Lysine‐Targeting Covalent Inhibitors von Pettinger, Jonathan, Jones, Keith, Cheeseman, Matthew D.

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Kinetic Optimization of Lysine-Targeting Covalent Inhibitors of HSP72 von Pettinger, Jonathan, Carter, Michael, Jones, Keith, Cheeseman, Matthew D

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Investigating Apoptozole as a Chemical Probe for HSP70 Inhibition von Evans, Lindsay E, Cheeseman, Matthew D, Yahya, Norhakim, Jones, Keith

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Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen von Cheeseman, Matthew D, Chessum, Nicola E. A, Rye, Carl S, Pasqua, A. Elisa, Tucker, Michael J, Wilding, Birgit, Evans, Lindsay E, Lepri, Susan, Richards, Meirion, Sharp, Swee Y, Ali, Salyha, Rowlands, Martin, O’Fee, Lisa, Miah, Asadh, Hayes, Angela, Henley, Alan T, Powers, Marissa, te Poele, Robert, De Billy, Emmanuel, Pellegrino, Loredana, Raynaud, Florence, Burke, Rosemary, van Montfort, Rob L. M, Eccles, Suzanne A, Workman, Paul, Jones, Keith

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Exploiting Protein Conformational Change to Optimize Adenosine-Derived Inhibitors of HSP70 von Cheeseman, Matthew D, Westwood, Isaac M, Barbeau, Olivier, Rowlands, Martin, Dobson, Sarah, Jones, Alan M, Jeganathan, Fiona, Burke, Rosemary, Kadi, Nadia, Workman, Paul, Collins, Ian, van Montfort, Rob L. M, Jones, Keith

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Flexible Strategy for the Synthesis of Pyrrolizidine Alkaloids von Donohoe, Timothy J, Thomas, Rhian E, Cheeseman, Matthew D, Rigby, Caroline L, Bhalay, Gurdip, Linney, Ian D

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Demonstrating In-Cell Target Engagement Using a Pirin Protein Degradation Probe (CCT367766) von Chessum, Nicola E. A, Sharp, Swee Y, Caldwell, John J, Pasqua, A. Elisa, Wilding, Birgit, Colombano, Giampiero, Collins, Ian, Ozer, Bugra, Richards, Meirion, Rowlands, Martin, Stubbs, Mark, Burke, Rosemary, McAndrew, P. Craig, Clarke, Paul A, Workman, Paul, Cheeseman, Matthew D, Jones, Keith

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Targeting secondary protein complexes in drug discovery: studying the druggability and chemical biology of the HSP70/BAG1 complex von Evans, Lindsay E, Jones, Keith, Cheeseman, Matthew D

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An Irreversible Inhibitor of HSP72 that Unexpectedly Targets Lysine‐56 von Pettinger, Jonathan, Le Bihan, Yann‐Vaï, Widya, Marcella, van Montfort, Rob L. M., Jones, Keith, Cheeseman, Matthew D.

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Determination of Ligand-Binding Affinity (K d) Using Transverse Relaxation Rate (R 2) in the Ligand-Observed 1H NMR Experiment and Applications to Fragment-Based Drug Discovery von Liu, Manjuan, Mirza, Amin, McAndrew, P. Craig, Thapaliya, Arjun, Pierrat, Olivier A., Stubbs, Mark, Hahner, Tamas, Chessum, Nicola E. A., Innocenti, Paolo, Caldwell, John, Cheeseman, Matthew D., Bellenie, Benjamin R., van Montfort, Rob L. M., Newton, Gary K., Burke, Rosemary, Collins, Ian, Hoelder, Swen

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Determination of Ligand-Binding Affinity ( K d ) Using Transverse Relaxation Rate ( R 2 ) in the Ligand-Observed 1 H NMR Experiment and Applications to Fragment-Based Drug Discover... von Liu, Manjuan, Mirza, Amin, McAndrew, P Craig, Thapaliya, Arjun, Pierrat, Olivier A, Stubbs, Mark, Hahner, Tamas, Chessum, Nicola E A, Innocenti, Paolo, Caldwell, John, Cheeseman, Matthew D, Bellenie, Benjamin R, van Montfort, Rob L M, Newton, Gary K, Burke, Rosemary, Collins, Ian, Hoelder, Swen

