Targeting the p300/CBP Axis in Lethal Prostate Cancer von Welti, Jonathan, Sharp, Adam, Brooks, Nigel, Yuan, Wei, McNair, Christopher, Chand, Saswati N., Pal, Abhijit, Figueiredo, Ines, Riisnaes, Ruth, Gurel, Bora, Rekowski, Jan, Bogdan, Denisa, West, William, Young, Barbara, Raja, Meera, Prosser, Amy, Lane, Jordan, Thomson, Stuart, Worthington, Jenny, Onions, Stuart, Shannon, Jonathan, Paoletta, Silvia, Brown, Richard, Smyth, Don, Harbottle, Gareth W., Gil, Veronica S., Miranda, Susana, Crespo, Mateus, Ferreira, Ana, Pereira, Rita, Tunariu, Nina, Carreira, Suzanne, Neeb, Antje J., Ning, Jian, Swain, Amanda, Taddei, David, Schiewer, Matthew J., Knudsen, Karen E., Pegg, Neil, de Bono, Johann S.

Volltext

The circadian cryptochrome, CRY1, is a pro-tumorigenic factor that rhythmically modulates DNA repair von Shafi, Ayesha A., McNair, Chris M., McCann, Jennifer J., Alshalalfa, Mohammed, Shostak, Anton, Severson, Tesa M., Zhu, Yanyun, Bergman, Andre, Gordon, Nicolas, Mandigo, Amy C., Chand, Saswati N., Gallagher, Peter, Dylgjeri, Emanuela, Laufer, Talya S., Vasilevskaya, Irina A., Schiewer, Matthew J., Brunner, Michael, Feng, Felix Y., Zwart, Wilbert, Knudsen, Karen E.

Volltext

Posttranscriptional Upregulation of IDH1 by HuR Establishes a Powerful Survival Phenotype in Pancreatic Cancer Cells von Zarei, Mahsa, Lal, Shruti, Parker, Seth J, Nevler, Avinoam, Vaziri-Gohar, Ali, Dukleska, Katerina, Mambelli-Lisboa, Nicole C, Moffat, Cynthia, Blanco, Fernando F, Chand, Saswati N, Jimbo, Masaya, Cozzitorto, Joseph A, Jiang, Wei, Yeo, Charles J, Londin, Eric R, Seifert, Erin L, Metallo, Christian M, Brody, Jonathan R, Winter, Jordan M

Volltext

RB/E2F1 as a Master Regulator of Cancer Cell Metabolism in Advanced Disease von Mandigo, Amy C., Yuan, Wei, Xu, Kexin, Gallagher, Peter, Pang, Angel, Guan, Yi Fang, Shafi, Ayesha A., Thangavel, Chellappagounder, Sheehan, Beshara, Bogdan, Denisa, Paschalis, Alec, McCann, Jennifer J., Laufer, Talya S., Gordon, Nicolas, Vasilevskaya, Irina A., Dylgjeri, Emanuela, Chand, Saswati N., Schiewer, Matthew J., Domingo-Domenech, Josep, Den, Robert B., Holst, Jeff, McCue, Peter A., de Bono, Johann S., McNair, Christopher, Knudsen, Karen E.

Volltext

Posttranscriptional Regulation of PARG mRNA by HuR Facilitates DNA Repair and Resistance to PARP Inhibitors von Chand, Saswati N, Zarei, Mahsa, Schiewer, Matthew J, Kamath, Akshay R, Romeo, Carmella, Lal, Shruti, Cozzitorto, Joseph A, Nevler, Avinoam, Scolaro, Laura, Londin, Eric, Jiang, Wei, Meisner-Kober, Nicole, Pishvaian, Michael J, Knudsen, Karen E, Yeo, Charles J, Pascal, John M, Winter, Jordan M, Brody, Jonathan R

