Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR von Reaper, Philip M, Griffiths, Matthew R, Long, Joanna M, Charrier, Jean-Damien, MacCormick, Somhairle, Charlton, Peter A, Golec, Julian M C, Pollard, John R

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Potentiation of tumor responses to DNA damaging therapy by the selective ATR inhibitor VX-970 von Hall, Amy B, Newsome, Dave, Wang, Yuxin, Boucher, Diane M, Eustace, Brenda, Gu, Yong, Hare, Brian, Johnson, Mac A, Milton, Sean, Murphy, Cheryl E, Takemoto, Darin, Tolman, Crystal, Wood, Mark, Charlton, Peter, Charrier, Jean-Damien, Furey, Brinley, Golec, Julian, Reaper, Philip M, Pollard, John R

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Discovery of Potent and Selective Inhibitors of Ataxia Telangiectasia Mutated and Rad3 Related (ATR) Protein Kinase as Potential Anticancer Agents von Charrier, Jean-Damien, Durrant, Steven J, Golec, Julian M. C, Kay, David P, Knegtel, Ronald M. A, MacCormick, Somhairle, Mortimore, Michael, O'Donnell, Michael E, Pinder, Joanne L, Reaper, Philip M, Rutherford, Alistair P, Wang, Paul S. H, Young, Stephen C, Pollard, John R

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The discovery of the potent aurora inhibitor MK-0457 (VX-680) von Bebbington, David, Binch, Hayley, Charrier, Jean-Damien, Everitt, Simon, Fraysse, Damien, Golec, Julian, Kay, David, Knegtel, Ronald, Mak, Chau, Mazzei, Francesca, Miller, Andrew, Mortimore, Michael, O’Donnell, Michael, Patel, Sanjay, Pierard, Francoise, Pinder, Joanne, Pollard, John, Ramaya, Sharn, Robinson, Daniel, Rutherford, Alistair, Studley, John, Westcott, James

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Rational Design of 5‑(4-(Isopropylsulfonyl)­phenyl)-3-(3-(4-((methylamino)­methyl)­phenyl)­isoxazol-5-yl)­pyrazin-2-amine (VX-970, M6620): Optimization of Intra- and Intermolecular... von Knegtel, Ronald, Charrier, Jean-Damien, Durrant, Steven, Davis, Chris, O’Donnell, Michael, Storck, Pierre, MacCormick, Somhairle, Kay, David, Pinder, Joanne, Virani, Anisa, Twin, Heather, Griffiths, Matthew, Reaper, Philip, Littlewood, Peter, Young, Steve, Golec, Julian, Pollard, John

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Synthesis and evaluation of novel prodrugs of caspase inhibitors von Charrier, Jean-Damien, Durrant, Steven J., Studley, John, Lawes, Linda, Weber, Peter

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2-Chloro-4-tetrafluorophenoxypyrimidine: a versatile reagent for C-2 prior to C-4 functionalizations von O’Donnell, Michael, Charrier, Jean-Damien

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A complementary route to diaminopyrimidines through regioselective SNAr amination reactions von O'Donnell, Michael, Charrier, Jean-Damien

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A facile, one-pot procedure for the formation of benzimidazoles from esters using DABAL-Me3, an air stable source of AlMe3 von Pinder, Joanne L., Davis, Rebecca E., Charrier, Jean-Damien

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Discovery and Structure−Activity Relationship of 3-Aminopyrid-2-ones as Potent and Selective Interleukin-2 Inducible T-Cell Kinase (Itk) Inhibitors von Charrier, Jean-Damien, Miller, Andrew, Kay, David P, Brenchley, Guy, Twin, Heather C, Collier, Philip N, Ramaya, Sharn, Keily, Shazia B, Durrant, Steven J, Knegtel, Ronald M. A, Tanner, Adam J, Brown, Kieron, Curnock, Adam P, Jimenez, Juan-Miguel

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Synthesis of (2S,3R)-[3',3',3'-2H3]-valine and (2S,3S)-4-fluorovaline von Charrier, Jean-Damien, Hitchcock, Peter B, Young, Douglas W

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Synthesis, Structural and Biological Studies of Ubiquitin Mutants Containing (2S, 4S)-5-Fluoroleucine Residues Strategically Placed in the Hydrophobic Core von Alexeev, Dmitriy, Barlow, Paul N, Bury, Stella M, Charrier, Jean-Damien, Cooper, Alan, Hadfield, David, Jamieson, Craig, Kelly, Sharon M, Layfield, Robert, Mayer, R. John, McSparron, Helen, Price, Nicholas C, Ramage, Robert, Sawyer, Lindsay, Starkmann, Bernard A, Uhrin, Dusan, Wilken, Jill, Young, Douglas W

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From benzil arylimines to 2H-benzo-1,4-thiazines, benzothiazoles or indoles von Charrier, Jean-Damien, Landreau, Cyrille, Deniaud, David, Reliquet, Françoise, Reliquet, Alain, Meslin, Jean Claude

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Synthesis of (2S,4S)- and (2S,4R)-5-fluoroleucine and (2S,4S)-[5,5-2H2]-5-fluoroleucine von Charrier, Jean-Damien, Hadfield, David S, Hitchcock, Peter B, Young, Douglas W

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Synthesis of (2S,3S)-3'-fluoroisoleucine von Charrier, Jean-Damien, Hadfield, David S, Hitchcock, Peter B, Young, Douglas W

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ChemInform Abstract: 2‐Chloro‐4‐tetrafluorophenoxypyrimidine: A Versatile Reagent for C‐2 Prior to C‐4 Functionalizations von O'Donnell, Michael, Charrier, Jean‐Damien

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ChemInform Abstract: A Complementary Route to Diaminopyrimidines Through Regioselective SNAr Amination Reactions von O'Donnell, Michael, Charrier, Jean-Damien

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A facile, one-pot procedure for the formation of benzimidazoles from esters using DABAL-Me sub(3), an air stable source of AlMe sub(3) von Pinder, Joanne L, Davis, Rebecca E, Charrier, Jean-Damien

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Reinvestigation of the alkylation of pyroglutamate ester urethanes von Charrier, Jean-Damien, Duffy, James E.S., Hitchcock, Peter B., Young, Douglas W.

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Synthesis of a new type of N2S2 tetradentate ligand von Charrier, Jean-Damien, Reliquet, Alain, Meslin, Jean-Claude

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