Abstract 14173: Generation and Characterization of Clinically Relevant Disease Models for Port Wine Birthmark Using Induced Pluripotent Stem Cells von Nguyen, Vi, Gao, Chao, Hochman, Marcelo L, Friedman, Harold I, Chen, Elliot H, Wang, Yunguan, Jegga, Anil, Nelson, John S, Tan, Wenbin

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Mammary tumour cells remodel the bone marrow vascular microenvironment to support metastasis von Yip, Raymond K. H., Rimes, Joel S., Capaldo, Bianca D., Vaillant, François, Mouchemore, Kellie A., Pal, Bhupinder, Chen, Yunshun, Surgenor, Elliot, Murphy, Andrew J., Anderson, Robin L., Smyth, Gordon K., Lindeman, Geoffrey J., Hawkins, Edwin D., Visvader, Jane E.

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Loss-of-function mutations in TGFB2 cause a syndromic presentation of thoracic aortic aneurysm von Lindsay, Mark E, Schepers, Dorien, Bolar, Nikhita Ajit, Doyle, Jefferson J, Gallo, Elena, Fert-Bober, Justyna, Kempers, Marlies J E, Fishman, Elliot K, Chen, Yichun, Myers, Loretha, Bjeda, Djahita, Oswald, Gretchen, Elias, Abdallah F, Levy, Howard P, Anderlid, Britt-Marie, Yang, Margaret H, Bongers, Ernie M H F, Timmermans, Janneke, Braverman, Alan C, Canham, Natalie, Mortier, Geert R, Brunner, Han G, Byers, Peter H, Van Eyk, Jennifer, Van Laer, Lut, Dietz, Harry C, Loeys, Bart L

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Homozygous MTAP deletion in primary human glioblastoma is not associated with elevation of methylthioadenosine von Barekatain, Yasaman, Ackroyd, Jeffrey J., Yan, Victoria C., Khadka, Sunada, Wang, Lin, Chen, Ko-Chien, Poral, Anton H., Tran, Theresa, Georgiou, Dimitra K., Arthur, Kenisha, Lin, Yu-Hsi, Satani, Nikunj, Ballato, Elliot S., Behr, Eliot I., deCarvalho, Ana C., Verhaak, Roel G. W., de Groot, John, Huse, Jason T., Asara, John M., Kalluri, Raghu, Muller, Florian L.

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In vivo photoreceptor base editing ameliorates rhodopsin-E150K autosomal-recessive retinitis pigmentosa in mice von Du, Samuel W, Newby, Gregory A, Salom, David, Gao, Fangyuan, Menezes, Carolline Rodrigues, Suh, Susie, Choi, Elliot H, Chen, Paul Z, Liu, David R, Palczewski, Krzysztof

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Schizophrenia risk from complex variation of complement component 4 von Sekar, Aswin, Bialas, Allison R., de Rivera, Heather, Davis, Avery, Hammond, Timothy R., Kamitaki, Nolan, Tooley, Katherine, Presumey, Jessy, Baum, Matthew, Van Doren, Vanessa, Genovese, Giulio, Rose, Samuel A., Handsaker, Robert E., Daly, Mark J., Carroll, Michael C., Stevens, Beth, McCarroll, Steven A.

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LD Score regression distinguishes confounding from polygenicity in genome-wide association studies von Bulik-Sullivan, Brendan K, Loh, Po-Ru, Finucane, Hilary K, Ripke, Stephan, Yang, Jian, Patterson, Nick, Daly, Mark J, Price, Alkes L, Neale, Benjamin M

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Cerebral blood flow and cardiovascular risk effects on resting brain regional homogeneity von Adhikari, Bhim M., Hong, L. Elliot, Zhao, Zhiwei, Wang, Danny J.J., Thompson, Paul M., Jahanshad, Neda, Zhu, Alyssa H., Holiga, Stefan, Turner, Jessica A., van Erp, Theo G.M., Calhoun, Vince D., Hatch, Kathryn S., Bruce, Heather, Hare, Stephanie M., Chiappelli, Joshua, Goldwaser, Eric L., Kvarta, Mark D., Ma, Yizhou, Du, Xiaoming, Nichols, Thomas E., Shuldiner, Alan R., Mitchell, Braxton D., Dukart, Juergen, Chen, Shuo, Kochunov, Peter