Volltext

PARP‐1 regulates DNA repair factor availability von Schiewer, Matthew J, Mandigo, Amy C, Gordon, Nicolas, Huang, Fangjin, Gaur, Sanchaika, de Leeuw, Renée, Zhao, Shuang G, Evans, Joseph, Han, Sumin, Parsons, Theodore, Birbe, Ruth, McCue, Peter, McNair, Christopher, Chand, Saswati N, Cendon‐Florez, Ylenia, Gallagher, Peter, McCann, Jennifer J, Poudel Neupane, Neermala, Shafi, Ayesha A, Dylgjeri, Emanuela, Brand, Lucas J, Visakorpi, Tapio, Raj, Ganesh V, Lallas, Costas D, Trabulsi, Edouard J, Gomella, Leonard G, Dicker, Adam P, Kelly, Wm. Kevin, Leiby, Benjamin E, Knudsen, Beatrice, Feng, Felix Y, Knudsen, Karen E

Volltext

WEE1 inhibition in pancreatic cancer cells is dependent on DNA repair status in a context dependent manner von Lal, Shruti, Zarei, Mahsa, Chand, Saswati N., Dylgjeri, Emanuela, Mambelli-Lisboa, Nicole C., Pishvaian, Michael J., Yeo, Charles J., Winter, Jordan M., Brody, Jonathan R.

Volltext

HuR is a post-transcriptional regulator of core metabolic enzymes in pancreatic cancer von Burkhart, Richard A, Pineda, Danielle M, Chand, Saswati N, Romeo, Carmella, Londin, Eric R, Karoly, Edward D, Cozzitorto, Joseph A, Rigoutsos, Isidore, Yeo, Charles J, Brody, Jonathan R, Winter, Jordan M

Volltext

RNA binding protein HuR regulates extracellular matrix gene expression and pH homeostasis independent of controlling HIF-1α signaling in nucleus pulposus cells von Pan, Hehai, Strickland, Adam, Madhu, Vedavathi, Johnson, Zariel I., Chand, Saswati N., Brody, Jonathan R., Fertala, Andrzej, Zheng, Zhaomin, Shapiro, Irving M., Risbud, Makarand V.

Volltext

AR coactivators, CBP/p300, are critical mediators of DNA repair in prostate cancer von Sardar, Sumaira, McNair, Christopher M., Ravindranath, Lakshmi, Chand, Saswati N., Yuan, Wei, Bogdan, Denisa, Welti, Jon, Sharp, Adam, Ryan, Natalie K., Knudsen, Liam A., Schiewer, Matthew J., DeArment, Elise G., Janas, Thomas, Su, Xiaofeng A., Butler, Lisa M., de Bono, Johann S., Frese, Kris, Brooks, Nigel, Pegg, Neil, Knudsen, Karen E., Shafi, Ayesha A.

Volltext

Poly (ADP) Ribose Glycohydrolase Can Be Effectively Targeted in Pancreatic Cancer von Jain, Aditi, Agostini, Lebaron C, McCarthy, Grace A, Chand, Saswati N, Ramirez, AnnJosette, Nevler, Avinoam, Cozzitorto, Joseph, Schultz, Christopher W, Lowder, Cinthya Yabar, Smith, Kate M, Waddell, Ian D, Raitses-Gurevich, Maria, Stossel, Chani, Gorman, Yulia Glick, Atias, Dikla, Yeo, Charles J, Winter, Jordan M, Olive, Kenneth P, Golan, Talia, Pishvaian, Michael J, Ogilvie, Donald, James, Dominic I, Jordan, Allan M, Brody, Jonathan R

Volltext

HuR Contributes to TRAIL Resistance by Restricting Death Receptor 4 Expression in Pancreatic Cancer Cells von Romeo, Carmella, Weber, Matthew C, Zarei, Mahsa, DeCicco, Danielle, Chand, Saswati N, Lobo, Angie D, Winter, Jordan M, Sawicki, Janet A, Sachs, Jonathan N, Meisner-Kober, Nicole, Yeo, Charles J, Vadigepalli, Rajanikanth, Tykocinski, Mark L, Brody, Jonathan R

