A single-nucleus transcriptomic atlas of medium spiny neurons in the rat nucleus accumbens von Reiner, Benjamin C., Chehimi, Samar N., Merkel, Riley, Toikumo, Sylvanus, Berrettini, Wade H., Kranzler, Henry R., Sanchez-Roige, Sandra, Kember, Rachel L., Schmidt, Heath D., Crist, Richard C.

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Unraveling Psychiatric Disorders through Neural Single-Cell Transcriptomics Approaches von Chehimi, Samar N, Crist, Richard C, Reiner, Benjamin C

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Enhancing translation: A need to leverage complex preclinical models of addictive drugs to accelerate substance use treatment options von Corley, Christa, Craig, Ashley, Sadek, Safiyah, Marusich, Julie A., Chehimi, Samar N., White, Ashley M., Holdiness, Lexi J., Reiner, Benjamin C., Gipson, Cassandra D.

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Differences in DNA methylation status explain phenotypic variability in patients with 5p- syndrome von Almeida, Vanessa Tavares, Chehimi, Samar N, Carvalho, Gleyson F S, Gasparini, Yanca, Nascimento, Amom M, Vieira, Lucas L, Wolff, Beatriz M, Montenegro, Marília M, Kulikowski, Leslie D

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Genomic profiling informs diagnoses and treatment in vascular anomalies von Li, Dong, Sheppard, Sarah E., March, Michael E., Battig, Mark R., Surrey, Lea F., Srinivasan, Abhay S., Matsuoka, Leticia S., Tian, Lifeng, Wang, Fengxiang, Seiler, Christoph, Dayneka, Jill, Borst, Alexandra J., Matos, Mary C., Paulissen, Scott M., Krishnamurthy, Ganesh, Nriagu, Bede, Sikder, Tamjeed, Casey, Melissa, Williams, Lydia, Rangu, Sneha, O’Connor, Nora, Thomas, Alexandria, Pinto, Erin, Hou, Cuiping, Nguyen, Kenny, Pellegrino da Silva, Renata, Chehimi, Samar N., Kao, Charlly, Biroc, Lauren, Britt, Allison D., Queenan, Maria, Reid, Janet R., Napoli, Joseph A., Low, David M., Vatsky, Seth, Treat, James, Smith, Christopher L., Cahill, Anne Marie, Snyder, Kristen M., Adams, Denise M., Dori, Yoav, Hakonarson, Hakon

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Application of Whole-Exome Sequencing in Detecting Copy Number Variants in Patients with Developmental Delay and/or Multiple Congenital Malformations von Zanardo, Évelin A., Monteiro, Fabíola P., Chehimi, Samar N., Oliveira, Yanca G., Dias, Alexandre T., Costa, Larissa A., Ramos, Luiza L., Novo-Filho, Gil M., Montenegro, Marília M., Nascimento, Amom M., Kitajima, João P., Kok, Fernando, Kulikowski, Leslie D.

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Mosaic Trisomy 12 Associated with Overgrowth Detected in Fibroblast Cell Lines von Gasparini, Yanca, Montenegro, Marília M., Novo-Filho, Gil M., Ceroni, José R.M., Honjo, Rachel S., Zanardo, Évelin A., Dias, Alexandre T., Nascimento, Amon M., Costa, Taís V.M.M., Madia, Fabrícia A., Chehimi, Samar N., Damasceno, Jullian G., Kim, Chong A., Kulikowski, Leslie D.

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Cri-du-Chat Syndrome: Revealing a Familial Atypical Deletion in 5p von Almeida, Vanessa T., Chehimi, Samar N., Gasparini, Yanca, Nascimento, Amom M., Carvalho, Gleyson F.S., Montenegro, Marília M., Zanardo, Évelin Aline, Dias, Alexandre T., Assunção, Nilson A., Kim, Chong A., Kulikowski, Leslie D.

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Alterations in microRNA of extracellular vesicles associated with major depression, attention-deficit/hyperactivity and anxiety disorders in adolescents von Honorato-Mauer, Jessica, Xavier, Gabriela, Ota, Vanessa Kiyomi, Chehimi, Samar Nasser, Mafra, Fernanda, Cuóco, Cássia, Ito, Lucas Toshio, Ormond, Rafaella, Asprino, Paula Fontes, Oliveira, Adrielle, Bugiga, Amanda Victoria Gomes, Torrecilhas, Ana Claudia, Bressan, Rodrigo, Manfro, Gisele Gus, Miguel, Euripedes Constantino, Rohde, Luis Augusto, Pan, Pedro Mario, Salum, Giovanni Abrahão, Pellegrino, Renata, Belangero, Sintia, Santoro, Marcos Leite

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The interaction between polygenic risk score and trauma affects the likelihood of post-traumatic stress disorder in female victims of sexual assault von Bugiga, Amanda Victória Gomes, Carvalho, Carolina Muniz, Oliveira, Adrielle Martins, Coimbra, Bruno Messina, Chehimi, Samar Nasser, Zanardo, Evelin Aline, Kulikowski, Leslie Domenici, Mello, Andrea Feijó, Ota, Vanessa Kiyomi, Mello, Marcelo Feijo, Belangero, Sintia Iole

