Comprehensive Dual- and Triple-Feature Intersectional Single-Vector Delivery of Diverse Functional Payloads to Cells of Behaving Mammals von Fenno, Lief E., Ramakrishnan, Charu, Kim, Yoon Seok, Evans, Kathryn E., Lo, Maisie, Vesuna, Sam, Inoue, Masatoshi, Cheung, Kathy Y.M., Yuen, Elle, Pichamoorthy, Nandini, Hong, Alice S.O., Deisseroth, Karl

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P228 - Assay calibration to refine prediction of OATP1B1/1B3 mediated drug-drug interactions (DDI) based on in vitro uptake transport assay data von Kovacs, Peter, Sane, Rucha, Kathy Cheung, Kit Wun, Kis, Emese, Plise, Emile, Gaborik, Zsuzsanna

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Kinetic and structural studies on 'tethered' Ru(II) arene ketone reduction catalysts von Cheung, Fung Kei Kathy, Clarke, Adam J, Clarkson, Guy J, Fox, David J, Graham, Mark A, Lin, Changxue, Crivillé, Adriana Lorente, Wills, Martin

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Calibrating the In Vitro-In Vivo Correlation for OATP-Mediated Drug-Drug Interactions with Rosuvastatin Using Static and PBPK Models von Sane, Rucha, Cheung, Kit Wun Kathy, Kovacs, Peter, Farasyn, Taleah, Li, Ruina, Bui, Annamaria, Musib, Luna, Kis, Emese, Plise, Emile, Gaborik, Zsuzsanna

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The design, synthesis and evaluation of low molecular weight acidic sulfonamides as URAT1 inhibitors for the treatment of gout von Pike, Andy, Storer, R. Ian, Owen, Robert M., Armstrong, Emma, Benn, Caroline L., Bictash, Magda, Cheung, Kathy F. K., Costelloe, Kathryn, Dardennes, Emmanuel, Impey, Emma, Milliken, Philip H., Mortimer-Cassen, Elisabeth, Pearce, Hannah J.

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Incorporating Ontogeny in Physiologically Based Pharmacokinetic Modeling to Improve Pediatric Drug Development: What We Know About Developmental Changes in Membrane Transporters von Cheung, Kit Wun Kathy, Groen, Bianca D., Burckart, Gilbert J., Zhang, Lei, Wildt, Saskia N., Huang, Shiew‐Mei

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“Tethered” Ru(II) Catalysts for Asymmetric Transfer Hydrogenation of Ketones von Cheung, Fung Kei (Kathy), Hayes, Aidan M, Hannedouche, Jerome, Yim, Aveline S. Y, Wills, Martin

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Unraveling the functional role of the orphan solute carrier, SLC22A24 in the transport of steroid conjugates through metabolomic and genome-wide association studies von Yee, Sook Wah, Stecula, Adrian, Chien, Huan-Chieh, Zou, Ling, Feofanova, Elena V, van Borselen, Marjolein, Cheung, Kit Wun Kathy, Yousri, Noha A, Suhre, Karsten, Kinchen, Jason M, Boerwinkle, Eric, Irannejad, Roshanak, Yu, Bing, Giacomini, Kathleen M

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Exploring the Impact of Hepatic Impairment on Pralsetinib Pharmacokinetics von Cheung, Kit Wun Kathy, Tang, Yang, Anders, Doreen, Barata, Teresa, Scalori, Astrid, Agarwal, Priya, Sane, Rucha, Cheeti, Sravanthi

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Effect of Hepatic Impairment on Cobimetinib Pharmacokinetics: The Complex Interplay Between Physiological Changes and Drug Characteristics von Cheeti, Sravanthi, Deng, Yuzhong, Chang, Ilsung, Georgescu, Isabela, Templeton, Ian, Choong, Nicholas, Cheung, Kit Wun Kathy, Girish, Sandhya, Musib, Luna

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Maximum likelihood estimation of renal transporter ontogeny profiles for pediatric PBPK modeling von Hunt, J. Porter, Dubinsky, Samuel, McKnite, Autumn M., Cheung, Kit Wun Kathy, Groen, Bianca D., Giacomini, Kathleen M., Wildt, Saskia N., Edginton, Andrea N., Watt, Kevin M.