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The Cognitive and Behavioral Phenotype of the 16p11.2 Deletion in a Clinically Ascertained Population von Hanson, Ellen, Bernier, Raphael, Porche, Ken, Jackson, Frank I, Goin-Kochel, Robin P, Snyder, LeeAnne Green, Snow, Anne V, Wallace, Arianne Stevens, Campe, Katherine L, Zhang, Yuan, Chen, Qixuan, D’Angelo, Debra, Moreno-De-Luca, Andres, Orr, Patrick T, Boomer, K.B, Evans, David W, Kanne, Stephen, Berry, Leandra, Miller, Fiona K, Olson, Jennifer, Sherr, Elliot, Martin, Christa L, Ledbetter, David H, Spiro, John E, Chung, Wendy K

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A functional splice variant associated with decreased asthma risk abolishes the ability of gasdermin B to induce epithelial cell pyroptosis von Panganiban, Ronald A., Sun, Maoyun, Dahlin, Amber, Park, Hae-Ryung, Kan, Mengyuan, Himes, Blanca E., Mitchel, Jennifer A., Iribarren, Carlos, Jorgenson, Eric, Randell, Scott H., Israel, Elliot, Tantisira, Kelan, Shore, Stephanie, Park, Jin-Ah, Weiss, Scott T., Wu, Ann Chen, Lu, Quan

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Complement genes contribute sex-biased vulnerability in diverse disorders von Kamitaki, Nolan, Sekar, Aswin, Handsaker, Robert E., de Rivera, Heather, Tooley, Katherine, Morris, David L., Taylor, Kimberly E., Whelan, Christopher W., Tombleson, Philip, Loohuis, Loes M. Olde, Boehnke, Michael, Kimberly, Robert P., Kaufman, Kenneth M., Harley, John B., Langefeld, Carl D., Seidman, Christine E., Pato, Michele T., Pato, Carlos N., Ophoff, Roel A., Graham, Robert R., Criswell, Lindsey A., Vyse, Timothy J., McCarroll, Steven A.

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The NIH Somatic Cell Genome Editing program von Saha, Krishanu, Sontheimer, Erik J., Brooks, P. J., Dwinell, Melinda R., Gersbach, Charles A., Liu, David R., Murray, Stephen A., Tsai, Shengdar Q., Wilson, Ross C., Anderson, Daniel G., Asokan, Aravind, Banfield, Jillian F., Bankiewicz, Krystof S., Bao, Gang, Bulte, Jeff W. M., Bursac, Nenad, Campbell, Jarryd M., Carlson, Daniel F., Chaikof, Elliot L., Chen, Zheng-Yi, Cheng, R. Holland, Clark, Karl J., Curiel, David T., Dahlman, James E., Deverman, Benjamin E., Dickinson, Mary E., Doudna, Jennifer A., Ekker, Stephen C., Emborg, Marina E., Feng, Guoping, Freedman, Benjamin S., Gamm, David M., Gao, Guangping, Ghiran, Ionita C., Glazer, Peter M., Gong, Shaoqin, Heaney, Jason D., Hennebold, Jon D., Hinson, John T., Khvorova, Anastasia, Kiani, Samira, Lagor, William R., Lam, Kit S., Leong, Kam W., Levine, Jon E., Lewis, Jennifer A., Lutz, Cathleen M., Ly, Danith H., Maragh, Samantha, McCray, Paul B., McDevitt, Todd C., Mirochnitchenko, Oleg, Morizane, Ryuji, Murthy, Niren, Prather, Randall S., Ronald, John A., Roy, Subhojit, Roy, Sushmita, Sabbisetti, Venkata, Saltzman, W. Mark, Santangelo, Philip J., Segal, David J., Shimoyama, Mary, Skala, Melissa C., Tarantal, Alice F., Tilton, John C., Truskey, George A., Vandsburger, Moriel, Watts, Jonathan K., Wells, Kevin D., Wolfe, Scot A., Xu, Qiaobing, Xue, Wen, Yi, Guohua, Zhou, Jiangbing

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Carbon foam derived from various precursors von Chen, Chong, Kennel, Elliot B., Stiller, Alfred H., Stansberry, Peter G., Zondlo, John W.

