Heterozygous mutations in PALB2 cause DNA replication and damage response defects von Nikkilä, Jenni, Christin Parplys, Ann, Pylkäs, Katri, Bose, Muthiah, Huo, Yanying, Borgmann, Kerstin, Rapakko, Katrin, Nieminen, Pentti, Xia, Bing, Pospiech, Helmut, Winqvist, Robert

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Cdc45 is limiting for replication initiation in humans von Köhler, Carsten, Koalick, Dennis, Fabricius, Anja, Parplys, Ann Christin, Borgmann, Kerstin, Pospiech, Helmut, Grosse, Frank

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Impaired Degradation of Neutrophil Extracellular Traps: A Possible Severity Factor of Elderly Male COVID-19 Patients von de Buhr, Nicole, Parplys, Ann Christin, Schroeder, Maria, Henneck, Timo, Schaumburg, Berfin, Stanelle-Bertram, Stephanie, Jarczak, Dominik, Nierhaus, Axel, Hiller, Jens, Peine, Sven, Kluge, Stefan, Klingel, Karin, Gabriel, Gülsah, von Köckritz-Blickwede, Maren

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Prevention of DNA Replication Stress by CHK1 Leads to Chemoresistance Despite a DNA Repair Defect in Homologous Recombination in Breast Cancer von Meyer, Felix, Becker, Saskia, Classen, Sandra, Parplys, Ann Christin, Mansour, Wael Yassin, Riepen, Britta, Timm, Sara, Ruebe, Claudia, Jasin, Maria, Wikman, Harriet, Petersen, Cordula, Rothkamm, Kai, Borgmann, Kerstin

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DNA damage by X-rays and their impact on replication processes von Parplys, Ann Christin, Petermann, Eva, Petersen, Cordula, Dikomey, Ekkehard, Borgmann, Kerstin

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BRCA1 mislocalization leads to aberrant DNA damage response in heterozygous ABRAXAS1 mutation carrier cells von Bose, Muthiah, Sachsenweger, Juliane, Laurila, Niina, Parplys, Ann Christin, Willmann, Jonas, Jungwirth, Johannes, Groth, Marco, Rapakko, Katrin, Nieminen, Pentti, Friedl, Thomas W P, Heiserich, Lisa, Meyer, Felix, Tuppurainen, Hanna, Peltoketo, Hellevi, Nevanlinna, Heli, Pylkäs, Katri, Borgmann, Kerstin, Wiesmüller, Lisa, Winqvist, Robert, Pospiech, Helmut

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Dual PI3K/mTOR Inhibitor NVP-BEZ235 Leads to a Synergistic Enhancement of Cisplatin and Radiation in Both HPV-Negative and -Positive HNSCC Cell Lines von Subtil, Florentine S. B., Gröbner, Carolin, Recknagel, Niklas, Parplys, Ann Christin, Kohl, Sibylla, Arenz, Andrea, Eberle, Fabian, Dikomey, Ekkehard, Engenhart-Cabillic, Rita, Schötz, Ulrike

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Exploiting Chromosomal Instability of PTEN-Deficient Triple-Negative Breast Cancer Cell Lines for the Sensitization Against PARP1 Inhibition in a Replication-Dependent Manner von Rieckhoff, Johanna, Meyer, Felix, Classen, Sandra, Zielinski, Alexandra, Riepen, Britta, Wikman, Harriet, Petersen, Cordula, Rothkamm, Kai, Borgmann, Kerstin, Parplys, Ann Christin

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High levels of RAD51 perturb DNA replication elongation and cause unscheduled origin firing due to impaired CHK1 activation von Parplys, Ann Christin, Seelbach, Jasna Irena, Becker, Saskia, Behr, Matthias, Wrona, Agnieszka, Jend, Camilla, Mansour, Wael Yassin, Joosse, Simon Andreas, Stuerzbecher, Horst-Werner, Pospiech, Helmut, Petersen, Cordula, Dikomey, Ekkehard, Borgmann, Kerstin

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Directed Alternative Splicing in Nijmegen Breakage Syndrome: Proof of Principle Concerning Its Therapeutical Application von Salewsky, Bastian, Hildebrand, Gabriele, Rothe, Susanne, Parplys, Ann Christin, Radszewski, Janina, Kieslich, Moritz, Wessendorf, Petra, Krenzlin, Harald, Borgmann, Kerstin, Nussenzweig, André, Sperling, Karl, Digweed, Martin

