Acyl-coenzyme A:cholesterol acyltransferases von Chang, Ta-Yuan, Li, Bo-Liang, Chang, Catherine C. Y, Urano, Yasuomi

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Structural insights into the inhibition mechanism of human sterol O-acyltransferase 1 by a competitive inhibitor von Guan, Chengcheng, Niu, Yange, Chen, Si-Cong, Kang, Yunlu, Wu, Jing-Xiang, Nishi, Koji, Chang, Catherine C. Y., Chang, Ta-Yuan, Luo, Tuoping, Chen, Lei

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Acute ACAT1/SOAT1 Blockade Increases MAM Cholesterol and Strengthens ER-Mitochondria Connectivity von Harned, Taylor C, Stan, Radu V, Cao, Ze, Chakrabarti, Rajarshi, Higgs, Henry N, Chang, Catherine C Y, Chang, Ta Yuan

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ACAT1/SOAT1 Blockade Suppresses LPS-Mediated Neuroinflammation by Modulating the Fate of Toll-like Receptor 4 in Microglia von Li, Haibo, Huynh, Thao N, Duong, Michael Tran, Gow, James G, Chang, Catherine C Y, Chang, Ta Yuan

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Stealth Liposomes Encapsulating a Potent ACAT1/SOAT1 Inhibitor F12511: Pharmacokinetic, Biodistribution, and Toxicity Studies in Wild-Type Mice and Efficacy Studies in Triple Trans... von De La Torre, Adrianna L, Huynh, Thao N, Chang, Catherine C Y, Pooler, Darcy B, Ness, Dylan B, Lewis, Lionel D, Pannem, Sanjana, Feng, Yichen, Samkoe, Kimberley S, Hickey, William F, Chang, Ta Yuan

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Cholesterol and fatty acids regulate cysteine ubiquitylation of ACAT2 through competitive oxidation von Wang, Yong-Jian, Bian, Yan, Luo, Jie, Lu, Ming, Xiong, Ying, Guo, Shu-Yuan, Yin, Hui-Yong, Lin, Xu, Li, Qin, Chang, Catherine C. Y., Chang, Ta-Yuan, Li, Bo-Liang, Song, Bao-Liang

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Inhibiting the Cholesterol Storage Enzyme ACAT1/SOAT1 in Myelin Debris-Treated Microglial Cell Lines Activates the Gene Expression of Cholesterol Efflux Transporter ABCA1 von Huynh, Thao N, Havrda, Matthew C, Zanazzi, George J, Chang, Catherine C Y, Chang, Ta Yuan

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Cholesterol, Atherosclerosis, and APOE in Vascular Contributions to Cognitive Impairment and Dementia (VCID): Potential Mechanisms and Therapy von Duong, Michael Tran, Nasrallah, Ilya M., Wolk, David A., Chang, Catherine C. Y., Chang, Ta-Yuan

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ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD von Bryleva, Elena Y, Rogers, Maximillian A, Chang, Catherine C.Y, Buen, Floyd, Harris, Brent T, Rousselet, Estelle, Seidah, Nabil G, Oddo, Salvatore, LaFerla, Frank M, Spencer, Thomas A, Hickey, William F, Chang, Ta-Yuan

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Characterization of Stealth Liposome-Based Nanoparticles Encapsulating the ACAT1/SOAT1 Inhibitor F26: Efficacy and Toxicity Studies In Vitro and in Wild-Type Mice von Lee, Junghoon, De La Torre, Adrianna L, Rawlinson, Felix L, Ness, Dylan B, Lewis, Lionel D, Hickey, William F, Chang, Catherine C Y, Chang, Ta Yuan

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Binding between the Niemann-Pick C1 Protein and a Photoactivatable Cholesterol Analog Requires a Functional Sterol-Sensing Domain von Ohgami, Nobutaka, Ko, Dennis C., Thomas, Matthew, Scott, Matthew P., Catherine C. Y. Chang, Chang, Ta-Yuan, Vagelos, P. Roy

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Transport of LDL-derived cholesterol from the NPC1 compartment to the ER involves the trans-Golgi network and the SNARE protein complex von Urano, Yasuomi, Watanabe, Hiroshi, Murphy, Stephanie R, Shibuya, Yohei, Geng, Yong, Peden, Andrew A, Chang, Catherine C.Y, Chang, Ta Yuan

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Purification of Recombinant Acyl-Coenzyme A:Cholesterol Acyltransferase 1 (ACAT1) from H293 Cells and Binding Studies between the Enzyme and Substrates Using Difference Intrinsic F... von Chang, Catherine C. Y, Miyazaki, Akira, Dong, Ruhong, Kheirollah, Alireza, Yu, Chunjiang, Geng, Yong, Higgs, Henry N, Chang, Ta-Yuan

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TNF-alpha stimulates the ACAT1 expression in differentiating monocytes to promote the CE-laden cell formation von Lei, Lei, Xiong, Ying, Chen, Jia, Yang, Jin-Bo, Wang, Yi, Yang, Xin-Ying, Chang, Catherine C.Y., Song, Bao-Liang, Chang, Ta-Yuan, Li, Bo-Liang

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Acyl-CoA:cholesterol acyltransferases (ACATs/SOATs): Enzymes with multiple sterols as substrates and as activators von Rogers, Maximillian A., Liu, Jay, Song, Bao-Liang, Li, Bo-Liang, Chang, Catherine C.Y., Chang, Ta-Yuan

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Cholesterol sensing, trafficking, and esterification von Chang, Ta-Yuan, Chang, Catherine C Y, Ohgami, Nobutaka, Yamauchi, Yoshio

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Identification of Soat1 as a quantitative trait locus gene on mouse chromosome 1 contributing to hyperlipidemia von Lu, Zongji, Yuan, Zuobiao, Miyoshi, Toru, Wang, Qian, Su, Zhiguang, Chang, Catherine C, Shi, Weibin

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MiR-9 reduces human acyl-coenzyme A：cholesterol acyltransferase-1 to decrease THP-1 macrophage-derived foam cell formation von Xu, Jiajia, Hu, Guangjing, Lu, Ming, Xiong, Ying, Li, Qin, Chang, Catherine C Y, Song, Baoliang, Chang, Tayuan, Li, Boliang

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Acat1/Soat1 knockout extends the mutant Npc1 mouse lifespan and ameliorates functional deficiencies in multiple organelles of mutant cells von Rogers, Maximillian A, Chang, Catherine C Y, Maue, Robert A, Melton, Elaina M, Peden, Andrew A, Garver, William S, Lee, Junghoon, Schroen, Peter, Huang, Mitchell, Chang, Ta-Yuan

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Triton X-100 or octyl glucoside inactivates acyl-CoA:cholesterol acyltransferase 1 by dissociating it from a two-fold dimer to a two-fold monomer von Neumann, Bryan, Chang, Catherine C.Y., Chang, Ta-Yuan

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