The Multi-faceted Ecto-enzyme CD38: Roles in Immunomodulation, Cancer, Aging, and Metabolic Diseases von Hogan, Kelly A, Chini, Claudia C S, Chini, Eduardo N

Volltext

Mitochondrial dysfunction in cell senescence and aging von Miwa, Satomi, Kashyap, Sonu, Chini, Eduardo, von Zglinicki, Thomas

Volltext

CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism von Camacho-Pereira, Juliana, Tarragó, Mariana G., Chini, Claudia C.S., Nin, Veronica, Escande, Carlos, Warner, Gina M., Puranik, Amrutesh S., Schoon, Renee A., Reid, Joel M., Galina, Antonio, Chini, Eduardo N.

Volltext

The Pharmacology of CD38/NADase: An Emerging Target in Cancer and Diseases of Aging von Chini, Eduardo N., Chini, Claudia C.S., Espindola Netto, Jair Machado, de Oliveira, Guilherme C., van Schooten, Wim

Volltext

A Potent and Specific CD38 Inhibitor Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD+ Decline von Tarragó, Mariana G., Chini, Claudia C.S., Kanamori, Karina S., Warner, Gina M., Caride, Ariel, de Oliveira, Guilherme C., Rud, Micaela, Samani, Adrienne, Hein, Kyaw Z., Huang, Runqing, Jurk, Diana, Cho, Dong Seong, Boslett, James J., Miller, Jordan D., Zweier, Jay L., Passos, João F., Doles, Jason D., Becherer, David J., Chini, Eduardo N.

Volltext

NAD and the aging process: Role in life, death and everything in between von Chini, Claudia C.S., Tarragó, Mariana G., Chini, Eduardo N.

Volltext

Food Restriction Ameliorates the Development of Polycystic Kidney Disease von Warner, Gina, Hein, Kyaw Zaw, Nin, Veronica, Edwards, Marika, Chini, Claudia C S, Hopp, Katharina, Harris, Peter C, Torres, Vicente E, Chini, Eduardo N

Volltext

The NADase CD38 is induced by factors secreted from senescent cells providing a potential link between senescence and age-related cellular NAD+ decline von Chini, Claudia, Hogan, Kelly A., Warner, Gina M., Tarragó, Mariana G., Peclat, Thais R., Tchkonia, Tamar, Kirkland, James L., Chini, Eduardo

Volltext

Cellular Senescence in Type 2 Diabetes: A Therapeutic Opportunity von Palmer, Allyson K, Tchkonia, Tamara, LeBrasseur, Nathan K, Chini, Eduardo N, Xu, Ming, Kirkland, James L

Volltext

Evaluation of the Aging Effect on Peripheral Nerve Regeneration: A Systematic Review von Maita, Karla C., Garcia, John P., Avila, Francisco R., Torres-Guzman, Ricardo A., Ho, Olivia, Chini, Claudia C.S., Chini, Eduardo N., Forte, Antonio J.

Volltext

Targeting of NAD Metabolism in Pancreatic Cancer Cells: Potential Novel Therapy for Pancreatic Tumors von CHINI, Claudia C. S, GUERRICO, Anatilde M. Gonzalez, NIN, Veronica, CAMACHO-PEREIRA, Juliana, ESCANDE, Carlos, BARBOSA, Maria Thereza, CHINI, Eduardo N

Volltext

CD38 inhibitor 78c increases mice lifespan and healthspan in a model of chronological aging von Peclat, Thais R., Thompson, Katie L., Warner, Gina M., Chini, Claudia C.S., Tarragó, Mariana G., Mazdeh, Delaram Z., Zhang, Chunlian, Zavala‐Solorio, Jose, Kolumam, Ganesh, Liang Wong, Yao, Cohen, Robert L., Chini, Eduardo N.

Volltext

A stress-induced cilium-to-PML-NB route drives senescence initiation von Ma, Xiaoyu, Zhang, Yingyi, Zhang, Yuanyuan, Zhang, Xu, Huang, Yan, He, Kai, Chen, Chuan, Hao, Jielu, Zhao, Debiao, LeBrasseur, Nathan K., Kirkland, James L., Chini, Eduardo N., Wei, Qing, Ling, Kun, Hu, Jinghua

Volltext

Dihydronicotinamide Riboside Is a Potent NAD + Precursor Promoting a Pro-Inflammatory Phenotype in Macrophages von Chini, Claudia C S, Peclat, Thais R, Gomez, Lilian S, Zeidler, Julianna D, Warner, Gina M, Kashyap, Sonu, Mazdeh, Delaram Z, Hayat, Faisal, Migaud, Marie E, Paulus, Aneel, Chanan-Khan, Asher A, Chini, Eduardo N

Volltext

Heavy-chain antibody targeting of CD38 NAD+ hydrolase ectoenzyme to prevent fibrosis in multiple organs von Shi, Bo, Amin, Asif, Dalvi, Pranjali, Wang, Wenxia, Lukacs, Nicholas, Kai, Li, Cheresh, Paul, Peclat, Thais R., Chini, Claudia C., Chini, Eduardo N., van Schooten, Wim, Varga, John

Volltext

Flavonoid Apigenin Is an Inhibitor of the NAD+ase CD38: Implications for Cellular NAD+ Metabolism, Protein Acetylation, and Treatment of Metabolic Syndrome von ESCANDE, Carlos, NIN, Veronica, PRICE, Nathan L, CAPELLINI, Verena, GOMES, Ana P, BARBOSA, Maria Thereza, O'NEIL, Luke, WHITE, Thomas A, SINCLAIR, David A, CHINI, Eduardo N

Volltext

DBC1 (Deleted in Breast Cancer 1) modulates the stability and function of the nuclear receptor Rev-erbα von Chini, Claudia C S, Escande, Carlos, Nin, Veronica, Chini, Eduardo N

Volltext

Role of Deleted in Breast Cancer 1 (DBC1) Protein in SIRT1 Deacetylase Activation Induced by Protein Kinase A and AMP-activated Protein Kinase von Nin, Veronica, Escande, Carlos, Chini, Claudia C., Giri, Shailendra, Camacho-Pereira, Juliana, Matalonga, Jonathan, Lou, Zhenkun, Chini, Eduardo N.

Volltext

Benefits in cardiac function by CD38 suppression: Improvement in NAD+ levels, exercise capacity, heart rate variability and protection against catecholamine-induced ventricular arr... von Agorrody, Guillermo, Peclat, Thais R., Peluso, Gonzalo, Gonano, Luis A., Santos, Leonardo, van Schooten, Wim, Chini, Claudia C.S., Escande, Carlos, Chini, Eduardo N., Contreras, Paola

Volltext

CD38‐NADase is a new major contributor to Duchenne muscular dystrophic phenotype von de Zélicourt, Antoine, Fayssoil, Abdallah, Dakouane‐Giudicelli, Mbarka, De Jesus, Isley, Karoui, Ahmed, Zarrouki, Faouzi, Lefebvre, Florence, Mansart, Arnaud, Launay, Jean‐Marie, Piquereau, Jerome, Tarragó, Mariana G, Bonay, Marcel, Forand, Anne, Moog, Sophie, Piétri‐Rouxel, France, Brisebard, Elise, Chini, Claudia C S, Kashyap, Sonu, Fogarty, Matthew J, Sieck, Gary C, Mericskay, Mathias, Chini, Eduardo N, Gomez, Ana Maria, Cancela, José‐Manuel, de la Porte, Sabine

Volltext