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Abstract 339: Heterozygous germline mutation in ABRAXAS causes BRCA1 mislocalization and DNA damage response defects von Winqvist, Robert, Bose, Muthiah, Sachsenweger, Juliane, Laurila, Niina, Parplys, Ann Christin, Willmann, Jonas, Eshraghi, Leila, Dunlop, Thomas W., Groth, Marco, Rapakko, Katrin, Nieminen, Pentti, Friedl, Thomas W., Heiserich, Lisa, Meyer, Felix, Tuppurainen, Hanna, Devarajan, Ganapathy Raman, Peltoketo, Hellevi, Nevanlinna, Heli, Pylkäs, Katri, Borgmann, Kerstin, Wiesmuller, Lisa, Pospiech, Helmut

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CBMT-16. EGFRvIII EXPRESSION CONFERS CHEMOSENSITIVITY BY INCREASING DNA MISMATCH REPAIR PROTEIN EXPRESSION AND REPLICATION STRESS von Struve, Nina, Binder, Zev A, Stead, Lucy F, Brend, Tim, Bagley, Stephen J, Faulkner, Claire, Ott, Leonie, Müller-Goebel, Justus, Weik, Anna-Sophie, Hoffer, Konstantin, Rieckmann, Thorsten, Christin Parplys, Ann, Burmester, Jasmin, Henze, Marvin, Morrissette, Jennifer J D, Schüller, Ulrich, Petersen, Cordula, Rothkamm, Kai, Kurian, Kathreena M, Short, Susan C, Kriegs, Malte

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Constitutive gp130 activation rapidly accelerates the transformation of human hepatocytes via an impaired oxidative stress response von Heim, Denise, Gil-Ibanez, Ines, Herden, Johannes, Parplys, Ann Christin, Borgmann, Kerstin, Schmidt-Arras, Dirk, Lohse, Ansgar W, Rose-John, Stefan, Wege, Henning

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Increased replication stress and R-loop accumulation in EGFRvIII-expressing glioblastoma present new therapeutic opportunities von Struve, Nina, Hoffer, Konstantin, Weik, Anna-Sophie, Riepen, Britta, Krug, Leonie, Cetin, Meryem H, Burmester, Jasmin, Ott, Leonie, Liebing, Jana, Gatzemeier, Fruzsina, Müller-Goebel, Justus, Gerbach, Mirja, Bußmann, Lara, Parplys, Ann Christin, Unger, Kristian, Mansour, Wael Y, Schüller, Ulrich, Rieckmann, Thorsten, Petersen, Cordula, Rothkamm, Kai, Short, Susan C, Kriegs, Malte

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High levels of RAD51 perturb DNA replication elongation and cause unscheduled origin firing due to impaired CHK1 activation von Parplys, Ann Christin, Seelbach, Jasna Irena, Becker, Saskia, Behr, Matthias, Wrona, Agnieszka, Jend, Camilla, Mansour, Wael Yassin, Joosse, Simon Andreas, Horst-Werner Stuerzbecher, Pospiech, Helmut, Petersen, Cordula, Dikomey, Ekkehard, Borgmann, Kerstin

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Bedeutung von Rad51 für Reparatur Replikationsassoziierter DNA-Schäden in humanen Tumorzellen von Parplys, Ann Christin

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Cdc45 is limiting for replication initiation in humans von Köhler, Carsten, Koalick, Dennis, Fabricius, Anja, Parplys, Ann Christin, Borgmann, Kerstin, Pospiech, Helmut, Grosse, Frank

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Cdc45 is limiting for replication initiation in humans von Köhler, Carsten, Koalick, Dennis, Fabricius, Anja, Parplys, Ann Christin, Borgmann, Kerstin, Pospiech, Helmut, Grosse, Frank

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High levels of RAD51 perturb DNA replication elongation and cause unscheduled origin firing due to impaired CHK1 activation von Parplys, Ann Christin, Seelbach, Jasna Irena, Becker, Saskia, Behr, Matthias, Wrona, Agnieszka, Jend, Camilla, Mansour, Wael Yassin, Joosse, Simon Andreas, Stuerzbecher, Horst-Werner, Pospiech, Helmut, Petersen, Cordula, Dikomey, Ekkehard, Borgmann, Kerstin

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Bedeutung von Rad51 für Reparatur replikationsassoziierter DNA-Schäden in humanen Tumorzellen von Parplys, Ann Christin

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