Fibroblast Growth Factor Receptors (FGFRs): Structures and Small Molecule Inhibitors von Dai, Shuyan, Zhou, Zhan, Chen, Zhuchu, Xu, Guangyu, Chen, Yongheng

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Structural insight into the molecular mechanism of p53-mediated mitochondrial apoptosis von Wei, Hudie, Qu, Lingzhi, Dai, Shuyan, Li, Yun, Wang, Haolan, Feng, Yilu, Chen, Xiaojuan, Jiang, Longying, Guo, Ming, Li, Jun, Chen, Zhuchu, Chen, Lin, Zhang, Ye, Chen, Yongheng

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Computational repositioning of dimethyl fumarate for treating alcoholic liver disease von Zhang, Ye, Zhao, Shuang, Fu, Ying, Yan, Lu, Feng, Yilu, Chen, Yaqi, Wu, Yijia, Deng, Yalan, Zhang, Guiying, Chen, Zhuchu, Chen, Yongheng, Liu, Ting

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Structures of p53/BCL-2 complex suggest a mechanism for p53 to antagonize BCL-2 activity von Wei, Hudie, Wang, Haolan, Wang, Genxin, Qu, Lingzhi, Jiang, Longying, Dai, Shuyan, Chen, Xiaojuan, Zhang, Ye, Chen, Zhuchu, Li, Youjun, Guo, Ming, Chen, Yongheng

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LY2874455 potently inhibits FGFR gatekeeper mutants and overcomes mutation-based resistance von Wu, Daichao, Guo, Ming, Min, Xiaoli, Dai, Shuyan, Li, Meixiang, Tan, Sijie, Li, Guoqing, Chen, Xiaojuan, Ma, Yao, Li, Jun, Jiang, Longying, Qu, Lingzhi, Zhou, Zhan, Chen, Zhuchu, Chen, Lin, Xu, Guangyu, Chen, Yongheng

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Amyloid aggregates induced by the p53-R280T mutation lead to loss of p53 function in nasopharyngeal carcinoma von Li, Jingzhi, Guo, Ming, Chen, Lin, Chen, Zhuchu, Fu, Ying, Chen, Yongheng

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p53 amyloid aggregation in cancer: function, mechanism, and therapy von Li, Jingzhi, Guo, Ming, Chen, Lin, Chen, Zhuchu, Fu, Ying, Chen, Yongheng

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Mass spectrometry-based proteomic capture of proteins bound to the MACC1 promoter in colon cancer von Huang, Yahui, Xiang, Yi, Xie, Zhongpeng, Cai, Yuxiang, Yang, Qiongzhi, Huang, Huichao, Chen, Zhuchu, Xiao, Zhefeng, He, Qiongqiong

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Structure of the Forkhead Domain of FOXA2 Bound to a Complete DNA Consensus Site von Li, Jun, Dantas Machado, Ana Carolina, Guo, Ming, Sagendorf, Jared M, Zhou, Zhan, Jiang, Longying, Chen, Xiaojuan, Wu, Daichao, Qu, Lingzhi, Chen, Zhuchu, Chen, Lin, Rohs, Remo, Chen, Yongheng

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Down-regulation of miR-675-5p contributes to tumor progression and development by targeting pro-tumorigenic GPR55 in non-small cell lung cancer von He, Dan, Wang, Jun, Zhang, Chunfang, Shan, Bin, Deng, Xiyun, Li, Bin, Zhou, Yanwu, Chen, Wei, Hong, Jidong, Gao, Yang, Chen, Zhuchu, Duan, Chaojun

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CapG promoted nasopharyngeal carcinoma cell motility involving Rho motility pathway independent of ROCK von Fu, Ying, Zhang, Xiuzhi, Liang, Xujun, Chen, Yongheng, Chen, Zhuchu, Xiao, Zhefeng

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Crystal Structure of the FGFR4/LY2874455 Complex Reveals Insights into the Pan-FGFR Selectivity of LY2874455 von Wu, Daichao, Guo, Ming, Philips, Michael A, Qu, Lingzhi, Jiang, Longying, Li, Jun, Chen, Xiaojuan, Chen, Zhuchu, Chen, Lin, Chen, Yongheng

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Structure of p53 binding to the BAX response element reveals DNA unwinding and compression to accommodate base-pair insertion von Chen, Yongheng, Zhang, Xiaojun, Dantas Machado, Ana Carolina, Ding, Yuan, Chen, Zhuchu, Qin, Peter Z, Rohs, Remo, Chen, Lin

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Structural insights into the potency and selectivity of covalent pan-FGFR inhibitors von Qu, Lingzhi, Chen, Xiaojuan, Wei, Hudie, Guo, Ming, Dai, Shuyan, Jiang, Longying, Li, Jun, Yue, Sitong, Chen, Zhuchu, Chen, Yongheng

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Proteomic analysis of stromal proteins in different stages of colorectal cancer establishes Tenascin-C as a stromal biomarker for colorectal cancer metastasis von Li, Maoyu, Peng, Fang, Li, Guoqing, Fu, Yang, Huang, Ying, Chen, Zhuchu, Chen, Yongheng

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Suberoylanilide Hydroxamic Acid (SAHA) Treatment Reveals Crosstalk Among Proteome, Phosphoproteome, and Acetylome in Nasopharyngeal Carcinoma Cells von Huang, Huichao, Fu, Ying, Duan, Yankun, Zhang, Ye, Lu, Miaolong, Chen, Zhuchu, Li, Maoyu, Chen, Yongheng

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Afatinib Reverses EMT via Inhibiting CD44-Stat3 Axis to Promote Radiosensitivity in Nasopharyngeal Carcinoma von Huang, Huichao, Huang, Fangling, Liang, Xujun, Fu, Ying, Cheng, Zhe, Huang, Yan, Chen, Zhuchu, Duan, Yankun, Chen, Yongheng

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Structural basis of the farnesoid X receptor/retinoid X receptor heterodimer on inverted repeat DNA von Jiang, Longying, Liu, Xueke, Liang, Xujun, Dai, Shuyan, Wei, Hudie, Guo, Ming, Chen, Zhuchu, Xiao, Desheng, Chen, Yongheng

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Correction to: Mass spectrometry-based proteomic capture of proteins bound to the MACC1 promoter in colon cancer von Huang, Yahui, Xiang, Yi, Xie, Zhongpeng, Cai, Yuxiang, Yang, Qiongzhi, Huang, Huichao, Chen, Zhuchu, Xiao, Zhefeng, He, Qiongqiong

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Coupling of Cell Surface Biotinylation and SILAC-Based Quantitative Proteomics Identified Myoferlin as a Potential Therapeutic Target for Nasopharyngeal Carcinoma Metastasis von Li, Maoyu, Peng, Fang, Wang, Guoqiang, Liang, Xujun, Shao, Meiying, Chen, Zhuchu, Chen, Yongheng

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