Characterization of a Novel PKA Phosphorylation Site, Serine-2030, Reveals No PKA Hyperphosphorylation of the Cardiac Ryanodine Receptor in Canine Heart Failure von Xiao, Bailong, Jiang, Ming Tao, Zhao, Mingcai, Yang, Dongmei, Sutherland, Cindy, Lai, F Anthony, Walsh, Michael P, Warltier, David C, Cheng, Heping, Chen, S R.Wayne

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RyR2‐dependent modulation of neuronal hyperactivity: A potential therapeutic target for treating Alzheimer's disease von Yao, Jinjing, Chen, S. R. Wayne

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Structural basis for the gating mechanism of the type 2 ryanodine receptor RyR2 von Peng, Wei, Shen, Huaizong, Wu, Jianping, Guo, Wenting, Pan, Xiaojing, Wang, Ruiwu, Chen, S. R. Wayne, Yan, Nieng

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Modulation of cardiac ryanodine receptor 2 by calmodulin von Gong, Deshun, Chi, Ximin, Wei, Jinhong, Zhou, Gewei, Huang, Gaoxingyu, Zhang, Lin, Wang, Ruiwu, Lei, Jianlin, Chen, S. R. Wayne, Yan, Nieng

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A Gating Mutation in Ryanodine Receptor Type 2 Rescues Phenotypes of Alzheimer's Disease Mouse Models by Upregulating Neuronal Autophagy von Zhang, Hua, Knight, Caitlynn, Chen, S R Wayne, Bezprozvanny, Ilya

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Increased RyR2 open probability induces neuronal hyperactivity and memory loss with or without Alzheimer's disease–causing gene mutations von Yao, Jinjing, Liu, Yajing, Sun, Bo, Zhan, Xiaoqin, Estillore, John Paul, Turner, Ray W., Chen, S. R. Wayne

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The central domain of cardiac ryanodine receptor governs channel activation, regulation, and stability von Guo, Wenting, Sun, Bo, Estillore, John Paul, Wang, Ruiwu, Chen, S. R.Wayne

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Limiting RyR2 open time prevents Alzheimer's disease‐related deficits in the 3xTG‐AD mouse model von Liu, Yajing, Yao, Jinjing, Song, Zhenpeng, Guo, Wenting, Sun, Bo, Wei, Jinhong, Estillore, John Paul, Back, Thomas G., Chen, S. R. Wayne

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A Gain-of-function Mutation in the Gating Domain of ITPR1 Impairs Motor Movement and Increases Thermal and Mechanical Sensitivity von Yao, Jinjing, Ni, Mingke, Tian, Shanshan, Sun, Bo, Wang, Ruiwu, Estillore, John Paul, Back, Thomas G., Chen, S.R. Wayne

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Mitochondrial fusion dynamics is robust in the heart and depends on calcium oscillations and contractile activity von Eisner, Verónica, Cupo, Ryan R., Gao, Erhe, Csordás, György, Slovinsky, William S., Paillard, Melanie, Cheng, Lan, Ibetti, Jessica, Chen, S. R. Wayne, Chuprun, J. Kurt, Hoek, Jan B., Koch, Walter J., Hajnóczky, György

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Foxp3-mediated blockage of ryanodine receptor 2 underlies contact-based suppression by regulatory T cells von Wang, Xiaobo, Geng, Shuang, Meng, Junchen, Kang, Ning, Liu, Xinyi, Xu, Yanni, Lyu, Huiyun, Xu, Ying, Xu, Xun, Song, Xinrong, Zhang, Bin, Wang, Xin, Nuerbulati, Nuerdida, Zhang, Ze, Zhai, Di, Mao, Xin, Sun, Ruya, Wang, Xiaoting, Wang, Ruiwu, Guo, Jie, Chen, S R Wayne, Zhou, Xuyu, Xia, Tie, Qi, Hai, Hu, Xiaoyu, Shi, Yan

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R-carvedilol, a potential new therapy for Alzheimer's disease von Yao, Jinjing, Chen, S R Wayne

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Genetically and pharmacologically limiting RyR2 open time prevents neuronal hyperactivity of hippocampal CA1 neurons in brain slices of 5xFAD mice von Sun, Bo, Yao, Jinjing, Chen, Alexander W., Estillore, John Paul, Wang, Ruiwu, Back, Thomas G., Chen, S.R. Wayne

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Role of cardiac ryanodine receptor calmodulin‐binding domains in mediating the action of arrhythmogenic calmodulin N‐domain mutation N54I von Søndergaard, Mads T., Liu, Yingjie, Guo, Wenting, Wei, Jinhong, Wang, Ruiwu, Brohus, Malene, Overgaard, Michael T., Chen, S. R. Wayne

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Two pools of IRE1α in cardiac and skeletal muscle cells von Wang, Qian, Groenendyk, Jody, Paskevicius, Tautvydas, Qin, Wenying, Kor, Kaylen C., Liu, Yingjie, Hiess, Florian, Knollmann, Bjorn C., Chen, S. R. Wayne, Tang, Jingfeng, Chen, Xing‐Zhen, Agellon, Luis B., Michalak, Marek

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Junctophilin Proteins Tether a Cav1-RyR2-KCa3.1 Tripartite Complex to Regulate Neuronal Excitability von Sahu, Giriraj, Wazen, Rima-Marie, Colarusso, Pina, Chen, S.R. Wayne, Zamponi, Gerald W., Turner, Ray W.

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Limiting RyR2 Open Time Prevents Alzheimer’s Disease-Related Neuronal Hyperactivity and Memory Loss but Not β-Amyloid Accumulation von Yao, Jinjing, Sun, Bo, Institoris, Adam, Zhan, Xiaoqin, Guo, Wenting, Song, Zhenpeng, Liu, Yajing, Hiess, Florian, Boyce, Andrew K.J., Ni, Mingke, Wang, Ruiwu, ter Keurs, Henk, Back, Thomas G., Fill, Michael, Thompson, Roger J., Turner, Ray W., Gordon, Grant R., Chen, S.R. Wayne

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RyR2 C-terminal Truncating Variants Identified in Patients with Arrhythmic Phenotypes Exert a Dominant Negative Effect through Formation of Wildtype-truncation Heteromers von Tian, Shanshan, Zhong, Xiaowei, Wang, Hui, Wei, Jinhong, Guo, Wenting, Wang, Ruiwu, Estillore, John Paul, Napolitano, Carlo, Duff, Henry J, Ilhan, Erkan, Knight, Linda M, Lloyd, Michael S, Roberts, Jason D, Priori, Silvia G, Chen, S R Wayne

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Human RyR2 (Ryanodine Receptor 2) Loss-of-Function Mutations: Clinical Phenotypes and In Vitro Characterization von Li, Yanhui, Wei, Jinhong, Guo, Wenting, Sun, Bo, Estillore, John Paul, Wang, Ruiwu, Yoruk, Ayhan, Roston, Thomas M., Sanatani, Shubhayan, Wilde, Arthur A.M., Gollob, Michael H., Roberts, Jason D., Tseng, Zian H., Jensen, Henrik K., Chen, S.R. Wayne

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Editorial: Repurposing β-blockers for non-cardiovascular diseases von Shahid, Ayaz, Wang, Jeffrey, Andresen, Bradley T, Chen, S R Wayne, Huang, Ying

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