USP1 inhibitors show robust combination activity and a distinct resistance profile from PARP inhibitors von Sullivan, P., Shenker, S., McGuire, M., Grasberger, P., Sinkevicius, K., Tobin, E., Chipumuro, E., Histen, G., Hafeez, N., Rahal, R., Schlabach, M., Stegmeier, F., Cadzow, L., Wylie, A.

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Development of KSQ-4279 as a first-in-class USP1 inhibitor for the treatment of BRCA-deficient cancers von Cadzow, L., Brenneman, J., Sullivan, P., Liu, H., Shenker, S., McGuire, M., Grasberger, P., Sinkevicius, K., Hafeez, N., Histen, G., Chipumuro, E., Hixon, J., Krall, E., Cogan, S., Wilt, J., Schlabach, M., Stegmeier, F., Olaharski, A., Wylie, A.

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CDK12 loss in cancer cells affects DNA damage response genes through premature cleavage and polyadenylation von Krajewska, Malgorzata, Dries, Ruben, Grassetti, Andrew V., Dust, Sofia, Gao, Yang, Huang, Hao, Sharma, Bandana, Day, Daniel S., Kwiatkowski, Nicholas, Pomaville, Monica, Dodd, Oliver, Chipumuro, Edmond, Zhang, Tinghu, Greenleaf, Arno L., Yuan, Guo-Cheng, Gray, Nathanael S., Young, Richard A., Geyer, Matthias, Gerber, Scott A., George, Rani E.

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Overcoming Resistance to the THZ Series of Covalent Transcriptional CDK Inhibitors von Gao, Yang, Zhang, Tinghu, Terai, Hideki, Ficarro, Scott B., Kwiatkowski, Nicholas, Hao, Ming-Feng, Sharma, Bandana, Christensen, Camilla L., Chipumuro, Edmond, Wong, Kwok-kin, Marto, Jarrod A., Hammerman, Peter S., Gray, Nathanael S., George, Rani E.

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Targeting Transcriptional Addictions in Small Cell Lung Cancer with a Covalent CDK7 Inhibitor von Christensen, Camilla L., Kwiatkowski, Nicholas, Abraham, Brian J., Carretero, Julian, Al-Shahrour, Fatima, Zhang, Tinghu, Chipumuro, Edmond, Herter-Sprie, Grit S., Akbay, Esra A., Altabef, Abigail, Zhang, Jianming, Shimamura, Takeshi, Capelletti, Marzia, Reibel, Jakob B., Cavanaugh, Jillian D., Gao, Peng, Liu, Yan, Michaelsen, Signe R., Poulsen, Hans S., Aref, Amir R., Barbie, David A., Bradner, James E., George, Rani E., Gray, Nathanael S., Young, Richard A., Wong, Kwok-Kin

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MiR-338-3p regulates neuronal maturation and suppresses glioblastoma proliferation von Howe, 6th, James R, Li, Emily S, Streeter, Sarah E, Rahme, Gilbert J, Chipumuro, Edmond, Russo, Grace B, Litzky, Julia F, Hills, L Benjamin, Rodgers, Kyla R, Skelton, Patrick D, Luikart, Bryan W

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CDK7 Inhibition Suppresses Super-Enhancer-Linked Oncogenic Transcription in MYCN-Driven Cancer von Chipumuro, Edmond, Marco, Eugenio, Christensen, Camilla L., Kwiatkowski, Nicholas, Zhang, Tinghu, Hatheway, Clark M., Abraham, Brian J., Sharma, Bandana, Yeung, Caleb, Altabef, Abigail, Perez-Atayde, Antonio, Wong, Kwok-Kin, Yuan, Guo-Cheng, Gray, Nathanael S., Young, Richard A., George, Rani E.

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Pan-Cancer Analysis of Homologous Recombination Deficiency in Cell Lines von Dodson, Anne E, Shenker, Sol, Sullivan, Pamela, Nayak, Sumeet U, Middleton, Chris, McGuire, Michael, Chipumuro, Edmond, Mishina, Yuji, Tobin, Erica R, Cadzow, Louise, Wylie, Andrew A, Sangurdekar, Dipen

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Abstract 2195: A high-throughput chemical screen identifies synergistic activity between crizotinib and transcriptional CDK inhibitors in ALK-mutated neuroblastoma von Moore, Nathan F., Chipumuro, Edmond, Hatheway, Clark M., Zhang, Tinghu, Gray, Nathanael S., George, Rani E.

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Abstract B74: Combined inhibition of ALK and CDKs involved in transcriptional regulation is synergistic in ALK-mutated neuroblastoma von Moore, Nathan F., Chipumuro, Edmond, Hatheway, Clark M., Zhang, Tinghu, Gray, Nathanael S., George, Rani E.

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Abstract PR04: Targeting super-enhancer driven oncogene transcription through cyclin-dependent kinase inhibitors von Krajewska, Malgorzata, Moore, Nathan F., Chipumuro, Edmond, Zhang, Tinghu, Marco, Eugenio, Hatheway, Clark, Sharma, Bandana, Kwiatkowski, Nicholas, Yuan, Guo-Cheng, Young, Richard A., Gray, Nathanael S., George, Rani E.

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Abstract PR05: Targeting of CDK7 inhibits super-enhancer-associated oncogenic programs in MYCN-amplified tumor cells von Chipumuro, Edmond, Marco, Eugenio, Christensen, Camilla L., Kwiatkowski, Nicholas, Zhang, Tinghu, Hatheway, Clark M., Abraham, Brian J., Sharma, Bandana, Yeung, Caleb, Altabef, Abigail, Perez-Atayde, Antonio, Wong, Kwok-Kin, Yuan, Guo-Cheng, Gray, Nathanael S., Young, Richard A., George, Rani E.

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Abstract LB-125: Selective inhibition of CDK7 targets MYCN-driven transcriptional amplification in neuroblastoma von Chipumuro, Edmond, Marco, Eugenio, Zhang, Tinghu, Christensen, Camilla, Kwiatkowski, Nicholas, Sharma, Bandana, Hatheway, Clark, Altabef, Abigail, Abraham, Brian J., Wong, Kwok-Kin, Yuan, Guo-Cheng, Young, Richard A., Gray, Nathanael S., George, Rani E.

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Targeting Transcriptional Addictions in Small Cell Lung Cancer with a Covalent CDK7 Inhibitor von Christensen, Camilla L., Kwiatkowski, Nicholas, Abraham, Brian J., Carretero, Julian, Al-Shahrour, Fatima, Zhang, Tinghu, Chipumuro, Edmond, Herter-Sprie, Grit S., Akbay, Esra A., Altabef, Abigail, Zhang, Jianming, Shimamura, Takeshi, Capelletti, Marzia, Reibel, Jakob B., Cavanaugh, Jillian D., Gao, Peng, Liu, Yan, Michaelsen, Signe R., Poulsen, Hans S., Aref, Amir R., Barbie, David A., Bradner, James E., George, Rani E., Gray, Nathanael S., Young, Richard A., Wong, Kwok-Kin

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