A review and update of the current status of the vasculature-disabling agent combretastatin-A4 phosphate (CA4P) von Siemann, Dietmar W, Chaplin, David J, Walicke, Patricia A

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Synthesis and biological evaluation of indole-based, anti-cancer agents inspired by the vascular disrupting agent 2-(3′-hydroxy-4′-methoxyphenyl)-3-(3″,4″,5″-trimethoxybenzoyl)-6-m... von MacDonough, Matthew T., Strecker, Tracy E., Hamel, Ernest, Hall, John J., Chaplin, David J., Trawick, Mary Lynn, Pinney, Kevin G.

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Vascular‐targeting therapies for treatment of malignant disease von Siemann, Dietmar W., Chaplin, David J., Horsman, Michael R.

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Design, synthesis, and biological evaluation of water-soluble amino acid prodrug conjugates derived from combretastatin, dihydronaphthalene, and benzosuberene-based parent vascular... von Devkota, Laxman, Lin, Chen-Ming, Strecker, Tracy E., Wang, Yifan, Tidmore, Justin K., Chen, Zhi, Guddneppanavar, Rajsekhar, Jelinek, Christopher J., Lopez, Ramona, Liu, Li, Hamel, Ernest, Mason, Ralph P., Chaplin, David J., Trawick, Mary Lynn, Pinney, Kevin G.

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Low-dose metronomic cyclophosphamide combined with vascular disrupting therapy induces potent antitumor activity in preclinical human tumor xenograft models von Daenen, Laura G, Shaked, Yuval, Man, Shan, Xu, Ping, Voest, Emile E, Hoffman, Robert M, Chaplin, David J, Kerbel, Robert S

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The development and use of vascular targeted therapy in ovarian cancer von Chase, Dana M, Chaplin, David J, Monk, Bradley J

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The development of combretastatin A4 phosphate as a vascular targeting agent von Chaplin, David J, Hill, Sally A

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Structure Guided Design, Synthesis, and Biological Evaluation of Novel Benzosuberene Analogues as Inhibitors of Tubulin Polymerization von Niu, Haichan, Strecker, Tracy E, Gerberich, Jeni L, Campbell, James W, Saha, Debabrata, Mondal, Deboprosad, Hamel, Ernest, Chaplin, David J, Mason, Ralph P, Trawick, Mary Lynn, Pinney, Kevin G

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Bioreductively Activatable Prodrug Conjugates of Combretastatin A‑1 and Combretastatin A‑4 as Anticancer Agents Targeted toward Tumor-Associated Hypoxia von Winn, Blake A, Devkota, Laxman, Kuch, Bunnarack, MacDonough, Matthew T, Strecker, Tracy E, Wang, Yifan, Shi, Zhe, Gerberich, Jeni L, Mondal, Deboprosad, Ramirez, Alejandro J, Hamel, Ernest, Chaplin, David J, Davis, Peter, Mason, Ralph P, Trawick, Mary Lynn, Pinney, Kevin G

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Combretastatin A4 phosphate induces rapid regression of tumor neovessels and growth through interference with vascular endothelial-cadherin signaling von Vincent, Loïc, Kermani, Pouneh, Young, Lauren M, Cheng, Joseph, Zhang, Fan, Shido, Koji, Lam, George, Bompais-Vincent, Heidi, Zhu, Zhenping, Hicklin, Daniel J, Bohlen, Peter, Chaplin, David J, May, Chad, Rafii, Shahin

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Combretastatin A4 phosphate: background and current clinical status von Young, Scott L, Chaplin, David J

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Pharmacological inhibition of the hypertensive response to combretastatin A-4 phosphate in rats von Ke, Qingen, Bodyak, Natalya, Rigor, Debra L, Hurst, Nicole W, Chaplin, David J, Kang, Peter M

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Bioreductively activatable prodrug conjugates of phenstatin designed to target tumor hypoxia von Winn, Blake A., Shi, Zhe, Carlson, Graham J., Wang, Yifan, Nguyen, Benson L., Kelly, Evan M., Ross, R. David, Hamel, Ernest, Chaplin, David J., Trawick, Mary L., Pinney, Kevin G.

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The first international conference on vascular targeting: meeting overview von Thorpe, Philip E, Chaplin, David J, Blakey, David C

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The vascular disrupting activity of OXi8006 in endothelial cells and its phosphate prodrug OXi8007 in breast tumor xenografts von Strecker, Tracy E, Odutola, Samuel O, Lopez, Ramona, Cooper, Morgan S, Tidmore, Justin K, Charlton-Sevcik, Amanda K, Li, Li, MacDonough, Matthew T, Hadimani, Mallinath B, Ghatak, Anjan, Liu, Li, Chaplin, David J, Mason, Ralph P, Pinney, Kevin G, Trawick, Mary Lynn

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Synthesis of a 2‑Aryl-3-aroyl Indole Salt (OXi8007) Resembling Combretastatin A‑4 with Application as a Vascular Disrupting Agent von Hadimani, Mallinath B, MacDonough, Matthew T, Ghatak, Anjan, Strecker, Tracy E, Lopez, Ramona, Sriram, Madhavi, Nguyen, Benson L, Hall, John J, Kessler, Raymond J, Shirali, Anupama R, Liu, Li, Garner, Charles M, Pettit, George R, Hamel, Ernest, Chaplin, David J, Mason, Ralph P, Trawick, Mary Lynn, Pinney, Kevin G

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Synthesis of structurally diverse benzosuberene analogues and their biological evaluation as anti-cancer agents von Tanpure, Rajendra P., George, Clinton S., Strecker, Tracy E., Devkota, Laxman, Tidmore, Justin K., Lin, Chen-Ming, Herdman, Christine A., MacDonough, Matthew T., Sriram, Madhavi, Chaplin, David J., Trawick, Mary Lynn, Pinney, Kevin G.

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Structural interrogation of benzosuberene-based inhibitors of tubulin polymerization von Herdman, Christine A., Devkota, Laxman, Lin, Chen-Ming, Niu, Haichan, Strecker, Tracy E., Lopez, Ramona, Liu, Li, George, Clinton S., Tanpure, Rajendra P., Hamel, Ernest, Chaplin, David J., Mason, Ralph P., Trawick, Mary Lynn, Pinney, Kevin G.

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Synthesis and biological evaluation of a water-soluble phosphate prodrug salt and structural analogues of KGP94, a lead inhibitor of cathepsin L von Parker, Erica N., Odutola, Samuel O., Wang, Yifan, Strecker, Tracy E., Mukherjee, Rajeswari, Shi, Zhe, Chaplin, David J., Trawick, Mary Lynn, Pinney, Kevin G.

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Chemosensitizing AML cells by targeting bone marrow endothelial cells von Bosse, Raphael C, Wasserstrom, Briana, Meacham, Amy, Wise, Elizabeth, Drusbosky, Leylah, Walter, Glenn A, Chaplin, David J, Siemann, Dietmar W, Purich, Daniel L, Cogle, Christopher R

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