Notch1 mutations drive clonal expansion in normal esophageal epithelium but impair tumor growth von Abby, Emilie, Dentro, Stefan C., Hall, Michael W. J., Fowler, Joanna C., Ong, Swee Hoe, Sood, Roshan, Herms, Albert, Piedrafita, Gabriel, Abnizova, Irina, Siebel, Christian W., Gerstung, Moritz, Hall, Benjamin A., Jones, Philip H.

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Endothelial Notch1 Activity Facilitates Metastasis von Wieland, Elfriede, Rodriguez-Vita, Juan, Liebler, Sven S., Mogler, Carolin, Moll, Iris, Herberich, Stefanie E., Espinet, Elisa, Herpel, Esther, Menuchin, Amitai, Chang-Claude, Jenny, Hoffmeister, Michael, Gebhardt, Christoffer, Brenner, Hermann, Trumpp, Andreas, Siebel, Christian W., Hecker, Markus, Utikal, Jochen, Sprinzak, David, Fischer, Andreas

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Opposing Activities of Notch and Wnt Signaling Regulate Intestinal Stem Cells and Gut Homeostasis von Tian, Hua, Biehs, Brian, Chiu, Cecilia, Siebel, Christian W., Wu, Yan, Costa, Mike, de Sauvage, Frederic J., Klein, Ophir D.

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Cutting Edge: Notch Signaling Promotes the Plasticity of Group-2 Innate Lymphoid Cells von Zhang, Kangning, Xu, Xingyuan, Pasha, Muhammad Asghar, Siebel, Christian W, Costello, Angelica, Haczku, Angela, MacNamara, Katherine, Liang, Tingbo, Zhu, Jinfang, Bhandoola, Avinash, Maillard, Ivan, Yang, Qi

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Notch Signaling Facilitates In Vitro Generation of Cross-Presenting Classical Dendritic Cells von Kirkling, Margaret E., Cytlak, Urszula, Lau, Colleen M., Lewis, Kanako L., Resteu, Anastasia, Khodadadi-Jamayran, Alireza, Siebel, Christian W., Salmon, Hélène, Merad, Miriam, Tsirigos, Aristotelis, Collin, Matthew, Bigley, Venetia, Reizis, Boris

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A large pool of actively cycling progenitors orchestrates self-renewal and injury repair of an ectodermal appendage von Sharir, Amnon, Marangoni, Pauline, Zilionis, Rapolas, Wan, Mian, Wald, Tomas, Hu, Jimmy K., Kawaguchi, Kyogo, Castillo-Azofeifa, David, Epstein, Leo, Harrington, Kyle, Pagella, Pierfrancesco, Mitsiadis, Thimios, Siebel, Christian W., Klein, Allon M., Klein, Ophir D.

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Therapeutic antibodies reveal Notch control of transdifferentiation in the adult lung von Lafkas, Daniel, Shelton, Amy, Chiu, Cecilia, de Leon Boenig, Gladys, Chen, Yongmei, Stawicki, Scott S., Siltanen, Christian, Reichelt, Mike, Zhou, Meijuan, Wu, Xiumin, Eastham-Anderson, Jeffrey, Moore, Heather, Roose-Girma, Meron, Chinn, Yvonne, Hang, Julie Q., Warming, Søren, Egen, Jackson, Lee, Wyne P., Austin, Cary, Wu, Yan, Payandeh, Jian, Lowe, John B., Siebel, Christian W.

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An antibody to Notch3 reverses the skeletal phenotype of lateral meningocele syndrome in male mice von Yu, Jungeun, Siebel, Christian W., Schilling, Lauren, Canalis, Ernesto

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Heterotypic cell–cell communication regulates glandular stem cell multipotency von Centonze, Alessia, Lin, Shuheng, Tika, Elisavet, Sifrim, Alejandro, Fioramonti, Marco, Malfait, Milan, Song, Yura, Wuidart, Aline, Van Herck, Jens, Dannau, Anne, Bouvencourt, Gaelle, Dubois, Christine, Dedoncker, Nina, Sahay, Amar, de Maertelaer, Viviane, Siebel, Christian W., Van Keymeulen, Alexandra, Voet, Thierry, Blanpain, Cédric

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Dll1+ quiescent tumor stem cells drive chemoresistance in breast cancer through NF-κB survival pathway von Kumar, Sushil, Nandi, Ajeya, Singh, Snahlata, Regulapati, Rohan, Li, Ning, Tobias, John W., Siebel, Christian W., Blanco, Mario Andres, Klein-Szanto, Andres J., Lengner, Christopher, Welm, Alana L., Kang, Yibin, Chakrabarti, Rumela

