Pyruvate carboxylase is required for glutamine-independent growth of tumor cells von Cheng, Tzuling, Sudderth, Jessica, Yang, Chendong, Mullen, Andrew R, Jin, Eunsook S, Matés, José M, DeBerardinis, Ralph J

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Substrate and Functional Diversity of Lysine Acetylation Revealed by a Proteomics Survey von Kim, Sung Chan, Sprung, Robert, Chen, Yue, Xu, Yingda, Ball, Haydn, Pei, Jimin, Cheng, Tzuling, Kho, Yoonjung, Xiao, Hao, Xiao, Lin, Grishin, Nick V., White, Michael, Yang, Xiang-Jiao, Zhao, Yingming

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TBK1 Directly Engages Akt/PKB Survival Signaling to Support Oncogenic Transformation von Ou, Yi-Hung, Torres, Michael, Ram, Rosalyn, Formstecher, Etienne, Roland, Christina, Cheng, Tzuling, Brekken, Rolf, Wurz, Ryan, Tasker, Andrew, Polverino, Tony, Tan, Seng-Lai, White, Michael A.

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RalB and the Exocyst Mediate the Cellular Starvation Response by Direct Activation of Autophagosome Assembly von Bodemann, Brian O., Orvedahl, Anthony, Cheng, Tzuling, Ram, Rosalyn R., Ou, Yi-Hung, Formstecher, Etienne, Maiti, Mekhala, Hazelett, C. Clayton, Wauson, Eric M., Balakireva, Maria, Camonis, Jacques H., Yeaman, Charles, Levine, Beth, White, Michael A.

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Glutaminase isoforms expression switches microRNA levels and oxidative status in glioblastoma cells von de los Santos-jimenez, Juan, Campos-Sandoval, Jose A., Marquez-Torres, Clara, Urbano-Polo, Nieves, Brondegaard, David, Martin-Rufian, Mercedes, Lobo, Carolina, Penalver, Ana, Gomez-Garcia, Maria C., Martin-Campos, Janet, Cardona, Carolina, Castilla, Laura, da Costa Souza, Felipe, Cheng, Tzuling, Segura, Juan A., Alonso, Francisco J., Curi, Rui, Colquhoun, Alison, DeBerardinis, Ralph J., Marquez, Javier, Mates, Jose M.

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Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer von DeBerardinis, R J, Cheng, T

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Reductive carboxylation supports growth in tumour cells with defective mitochondria von Mullen, Andrew R., Wheaton, William W., Jin, Eunsook S., Chen, Pei-Hsuan, Sullivan, Lucas B., Cheng, Tzuling, Yang, Youfeng, Linehan, W. Marston, Chandel, Navdeep S., DeBerardinis, Ralph J.

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ARC-20: A phase 1 dose-escalation and dose-expansion study to investigate the safety, tolerability, and pharmacology of HIF-2α inhibitor AB521 monotherapy in patients with clear ce... von Choueiri, Toni K., Garmezy, Benjamin, Paterson, Elaine, Ghasemi, Mohammad, Cheng, Tzuling, Foster, Paul G., Hauke, Ralph J., Patnaik, Amita

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A Small-Molecule Antagonist of HIF2α Is Efficacious in Preclinical Models of Renal Cell Carcinoma von Wallace, Eli M, Rizzi, James P, Han, Guangzhou, Wehn, Paul M, Cao, Zhaodan, Du, Xinlin, Cheng, Tzuling, Czerwinski, Robert M, Dixon, Darryl D, Goggin, Barry S, Grina, Jonas A, Halfmann, Megan M, Maddie, Melissa A, Olive, Sarah R, Schlachter, Stephen T, Tan, Huiling, Wang, Bin, Wang, Keshi, Xie, Shanhai, Xu, Rui, Yang, Hanbiao, Josey, John A

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Design and Activity of Specific Hypoxia-Inducible Factor-2α (HIF-2α) Inhibitors for the Treatment of Clear Cell Renal Cell Carcinoma: Discovery of Clinical Candidate ( S)-3-((2,2-D... von Wehn, Paul M, Rizzi, James P, Dixon, Darryl D, Grina, Jonas A, Schlachter, Stephen T, Wang, Bin, Xu, Rui, Yang, Hanbiao, Du, Xinlin, Han, Guangzhou, Wang, Keshi, Cao, Zhaodan, Cheng, Tzuling, Czerwinski, Robert M, Goggin, Barry S, Huang, Heli, Halfmann, Megan M, Maddie, Melissa A, Morton, Emily L, Olive, Sarah R, Tan, Huiling, Xie, Shanhai, Wong, Tai, Josey, John A, Wallace, Eli M

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Design and Activity of Specific Hypoxia-Inducible Factor-2α (HIF-2α) Inhibitors for the Treatment of Clear Cell Renal Cell Carcinoma: Discovery of Clinical Candidate (S)‑3-((2,2-Di... von Wehn, Paul M, Rizzi, James P, Dixon, Darryl D, Grina, Jonas A, Schlachter, Stephen T, Wang, Bin, Xu, Rui, Yang, Hanbiao, Du, Xinlin, Han, Guangzhou, Wang, Keshi, Cao, Zhaodan, Cheng, Tzuling, Czerwinski, Robert M, Goggin, Barry S, Huang, Heli, Halfmann, Megan M, Maddie, Melissa A, Morton, Emily L, Olive, Sarah R, Tan, Huiling, Xie, Shanhai, Wong, Tai, Josey, John A, Wallace, Eli M

