Immune checkpoint blockade in glioblastoma: from tumor heterogeneity to personalized treatment von Arrieta, Víctor A, Dmello, Crismita, McGrail, Daniel J, Brat, Daniel J, Lee-Chang, Catalina, Heimberger, Amy B, Chand, Dhan, Stupp, Roger, Sonabend, Adam M

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Next-generation CTLA-4 targeting molecules and combination therapy: promising strategies for improving cancer immunotherapy von Rudqvist, Nils-Petter, Avagyan, Manushak, Chand, Dhan

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Stress and reproduction: Controversies and challenges von Chand, Dhan, Lovejoy, David A

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A phase 1/2 clinical trial of invariant natural killer T cell therapy in moderate-severe acute respiratory distress syndrome von Hammond, Terese C., Purbhoo, Marco A., Kadel, Sapana, Ritz, Jerome, Nikiforow, Sarah, Daley, Heather, Shaw, Kit, van Besien, Koen, Gomez-Arteaga, Alexandra, Stevens, Don, Ortuzar, Waldo, Michelet, Xavier, Smith, Rachel, Moskowitz, Darrian, Masakayan, Reed, Yigit, Burcu, Boi, Shannon, Soh, Kah Teong, Chamberland, John, Song, Xin, Qin, Yu, Mishchenko, Ilya, Kirby, Maurice, Nasonenko, Valeriia, Buffa, Alexa, Buell, Jennifer S., Chand, Dhan, van Dijk, Marc, Stebbing, Justin, Exley, Mark A.

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Toxicological and pharmacological assessment of AGEN1884, a novel human IgG1 anti-CTLA-4 antibody von Gombos, Randi B, Gonzalez, Ana, Manrique, Mariana, Chand, Dhan, Savitsky, David, Morin, Benjamin, Breous-Nystrom, Ekaterina, Dupont, Christopher, Ward, Rebecca A, Mundt, Cornelia, Duckless, Benjamin, Tang, Hao, Findeis, Mark A, Schuster, Andrea, Waight, Jeremy D, Underwood, Dennis, Clarke, Christopher, Ritter, Gerd, Merghoub, Taha, Schaer, David, Wolchok, Jedd D, van Dijk, Marc, Buell, Jennifer S, Cuillerot, Jean-Marie, Stein, Robert, Drouin, Elise E, Wilson, Nicholas S

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Identification of members of the gonadotropin-releasing hormone (GnRH), corticotropin-releasing factor (CRF) families in the genome of the holocephalan, Callorhinchus milii (elepha... von Nock, Tanya G, Chand, Dhan, Lovejoy, David A

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70 Beyond PD-L1: novel PD-1 biomarkers identified by driving T cell dysfunction in vitro von Pabla, Simarjot, Khendu, Tenzing, Chand, Dhan, Aksoy, Bulent, Duckless, Benjamin, Basinski, Andrew, Joyce, Cailin, Horn, Thomas, Swiech, Lukasz, Waight, Jeremy, Savitsky, David, Buell, Jennifer

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377 AGEN2373 is a CD137 agonist antibody designed to leverage optimal CD137 and FcγR co-targeting to promote antitumor immunologic effects von Galand, Claire, Venkatraman, Vignesh, Marques, Marilyn, Strauss, James, Carvajal, Richard, Lim, Min, Morin, Benjamin, Ignatovich, Olga, Findeis, Mark, Underwood, Dennis, Dijk, Marc Van, Shapiro, Irina, Ohanjanian, Lernik, Wijatyk, Anna, Wilson, Nicholas, Buell, Jennifer, Chand, Dhan, Savitsky, David, Tolcher, Anthony

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Differentiated activity profile for the PD-1 inhibitor balstilimab von Joyce, Cailin, Chand, Dhan, Duckless, Benjamin, Hidalgo, Manuel, Grossman, Joseph Elan, Kaleta, Remigiusz, O'Malley, David M.

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Treatment with doxorubicin and PD-1/CTLA-4 blockade improves T cell activation and anti-tumor efficacy in MCA-205 murine fibrosarcoma von Therrien, Nicholas R, Tellez, Cristiam Morreno, Kemp, Lindsey E, Powers, Kyle N, Levey, Daniel, Chand, Dhan, Wilkens, Margaret, Grossman, Joseph, Goodspeed, Andrew, Davila, Eduardo, Wilky, Breelyn A

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Selective FcγR Co-engagement on APCs Modulates the Activity of Therapeutic Antibodies Targeting T Cell Antigens von Waight, Jeremy D., Chand, Dhan, Dietrich, Sylvia, Gombos, Randi, Horn, Thomas, Gonzalez, Ana M., Manrique, Mariana, Swiech, Lukasz, Morin, Benjamin, Brittsan, Christine, Tanne, Antoine, Akpeng, Belinda, Croker, Ben A., Buell, Jennifer S., Stein, Robert, Savitsky, David A., Wilson, Nicholas S.

