A high-throughput screen for TMPRSS2 expression identifies FDA-approved compounds that can limit SARS-CoV-2 entry von Chen, Yanwen, Lear, Travis B., Evankovich, John W., Larsen, Mads B., Lin, Bo, Alfaras, Irene, Kennerdell, Jason R., Salminen, Laura, Camarco, Daniel P., Lockwood, Karina C., Tuncer, Ferhan, Liu, Jie, Myerburg, Michael M., McDyer, John F., Liu, Yuan, Finkel, Toren, Chen, Bill B.

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Lipopolysaccharide Primes the NALP3 Inflammasome by Inhibiting Its Ubiquitination and Degradation Mediated by the SCFFBXL2 E3 Ligase von Han, SeungHye, Lear, Travis B., Jerome, Jacob A., Rajbhandari, Shristi, Snavely, Courtney A., Gulick, Dexter L., Gibson, Kevin F., Zou, Chunbin, Chen, Bill B., Mallampalli, Rama K.

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The mito-DAMP cardiolipin blocks IL-10 production causing persistent inflammation during bacterial pneumonia von Chakraborty, Krishnendu, Raundhal, Mahesh, Chen, Bill B., Morse, Christina, Tyurina, Yulia Y., Khare, Anupriya, Oriss, Timothy B., Huff, Rachael, Lee, Janet S., St. Croix, Claudette M., Watkins, Simon, Mallampalli, Rama K., Kagan, Valerian E., Ray, Anuradha, Ray, Prabir

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F-box protein FBXL19–mediated ubiquitination and degradation of the receptor for IL-33 limits pulmonary inflammation von Zhao, Jing, Wei, Jianxin, Mialki, Rachel K, Mallampalli, Daniel F, Chen, Bill B, Coon, Tiffany, Zou, Chunbin, Mallampalli, Rama K, Zhao, Yutong

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A combinatorial F box protein directed pathway controls TRAF adaptor stability to regulate inflammation von Chen, Bill B, Coon, Tiffany A, Glasser, Jennifer R, McVerry, Bryan J, Zhao, Jing, Zhao, Yutong, Zou, Chunbin, Ellis, Bryon, Sciurba, Frank C, Zhang, Yingze, Mallampalli, Rama K

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Targeting the deubiquitinase STAMBP inhibits NALP7 inflammasome activity von Bednash, Joseph S., Weathington, Nathaniel, Londino, James, Rojas, Mauricio, Gulick, Dexter L., Fort, Robert, Han, SeungHye, McKelvey, Alison C., Chen, Bill B., Mallampalli, Rama K.

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Deoxycholic Acid-Mediated Sphingosine-1-Phosphate Receptor 2 Signaling Exacerbates DSS-Induced Colitis through Promoting Cathepsin B Release von Wu, Jin, Cai, Wei, Xu, Congfeng, Zhou, Jiefei, Wang, Lingyu, Tian, Chunyan, Du, Xixi, Gong, Zizhen, Zhao, Shengnan, Chen, Yingwei

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The Proapoptotic F-box Protein Fbxl7 Regulates Mitochondrial Function by Mediating the Ubiquitylation and Proteasomal Degradation of Survivin von Liu, Yuan, Lear, Travis, Iannone, Olivia, Shiva, Sruti, Corey, Catherine, Rajbhandari, Shristi, Jerome, Jacob, Chen, Bill B., Mallampalli, Rama K.

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Natural Products as Targeted Modulators of the Immune System von Wang, Kai, Conlon, Michael, Ren, Wenkai, Chen, Bill B., Bączek, Tomasz

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Cyanidin-3-glucoside Alleviates 4-Hydroxyhexenal-Induced NLRP3 Inflammasome Activation via JNK-c-Jun/AP-1 Pathway in Human Retinal Pigment Epithelial Cells von Ji, Baoping, Liu, Tingting, Wu, Wei, Wang, Chengtao, Jin, Xiao-Lu, Zhou, Feng

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Targeted degradation of extracellular mitochondrial aspartyl-tRNA synthetase modulates immune responses von Johnson, Benjamin S., Farkas, Daniela, El-Mergawy, Rabab, Adair, Jessica A., Elhance, Ajit, Eltobgy, Moemen, Coan, Francesca M., Chafin, Lexie, Joseph, Jessica A., Cornwell, Alex, Johns, Finny J., Rosas, Lorena, Rojas, Mauricio, Farkas, Laszlo, Bednash, Joseph S., Londino, James D., Ray, Prabir, Ray, Anuradha, Kagan, Valerian, Lee, Janet S., Chen, Bill B., Mallampalli, Rama K.

