The Multi-faceted Ecto-enzyme CD38: Roles in Immunomodulation, Cancer, Aging, and Metabolic Diseases von Hogan, Kelly A, Chini, Claudia C S, Chini, Eduardo N

Volltext

Evolving concepts in NAD(+) metabolism von Chini, Claudia C. S., Zeidler, Julianna D., Kashyap, Sonu, Warner, Gina, Chini, Eduardo Nunes

Volltext

CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism von Camacho-Pereira, Juliana, Tarragó, Mariana G., Chini, Claudia C.S., Nin, Veronica, Escande, Carlos, Warner, Gina M., Puranik, Amrutesh S., Schoon, Renee A., Reid, Joel M., Galina, Antonio, Chini, Eduardo N.

Volltext

The Pharmacology of CD38/NADase: An Emerging Target in Cancer and Diseases of Aging von Chini, Eduardo N., Chini, Claudia C.S., Espindola Netto, Jair Machado, de Oliveira, Guilherme C., van Schooten, Wim

Volltext

NAD and the aging process: Role in life, death and everything in between von Chini, Claudia C.S., Tarragó, Mariana G., Chini, Eduardo N.

Volltext

A Potent and Specific CD38 Inhibitor Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD+ Decline von Tarragó, Mariana G., Chini, Claudia C.S., Kanamori, Karina S., Warner, Gina M., Caride, Ariel, de Oliveira, Guilherme C., Rud, Micaela, Samani, Adrienne, Hein, Kyaw Z., Huang, Runqing, Jurk, Diana, Cho, Dong Seong, Boslett, James J., Miller, Jordan D., Zweier, Jay L., Passos, João F., Doles, Jason D., Becherer, David J., Chini, Eduardo N.

Volltext

Targeting of NAD Metabolism in Pancreatic Cancer Cells: Potential Novel Therapy for Pancreatic Tumors von CHINI, Claudia C. S, GUERRICO, Anatilde M. Gonzalez, NIN, Veronica, CAMACHO-PEREIRA, Juliana, ESCANDE, Carlos, BARBOSA, Maria Thereza, CHINI, Eduardo N

Volltext

Food Restriction Ameliorates the Development of Polycystic Kidney Disease von Warner, Gina, Hein, Kyaw Zaw, Nin, Veronica, Edwards, Marika, Chini, Claudia C S, Hopp, Katharina, Harris, Peter C, Torres, Vicente E, Chini, Eduardo N

Volltext

The NADase CD38 is induced by factors secreted from senescent cells providing a potential link between senescence and age-related cellular NAD+ decline von Chini, Claudia, Hogan, Kelly A., Warner, Gina M., Tarragó, Mariana G., Peclat, Thais R., Tchkonia, Tamar, Kirkland, James L., Chini, Eduardo

Volltext

CD38 inhibitor 78c increases mice lifespan and healthspan in a model of chronological aging von Peclat, Thais R., Thompson, Katie L., Warner, Gina M., Chini, Claudia C.S., Tarragó, Mariana G., Mazdeh, Delaram Z., Zhang, Chunlian, Zavala‐Solorio, Jose, Kolumam, Ganesh, Liang Wong, Yao, Cohen, Robert L., Chini, Eduardo N.

Volltext

Deleted in breast cancer-1 regulates SIRT1 activity and contributes to high-fat diet-induced liver steatosis in mice von Escande, Carlos, Chini, Claudia C S, Nin, Veronica, Dykhouse, Katherine Minter, Novak, Colleen M, Levine, James, van Deursen, Jan, Gores, Gregory J, Chen, Junjie, Lou, Zhenkun, Chini, Eduardo Nunes

Volltext

Evaluation of the Aging Effect on Peripheral Nerve Regeneration: A Systematic Review von Maita, Karla C., Garcia, John P., Avila, Francisco R., Torres-Guzman, Ricardo A., Ho, Olivia, Chini, Claudia C.S., Chini, Eduardo N., Forte, Antonio J.

