Therapeutic potential of α7 nicotinic acetylcholine receptor agonists to combat obesity, diabetes, and inflammation von Xie, Han, Yepuri, Natesh, Meng, Qinghe, Dhawan, Ravi, Leech, Colin A., Chepurny, Oleg G., Holz, George G., Cooney, Robert N.

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Cytotoxic Activity of Novel GnRH Analogs Conjugated with Mitoxantrone in Ovarian Cancer Cells von Markatos, Christos, Biniari, Georgia, Chepurny, Oleg G, Karageorgos, Vlasios, Tsakalakis, Nikos, Komontachakis, Georgios, Vlata, Zacharenia, Venihaki, Maria, Holz, George G, Tselios, Theodore, Liapakis, George

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Isoform-specific antagonists of exchange proteins directly activated by cAMP von Tsalkova, Tamara, Mei, Fang C, Li, Sheng, Chepurny, Oleg G, Leech, Colin A, Liu, Tong, Holz, George G, Woods, Virgil L, Cheng, Xiaodong

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Cell physiology of cAMP sensor Epac von Holz, George G., Kang, Guoxin, Harbeck, Mark, Roe, Michael W., Chepurny, Oleg G.

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A peptide triple agonist of GLP-1, neuropeptide Y1, and neuropeptide Y2 receptors promotes glycemic control and weight loss von Chichura, Kylie S., Elfers, Clinton T., Salameh, Therese S., Kamat, Varun, Chepurny, Oleg G., McGivney, Aelish, Milliken, Brandon T., Holz, George G., Applebey, Sarah V., Hayes, Matthew R., Sweet, Ian R., Roth, Christian L., Doyle, Robert P.

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Identification and Characterization of Small Molecules as Potent and Specific EPAC2 Antagonists von Chen, Haijun, Tsalkova, Tamara, Chepurny, Oleg G, Mei, Fang C, Holz, George G, Cheng, Xiaodong, Zhou, Jia

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Corrination of a GLP-1 Receptor Agonist for Glycemic Control without Emesis von Borner, Tito, Workinger, Jayme L., Tinsley, Ian C., Fortin, Samantha M., Stein, Lauren M., Chepurny, Oleg G., Holz, George G., Wierzba, Aleksandra J., Gryko, Dorota, Nexø, Ebba, Shaulson, Evan D., Bamezai, Ankur, Da Silva, Valentina A. Rodriguez, De Jonghe, Bart C., Hayes, Matthew R., Doyle, Robert P.

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Nonpeptidic Z360-Analogs Tagged with Trivalent Radiometals as Anti-CCK2R Cancer Theranostic Agents: A Preclinical Study von Nock, Berthold A., Kanellopoulos, Panagiotis, Chepurny, Oleg G., Rouchota, Maritina, Loudos, George, Holz, George G., Krenning, Eric P., Maina, Theodosia

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Rp-cAMPS Prodrugs Reveal the cAMP Dependence of First-Phase Glucose-Stimulated Insulin Secretion von Schwede, Frank, Chepurny, Oleg G, Kaufholz, Melanie, Bertinetti, Daniela, Leech, Colin A, Cabrera, Over, Zhu, Yingmin, Mei, Fang, Cheng, Xiaodong, Manning Fox, Jocelyn E, MacDonald, Patrick E, Genieser, Hans-G, Herberg, Friedrich W, Holz, George G

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Stimulation of Proglucagon Gene Expression by Human GPR119 in Enteroendocrine L-cell Line GLUTag von Chepurny, Oleg G, Bertinetti, Daniela, Diskar, Mandy, Leech, Colin A, Afshari, Parisa, Tsalkova, Tamara, Cheng, Xiaodong, Schwede, Frank, Genieser, Hans-G, Herberg, Friedrich W, Holz, George G

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Intra-islet glucagon confers β-cell glucose competence for first-phase insulin secretion and favors GLP-1R stimulation by exogenous glucagon von Cabrera, Over, Ficorilli, James, Shaw, Janice, Echeverri, Felipe, Schwede, Frank, Chepurny, Oleg G., Leech, Colin A., Holz, George G.

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A Novel Cyclic Adenosine Monophosphate–Responsive Luciferase Reporter Incorporating a Nonpalindromic Cyclic Adenosine Monophosphate Response Element Provides Optimal Performance fo... von Chepurny, Oleg G., Holz, George G.

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PI3 kinases p110 α and PI3K-C2 β negatively regulate cAMP via PDE3/8 to control insulin secretion in mouse and human islets von Kolic, Jelena, Manning Fox, Jocelyn E, Chepurny, Oleg G, Spigelman, Aliya F, Ferdaoussi, Mourad, Schwede, Frank, Holz, George G, MacDonald, Patrick E

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Nonconventional glucagon and GLP-1 receptor agonist and antagonist interplay at the GLP-1 receptor revealed in high-throughput FRET assays for cAMP von Chepurny, Oleg G., Matsoukas, Minos-Timotheos, Liapakis, George, Leech, Colin A., Milliken, Brandon T., Doyle, Robert P., Holz, George G.

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Phospholipase C-ε links Epac2 activation to the potentiation of glucose-stimulated insulin secretion from mouse islets of Langerhans von Dzhura, Igor, Chepurny, Oleg G., Leech, Colin A., Roe, Michael W., Dzhura, Elvira, Xu, Xin, Lu, Youming, Schwede, Frank, Genieser, Hans-G., Smrcka, Alan V., Holz, George G.

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Restoration of Glucose-Stimulated Cdc42-Pak1 Activation and Insulin Secretion by a Selective Epac Activator in Type 2 Diabetic Human Islets von Veluthakal, Rajakrishnan, Chepurny, Oleg G, Leech, Colin A, Schwede, Frank, Holz, George G, Thurmond, Debbie C

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Epac-selective cAMP analogs: New tools with which to evaluate the signal transduction properties of cAMP-regulated guanine nucleotide exchange factors von Holz, George G., Chepurny, Oleg G., Schwede, Frank

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Design and Evaluation of Peptide Dual-Agonists of GLP‑1 and NPY2 Receptors for Glucoregulation and Weight Loss with Mitigated Nausea and Emesis von Milliken, Brandon T, Elfers, Clinton, Chepurny, Oleg G, Chichura, Kylie S, Sweet, Ian R, Borner, Tito, Hayes, Matthew R, De Jonghe, Bart C, Holz, George G, Roth, Christian L, Doyle, Robert P

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The alpha‐7 nicotinic acetylcholine receptor agonist GTS‐21 engages the glucagon‐like peptide‐1 incretin hormone axis to lower levels of blood glucose in db/db mice von Meng, Qinghe, Chepurny, Oleg G., Leech, Colin A., Pruekprasert, Napat, Molnar, Megan E., Collier, James Jason, Cooney, Robert N., Holz, George G.

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Corrination mitigates peptide aggregation as exemplified for Glucagon von Liles, Amber, Cham, Nancy, Opp, Morgan L, Tinsley, Ian C, Chepurny, Oleg G, Holz, George G, Doyle, Robert P

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