrointestinal organoid units as a potential in vitro tool for drug discovery and development von Olayanju, Adedamola, Jones, Lauren, Greco, Karin, Goldring, Christopher E., Ansari, Tahera

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The Nrf2-Keapl defence pathway : Role in protection against drug-induced toxicity von COPPLE, Ian M, GOLDRING, Christopher E, KITTERINGHAM, Neil R, PARK, B. Kevin

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The Nrf2–Keap1 defence pathway: Role in protection against drug-induced toxicity von Copple, Ian M, Goldring, Christopher E, Kitteringham, Neil R, Park, B. Kevin

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Gene Signatures Reduce the Stress of Preclinical Drug Hepatotoxicity Screening von Copple, Ian M., Park, B. Kevin, Goldring, Christopher E., Corey, Kathleen E., Malhi, Harmeet

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VEGF Stimulates Activation of ERK5 in the Absence of C-Terminal Phosphorylation Preventing Nuclear Localization and Facilitating AKT Activation in Endothelial Cells von Mondru, Anil Kumar, Aljasir, Mohammad A, Alrumayh, Ahmed, Nithianandarajah, Gopika N, Ahmed, Katie, Muller, Jurgen, Goldring, Christopher E P, Wilm, Bettina, Cross, Michael J

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Safety perspectives on presently considered drugs for the treatment of COVID‐19 von Penman, Sophie L., Kiy, Robyn T., Jensen, Rebecca L., Beoku‐Betts, Christopher, Alfirevic, Ana, Back, David, Khoo, Saye H., Owen, Andrew, Pirmohamed, Munir, Park, B. Kevin, Meng, Xiaoli, Goldring, Christopher E., Chadwick, Amy E.

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The Generation, Detection, and Effects of Reactive Drug Metabolites von Stachulski, Andrew V., Baillie, Thomas A., Kevin Park, B., Scott Obach, R., Dalvie, Deepak K., Williams, Dominic P., Srivastava, Abhishek, Regan, Sophie L., Antoine, Daniel J., Goldring, Christopher E. P., Chia, Alvin J. L., Kitteringham, Neil R., Randle, Laura E., Callan, Hayley, Castrejon, J. Luis, Farrell, John, Naisbitt, Dean J., Lennard, Martin S.

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