Volltext

SIRT1-Activating Compounds (STAC) Negatively Regulate Pancreatic Cancer Cell Growth and Viability Through a SIRT1 Lysosomal-Dependent Pathway von Chini, Claudia C S, Espindola-Netto, Jair M, Mondal, Gourish, Guerrico, Anatilde M Gonzalez, Nin, Veronica, Escande, Carlos, Sola-Penna, Mauro, Zhang, Jin-San, Billadeau, Daniel D, Chini, Eduardo N

Volltext

CD38‐NADase is a new major contributor to Duchenne muscular dystrophic phenotype von de Zélicourt, Antoine, Fayssoil, Abdallah, Dakouane‐Giudicelli, Mbarka, De Jesus, Isley, Karoui, Ahmed, Zarrouki, Faouzi, Lefebvre, Florence, Mansart, Arnaud, Launay, Jean‐Marie, Piquereau, Jerome, Tarragó, Mariana G, Bonay, Marcel, Forand, Anne, Moog, Sophie, Piétri‐Rouxel, France, Brisebard, Elise, Chini, Claudia C S, Kashyap, Sonu, Fogarty, Matthew J, Sieck, Gary C, Mericskay, Mathias, Chini, Eduardo N, Gomez, Ana Maria, Cancela, José‐Manuel, de la Porte, Sabine

Volltext

CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD+ and NMN levels von Chini, Claudia C. S., Peclat, Thais R., Warner, Gina M., Kashyap, Sonu, Espindola-Netto, Jair Machado, de Oliveira, Guilherme C., Gomez, Lilian S., Hogan, Kelly A., Tarragó, Mariana G., Puranik, Amrutesh S., Agorrody, Guillermo, Thompson, Katie L., Dang, Kevin, Clarke, Starlynn, Childs, Bennett G., Kanamori, Karina S., Witte, Micaela A., Vidal, Paola, Kirkland, Anna L., De Cecco, Marco, Chellappa, Karthikeyani, McReynolds, Melanie R., Jankowski, Connor, Tchkonia, Tamara, Kirkland, James L., Sedivy, John M., van Deursen, Jan M., Baker, Darren J., van Schooten, Wim, Rabinowitz, Joshua D., Baur, Joseph A., Chini, Eduardo N.

Volltext

HDAC3 Is Negatively Regulated by the Nuclear Protein DBC1 von Chini, Claudia C.S., Escande, Carlos, Nin, Veronica, Chini, Eduardo N.

Volltext

The CD38 glycohydrolase and the NAD sink: implications for pathological conditions von Zeidler, Julianna D, Hogan, Kelly A, Agorrody, Guillermo, Peclat, Thais R, Kashyap, Sonu, Kanamori, Karina S, Gomez, Lilian Sales, Mazdeh, Delaram Z, Warner, Gina M, Thompson, Katie L, Chini, Claudia C S, Chini, Eduardo Nunes

Volltext

Critical Role of Astrocyte NAD + Glycohydrolase in Myelin Injury and Regeneration von Langley, Monica R, Choi, Chan-Il, Peclat, Thais R, Guo, Yong, Simon, Whitney L, Yoon, Hyesook, Kleppe, Laurel, Lucchinetti, Claudia F, Chini, Claudia C S, Chini, Eduardo N, Scarisbrick, Isobel A

Volltext

Benefits in cardiac function by CD38 suppression: Improvement in NAD+ levels, exercise capacity, heart rate variability and protection against catecholamine-induced ventricular arr... von Agorrody, Guillermo, Peclat, Thais R., Peluso, Gonzalo, Gonano, Luis A., Santos, Leonardo, van Schooten, Wim, Chini, Claudia C.S., Escande, Carlos, Chini, Eduardo N., Contreras, Paola

Volltext

DBC1 (Deleted in Breast Cancer 1) modulates the stability and function of the nuclear receptor Rev-erbα von Chini, Claudia C S, Escande, Carlos, Nin, Veronica, Chini, Eduardo N

Volltext