Combinatorial mutagenesis en masse optimizes the genome editing activities of SpCas9 von Choi, Gigi C. G., Zhou, Peng, Yuen, Chaya T. L., Chan, Becky K. C., Xu, Feng, Bao, Siyu, Chu, Hoi Yee, Thean, Dawn, Tan, Kaeling, Wong, Koon Ho, Zheng, Zongli, Wong, Alan S. L.

Volltext

Massively parallel high-order combinatorial genetics in human cells von Wong, Alan S L, Choi, Gigi C G, Cheng, Allen A, Purcell, Oliver, Lu, Timothy K

Volltext

A Three-Way Combinatorial CRISPR Screen for Analyzing Interactions among Druggable Targets von Zhou, Peng, Chan, Becky K.C., Wan, Yuk Kei, Yuen, Chaya T.L., Choi, Gigi C.G., Li, Xinran, Tong, Cindy S.W., Zhong, Sophia S.W., Sun, Jieran, Bao, Yufan, Mak, Silvia Y.L., Chow, Maggie Z.Y., Khaw, Jien Vei, Leung, Suet Yi, Zheng, Zongli, Cheung, Lydia W.T., Tan, Kaeling, Wong, Koon Ho, Chan, H.Y. Edwin, Wong, Alan S.L.

Volltext

The metalloprotease ADAMTS8 displays antitumor properties through antagonizing EGFR-MEK-ERK signaling and is silenced in carcinomas by CpG methylation von Choi, Gigi C G, Li, Jisheng, Wang, Yajun, Li, Lili, Zhong, Lan, Ma, Brigette, Su, Xianwei, Ying, Jianming, Xiang, Tingxiu, Rha, Sun Young, Yu, Jun, Sung, Joseph J Y, Tsao, Sai Wah, Chan, Anthony T C, Tao, Qian

Volltext

Deciphering Combinatorial Genetics von Wong, Alan S.L, Choi, Gigi C.G, Lu, Timothy K

Volltext

Extensible combinatorial CRISPR screening in mammalian cells von Zhou, Peng, Wan, Yuk Kei, Chan, Becky K.C., Choi, Gigi C.G., Wong, Alan S.L.

Volltext

High-throughput 5′ UTR engineering for enhanced protein production in non-viral gene therapies von Cao, Jicong, Novoa, Eva Maria, Zhang, Zhizhuo, Chen, William C. W., Liu, Dianbo, Choi, Gigi C. G., Wong, Alan S. L., Wehrspaun, Claudia, Kellis, Manolis, Lu, Timothy K.

Volltext

Multiplexed barcoded CRISPR-Cas9 screening enabled by CombiGEM von Wong, Alan S. L., Choi, Gigi C. G., Cui, Cheryl H., Pregernig, Gabriela, Milani, Pamela, Adam, Miriam, Perli, Samuel D., Kazer, Samuel W., Gaillard, Aleth, Hermann, Mario, Shalek, Alex K., Fraenkel, Ernest, Lu, Timothy K.

Volltext

A synthetic transcription platform for programmable gene expression in mammalian cells von Chen, William C. W., Gaidukov, Leonid, Lai, Yong, Wu, Ming-Ru, Cao, Jicong, Gutbrod, Michael J., Choi, Gigi C. G., Utomo, Rachel P., Chen, Ying-Chou, Wroblewska, Liliana, Kellis, Manolis, Zhang, Lin, Weiss, Ron, Lu, Timothy K.

Volltext

Machine learning-coupled combinatorial mutagenesis enables resource-efficient engineering of CRISPR-Cas9 genome editor activities von Thean, Dawn G. L., Chu, Hoi Yee, Fong, John H. C., Chan, Becky K. C., Zhou, Peng, Kwok, Cynthia C. S., Chan, Yee Man, Mak, Silvia Y. L., Choi, Gigi C. G., Ho, Joshua W. K., Zheng, Zongli, Wong, Alan S. L.

Volltext

A Combinatorial CRISPR-Cas9 Screen Identifies Ifenprodil as an Adjunct to Sorafenib for Liver Cancer Treatment von Xu, Feng, Tong, Man, Tong, Cindy S W, Chan, Becky K C, Chu, Hoi Yee, Wong, Tin Lok, Fong, John H C, Cheung, Maggie S H, Mak, Kylie Hin-Man, Pardeshi, Lakhansing, Huang, Yuanhua, Wong, Koon Ho, Choi, Gigi C G, Ma, Stephanie, Wong, Alan S L

Volltext

High-Throughput Protein Engineering by Massively Parallel Combinatorial Mutagenesis von Wan, Yuk Kei, Choi, Gigi C. G., Wong, Alan S. L.

Volltext

High-fidelity KKH variant of Staphylococcus aureus Cas9 nucleases with improved base mismatch discrimination von Yuen, Chaya T L, Thean, Dawn G L, Chan, Becky K C, Zhou, Peng, Kwok, Cynthia C S, Chu, Hoi Yee, Cheung, Maggie S H, Wang, Bei, Chan, Yee Man, Mak, Silvia Y L, Leung, Anskar Y, Choi, Gigi C G, Zheng, Zongli, Wong, Alan S L

Volltext

High-throughput screening of genetic and cellular drivers of syncytium formation induced by the spike protein of SARS-CoV-2 von Chan, Charles W. F., Wang, Bei, Nan, Lang, Huang, Xiner, Mao, Tianjiao, Chu, Hoi Yee, Luo, Cuiting, Chu, Hin, Choi, Gigi C. G., Shum, Ho Cheung, Wong, Alan S. L.

Volltext

Methylation profiling of Epstein-Barr virus immediate-early gene promoters, BZLF1 and BRLF1 in tumors of epithelial, NK- and B-cell origins von Li, Lili, Su, Xianwei, Choi, Gigi Ching Gee, Cao, Ya, Ambinder, Richard F, Tao, Qian

Volltext