Current Development of siRNA Bioconjugates: From Research to the Clinic von Chernikov, Ivan V, Vlassov, Valentin V, Chernolovskaya, Elena L

Volltext

Structural Modifications of siRNA Improve Its Performance In Vivo von Chernikov, Ivan V, Ponomareva, Ulyana A, Chernolovskaya, Elena L

Volltext

Antisense oligonucleotide gapmers containing phosphoryl guanidine groups reverse MDR1-mediated multiple drug resistance of tumor cells von Kupryushkin, Maxim S., Filatov, Anton V., Mironova, Nadezhda L., Patutina, Olga A., Chernikov, Ivan V., Chernolovskaya, Elena L., Zenkova, Marina A., Pyshnyi, Dmitrii V., Stetsenko, Dmitry A., Altman, Sidney, Vlassov, Valentin V.

Volltext

Symmetric lipophilic polyamines exhibiting antitumor activity von Perevoshchikova, Ksenia A., Eshtukova-Shcheglova, Elizaveta A., Markov, Oleg V., Markov, Andrey V., Chernikov, Ivan V., Maslov, Mikhail A., Zenkova, Marina A.

Volltext

Cholesterol Conjugates of Small Interfering RNA: Linkers and Patterns of Modification von Chernikov, Ivan V, Ponomareva, Ul'yana A, Meschaninova, Mariya I, Bachkova, Irina K, Vlassov, Valentin V, Zenkova, Marina A, Chernolovskaya, Elena L

Volltext

1-Hydroxyanthraquinones Containing Aryl Substituents as Potent and Selective Anticancer Agents von Sirazhetdinova, Nafisa S, Savelyev, Victor A, Frolova, Tatyana S, Baev, Dmitry S, Klimenko, Lyubov S, Chernikov, Ivan V, Oleshko, Olga S, Sarojan, Teresa A, Pokrovskii, Andrey G, Shults, Elvira E

Volltext

Cholesterol-Containing Nuclease-Resistant siRNA Accumulates in Tumors in a Carrier-free Mode and Silences MDR1 Gene von Chernikov, Ivan V., Gladkikh, Daniil V., Meschaninova, Mariya I., Ven'yaminova, Alya G., Zenkova, Marina A., Vlassov, Valentin V., Chernolovskaya, Elena L.

Volltext

Soloxolone Methyl Reduces the Stimulatory Effect of Leptin on the Aggressive Phenotype of Murine Neuro2a Neuroblastoma Cells via the MAPK/ERK1/2 Pathway von Odarenko, Kirill V, Salomatina, Oksana V, Chernikov, Ivan V, Salakhutdinov, Nariman F, Zenkova, Marina A, Markov, Andrey V

Volltext

Transport Oligonucleotides-A Novel System for Intracellular Delivery of Antisense Therapeutics von Markov, Oleg V, Filatov, Anton V, Kupryushkin, Maxim S, Chernikov, Ivan V, Patutina, Olga A, Strunov, Anton A, Chernolovskaya, Elena L, Vlassov, Valentin V, Pyshnyi, Dmitrii V, Zenkova, Marina A

Volltext

Preparation, Determination of Activity, and Biodistribution of Cholesterol-Containing Nuclease-Resistant siRNAs In Vivo von Chernikov, Ivan V., Meschaninova, Mariya I., Chernolovskaya, Elena L.

Volltext

Carrier-free cellular uptake and the gene-silencing activity of the lipophilic siRNAs is strongly affected by the length of the linker between siRNA and lipophilic group von Petrova, Natalya S., Chernikov, Ivan V., Meschaninova, Mariya I., Dovydenko, IIya S., Venyaminova, Aliya G., Zenkova, Marina A., Vlassov, Valentin V., Chernolovskaya, Elena L.