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Partitioning Heritability of Regulatory and Cell-Type-Specific Variants across 11 Common Diseases von Trynka, Gosia, Stahl, Eli, Neale, Benjamin M., Farh, Kai-How, Pers, Tune H., Albus, Margot, Cahn, Wiepke, Cai, Guiqing, Carr, Vaughan J., Carrera, Noa, Cheng, Wei, Cheung, Eric F.C., Cohen, David, Cormican, Paul, Craddock, Nick, Demontis, Ditte, Djurovic, Srdjan, Donohoe, Gary, Dudbridge, Frank, Durmishi, Naser, Eriksson, Johan, Farrell, Martilias S., Freimer, Nelson B., Fromer, Menachem, Godard, Stephanie, Goldstein, Jacqueline I., Grove, Jakob, Hartmann, Annette M., Henskens, Frans A., Herms, Stefan, Hirschhorn, Joel N., Hoffmann, Per, Hougaard, David M., Ikeda, Masashi, Julià, Antonio, Kelly, Brian J., Kennedy, James L., Kucinskas, Vaidutis, Kuzelova-Ptackova, Hana, Laurent, Claudine, Lee, S. Hong, Li, Tao, Lieberman, Jeffrey, Limborska, Svetlana, Loughland, Carmel M., Lnnqvist, Jouko, Marsal, Sara, McCarley, Robert W., Meijer, Carin J., Melegh, Bela, Melle, Ingrid, Milani, Lili, Mors, Ole, Myin-Germeys, Inez, Nikitina-Zake, Liene, O’Callaghan, Eadbhard, O’Dushlaine, Colm, O’Neill, F. Anthony, Oh, Sang-Yun, Pantelis, Christos, Parkhomenko, Elena, Perkins, Diana O., Powell, John, Quested, Digby, Salomaa, Veikko, Schubert, Christian R., Shi, Jianxin, Sigurdsson, Engilbert, Sim, Kang, Stogmann, Elisabeth, Strengman, Eric, Suvisaari, Jaana, Thirumalai, Srinivas, Veijola, Juha, Walsh, Dermot, Weiser, Mark, Witt, Stephanie H., Wong, Emily H.M., Wu, Jing Qin, Stefansson, Kari, Blackwood, Douglas H.R., Ehrenreich, Hannelore, Gurling, Hugh, Hultman, Christina M., Kirov, George, Malhotra, Anil K., McCarroll, Steven A., McQuillin, Andrew, Palotie, Aarno, Rietschel, Marcella, Sham, Pak C., O’Donovan, Michael C., Bergen, Sarah, Magnusson, Patrik K.E., Scolnick, Edward, Purcell, Shaun M., Pasaniuc, Bogdan, Sullivan, Patrick F., Raychaudhuri, Soumya, Price, Alkes L.

