RUNX1-targeted therapy for AML expressing somatic or germline mutation in RUNX1 von Mill, Christopher P., Fiskus, Warren, DiNardo, Courtney D., Qian, Yimin, Raina, Kanak, Rajapakshe, Kimal, Perera, Dimuthu, Coarfa, Cristian, Kadia, Tapan M., Khoury, Joseph D., Saenz, Dyana T., Saenz, David N., Illendula, Anuradha, Takahashi, Koichi, Kornblau, Steven M., Green, Michael R., Futreal, Andrew P., Bushweller, John H., Crews, Craig M., Bhalla, Kapil N.

Volltext

Activity of menin inhibitor ziftomenib (KO-539) as monotherapy or in combinations against AML cells with MLL1 rearrangement or mutant NPM1 von Fiskus, Warren, Daver, Naval, Boettcher, Steffen, Mill, Christopher P., Sasaki, Koji, Birdwell, Christine E., Davis, John A., Das, Kaberi, Takahashi, Koichi, Kadia, Tapan M., DiNardo, Courtney D., Burrows, Francis, Loghavi, Sanam, Khoury, Joseph D., Ebert, Benjamin L., Bhalla, Kapil N.

Volltext

Effective therapy for AML with RUNX1 mutation by cotreatment with inhibitors of protein translation and BCL2 von Mill, Christopher P., Fiskus, Warren, DiNardo, Courtney D., Birdwell, Christine, Davis, John A., Kadia, Tapan M., Takahashi, Koichi, Short, Nicholas, Daver, Naval, Ohanian, Maro, Borthakur, Gautam, Kornblau, Steven M., Green, Michael R., Qi, Yuan, Su, Xiaoping, Khoury, Joseph D., Bhalla, Kapil N.

Volltext

Effective Menin inhibitor-based combinations against AML with MLL rearrangement or NPM1 mutation (NPM1c) von Fiskus, Warren, Boettcher, Steffen, Daver, Naval, Mill, Christopher P., Sasaki, Koji, Birdwell, Christine E., Davis, John A., Takahashi, Koichi, Kadia, Tapan M., DiNardo, Courtney D., Jin, Qi, Qi, Yuan, Su, Xiaoping, McGeehan, Gerard M., Khoury, Joseph D., Ebert, Benjamin L., Bhalla, Kapil N.

Volltext

BET protein bromodomain inhibitor-based combinations are highly active against post-myeloproliferative neoplasm secondary AML cells von Saenz, D T, Fiskus, W, Manshouri, T, Rajapakshe, K, Krieger, S, Sun, B, Mill, C P, DiNardo, C, Pemmaraju, N, Kadia, T, Parmar, S, Sharma, S, Coarfa, C, Qiu, P, Verstovsek, S, Bhalla, K N

Volltext

Targeting of epigenetic co-dependencies enhances anti-AML efficacy of Menin inhibitor in AML with MLL1-r or mutant NPM1 von Fiskus, Warren, Mill, Christopher P., Birdwell, Christine, Davis, John A., Das, Kaberi, Boettcher, Steffen, Kadia, Tapan M., DiNardo, Courtney D., Takahashi, Koichi, Loghavi, Sanam, Soth, Michael J., Heffernan, Tim, McGeehan, Gerard M., Ruan, Xinjia, Su, Xiaoping, Vakoc, Christopher R., Daver, Naval, Bhalla, Kapil N.

Volltext

The Yin and Yang of ERBB4: Tumor Suppressor and Oncoprotein von Lucas, Lauren M, Dwivedi, Vipasha, Senfeld, Jared I, Cullum, Richard L, Mill, Christopher P, Piazza, J Tyler, Bryant, Ianthe N, Cook, Laura J, Miller, S Tyler, Lott, 4th, James H, Kelley, Connor M, Knerr, Elizabeth L, Markham, Jessica A, Kaufmann, David P, Jacobi, Megan A, Shen, Jianzhong, Riese, 2nd, David J

Volltext

EVI1 dysregulation: impact on biology and therapy of myeloid malignancies von Birdwell, Christine, Fiskus, Warren, Kadia, Tapan M., DiNardo, Courtney D., Mill, Christopher P., Bhalla, Kapil N.

Volltext

Patterns and history of prescription drug use among opioid-related drug overdose cases in British Columbia, Canada, 2015–2016 von Smolina, Kate, Crabtree, Alexis, Chong, Mei, Zhao, Bin, Park, Mina, Mill, Christopher, Schütz, Christian G.

Volltext

Preclinical efficacy of targeting epigenetic mechanisms in AML with 3q26 lesions and EVI1 overexpression von Birdwell, Christine E., Fiskus, Warren, Kadia, Tapan M., Mill, Christopher P., Sasaki, Koji, Daver, Naval, DiNardo, Courtney D., Pemmaraju, Naveen, Borthakur, Gautam, Davis, John A., Das, Kaberi, Sharma, Sunil, Horrigan, Stephen, Ruan, Xinjia, Su, Xiaoping, Khoury, Joseph D., Kantarjian, Hagop, Bhalla, Kapil N.

