Safety and Efficacy of Mitapivat in Pyruvate Kinase Deficiency von Grace, Rachael F, Rose, Christian, Layton, D. Mark, Galactéros, Frédéric, Barcellini, Wilma, Morton, D. Holmes, van Beers, Eduard J, Yaish, Hassan, Ravindranath, Yaddanapudi, Kuo, Kevin H.M, Sheth, Sujit, Kwiatkowski, Janet L, Barbier, Ann J, Bodie, Susan, Silver, Bruce, Hua, Lei, Kung, Charles, Hawkins, Peter, Jouvin, Marie-Hélène, Bowden, Chris, Glader, Bertil

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Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy von Nicklin, Paul, Bergman, Philip, Zhang, Bailin, Triantafellow, Ellen, Wang, Henry, Nyfeler, Beat, Yang, Haidi, Hild, Marc, Kung, Charles, Wilson, Christopher, Myer, Vic E., MacKeigan, Jeffrey P., Porter, Jeffrey A., Wang, Y. Karen, Cantley, Lewis C., Finan, Peter M., Murphy, Leon O.

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Multi-Tissue Acceleration of the Mitochondrial Phosphoenolpyruvate Cycle Improves Whole-Body Metabolic Health von Abulizi, Abudukadier, Cardone, Rebecca L., Stark, Romana, Lewandowski, Sophie L., Zhao, Xiaojian, Hillion, Joelle, Ma, Lingjun, Sehgal, Raghav, Alves, Tiago C., Thomas, Craig, Kung, Charles, Wang, Bei, Siebel, Stephan, Andrews, Zane B., Mason, Graeme F., Rinehart, Jesse, Merrins, Matthew J., Kibbey, Richard G.

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AG-348 (Mitapivat), an allosteric activator of red blood cell pyruvate kinase, increases enzymatic activity, protein stability, and ATP levels over a broad range of PKLR genotypes von Rab, Minke A E, Van Oirschot, Brigitte A, Kosinski, Penelope A, Hixon, Jeffrey, Johnson, Kendall, Chubukov, Victor, Dang, Lenny, Pasterkamp, Gerard, Van Straaten, Stephanie, Van Solinge, Wouter W, Van Beers, Eduard J, Kung, Charles, Van Wijk, Richard

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ALDH2(E487K) mutation increases protein turnover and promotes murine hepatocarcinogenesis von Jin, Shengfang, Jiang Chen, Lizao Chen, Gavin Histen, Zhizhong Lin, Stefan Gross, Jeffrey Hixon, Yue Chen, Charles Kung, Yiwei Chen, Yufei Fu, Yuxuan Lu, Hui Lin, Xiujun Cai, Hua Yang, Rob A. Cairns, Marion Dorsch, Shinsan M. Su, Scott Biller, Tak W. Mak, Yong Cang

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The Ipl1-Aurora protein kinase activates the spindle checkpoint by creating unattached kinetochores von Biggins, Sue, Pinsky, Benjamin A, Kung, Charles, Shokat, Kevan M

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Safe and Efficient Gene Therapy for Pyruvate Kinase Deficiency von Garcia-Gomez, Maria, Calabria, Andrea, Garcia-Bravo, Maria, Benedicenti, Fabrizio, Kosinski, Penelope, López-Manzaneda, Sergio, Hill, Collin, del Mar Mañu-Pereira, María, Martín, Miguel A, Orman, Israel, Vives-Corrons, Joan-LLuis, Kung, Charles, Schambach, Axel, Jin, Shengfang, Bueren, Juan A, Montini, Eugenio, Navarro, Susana, Segovia, Jose C

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Distinct Hepatic PKA and CDK Signaling Pathways Control Activity-Independent Pyruvate Kinase Phosphorylation and Hepatic Glucose Production von Gassaway, Brandon M., Cardone, Rebecca L., Padyana, Anil K., Petersen, Max C., Judd, Evan T., Hayes, Sebastian, Tong, Shuilong, Barber, Karl W., Apostolidi, Maria, Abulizi, Abudukadier, Sheetz, Joshua B., Kshitiz, Aerni, Hans R., Gross, Stefan, Kung, Charles, Samuel, Varman T., Shulman, Gerald I., Kibbey, Richard G., Rinehart, Jesse

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Chemical inhibition of the TFIIH-associated kinase Cdk7/Kin28 does not impair global mRNA synthesis von Kanin, Elenita I, Kipp, Ryan T, Kung, Charles, Slattery, Matthew, Viale, Agnes, Hahn, Steven, Shokat, Kevan M, Ansari, Aseem Z

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Two Cyclin-Dependent Kinases Promote RNA Polymerase II Transcription and Formation of the Scaffold Complex von Liu, Ying, Kung, Charles, Fishburn, James, Ansari, Aseem Z., Shokat, Kevan M., Hahn, Steven

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Generation of a High Number of Healthy Erythroid Cells from Gene-Edited Pyruvate Kinase Deficiency Patient-Specific Induced Pluripotent Stem Cells von Garate, Zita, Quintana-Bustamante, Oscar, Crane, Ana M., Olivier, Emmanuel, Poirot, Laurent, Galetto, Roman, Kosinski, Penelope, Hill, Collin, Kung, Charles, Agirre, Xabi, Orman, Israel, Cerrato, Laura, Alberquilla, Omaira, Rodriguez-Fornes, Fatima, Fusaki, Noemi, Garcia-Sanchez, Felix, Maia, Tabita M., Ribeiro, Maria L., Sevilla, Julian, Prosper, Felipe, Jin, Shengfang, Mountford, Joanne, Guenechea, Guillermo, Gouble, Agnes, Bueren, Juan A., Davis, Brian R., Segovia, Jose C.