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Post-translational modification of the interferon-gamma receptor alters its stability and signaling von Londino, James D, Gulick, Dexter L, Lear, Travis B, Suber, Tomeka L, Weathington, Nathaniel M, Masa, Luke S, Chen, Bill B, Mallampalli, Rama K

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F-box protein FBXL2 targets cyclin D2 for ubiquitination and degradation to inhibit leukemic cell proliferation von Chen, Bill B., Glasser, Jennifer R., Coon, Tiffany A., Zou, Chunbin, Miller, Hannah L., Fenton, Moon, McDyer, John F., Boyiadzis, Michael, Mallampalli, Rama K.

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Targeting F box protein Fbxo3 to control cytokine-driven inflammation von Mallampalli, Rama K, Coon, Tiffany A, Glasser, Jennifer R, Wang, Claire, Dunn, Sarah R, Weathington, Nathaniel M, Zhao, Jing, Zou, Chunbin, Zhao, Yutong, Chen, Bill B

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A Repurposed Drug Screen for Compounds Regulating Aquaporin 5 Stability in Lung Epithelial Cells von Villandre, John, White, Virginia, Lear, Travis B, Chen, Yanwen, Tuncer, Ferhan, Vaiz, Emily, Tuncer, Beyza, Lockwood, Karina, Camarco, Dan, Liu, Yuan, Chen, Bill B, Evankovich, John

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A small molecule NRF2 activator BC-1901S ameliorates inflammation through DCAF1/NRF2 axis von Chen, Yanwen, Evankovich, John W., Lear, Travis B., Tuncer, Ferhan, Kennerdell, Jason R., Camarco, Daniel P., Shishido, Morgan S., Liu, Yuan, Chen, Bill B.

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Ubiquitin E3 ligase FIEL1 regulates fibrotic lung injury through SUMO-E3 ligase PIAS4 von Lear, Travis, McKelvey, Alison C, Rajbhandari, Shristi, Dunn, Sarah R, Coon, Tiffany A, Connelly, William, Zhao, Joe Y, Kass, Daniel J, Zhang, Yingze, Liu, Yuan, Chen, Bill B

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Acyl-CoA:Lysophosphatidylcholine Acyltransferase I (Lpcat1) Catalyzes Histone Protein O-Palmitoylation to Regulate mRNA Synthesis von Zou, Chunbin, Ellis, Bryon M., Smith, Rebecca M., Chen, Bill B., Zhao, Yutong, Mallampalli, Rama K.

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Masking of a Nuclear Signal Motif by Monoubiquitination Leads to Mislocalization and Degradation of the Regulatory Enzyme Cytidylyltransferase von Chen, Bill B., Mallampalli, Rama K.

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Dynamic regulation of cardiolipin by the lipid pump Atp8b1 determines the severity of lung injury in experimental pneumonia von Ray, Nancy B, Durairaj, Lakshmi, Chen, Bill B, McVerry, Bryan J, Ryan, Alan J, Donahoe, Michael, Waltenbaugh, Alisa K, O'Donnell, Christopher P, Henderson, Florita C, Etscheidt, Christopher A, McCoy, Diann M, Agassandian, Marianna, Hayes-Rowan, Emily C, Coon, Tiffany A, Butler, Phillip L, Gakhar, Lokesh, Mathur, Satya N, Sieren, Jessica C, Tyurina, Yulia Y, Kagan, Valerian E, McLennan, Geoffrey, Mallampalli, Rama K

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