Unlocking the therapeutic potential of targeting MALT1 in B-cell acute lymphoblastic leukemia von Samiksha, Samiksha, Chan, Lai N

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Metabolic gatekeeper function of B-lymphoid transcription factors von Chan, Lai N., Chen, Zhengshan, Braas, Daniel, Lee, Jae-Woong, Xiao, Gang, Geng, Huimin, Cosgun, Kadriye Nehir, Hurtz, Christian, Shojaee, Seyedmehdi, Cazzaniga, Valeria, Schjerven, Hilde, Ernst, Thomas, Hochhaus, Andreas, Kornblau, Steven M., Konopleva, Marina, Pufall, Miles A., Cazzaniga, Giovanni, Liu, Grace J., Milne, Thomas A., Koeffler, H. Phillip, Ross, Theodora S., Sánchez-García, Isidro, Borkhardt, Arndt, Yamamoto, Keith R., Dickins, Ross A., Graeber, Thomas G., Müschen, Markus

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Erk Negative Feedback Control Enables Pre-B Cell Transformation and Represents a Therapeutic Target in Acute Lymphoblastic Leukemia von Shojaee, Seyedmehdi, Caeser, Rebecca, Buchner, Maike, Park, Eugene, Swaminathan, Srividya, Hurtz, Christian, Geng, Huimin, Chan, Lai N., Klemm, Lars, Hofmann, Wolf-Karsten, Qiu, Yi Hua, Zhang, Nianxiang, Coombes, Kevin R., Paietta, Elisabeth, Molkentin, Jeffery, Koeffler, H. Phillip, Willman, Cheryl L., Hunger, Stephen P., Melnick, Ari, Kornblau, Steven M., Müschen, Markus

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Deciphering intratumoral heterogeneity using integrated clonal tracking and single-cell transcriptome analyses von Contreras-Trujillo, Humberto, Eerdeng, Jiya, Akre, Samir, Jiang, Du, Contreras, Jorge, Gala, Basia, Vergel-Rodriguez, Mary C., Lee, Yeachan, Jorapur, Aparna, Andreasian, Areen, Harton, Lisa, Bramlett, Charles S., Nogalska, Anna, Xiao, Gang, Lee, Jae-Woong, Chan, Lai N., Müschen, Markus, Merchant, Akil A., Lu, Rong

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Mechanistic rationale for targeting the unfolded protein response in pre-B acute lymphoblastic leukemia von Kharabi Masouleh, Behzad, Geng, Huimin, Hurtz, Christian, Chan, Lai N, Logan, Aaron C, Chang, Mi Sook, Huang, Chuanxin, Swaminathan, Srividya, Sun, Haibo, Paietta, Elisabeth, Melnick, Ari M, Koeffler, Phillip, Müschen, Markus

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SOX4 enables oncogenic survival signals in acute lymphoblastic leukemia von Ramezani-Rad, Parham, Geng, Huimin, Hurtz, Christian, Chan, Lai N., Chen, Zhengshan, Jumaa, Hassan, Melnick, Ari, Paietta, Elisabeth, Carroll, William L., Willman, Cheryl L., Lefebvre, Véronique, Müschen, Markus

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Epigenetic Control of Translation Checkpoint and Tumor Progression via RUVBL1‐EEF1A1 Axis von Li, Mingli, Yang, Lu, Chan, Anthony K. N., Pokharel, Sheela Pangeni, Liu, Qiao, Mattson, Nicole, Xu, Xiaobao, Chang, Wen‐Han, Miyashita, Kazuya, Singh, Priyanka, Zhang, Leisi, Li, Maggie, Wu, Jun, Wang, Jinhui, Chen, Bryan, Chan, Lai N., Lee, Jaewoong, Zhang, Xu Hannah, Rosen, Steven T., Müschen, Markus, Qi, Jun, Chen, Jianjun, Hiom, Kevin, Bishop, Alexander J. R., Chen, Chun‐Wei

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R-2-hydroxyglutarate attenuates aerobic glycolysis in leukemia by targeting the FTO/m6A/PFKP/LDHB axis von Qing, Ying, Dong, Lei, Gao, Lei, Li, Chenying, Li, Yangchan, Han, Li, Prince, Emily, Tan, Brandon, Deng, Xiaolan, Wetzel, Collin, Shen, Chao, Gao, Min, Chen, Zhenhua, Li, Wei, Zhang, Bin, Braas, Daniel, ten Hoeve, Johanna, Sanchez, Gerardo Javier, Chen, Huiying, Chan, Lai N., Chen, Chun-Wei, Ann, David, Jiang, Lei, Müschen, Markus, Marcucci, Guido, Plas, David R., Li, Zejuan, Su, Rui, Chen, Jianjun

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SYK and ZAP70 kinases in autoimmunity and lymphoid malignancies von Leveille, Etienne, Chan, Lai N., Mirza, Abu-Sayeef, Kume, Kohei, Müschen, Markus