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Functional genomic landscape of cancer-intrinsic evasion of killing by T cells von Lawson, Keith A., Sousa, Cristovão M., Zhang, Xiaoyu, Kim, Eiru, Akthar, Rummy, Caumanns, Joseph J., Yao, Yuxi, Mikolajewicz, Nicholas, Ross, Catherine, Brown, Kevin R., Zid, Abdelrahman Abou, Fan, Zi Peng, Hui, Shirley, Krall, Jordan A., Simons, Donald M., Slater, Chloe J., De Jesus, Victor, Tang, Lujia, Singh, Richa, Goldford, Joshua E., Martin, Sarah, Huang, Qian, Francis, Elizabeth A., Habsid, Andrea, Climie, Ryan, Tieu, David, Wei, Jiarun, Li, Ren, Tong, Amy Hin Yan, Aregger, Michael, Chan, Katherine S., Han, Hong, Wang, Xiaowei, Mero, Patricia, Brumell, John H., Finelli, Antonio, Ailles, Laurie, Bader, Gary, Smolen, Gromoslaw A., Kingsbury, Gillian A., Hart, Traver, Kung, Charles, Moffat, Jason

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A phase 1 dose escalation study of the pyruvate kinase activator mitapivat (AG-348) in sickle cell disease von Xu, Julia Z., Conrey, Anna, Frey, Ingrid, Gwaabe, Eveline, Menapace, Laurel A., Tumburu, Laxminath, Lundt, Maureen, Lequang, Timothy, Li, Quan, Glass, Kristen, Dunkelberger, Emily B., Iyer, Varsha, Mangus, Heidi, Kung, Charles, Dang, Lenny, Kosinski, Penelope A., Hawkins, Peter, Jeffries, Neal, Eaton, William A., Lay Thein, Swee

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AG-348 (mitapivat), an allosteric activator of red blood cell pyruvate kinase, increases enzymatic activity, protein stability, and adenosine triphosphate levels over a broad range... von Rab, Minke A. E., van Oirschot, Brigitte A., Kosinski, Penelope A., Hixon, Jeffrey, Johnson, Kendall, Chubukov, Victor, Dang, Lenny, Pasterkamp, Gerard, van Straaten, Stephanie, van Solinge, Wouter W., van Beers, Eduard J., Kung, Charles, van Wijk, Richard

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The pyruvate kinase activator mitapivat reduces hemolysis and improves anemia in a beta-thalassemia mouse model von Matte, Alessandro, Federti, Enrica, Kung, Charles, Kosinski, Penelope A., Narayanaswamy, Rohini, Russo, Roberta, Federico, Giorgia, Carlomagno, Francesca, Desbats, Maria Andrea, Salviati, Leonardo, Leboeuf, Christophe, Valenti, Maria Teresa, Turrini, Francesco, Janin, Anne, Yu, Shaoxia, Beneduce, Elisabetta, Ronseaux, Sebastien, Iatcenko, Iana, Dang, Lenny, Ganz, Tomas, Jung, Chun-Ling, Iolascon, Achille, Brugnara, Carlo, De Franceschi, Lucia

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Chemical genomic profiling to identify intracellular targets of a multiplex kinase inhibitor von Kung, C, Kenski, D.M, Dickerson, S.H, Howson, R.W, Kuyper, L.F, Madhani, H.D, Shokat, K.M

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120-LB: Small Molecule Activator of Pyruvate Kinase Regulates In Vivo Glucose Homeostasis von ABULIZI, ABUDUKADIER, CARDONE, REBECCA L., SIEBEL, STEPHAN, KUNG, CHARLES, KIBBEY, RICHARD

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AG-348 enhances pyruvate kinase activity in red blood cells from patients with pyruvate kinase deficiency von Kung, Charles, Hixon, Jeff, Kosinski, Penelope A., Cianchetta, Giovanni, Histen, Gavin, Chen, Yue, Hill, Collin, Gross, Stefan, Si, Yaguang, Johnson, Kendall, DeLaBarre, Byron, Luo, Zhiyong, Gu, Zhiwei, Yao, Gui, Tang, Huachun, Fang, Cheng, Xu, Yingxia, Lv, Xiaobing, Biller, Scott, Su, Shin-San Michael, Yang, Hua, Popovici-Muller, Janeta, Salituro, Francesco, Silverman, Lee, Dang, Lenny

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Decreased activity and stability of pyruvate kinase in sickle cell disease: a novel target for mitapivat therapy von Rab, Minke A.E., Bos, Jennifer, van Oirschot, Brigitte A., van Straaten, Stephanie, Kosinski, Penelope A., Chubukov, Victor, Kim, Hyeryun, Mangus, Heidi, Schutgens, Roger E.G., Pasterkamp, Gerard, Dang, Lenny, Kung, Charles, van Beers, Eduard J., van Wijk, Richard

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Structure‐Based Design of AG‐946, a Pyruvate Kinase Activator von Liu, Tao, Padyana, Anil K., Judd, Evan T., Jin, Lei, Hammoudeh, Dalia, Kung, Charles, Dang, Lenny

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