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Fetal gastroschisis: Maternal and fetal methylation profile von Freitas, Amanda Brasil de, Francisco, Rossana Pulcineli Vieira, Centofanti, Sandra Frankfurt, Damasceno, Jullian Gabriel, Chehimi, Samar Nasser, Osmundo‐Junior, Gilmar de Souza, Kulikowski, Leslie Domenici, Brizot, Maria de Lourdes

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Gene expression profile suggesting immunological dysregulation in two Brazilian Bloom's syndrome cases von Montenegro, Marilia M., Quaio, Caio R., Palmeira, Patricia, Gasparini, Yanca, Rangel‐Santos, Andreia, Damasceno, Julian, Novak, Estela M., Gimenez, Thamires M., Yamamoto, Guilherme L., Ronjo, Rachel S., Novo‐Filho, Gil M., Chehimi, Samar N., Zanardo, Evelin A., Dias, Alexandre T., Nascimento, Amom M., Costa, Thais V. M. M., Duarte, Alberto J. da S., Coutinho, Luiz L., Kim, Chong A., Kulikowski, Leslie D.

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Breakpoint delineation in 5p‐ patients leads to new insights about microcephaly and the typical high‐pitched cry von Chehimi, Samar N., Zanardo, Évelin A., Ceroni, José R. M., Nascimento, Amom M., Madia, Fabrícia A. R., Dias, Alexandre T., Filho, Gil M. N., Montenegro, Marília M., Damasceno, Jullian, Costa, Thaís V. M. M., Gasparini, Yanca, Kim, Chong A., Kulikowski, Leslie D.

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W95. SINGLE NUCLEUS ATAC-SEQ OF THE CENTRAL AMYGDALA REVEALS PATTERNS OF CHROMATIN ACCESSIBILITY ASSOCIATED WITH THE COCAINE SELF-ADMINISTRATION RATS von Crist, Richard, Chehimi, Samar, Merkel, Riley, Donze-Reiner, Teresa, Schmidt, Heath, Reiner, Benjamin

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F94. FENTANYL AND XYLAZINE POLYSUBSTANCE EXPOSURE INDUCES SHARED AND DIVERGENT ISOFORM- AND SEX-SPECIFIC ALTERATIONS IN THE NUCLEUS ACCUMBENS TRANSCRIPTOME von Chehimi, Samar Nasser, Crist, Richard, Merkel, Riley, Ferraro, Thomas, Schmidt, Heath, Reiner, Benjamin

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51. SINGLE NUCLEUS TRANSCRIPTOMIC ANALYSIS OF THE RAT NUCLEUS ACCUMBENS REVEALS NOVEL MEDIUM SPINY NEURON SUBTYPES AND DISTINCT PATTERNS OF POLYGENIC ENRICHMENT FOR SUBSTANCE USE P... von Crist, Richard, Reiner, Benjamin, Kember, Rachel, Toikumo, Sylvanus, Chehimi, Samar, Merkel, Riley, Kranzler, Henry, Berrettini, Wade, Schmidt, Heath

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W31. KETAMINE AND ELECTROCONVULSIVE THERAPY DEPRESSION TREATMENTS ALTER ISOFORM- AND CELL TYPE-SPECIFIC TRANSCRIPTOMES IN THE MOUSE PREFRONTAL FRONTAL CORTEX von Chehimi, Samar Nasser, Crist, Richard C, Batterman, Alexander I, Nguyen, Danial P, Williams, Aela, Keck, Thomas M, Berrettini, Wade, Buono, Russell J, Ferraro, Thomas, Reiner, Benjamin

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Expanding the Phenotype of 8p23.1 Deletion Syndrome: Eight New Cases Resembling the Clinical Spectrum of 22q11.2 Microdeletion von Montenegro, Marília Moreira, Camilotti, Débora, Quaio, Caio Robledo D’Anglioli Costa, Gasparini, Yanca, Zanardo, Évelin Aline, Rangel-Santos, Andreia, Novo-Filho, Gil Monteiro, Francisco, Gleyson, Liro, Lucas, Nascimento, Amom, Chehimi, Samar Nasser, Soares, Diogo Cordeiro Queiroz, Krepischi, Ana C.V., Grassi, Marcília Sierro, Honjo, Rachel Sayuri, Palmeira, Patricia, Kim, Chong Ae, Carneiro-Sampaio, Magda Maria Sales, Rosenberg, Carla, Kulikowski, Leslie Domenici

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Novel rearrangements between different chromosomes with direct impact on the diagnosis of 5p- syndrome von Chehimi, Samar Nasser, Almeida, Vanessa Tavares, Nascimento, Amom Mendes, Zanardo, Évelin Aline, de Oliveira, Yanca Gasparini, Carvalho, Gleyson Francisco da Silva, Wolff, Beatriz Martins, Montenegro, Marilia Moreira, de Assunção, Nilson Antônio, Kim, Chong Ae, Kulikowski, Leslie Domenici

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Identifying NAHR mechanism between two distinct Alu elements through breakpoint junction mapping by NGS von Novo-Filho, Gil M., Carvalho, Gleyson F.S., Nascimento, Amom M., Montenegro, Marilia M., Damasceno, Jullian G., Zanardo, Évelin A., Chehimi, Samar N., Oliveira, Yanca G., Dias, Alexandre T., Kim, Chong A., Kulikowski, Leslie D.

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