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Assessment of cytochrome P450 3A4-mediated drug–drug interactions for ipatasertib using a fit-for-purpose physiologically based pharmacokinetic model von Jing, Jing, Chen, Yuan, Musib, Luna, Jin, Jin Y., Cheung, Kit Wun Kathy, Yoshida, Kenta, Sane, Rucha

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P227 - Pharmacokinetics of GDC-0810 and its interaction with coproporphyrin i in the first-in-human, ascending dose study in women with locally advanced or metastatic estrogen rece... von Kathy Cheung, Kit Wun, Yoshida, Kenta, Cheeti, Sravanthi, Chen, Buyun, Morley, Roland, Chan, Iris T., Sahasranaman, Srikumar, Liu, Lichuan

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The Discovery of Potent Nonstructural Protein 5A (NS5A) Inhibitors with a Unique Resistance Profile-Part 2 von Wakenhut, Florian, Tran, Thien Duc, Pickford, Chris, Shaw, Stephen, Westby, Mike, Smith-Burchnell, Caroline, Watson, Lesa, Paradowski, Michael, Milbank, Jared, Stonehouse, David, Cheung, Kathy, Wybrow, Robert, Daverio, Felice, Crook, Samuel, Statham, Keith, Leese, David, Stead, Darren, Adam, Fiona, Hay, Duncan, Roberts, Lee R., Chiva, Jean-Yves, Nichols, Carly, Blakemore, David C., Goetz, Gilles H., Che, Ye, Gardner, Iain, Dayal, Satish, Pike, Andrew, Webster, Rob, Pryde, David C.

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The design, synthesis and evaluation of low molecular weight acidic sulfonamides as URAT1 inhibitors for the treatment of goutThe authors declare no competing interests.Electronic... von Pike, Andy, Storer, R. Ian, Owen, Robert M, Armstrong, Emma, Benn, Caroline L, Bictash, Magda, Cheung, Kathy F. K, Costelloe, Kathryn, Dardennes, Emmanuel, Impey, Emma, Milliken, Philip H, Mortimer-Cassen, Elisabeth, Pearce, Hannah J

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Evaluation of Ipatasertib Interactions with Itraconazole and Coproporphyrin I and III in a Single Drug Interaction Study in Healthy Subjects von Sane, Rucha S., Cheung, Kit Wun Kathy, Cho, Eunpi, Liederer, Bianca M., Hanover, Justin, Malhi, Vikram, Plise, Emile, Wong, Susan, Musib, Luna

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GDC-0810 Pharmacokinetics and Transporter-Mediated Drug Interaction Evaluation with an Endogenous Biomarker in the First-in-Human, Dose Escalation Study von Cheung, Kit Wun Kathy, Yoshida, Kenta, Cheeti, Sravanthi, Chen, Buyun, Morley, Roland, Chan, Iris T, Sahasranaman, Srikumar, Liu, Lichuan

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A Comprehensive Analysis of Ontogeny of Renal Drug Transporters: mRNA Analyses, Quantitative Proteomics, and Localization von Cheung, Kit Wun Kathy, Groen, Bianca D., Spaans, Edwin, Borselen, Marjolein D., Bruijn, Adrianus C.J.M., Simons‐Oosterhuis, Ytje, Tibboel, Dick, Samsom, Janneke N., Verdijk, Robert M., Smeets, Bart, Zhang, Lei, Huang, Shiew‐Mei, Giacomini, Kathleen M., Wildt, Saskia N.

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The Discovery of Potent Nonstructural Protein 5A (NS5A) Inhibitors with a Unique Resistance Profile--Part2 von Wakenhut, Florian, Tran, Thien Duc, Pickford, Chris, Shaw, Stephen, Westby, Mike, Smith-Burchnell, Caroline, Watson, Lesa, Paradowski, Michael, Milbank, Jared, Stonehouse, David, Cheung, Kathy, Wybrow, Robert, Daverio, Felice, Crook, Samuel, Statham, Keith, Leese, David, Stead, Darren, Adam, Fiona, Hay, Duncan, Roberts, Lee R, Chiva, Jean-Yves, Nichols, Carly, Blakemore, David C, Goetz, Gilles H, Che, Ye, Gardner, Iain, Dayal, Satish, Pike, Andrew, Webster, Rob, Pryde, David C

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The Effect of Uremic Solutes on the Organic Cation Transporter 2 von Cheung, Kit Wun Kathy, Hsueh, Chia-Hsiang, Zhao, Ping, Meyer, Timothy W., Zhang, Lei, Huang, Shiew-Mei, Giacomini, Kathleen M.

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