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Systematic evaluation of antibody-mediated siRNA delivery using an industrial platform of THIOMAB-siRNA conjugates von Cuellar, Trinna L, Barnes, Dwight, Nelson, Christopher, Tanguay, Joshua, Yu, Shang-Fan, Wen, Xiaohui, Scales, Suzie J, Gesch, Julie, Davis, David, van Brabant Smith, Anja, Leake, Devin, Vandlen, Richard, Siebel, Christian W

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Therapeutic antibody targeting of individual Notch receptors von Zha, Jiping, Dow, Graham J, Chen, Yongmei, Watts, Ryan J, Callahan, Christopher A, Finkle, David, Wu, Yan, Hagenbeek, Thijs J, Venook, Rayna, de Leon, Gladys P, Siebel, Christian W, Choy, Lisa, Cain-Hom, Carol, Choy, Robert, Schahin-Reed, Dorreyah, Ridgway, John, Yan, Minhong, Stawicki, Scott, Hymowitz, Sarah G, Wu, Xiumin, Shelton, Amy, Kadyk, Lisa, Howard, Peter, Zhang, Jeff

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Differential effects of targeting Notch receptors in a mouse model of liver cancer von Huntzicker, Erik G., Hötzel, Kathy, Choy, Lisa, Che, Li, Ross, Jed, Pau, Gregoire, Sharma, Neeraj, Siebel, Christian W., Chen, Xin, French, Dorothy M.

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Constitutive NOTCH3 Signaling Promotes the Growth of Basal Breast Cancers von Choy, Lisa, Hagenbeek, Thijs J, Solon, Margaret, French, Dorothy, Finkle, David, Shelton, Amy, Venook, Rayna, Brauer, Matthew J, Siebel, Christian W

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Resting innate-like B cells leverage sustained Notch2/mTORC1 signaling to achieve rapid and mitosis-independent plasma cell differentiation von Gaudette, Brian T, Roman, Carly J, Ochoa, Trini A, Gómez Atria, Daniela, Jones, Derek D, Siebel, Christian W, Maillard, Ivan, Allman, David

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Deletion of the RNA-binding proteins ZFP36L1 and ZFP36L2 leads to perturbed thymic development and T lymphoblastic leukemia von Hodson, Daniel J, Janas, Michelle L, Galloway, Alison, Bell, Sarah E, Andrews, Simon, Li, Cheuk M, Pannell, Richard, Siebel, Christian W, MacDonald, H Robson, De Keersmaecker, Kim, Ferrando, Adolfo A, Grutz, Gerald, Turner, Martin

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Blockade of individual Notch ligands and receptors controls graft-versus-host disease von Tran, Ivy T, Sandy, Ashley R, Carulli, Alexis J, Ebens, Christen, Chung, Jooho, Shan, Gloria T, Radojcic, Vedran, Friedman, Ann, Gridley, Thomas, Shelton, Amy, Reddy, Pavan, Samuelson, Linda C, Yan, Minhong, Siebel, Christian W, Maillard, Ivan

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AKT-dependent NOTCH3 activation drives tumor progression in a model of mesenchymal colorectal cancer von Varga, Julia, Nicolas, Adele, Petrocelli, Valentina, Pesic, Marina, Mahmoud, Abdelrahman, Michels, Birgitta E, Etlioglu, Emre, Yepes, Diego, Häupl, Björn, Ziegler, Paul K, Bankov, Katrin, Wild, Peter J, Wanninger, Stefan, Medyouf, Hind, Farin, Henner F, Tejpar, Sabine, Oellerich, Thomas, Ruland, Jürgen, Siebel, Christian W, Greten, Florian R

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Resting innate-like B cells leverage sustained Notch2/mTORC1 signaling to achieve rapid and mitosisindependent plasma cell differentiation von Gaudette, Brian T, Roman, Carly J, Ochoa, Trini A, Atria, Daniela Gómez, Jones, Derek D, Siebel, Christian W, Maillard, Ivan, Allman, David

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Notch inhibition overcomes resistance to tyrosine kinase inhibitors in EGFR-driven lung adenocarcinoma von Bousquet Mur, Emilie, Bernardo, Sara, Papon, Laura, Mancini, Maicol, Fabbrizio, Eric, Goussard, Marion, Ferrer, Irene, Giry, Anais, Quantin, Xavier, Pujol, Jean-Louis, Calvayrac, Olivier, Moll, Herwig P, Glasson, Yaël, Pirot, Nelly, Turtoi, Andrei, Cañamero, Marta, Wong, Kwok-Kin, Yarden, Yosef, Casanova, Emilio, Soria, Jean-Charles, Colinge, Jacques, Siebel, Christian W, Mazieres, Julien, Favre, Gilles, Paz-Ares, Luis, Maraver, Antonio

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