Design of a Chemical Probe for the Bromodomain and Plant Homeodomain Finger-Containing (BRPF) Family of Proteins von Igoe, Niall, Bayle, Elliott D, Tallant, Cynthia, Fedorov, Oleg, Meier, Julia C, Savitsky, Pavel, Rogers, Catherine, Morias, Yannick, Scholze, Sarah, Boyd, Helen, Cunoosamy, Danen, Andrews, David M, Cheasty, Anne, Brennan, Paul E, Müller, Susanne, Knapp, Stefan, Fish, Paul V

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922 A novel autotaxin inhibitor, IOA-289, modulates tumor, immune and stromal cell function and has monotherapy activity in fibrotic cancer models von Deken, Marcel, Niewola, Karolina, Matas-Rico, Elisa, Medhi, Ragini, Carruthers, Alan, Cheasty, Anne, Peyruchaud, Olivier, Fraser, Amy, Shah, Pritom, Moolenaar, Wouter, Veen, Lars van der, Lahn, Michael, Johnson, Zoe

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Discovery of potent inhibitors of the lyso phospholipase autotaxin von Shah, Pritom, Cheasty, Anne, Foxton, Caroline, Raynham, Tony, Farooq, Muddasar, Gutierrez, Irene Farre, Lejeune, Aurore, Pritchard, Michelle, Turnbull, Andrew, Pang, Leon, Owen, Paul, Boyd, Susan, Stowell, Alexandra, Jordan, Allan, Hamilton, Niall M., Hitchin, James R., Stockley, Martin, MacDonald, Ellen, Quesada, Mar Jimenez, Trivier, Elisabeth, Skeete, Jana, Ovaa, Huib, Moolenaar, Wouter H., Ryder, Hamish

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Optimization of Novel Acyl Pyrrolidine Inhibitors of Hepatitis C Virus RNA-Dependent RNA Polymerase Leading to a Development Candidate von Slater, Martin J, Amphlett, Elizabeth M, Andrews, David M, Bravi, Gianpaolo, Burton, George, Cheasty, Anne G, Corfield, John A, Ellis, Malcolm R, Fenwick, Rebecca H, Fernandes, Stephanie, Guidetti, Rossella, Haigh, David, Hartley, C. David, Howes, Peter D, Jackson, Deborah L, Jarvest, Richard L, Lovegrove, Victoria L. H, Medhurst, Katrina J, Parry, Nigel R, Price, Helen, Shah, Pritom, Singh, Onkar M. P, Stocker, Richard, Thommes, Pia, Wilkinson, Claire, Wonacott, Alan

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MNK Inhibition Sensitizes KRAS -Mutant Colorectal Cancer to mTORC1 Inhibition by Reducing eIF4E Phosphorylation and c-MYC Expression von Knight, John R P, Alexandrou, Constantinos, Skalka, George L, Vlahov, Nikola, Pennel, Kathryn, Officer, Leah, Teodosio, Ana, Kanellos, Georgios, Gay, David M, May-Wilson, Sebastian, Smith, Ewan M, Najumudeen, Arafath K, Gilroy, Kathryn, Ridgway, Rachel A, Flanagan, Dustin J, Smith, Rachael C L, McDonald, Laura, MacKay, Craig, Cheasty, Anne, McArthur, Kerri, Stanway, Emma, Leach, Joshua D, Jackstadt, Rene, Waldron, Joseph A, Campbell, Andrew D, Vlachogiannis, Georgios, Valeri, Nicola, Haigis, Kevin M, Sonenberg, Nahum, Proud, Christopher G, Jones, Neil P, Swarbrick, Martin E, McKinnon, Heather J, Faller, William J, Le Quesne, John, Edwards, Joanne, Willis, Anne E, Bushell, Martin, Sansom, Owen J

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Correction to “Discovery of a Thiadiazole–Pyridazine-Based Allosteric Glutaminase 1 Inhibitor Series That Demonstrates Oral Bioavailability and Activity in Tumor Xenograft Models”... von Finlay, M. Raymond V., Anderton, Mark, Bailey, Andrew, Boyd, Scott, Brookfield, Joanna, Cairnduff, Ceri, Charles, Mark, Cheasty, Anne, Critchlow, Susan E., Culshaw, Janet, Debreczeni, Judit, Ekwuru, Tennyson, Hollingsworth, Ian, Jones, Neil, Leroux, Fred, Littleson, Mairi, McCarron, Hollie, McKelvie, Jennifer, Mooney, Lorraine, Nissink, J. Willem M., Patel, Joe, Perkins, David, Powell, Steve, Quesada, Mar Jimenez, Raubo, Piotr, Sabin, Verity, Smith, James, Smith, Peter D., Stark, Andrew, Ting, Attilla, Wang, Peng, Wilson, Zena, Winter-Holt, Jon J., Wood, J. Matthew, Wrigley, Gail L., Yu, Guoqing, Zhang, Peng

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Establishing the selective phospholipid membrane coordination, permeation and lysis properties for a series of 'druggable' supramolecular self-associating antimicrobial amphiphiles von Boles, Jessica E, Bennett, Charlotte, Baker, Jennifer, Hilton, Kira L. F, Kotak, Hiral A, Clark, Ewan R, Long, Yifan, White, Lisa J, Lai, Hin Yuk, Hind, Charlotte K, Sutton, J. Mark, Garrett, Michelle D, Cheasty, Anne, Ortega-Roldan, Jose L, Charles, Mark, Haynes, Cally J. E, Hiscock, Jennifer R