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Abstract 1677: Characterization of the pharmacodynamic activity of AGEN1181, an Fc-enhanced CTLA-4 antibody, alone and in combination with the PD-1 antibody balstilimab von Shapiro, Irina, Lim, Min, Pabla, Simarjot, O'Day, Steven J., El-Khoueiry, Anthony, Ramamurthy, Chethan, Bullock, Andrea J., Gordon, Michael S., Buell, Jennifer, Chand, Dhan, Wijatyk, Anna

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A phase 1 study of AGEN2373, a novel CD137 agonist antibody designed to avoid hepatoxicity, in patients with advanced solid tumors von Barve, Minal A., Tolcher, Anthony W., Carvajal, Richard D., Izar, Benjamin, El-Khoueiry, Anthony B., Hanna, Diana L., Tarhini, Ahmad A., Whitman, Eric D., Bhatia, Shailender, Davar, Diwakar, Lutzky, Jose, Taylor, Matthew H., Tello, Monique, Rosenthal, Katherine, Danielyan, Anna, Yip, Wai Ki, Song, James, Savitsky, David, Chand, Dhan, Grossman, Joseph Elan

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Botensilimab plus balstilimab in relapsed/refractory microsatellite stable metastatic colorectal cancer: a phase 1 trial von Bullock, Andrea J., Schlechter, Benjamin L., Fakih, Marwan G., Tsimberidou, Apostolia M., Grossman, Joseph E., Gordon, Michael S., Wilky, Breelyn A., Pimentel, Agustin, Mahadevan, Daruka, Balmanoukian, Ani S., Sanborn, Rachel E., Schwartz, Gary K., Abou-Alfa, Ghassan K., Segal, Neil H., Bockorny, Bruno, Moser, Justin C., Sharma, Sunil, Patel, Jaymin M., Wu, Wei, Chand, Dhan, Rosenthal, Katherine, Mednick, Gabriel, Delepine, Chloe, Curiel, Tyler J., Stebbing, Justin, Lenz, Heinz-Josef, O’Day, Steven J., El-Khoueiry, Anthony B.

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Abstract 1878: Fc-enhanced anti-CTLA-4 antibody, AGEN1181: new mechanistic insights for potent antitumor immunity and combination potential in treatment-resistant solid tumors von Tanne, Antoine J., Galand, Claire, Abou-Slaybi, Abdo, Wilkens, Margaret, Marques, Marilyn, Ng, Serina, Han, Haiyong, Dietrich, Sylvia, Waight, Jeremy, Joshi, Bishnu, Yigit, Burcu, Michelet, Xavier, Levey, Daniel, Savitsky, David, Buell, Jennifer, Chand, Dhan

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EXTH-24. FC-ENHANCED ANTI-CTLA-4 IMMUNE CHECKPOINT BLOCKADE AND ITS COMBINATION WITH ANTI-PD-1 WITH CONCOMITANT DOXORUBICIN AND ULTRASOUND-MEDIATED BBB OPENING: A NOVEL IMMUNOTHERA... von Kim, Kwang-Soo, Habashy, Karl, Gould, Andrew, Najem, Hinda, Zhao, Junfei, Amidei, Christina, Saganty, Ruth, Arrieta, Victor, Dmello, Crismita, Chen, Li, Zhang, Daniel, Castro, Brandyn, Billingham, Leah, Levey, Daniel, Morin, Benjamin, Muzzio, Miguel, Canney, Michael, McCortney, Katy, Horbinski, Craig, Zhang, Peng, Miska, Jason, Rabadan, Raul, Heimberger, Amy, Stupp, Roger, Chand, Dhan, Lee-Chang, Catalina, Sonabend, Adam

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Preclinical functional characterization of AGEN1181, a clinical stage Fc-engineered anti-CTLA-4 antibody for the treatment of patients with early and advanced malignancies von Waight, Jeremy, Manrique, Mariana, Gombos, Randi, Costa, Matthew, Iyer, Priyadarshini, Vincent, Sylvia, Ward, Rebecca, Paltrinieri, Elena, Chand, Dhan, Wilson, Nicholas, Buell, Jennifer, Savitsky, David

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Abstract 922: Expanding the therapeutic potential of anti-PD-1 and anti-CTLA-4 therapy with innovative Fc engineering and rationale combinations for the treatment of solid tumors von Tanne, Antoine J., Vincent, Sylvia, Duckless, Benjamin, Paltrinieri, Elena, Pabla, Simarjot, Basinski, Andrew, Pawaria, Sudesh, Patel, Vidur, Wilkens, Margaret, Joshi, Bishnu, Hancock, Matthew, Levey, Daniel, Horn, Thomas, Joyce, Cailin, Savitsky, David, Gorman, Cori, Buell, Jennifer, Chand, Dhan

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AGEN1181, a clinical stage Fc-engineered anti-CTLA-4 antibody with improved therapeutic potential for the treatment of patients with advanced malignancies von O'Day, Steven, Ramamurthy, Chethan, Bullock, Andrea J., El-Khoueiry, Anthony B., Ohanjanian, Lernik, Wijatyk, Anna, Ortuzar Feliu, Waldo Ignacio, Shapiro, Irina, Ancukiewicz, Marek, Chand, Dhan, Buell, Jennifer, Gordon, Michael S.

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Transcriptomic Maps of Colorectal Liver Metastasis: Machine Learning of Gene Activation Patterns and Epigenetic Trajectories in Support of Precision Medicine von Ashekyan, Ohanes, Shahbazyan, Nerses, Bareghamyan, Yeva, Kudryavzeva, Anna, Mandel, Daria, Schmidt, Maria, Loeffler-Wirth, Henry, Uduman, Mohamed, Chand, Dhan, Underwood, Dennis, Armen, Garo, Arakelyan, Arsen, Nersisyan, Lilit, Binder, Hans

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