The L-Type Amino Acid Transporter LAT1-An Emerging Target in Cancer von Häfliger, Pascal, Charles, Roch-Philippe

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The LAT1 inhibitor JPH203 reduces growth of thyroid carcinoma in a fully immunocompetent mouse model von Häfliger, Pascal, Graff, Julien, Rubin, Matthias, Stooss, Amandine, Dettmer, Matthias S, Altmann, Karl-Heinz, Gertsch, Jürg, Charles, Roch-Philippe

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Optimization of TRPV6 Calcium Channel Inhibitors Using a 3D Ligand-Based Virtual Screening Method von Simonin, Céline, Awale, Mahendra, Brand, Michael, van Deursen, Ruud, Schwartz, Julian, Fine, Michael, Kovacs, Gergely, Häfliger, Pascal, Gyimesi, Gergely, Sithampari, Abilashan, Charles, Roch-Philippe, Hediger, Matthias A., Reymond, Jean-Louis

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Activating BRAF and PIK3CA mutations cooperate to promote anaplastic thyroid carcinogenesis von Charles, Roch-Philippe, Silva, Jillian, Iezza, Gioia, Phillips, Wayne A, McMahon, Martin

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A central role for RAF→MEK→ERK signaling in the genesis of pancreatic ductal adenocarcinoma von Collisson, Eric A, Trejo, Christy L, Silva, Jillian M, Gu, Shenda, Korkola, James E, Heiser, Laura M, Charles, Roch-Philippe, Rabinovich, Brian A, Hann, Byron, Dankort, David, Spellman, Paul T, Phillips, Wayne A, Gray, Joe W, McMahon, Martin

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epidermal barrier function is dependent on the serine protease CAP1/Prss8 von Leyvraz, Céline, Charles, Roch-Philippe, Rubera, Isabelle, Guitard, Marjorie, Rotman, Samuel, Breiden, Bernadette, Sandhoff, Konrad, Hummler, Edith

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Questioning the role of selected somatic PIK3C2B mutations in squamous non-small cell lung cancer oncogenesis von Kind, Marcus, Klukowska-Rötzler, Jolanta, Berezowska, Sabina, Arcaro, Alexandre, Charles, Roch-Philippe

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Colon-Specific Deletion of Epithelial Sodium Channel Causes Sodium Loss and Aldosterone Resistance von MALSURE, Sumedha, QING WANG, CHARLES, Roch-Philippe, SERGI, Chloe, PERRIER, Romain, CHRISTENSEN, Birgitte Mønster, MAILLARD, Marc, ROSSIER, Bernard C, HUMMLER, Edith

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Identifying Lysophosphatidic Acid Acyltransferase β (LPAAT‐β) as the Target of a Nanomolar Angiogenesis Inhibitor from a Phenotypic Screen Using the Polypharmacology Browser PPB2... von Poirier, Marion, Awale, Mahendra, Roelli, Matthias A., Giuffredi, Guy T., Ruddigkeit, Lars, Evensen, Lasse, Stooss, Amandine, Calarco, Serafina, Lorens, James B., Charles, Roch‐Philippe, Reymond, Jean‐Louis

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PIK3CA hotspot mutations differentially impact responses to MET targeting in MET-driven and non-driven preclinical cancer models von Nisa, Lluís, Häfliger, Pascal, Poliaková, Michaela, Giger, Roland, Francica, Paola, Aebersold, Daniel Matthias, Charles, Roch-Philippe, Zimmer, Yitzhak, Medová, Michaela

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ENaC‐mediated alveolar fluid clearance and lung fluid balance depend on the channel‐activating protease 1 von Planès, Carole, Randrianarison, Nadia H., Charles, Roch‐Philippe, Frateschi, Simona, Cluzeaud, Françoise, Vuagniaux, Grégoire, Soler, Paul, Clerici, Christine, Rossier, Bernard C., Hummler, Edith

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The channel-activating protease CAP1/Prss8 is required for placental labyrinth maturation von Hummler, Edith, Dousse, Aline, Rieder, Audrey, Stehle, Jean-Christophe, Rubera, Isabelle, Osterheld, Maria-Chiara, Beermann, Friedrich, Frateschi, Simona, Charles, Roch-Philippe

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Combined MEK and Pi3'-kinase inhibition reveals synergy in targeting thyroid cancer in vitro and in vivo von ElMokh, Oussama, Ruffieux-Daidié, Dorothée, Roelli, Matthias A, Stooss, Amandine, Phillips, Wayne A, Gertsch, Jürg, Dettmer, Matthias S, Charles, Roch-Philippe

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Vaccines against Covid-19, Different Strategies towards the Same Goal von Charles, Roch-Philippe

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SLC16 Family: From Atomic Structure to Human Disease von Bosshart, Patrick D., Charles, Roch-Philippe, Garibsingh, Rachel-Ann A., Schlessinger, Avner, Fotiadis, Dimitrios

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Overview of Genetically Engineered Mouse Models of Papillary and Anaplastic Thyroid Cancers: Enabling Translational Biology for Patient Care Improvement von Charles, Roch‐Philippe

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Vasopressin-inducible ubiquitin-specific protease 10 increases ENaC cell surface expression by deubiquitylating and stabilizing sorting nexin 3 von Boulkroun, Sheerazed, Ruffieux-Daidie, Dorothee, Vitagliano, Jean-Jacques, Poirot, Olivier, Charles, Roch-Philippe, Lagnaz, Dagmara, Firsov, Dmitri, Kellenberger, Stephan, Staub, Olivier

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Mutationally activated BRAF(V600E) elicits papillary thyroid cancer in the adult mouse von Charles, Roch-Philippe, Iezza, Gioia, Amendola, Elena, Dankort, David, McMahon, Martin

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Targeting CD47 in Anaplastic Thyroid Carcinoma Enhances Tumor Phagocytosis by Macrophages and Is a Promising Therapeutic Strategy von Schürch, Christian M., Roelli, Matthias A., Forster, Stefan, Wasmer, Marie-Hélène, Brühl, Frido, Maire, Renaud S., Di Pancrazio, Sergio, Ruepp, Marc-David, Giger, Roland, Perren, Aurel, Schmitt, Anja M., Krebs, Philippe, Charles, Roch-Philippe, Dettmer, Matthias S.

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Chemical probes to potently and selectively inhibit endocannabinoid cellular reuptake von Chicca, Andrea, Nicolussi, Simon, Bartholomäus, Ruben, Blunder, Martina, Rey, Alejandro Aparisi, Petrucci, Vanessa, del Carmen Reynoso-Moreno, Ines, Viveros-Paredes, Juan Manuel, Gens, Marianela Dalghi, Lutz, Beat, Schiöth, Helgi B., Soeberdt, Michael, Abels, Christoph, Charles, Roch-Philippe, Altmann, Karl-Heinz, Gertsch, Jürg

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