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Both GLS silencing and GLS2 overexpression synergize with oxidative stress against proliferation of glioma cells von Martín-Rufián, Mercedes, Nascimento-Gomes, Renata, Higuero, Ana, Crisma, Amanda R., Campos-Sandoval, José A., Gómez-García, María C., Cardona, Carolina, Cheng, Tzuling, Lobo, Carolina, Segura, Juan A., Alonso, Francisco J., Szeliga, Monika, Albrecht, Jan, Curi, Rui, Márquez, Javier, Colquhoun, Alison, DeBerardinis, Ralph J., Matés, José M.

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Abstract A002: Targeting hypoxia inducible factor (HIF)-2α with AB521, a novel and potent small molecule HIF-2α inhibitor, for the treatment of clear cell renal cell carcinoma von Piovesan, Dana, Cho, Soonweng, Lawson, Kenneth V., Liao, Kai H., Foster, Paul G., Cheng, Tzuling, Walters, Matthew J., Gauthier, Kelsey E. Sivick

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Comprehensive Mapping of the Human Kinome to Epidermal Growth Factor Receptor Signaling von Komurov, Kakajan, Padron, David, Cheng, Tzuling, Roth, Michael, Rosenblatt, Kevin P., White, Michael A.

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Abstract 1943: PARG inhibitors exhibit synthetic lethality with XRCC1 deficiency and a cellular mechanism of action that is distinct from PARP inhibition von Martin, Leenus, Cheng, Tzuling, James, Dominic I., Begum, Habiba, Smith, Kate M., Jordan, Allan, Waddell, Ian, Vaidya, Kedar, Fischer, Marcus, Yao, Bing, Drummond, Jason, Cleary, Leah, Martinez, Ruben, Sutton, James, Ravindran, Nandini, Joseph, James, Venetsanakos, Eleni, Dillon, Michael, Hager, Jeffrey H., Belmont, Lisa D.

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Abstract B140: PT2977, a novel HIF-2a antagonist, has potent antitumor activity and remodels the immunosuppressive tumor microenvironment in clear cell renal cell cancer von Wong, Tai W., Shrimali, Rajeev, Contreras, Cristina, Cheng, Tzuling, Czerwinski, Robert M., Dixon, Daryl D., Du, Xinlin, Fett, Craig, Goree, Jessica, Grina, Jonas A., Han, Guangzhou, Huang, Heli, Rizzi, Jim, Schlachter, Stephen T., Wang, Bin, Wang, Keshi, Wehn, Paul M., Xie, Shanhai, Xu, Rui, Yang, Hanbiao, Josey, John A., Wallace, Eli M.

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Abstract DDT01-01: PT2385: First-in-class HIF-2α antagonist for the treatment of renal cell carcinoma von Wallace, Eli M., Cao, Zhaodan, Cheng, Tzuling, Czerwinski, Robert, Dixon, Darryl D., Du, Xinlin, Goggin, Barry, Grina, Jonas, Halfmann, Megan, Han, Guangzhou, Huang, Heli, Josey, John A., Maddie, Melissa A., Olive, Sarah, Rizzi, James, Schlachter, Stephen T., Tan, Hui-Ling, Wang, Bin, Wang, Keshi, Wehn, Paul M., Xie, Shanhai, Xu, Rui, Yang, Hanbiao

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Critical Contribution of RAL GTPases to Growth and Survival of Breast Cancer Cells von Cheng, Tzuling

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Additional file 3 of Glutaminase isoforms expression switches microRNA levels and oxidative status in glioblastoma cells von Santos-Jiménez, Juan De Los, Campos-Sandoval, José A., Márquez-Torres, Clara, Urbano-Polo, Nieves, Brøndegaard, David, Martín-Rufián, Mercedes, Lobo, Carolina, Peñalver, Ana, Gómez-García, María C., Martín-Campos, Janet, Cardona, Carolina, Castilla, Laura, Souza, Felipe Da Costa, Tzuling Cheng, Segura, Juan A., Alonso, Francisco J., Curi, Rui, Colquhoun, Alison, DeBerardinis, Ralph J., Márquez, Javier, Matés, José M.

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Additional file 5 of Glutaminase isoforms expression switches microRNA levels and oxidative status in glioblastoma cells von Santos-Jiménez, Juan De Los, Campos-Sandoval, José A., Márquez-Torres, Clara, Urbano-Polo, Nieves, Brøndegaard, David, Martín-Rufián, Mercedes, Lobo, Carolina, Peñalver, Ana, Gómez-García, María C., Martín-Campos, Janet, Cardona, Carolina, Castilla, Laura, Souza, Felipe Da Costa, Tzuling Cheng, Segura, Juan A., Alonso, Francisco J., Curi, Rui, Colquhoun, Alison, DeBerardinis, Ralph J., Márquez, Javier, Matés, José M.

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