Volltext

Trimeric Small Interfering RNAs and Their Cholesterol-Containing Conjugates Exhibit Improved Accumulation in Tumors, but Dramatically Reduced Silencing Activity von Chernikov, Ivan V, Gladkikh, Daniil V, Karelina, Ulyana A, Meschaninova, Mariya I, Ven'yaminova, Alya G, Vlassov, Valentin V, Chernolovskaya, Elena L

Volltext

siRNA-Mediated Timp1 Silencing Inhibited the Inflammatory Phenotype during Acute Lung Injury von Chernikov, Ivan V, Staroseletz, Yaroslav Yu, Tatarnikova, Irina S, Sen'kova, Aleksandra V, Savin, Innokenty A, Markov, Andrey V, Logashenko, Evgeniya B, Chernolovskaya, Elena L, Zenkova, Marina A, Vlassov, Valentin V

Volltext

Cholesterol-Conjugated Supramolecular Multimeric siRNAs: Effect of siRNA Length on Accumulation and Silencing In Vitro and In Vivo von Chernikov, Ivan V, Ponomareva, Ul'yana A, Meschaninova, Mariya I, Bachkova, Irina K, Teterina, Anna A, Gladkikh, Daniil V, Savin, Innokenty A, Vlassov, Valentin V, Zenkova, Marina A, Chernolovskaya, Elena L

Volltext

A Novel 3-meta-Pyridine-1,2,4-oxadiazole Derivative of Glycyrrhetinic Acid as a Safe and Promising Candidate for Overcoming P‑Glycoprotein-Mediated Multidrug Resistance in Tumor Ce... von Moralev, Arseny D., Salomatina, Oksana V., Chernikov, Ivan V., Salakhutdinov, Nariman F., Zenkova, Marina A., Markov, Andrey V.

Volltext

Nuclease‐resistant 63‐bp trimeric siRNAs simultaneously silence three different genes in tumor cells von Gvozdeva, Olga V., Gladkih, Daniil V., Chernikov, Ivan V., Meschaninova, Mariya I., Venyaminova, Alya G., Zenkova, Marina A., Vlassov, Valentin V., Chernolovskaya, Elena L.

Volltext

Cholesterol-Modified Anti-Il6 siRNA Reduces the Severity of Acute Lung Injury in Mice von Chernikov, Ivan V, Bachkova, Irina K, Sen'kova, Aleksandra V, Meschaninova, Mariya I, Savin, Innokenty A, Vlassov, Valentin V, Zenkova, Marina A, Chernolovskaya, Elena L

Volltext

Folate-Equipped Cationic Liposomes Deliver Anti-MDR1-siRNA to the Tumor and Increase the Efficiency of Chemotherapy von Gladkikh, Daniil V., Sen′kova, Aleksandra V., Chernikov, Ivan V., Kabilova, Tatyana O., Popova, Nelly A., Nikolin, Valery P., Shmendel, Elena V., Maslov, Mikhail A., Vlassov, Valentin V., Zenkova, Marina A., Chernolovskaya, Elena L.

Volltext

Extracellular vesicle mimetics as delivery vehicles for oligonucleotide-based therapeutics and plasmid DNA von Oshchepkova, Anastasiya, Chernikov, Ivan, Miroshnichenko, Svetlana, Patutina, Olga, Markov, Oleg, Savin, Innokenty, Staroseletz, Yaroslav, Meschaninova, Mariya, Puchkov, Pavel, Zhukov, Sergey, Kupryushkin, Maxim, Maslov, Mikhail, Sen'kova, Aleksandra, Vlassov, Valentin, Chernolovskaya, Elena, Zenkova, Marina

Volltext

Autocrine-based selection of ligands for personalized CAR-T therapy of lymphoma von Stepanov, Alexey V, Markov, Oleg V, Chernikov, Ivan V, Gladkikh, Daniil V, Zhang, Hongkai, Jones, Teresa, Sen'kova, Alexandra V, Chernolovskaya, Elena L, Zenkova, Marina A, Kalinin, Roman S, Rubtsova, Maria P, Meleshko, Alexander N, Genkin, Dmitry D, Belogurov, Jr, Alexey A, Xie, Jia, Gabibov, Alexander G, Lerner, Richard A

Volltext