Volltext

SIRT2 Deacetylates and Inhibits the Peroxidase Activity of Peroxiredoxin-1 to Sensitize Breast Cancer Cells to Oxidant Stress-Inducing Agents von Fiskus, Warren, Coothankandaswamy, Veena, Chen, Jianguang, Ma, Hongwei, Ha, Kyungsoo, Saenz, Dyana T, Krieger, Stephanie S, Mill, Christopher P, Sun, Baohua, Huang, Peng, Mumm, Jeffrey S, Melnick, Ari M, Bhalla, Kapil N

Volltext

Causal linkage of presence of mutant NPM1 to efficacy of novel therapeutic agents against AML cells with mutant NPM1 von Mill, Christopher P., Fiskus, Warren, Das, Kaberi, Davis, John A., Birdwell, Christine E., Kadia, Tapan M., DiNardo, Courtney D., Daver, Naval, Takahashi, Koichi, Sasaki, Koji, McGeehan, Gerard M., Ruan, Xinjia, Su, Xiaoping, Loghavi, Sanam, Kantarjian, Hagop, Bhalla, Kapil N.

Volltext

Dynamic Regulation of Long-Chain Fatty Acid Oxidation by a Noncanonical Interaction between the MCL-1 BH3 Helix and VLCAD von Escudero, Silvia, Zaganjor, Elma, Lee, Susan, Mill, Christopher P., Morgan, Ann M., Crawford, Emily B., Chen, Jiahao, Wales, Thomas E., Mourtada, Rida, Luccarelli, James, Bird, Gregory H., Steidl, Ulrich, Engen, John R., Haigis, Marcia C., Opferman, Joseph T., Walensky, Loren D.

Volltext

BET proteolysis targeted chimera-based therapy of novel models of Richter Transformation-diffuse large B-cell lymphoma von Fiskus, Warren, Mill, Christopher P., Perera, Dimuthu, Birdwell, Christine, Deng, Qing, Yang, Haopeng, Lara, Bernardo H., Jain, Nitin, Burger, Jan, Ferrajoli, Alessandra, Davis, John A., Saenz, Dyana T., Jin, Wendy, Coarfa, Cristian, Crews, Craig M., Green, Michael R., Khoury, Joseph D., Bhalla, Kapil N.

Volltext

Mechanistic basis and efficacy of targeting the β-catenin–TCF7L2–JMJD6–c-Myc axis to overcome resistance to BET inhibitors von Saenz, Dyana T., Fiskus, Warren, Mill, Christopher P., Perera, Dimuthu, Manshouri, Taghi, Lara, Bernardo H., Karkhanis, Vrajesh, Sharma, Sunil, Horrigan, Stephen K., Bose, Prithviraj, Kadia, Tapan M., Masarova, Lucia, DiNardo, Courtney D., Borthakur, Gautam, Khoury, Joseph D., Takahashi, Koichi, Bhaskara, Srividya, Lin, Charles Y., Green, Michael R., Coarfa, Cristian, Crews, Craig M., Verstovsek, Srdan, Bhalla, Kapil N.

Volltext

Targeting nuclear β-catenin as therapy for post-myeloproliferative neoplasm secondary AML von Saenz, Dyana T., Fiskus, Warren, Manshouri, Taghi, Mill, Christopher P., Qian, Yimin, Raina, Kanak, Rajapakshe, Kimal, Coarfa, Cristian, Soldi, Raffaella, Bose, Prithviraj, Borthakur, Gautam, Kadia, Tapan M., Khoury, Joseph D., Masarova, Lucia, Nowak, Agnieszka J., Sun, Baohua, Saenz, David N., Kornblau, Steven M., Horrigan, Steve, Sharma, Sunil, Qiu, Peng, Crews, Craig M., Verstovsek, Srdan, Bhalla, Kapil N.

Volltext

Efficacy of novel agents against cellular models of familial platelet disorder with myeloid malignancy (FPD-MM) von Mill, Christopher P., Fiskus, Warren C., DiNardo, Courtney D., Reville, Patrick, Davis, John A., Birdwell, Christine E., Das, Kaberi, Hou, Hanxi, Takahashi, Koichi, Flores, Lauren, Ruan, Xinjia, Su, Xiaoping, Loghavi, Sanam, Khoury, Joseph D., Bhalla, Kapil N.

Volltext

Development and application of high-throughput screens for the discovery of compounds that disrupt ErbB4 signaling: Candidate cancer therapeutics von Cullum, Richard L, Lucas, Lauren M, Senfeld, Jared I, Piazza, John T, Neel, Logan T, Whig, Kanupriya, Zhai, Ling, Harris, Mackenzie H, Rael, Cristina C, Taylor, Darby C, Cook, Laura J, Kaufmann, David P, Mill, Christopher P, Jacobi, Megan A, Smith, Forrest T, Suto, Mark, Bostwick, Robert, Gupta, Ram B, David, Allan E, Riese Ii, David J

Volltext

Efficacy of CDK9 inhibition in therapy of post-myeloproliferative neoplasm (MPN) secondary (s) AML cells von Fiskus, Warren, Manshouri, Taghi, Birdwell, Christine, Mill, Christopher P., Masarova, Lucia, Bose, Prithviraj, Kadia, Tapan M., Daver, Naval, DiNardo, Courtney D., Borthakur, Gautam, Khoury, Joseph D., Verstovsek, Srdan, Bhalla, Kapil N.

Volltext

Superior efficacy of cotreatment with BET protein inhibitor and BCL2 or MCL1 inhibitor against AML blast progenitor cells von Fiskus, Warren, Cai, Tianyu, DiNardo, Courtney D., Kornblau, Steven M., Borthakur, Gautam, Kadia, Tapan M., Pemmaraju, Naveen, Bose, Prithviraj, Masarova, Lucia, Rajapakshe, Kimal, Perera, Dimuthu, Coarfa, Cristian, Mill, Christopher P., Saenz, Dyana T., Saenz, David N., Sun, Baohua, Khoury, Joseph D., Shen, Yu, Konopleva, Marina, Bhalla, Kapil N.

Volltext