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Loss of Pax5 Exploits Sca1-BCR-ABLp190 Susceptibility to Confer the Metabolic Shift Essential for pB-ALL von Martín-Lorenzo, Alberto, Auer, Franziska, Chan, Lai N., García-Ramírez, Idoia, González-Herrero, Inés, Rodríguez-Hernández, Guillermo, Bartenhagen, Christoph, Dugas, Martin, Gombert, Michael, Ginzel, Sebastian, Blanco, Oscar, Orfao, Alberto, Alonso-López, Diego, Rivas, Javier De Las, García-Cenador, Maria B., García-Criado, Francisco J., Müschen, Markus, Sánchez-García, Isidro, Borkhardt, Arndt, Vicente-Dueñas, Carolina, Hauer, Julia

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novel approach to tag and identify geranylgeranylated proteins von Chan, Lai N, Hart, Courtenay, Guo, Lea, Nyberg, Tamara, Davies, Brandon S.J, Fong, Loren G, Young, Stephen G, Agnew, Brian J, Tamanoi, Fuyuhiko

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Metabolic Gatekeepers of Pathological B Cell Activation von Sadras, Teresa, Chan, Lai N, Xiao, Gang, Müschen, Markus

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B-Cell-Specific Diversion of Glucose Carbon Utilization Reveals a Unique Vulnerability in B Cell Malignancies von Xiao, Gang, Chan, Lai N., Klemm, Lars, Braas, Daniel, Chen, Zhengshan, Geng, Huimin, Zhang, Qiuyi Chen, Aghajanirefah, Ali, Cosgun, Kadriye Nehir, Sadras, Teresa, Lee, Jaewoong, Mirzapoiazova, Tamara, Salgia, Ravi, Ernst, Thomas, Hochhaus, Andreas, Jumaa, Hassan, Jiang, Xiaoyan, Weinstock, David M., Graeber, Thomas G., Müschen, Markus

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Identification and characterization of mechanism of action of P61-E7, a novel phosphine catalysis-based inhibitor of geranylgeranyltransferase-I von Chan, Lai N, Fiji, Hannah D G, Watanabe, Masaru, Kwon, Ohyun, Tamanoi, Fuyuhiko

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Metabolic determinants of B-cell selection von Chan, Lai N., Aghania, Eamon, Leveille, Etienne, Muschen, Markus

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IFITM3 functions as a PIP3 scaffold to amplify PI3K signalling in B cells von Lee, Jaewoong, Robinson, Mark E., Ma, Ning, Artadji, Dewan, Ahmed, Mohamed A., Xiao, Gang, Sadras, Teresa, Deb, Gauri, Winchester, Janet, Cosgun, Kadriye Nehir, Geng, Huimin, Chan, Lai N., Kume, Kohei, Miettinen, Teemu P., Zhang, Ye, Nix, Matthew A., Klemm, Lars, Chen, Chun Wei, Chen, Jianjun, Khairnar, Vishal, Wiita, Arun P., Thomas-Tikhonenko, Andrei, Farzan, Michael, Jung, Jae U., Weinstock, David M., Manalis, Scott R., Diamond, Michael S., Vaidehi, Nagarajan, Müschen, Markus

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PTEN opposes negative selection and enables oncogenic transformation of pre-B cells von Shojaee, Seyedmehdi, Chan, Lai N, Buchner, Maike, Cazzaniga, Valeria, Cosgun, Kadriye Nehir, Geng, Huimin, Qiu, Yi Hua, von Minden, Marcus Dühren, Ernst, Thomas, Hochhaus, Andreas, Cazzaniga, Giovanni, Melnick, Ari, Kornblau, Steven M, Graeber, Thomas G, Wu, Hong, Jumaa, Hassan, Müschen, Markus

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Signalling input from divergent pathways subverts B cell transformation von Chan, Lai N., Murakami, Mark A., Robinson, Mark E., Caeser, Rebecca, Sadras, Teresa, Lee, Jaewoong, Cosgun, Kadriye Nehir, Kume, Kohei, Khairnar, Vishal, Xiao, Gang, Ahmed, Mohamed A., Aghania, Eamon, Deb, Gauri, Hurtz, Christian, Shojaee, Seyedmehdi, Hong, Chao, Pölönen, Petri, Nix, Matthew A., Chen, Zhengshan, Chen, Chun Wei, Chen, Jianjun, Vogt, Andreas, Heinäniemi, Merja, Lohi, Olli, Wiita, Arun P., Izraeli, Shai, Geng, Huimin, Weinstock, David M., Müschen, Markus

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PON2 subverts metabolic gatekeeper functions in B cells to promote leukemogenesis von Pan, Lili, Hong, Chao, Chan, Lai N., Xiao, Gang, Malvi, Parmanand, Robinson, Mark E., Geng, Huimin, Reddy, Srinivasa T., Lee, Jaewoong, Khairnar, Vishal, Cosgun, Kadriye Nehir, Xu, Liang, Kume, Kohei, Sadras, Teresa, Wang, Shaoyuan, Wajapeyee, Narendra, Müschen, Markus

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Rationale for targeting BCL6 in MLL -rearranged acute lymphoblastic leukemia von Hurtz, Christian, Chan, Lai N, Geng, Huimin, Ballabio, Erica, Xiao, Gang, Deb, Gauri, Khoury, Haytham, Chen, Chun-Wei, Armstrong, Scott A, Chen, Jianjun, Ernst, Patricia, Melnick, Ari, Milne, Thomas, Müschen, Markus

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