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HSF1 Pathway Inhibitor Clinical Candidate (CCT361814/NXP800) Developed from a Phenotypic Screen as a Potential Treatment for Refractory Ovarian Cancer and Other Malignancies von Pasqua, A. Elisa, Sharp, Swee Y., Chessum, Nicola E. A., Hayes, Angela, Pellegrino, Loredana, Tucker, Michael J., Miah, Asadh, Wilding, Birgit, Evans, Lindsay E., Rye, Carl S., Mok, N. Yi, Liu, Manjuan, Henley, Alan T., Gowan, Sharon, De Billy, Emmanuel, te Poele, Robert, Powers, Marissa, Eccles, Suzanne A., Clarke, Paul A., Raynaud, Florence I., Workman, Paul, Jones, Keith, Cheeseman, Matthew D.

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N–N Bond-Forming Cyclization for the One-Pot Synthesis of N-Aryl[3,4-d]pyrazolopyrimidines von Evans, Lindsay E, Cheeseman, Matthew D, Jones, Keith

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Synthesis of (+)-DGDP and (-)-7-epialexine von Donohoe, Timothy J, Cheeseman, Matthew D, O'Riordan, Timothy J C, Kershaw, Jessica A

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Investigating the phosphinic acid tripeptide mimetic DG013A as a tool compound inhibitor of the M1-aminopeptidase ERAP1 von Wilding, Birgit, Pasqua, A. Elisa, E. A. Chessum, Nicola, Pierrat, Olivier A., Hahner, Tamas, Tomlin, Kathy, Shehu, Erald, Burke, Rosemary, Richards, G. Meirion, Whitton, Bradleigh, Arwert, Esther N., Thapaliya, Arjun, Salimraj, Ramya, van Montfort, Rob, Skawinska, Agi, Hayes, Angela, Raynaud, Florence, Chopra, Rajesh, Jones, Keith, Newton, Gary, Cheeseman, Matthew D.

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A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms von Jones, Alan M., Westwood, Isaac M., Osborne, James D., Matthews, Thomas P., Cheeseman, Matthew D., Rowlands, Martin G., Jeganathan, Fiona, Burke, Rosemary, Lee, Diane, Kadi, Nadia, Liu, Manjuan, Richards, Meirion, McAndrew, Craig, Yahya, Norhakim, Dobson, Sarah E., Jones, Keith, Workman, Paul, Collins, Ian, van Montfort, Rob L. M.

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Privileged Structures and Polypharmacology within and between Protein Families von Meyers, Joshua, Chessum, Nicola E. A, Ali, Salyha, Mok, N. Yi, Wilding, Birgit, Pasqua, A. Elisa, Rowlands, Martin, Tucker, Michael J, Evans, Lindsay E, Rye, Carl S, O’Fee, Lisa, Le Bihan, Yann-Vaï, Burke, Rosemary, Carter, Michael, Workman, Paul, Blagg, Julian, Brown, Nathan, van Montfort, Rob L. M, Jones, Keith, Cheeseman, Matthew D

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Targeting the PPM1D phenotype; 2,4-bisarylthiazoles cause highly selective apoptosis in PPM1D amplified cell-lines von Cheeseman, Matthew D, Faisal, Amir, Rayter, Sydonia, Barbeau, Olivier R, Kalusa, Andrew, Westlake, Maura, Burke, Rosemary, Swan, Michael, van Montfort, Rob, Linardopoulos, Spiros, Jones, Keith

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Discovery of 4,6-disubstituted pyrimidines as potent inhibitors of the heat shock factor 1 (HSF1) stress pathway and CDK9 von Rye, Carl S, Chessum, Nicola E A, Lamont, Scott, Pike, Kurt G, Faulder, Paul, Demeritt, Julie, Kemmitt, Paul, Tucker, Julie, Zani, Lorenzo, Cheeseman, Matthew D, Isaac, Rosie, Goodwin, Louise, Boros, Joanna, Raynaud, Florence, Hayes, Angela, Henley, Alan T, de Billy, Emmanuel, Lynch, Christopher J, Sharp, Swee Y, Te Poele, Robert, Fee, Lisa O', Foote, Kevin M, Green, Stephen, Workman, Paul, Jones, Keith

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An Irreversible Inhibitor of HSP72 that Unexpectedly Targets Lysine‐56 von Pettinger, Jonathan, Le Bihan, Yann‐Vaï, Widya, Marcella, van Montfort, Rob L. M., Jones, Keith, Cheeseman, Matthew D.

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