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Immunology of COVID-19: Current State of the Science von Vabret, Nicolas, Britton, Graham J., Gruber, Conor, Hegde, Samarth, Kim, Joel, Kuksin, Maria, Levantovsky, Rachel, Malle, Louise, Moreira, Alvaro, Park, Matthew D., Pia, Luisanna, Risson, Emma, Saffern, Miriam, Salomé, Bérengère, Esai Selvan, Myvizhi, Spindler, Matthew P., Tan, Jessica, van der Heide, Verena, Gregory, Jill K., Alexandropoulos, Konstantina, Bhardwaj, Nina, Brown, Brian D., Greenbaum, Benjamin, Gümüş, Zeynep H., Homann, Dirk, Horowitz, Amir, Kamphorst, Alice O., Curotto de Lafaille, Maria A., Mehandru, Saurabh, Merad, Miriam, Samstein, Robert M., Agrawal, Manasi, Aleynick, Mark, Belabed, Meriem, Brown, Matthew, Casanova-Acebes, Maria, Catalan, Jovani, Centa, Monica, Charap, Andrew, Chan, Andrew, Chen, Steven T., Chung, Jonathan, Bozkus, Cansu Cimen, Cody, Evan, Cossarini, Francesca, Dalla, Erica, Fernandez, Nicolas, Grout, John, Ruan, Dan Fu, Hamon, Pauline, Humblin, Etienne, Jha, Divya, Kodysh, Julia, Leader, Andrew, Lin, Matthew, Lindblad, Katherine, Lozano-Ojalvo, Daniel, Lubitz, Gabrielle, Magen, Assaf, Mahmood, Zafar, Martinez-Delgado, Gustavo, Mateus-Tique, Jaime, Meritt, Elliot, Moon, Chang, Noel, Justine, O’Donnell, Tim, Ota, Miyo, Plitt, Tamar, Pothula, Venu, Redes, Jamie, Reyes Torres, Ivan, Roberto, Mark, Sanchez-Paulete, Alfonso R., Shang, Joan, Schanoski, Alessandra Soares, Suprun, Maria, Tran, Michelle, Vaninov, Natalie, Wilk, C. Matthias, Aguirre-Ghiso, Julio, Bogunovic, Dusan, Cho, Judy, Faith, Jeremiah, Grasset, Emilie, Heeger, Peter, Kenigsberg, Ephraim, Krammer, Florian, Laserson, Uri

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PT320, Sustained-Release Exendin-4, Mitigates L-DOPA-Induced Dyskinesia in a Rat 6-Hydroxydopamine Model of Parkinson's Disease von Yu, Seong-Jin, Chen, Shuchun, Yang, Yung-Yung, Glotfelty, Elliot J, Jung, Jin, Kim, Hee Kyung, Choi, Ho-Il, Choi, Doo-Sup, Hoffer, Barry J, Greig, Nigel H, Wang, Yun

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Development of high-repetition-rate laser pump/x-ray probe methodologies for synchrotron facilities von March, Anne Marie, Stickrath, Andrew, Doumy, Gilles, Kanter, Elliot P., Krässig, Bertold, Southworth, Stephen H., Attenkofer, Klaus, Kurtz, Charles A., Chen, Lin X., Young, Linda

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A Site‐Wise Reliability Analysis of the ABCD Diffusion Fractional Anisotropy and Cortical Thickness: Impact of Scanner Platforms von Pan, Yezhi, Hong, L. Elliot, Acheson, Ashley, Thompson, Paul M., Jahanshad, Neda, Zhu, Alyssa H., Yu, Jiaao, Chen, Chixiang, Ma, Tianzhou, Liu, Ho‐Ling, Veraart, Jelle, Fieremans, Els, Karcher, Nicole R., Kochunov, Peter, Chen, Shuo

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Contrasting genetic architectures of schizophrenia and other complex diseases using fast variance-components analysis von Loh, Po-Ru, Bhatia, Gaurav, Gusev, Alexander, Finucane, Hilary K, Bulik-Sullivan, Brendan K, Pollack, Samuela J, de Candia, Teresa R, Lee, Sang Hong, Wray, Naomi R, Kendler, Kenneth S, O'Donovan, Michael C, Neale, Benjamin M, Patterson, Nick, Price, Alkes L

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Efficacy of Ruxolitinib in Patients With Chronic Neutrophilic Leukemia and Atypical Chronic Myeloid Leukemia von Dao, Kim-Hien T, Gotlib, Jason, Deininger, Michael M N, Oh, Stephen T, Cortes, Jorge E, Collins, Jr, Robert H, Winton, Elliot F, Parker, Dana R, Lee, Hyunjung, Reister, Anna, Schultz, Savage, Samantha, Stevens, Brockett, Chase, Subbiah, Nan, Press, Richard D, Raess, Philipp W, Cascio, Michael, Dunlap, Jennifer, Chen, Yiyi, Degnin, Catherine, Maxson, Julia E, Tognon, Cristina E, Macey, Tara, Druker, Brian J, Tyner, Jeffrey W

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