Volltext

Pleiotropic Impact of DNA-PK in Cancer and Implications for Therapeutic Strategies von Dylgjeri, Emanuela, McNair, Christopher, Goodwin, Jonathan F, Raymon, Heather K, McCue, Peter A, Shafi, Ayesha A, Leiby, Benjamin E, de Leeuw, Renée, Kothari, Vishal, McCann, Jennifer J, Mandigo, Amy C, Chand, Saswati N, Schiewer, Matthew J, Brand, Lucas J, Vasilevskaya, Irina, Gordon, Nicolas, Laufer, Talya S, Gomella, Leonard G, Lallas, Costas D, Trabulsi, Edouard J, Feng, Felix Y, Filvaroff, Ellen H, Hege, Kristin, Rathkopf, Dana, Knudsen, Karen E

Volltext

CRISPR Knockout of the HuR Gene Causes a Xenograft Lethal Phenotype von Lal, Shruti, Cheung, Edwin C, Zarei, Mahsa, Preet, Ranjan, Chand, Saswati N, Mambelli-Lisboa, Nicole C, Romeo, Carmella, Stout, Matthew C, Londin, Eric, Goetz, Austin, Lowder, Cinthya Y, Nevler, Avinoam, Yeo, Charles J, Campbell, Paul M, Winter, Jordan M, Dixon, Dan A, Brody, Jonathan R

Volltext

Abstract 1847: The mRNA-binding protein HuR, regulates mutant and wild type IDH1 expression in IDH1-mutated cancer von Zarei, Mahsa, Lal, Shruti, Mambelli-Lisboa, Nicole C., Cheung, Edwin, Chand, Saswati N., Yeo, Charles J., Brody, Jonathan R., Winter, Jordan M.

Volltext

Abstract 1995: HuR dependent inhibition of PARG enhances PARP inhibitor therapy for DNA repair proficient and deficient pancreatic cancer cells von Chand, Saswati N., Zarei, Mahsa, Kamath, Akshay R., Schiewer, Matthew J., Romeo, Carmella, Cozzitorto, Joseph A., Meisner-Kober, Nicole, Londin, Eric, Rigoutsos, Isidore, Knudsen, Karen, Pascal, John M., Yeo, Charles J., Winter, Jordan M., Brody, Jonathan R.

Volltext

PARP inhibitors for chemoprevention--letter von Chand, Saswati N, Blanco, Fernando F, Jimbo, Masaya, Tsangaris, Theodore N, Cristofanilli, Massimo, Yeo, Charles J, Winter, Jordan M, Pishvaian, Michael J, Brody, Jonathan R

Volltext

129 – Repurposing the Fda Approved Drug Pyrvinium Pamoate to Target Hur in Pancreatic Ductal Adenocarcinoma von Schultz, Christopher, Dhir, Teena, Haber, Alex, Jiang, Wei, Chand, Saswati N., Samantha, Brown, Petricoin, Emanuel, Yeo, Charles J., Brody, Jonathan R.

Volltext

Abstract 1656: MK-1775 (WEE1 inhibition) lacks efficacy against DNA repair deficient pancreatic cancer cells von Lal, Shruti, Chand, Saswati N., Dylgjeri, Emanuela, Yeo, Charles J., Winter, Jordan M., Brody, Jonathan R.

Volltext

Abstract 1973: Targeting PARG in pancreatic cancer: Implications for synthetic lethal therapeutic strategies von Chand, Saswati N., Ramirez, AnnJosette, Jain, Aditi, Nevler, Avinoam, Yabar-Lowder, Cinthya, Cozzitorto, Joseph A., James, Dominic I., Jordan, Allan, Smith, Kate M., Waddell, Ian, Yeo, Charles J., Winter, Jordan M., Brody, Jonathan R.

Volltext