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Design of a Biased Potent Small Molecule Inhibitor of the Bromodomain and PHD Finger-Containing (BRPF) Proteins Suitable for Cellular and in Vivo Studies von Igoe, Niall, Bayle, Elliott D, Fedorov, Oleg, Tallant, Cynthia, Savitsky, Pavel, Rogers, Catherine, Owen, Dafydd R, Deb, Gauri, Somervaille, Tim C. P, Andrews, David M, Jones, Neil, Cheasty, Anne, Ryder, Hamish, Brennan, Paul E, Müller, Susanne, Knapp, Stefan, Fish, Paul V

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Discovery of a Thiadiazole–Pyridazine-Based Allosteric Glutaminase 1 Inhibitor Series That Demonstrates Oral Bioavailability and Activity in Tumor Xenograft Models von Finlay, M. Raymond V, Anderton, Mark, Bailey, Andrew, Boyd, Scott, Brookfield, Joanna, Cairnduff, Ceri, Charles, Mark, Cheasty, Anne, Critchlow, Susan E, Culshaw, Janet, Ekwuru, Tennyson, Hollingsworth, Ian, Jones, Neil, Leroux, Fred, Littleson, Mairi, McCarron, Hollie, McKelvie, Jennifer, Mooney, Lorraine, Nissink, J. Willem M, Perkins, David, Powell, Steve, Quesada, Mar Jimenez, Raubo, Piotr, Sabin, Verity, Smith, James, Smith, Peter D, Stark, Andrew, Ting, Attilla, Wang, Peng, Wilson, Zena, Winter-Holt, Jon J, Wood, J. Matthew, Wrigley, Gail L, Yu, Guoqing, Zhang, Peng

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Discovery of potent inhibitors of the lysophospholipase autotaxin von Shah, Pritom, Cheasty, Anne, Foxton, Caroline, Raynham, Tony, Farooq, Muddasar, Gutierrez, Irene Farre, Lejeune, Aurore, Pritchard, Michelle, Turnbull, Andrew, Pang, Leon, Owen, Paul, Boyd, Susan, Stowell, Alexandra, Jordan, Allan, Hamilton, Niall M., Hitchin, James R., Stockley, Martin, MacDonald, Ellen, Quesada, Mar Jimenez, Trivier, Elisabeth, Skeete, Jana, Ovaa, Huib, Moolenaar, Wouter H., Ryder, Hamish

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Discovery, Development, and SAR of Aminothiazoles as LIMK Inhibitors with Cellular Anti-Invasive Properties von Charles, Mark D, Brookfield, Joanna L, Ekwuru, Tennyson C, Stockley, Martin, Dunn, John, Riddick, Michelle, Hammonds, Tim, Trivier, Elisabeth, Greenland, Gavin, Wong, Ai Ching, Cheasty, Anne, Boyd, Susan, Crighton, Diane, Olson, Michael F

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Abstract 2636: Targeting Autotaxin to suppress stromal signaling in the tumor microenvironment to improve outcome to therapy in fibrotic tumor types von Johnson, Zoe, Deken, Marcel, Medhi, Ragini, Maggs, Lauren, Carruthers, Alan, Cheasty, Anne, Tagliavini, Alessia, Nizzardo, Andrea, Pergher, Marco, Niewola, Karolina, Fraser, Amy, van der Veen, Lars, Shah, Pritom, ZIviani, Luigi, Milleri, Stefano, Lahn, Michael

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Discovery of potent inhibitors of the lysophospholipase autotaxin von Shah, Pritom, Cheasty, Anne, Foxton, Caroline, Raynham, T, Farooq, Muddasar, Gutierrez, Irene Farre, Lejeune, Aurore, Pritchard, Michelle, Turnbull, Andrew, Pang, Leon, Owen, Paul, Boyd, Susan, Stowell, Alexandra, Jordan, Allan, Hamilton, Niall M, Hitchin, James R, Stockley, Martin, MacDonald, Ellen, Quesada, Mar Jimenez, Trivier, Elisabeth, Skeete, Jana, Ovaa, Huib, Moolenaar, Wouter H, Ryder, Hamish

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Establishing the selective phospholipid membrane coordination, permeation and lysis properties for a series of 'druggable' supramolecular self-associating antimicrobial amphiphiles von Boles, Jessica E, Bennett, Charlotte, Baker, Jennifer, Hilton, Kira LF, Kotak, Hiral A, Clark, Ewan R, Long, Yifan, White, Lisa J, Lai, Hin Yuk, Hind, Charlotte K, Sutton, J Mark, Garrett, Michelle D, Cheasty, Anne, Ortega-Roldan, Jose L, Charles, Mark, Haynes, Cally JE, Hiscock, Jennifer R

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4-CARBOXY PYRAZOLE DERIVATIVES AS ANTI-VIRAL AGENTS von CHEASTY, ANNE GORETTI, SHAH, PRITOM, WHITE, GEMMA VICTORIA, HARTLEY, CHARLES DAVID, SLATER, MARTIN JOHN, BRAVI, GIANPAOLO, HARRISON, DAVID, HOWES, PETER DAVID, MEDHURST, KATRINA JANE, GRIMES, RICHARD MARTIN, CORFIELD, JOHN ANDREW, MEESON, MALCOLM LEES, MORDAUNT, JACQUELINE ELIZABETH

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