Heterogeneity and clinical significance of ESR1 mutations in ER-positive metastatic breast cancer patients receiving fulvestrant von Spoerke, Jill M., Gendreau, Steven, Walter, Kimberly, Qiu, Jiaheng, Wilson, Timothy R., Savage, Heidi, Aimi, Junko, Derynck, Mika K., Chen, Meng, Chan, Iris T., Amler, Lukas C., Hampton, Garret M., Johnston, Stephen, Krop, Ian, Schmid, Peter, Lackner, Mark R.

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Conditional expression of oncogenic K-ras from its endogenous promoter induces a myeloproliferative disease von Chan, Iris T., Kutok, Jeffery L., Williams, Ifor R., Cohen, Sarah, Kelly, Lauren, Shigematsu, Hirokazu, Johnson, Leisa, Akashi, Koichi, Tuveson, David A., Jacks, Tyler, Gilliland, D. Gary

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Is Alcohol Use Disorder Identification Test (AUDIT) or its shorter versions more useful to identify risky drinkers in a Chinese population? A diagnostic study von Yip, Benjamin H K, Chung, Roger Y, Chung, Vincent C H, Kim, Jean, Chan, Iris W T, Wong, Martin C S, Wong, Samuel Y S, Griffiths, Sian M

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Conditional expression of oncogenic K-ras from its endogenous promoter induces a myeloproliferative disease von Chan, Iris T, Kutok, Jeffery L, Williams, Ifor R, Cohen, Sarah, Kelly, Lauren, Shigematsu, Hirokazu, Johnson, Leisa, Akashi, Koichi, Tuveson, David A, Jacks, Tyler, Gilliland, D Gary

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GDC-0810 Pharmacokinetics and Transporter-Mediated Drug Interaction Evaluation with an Endogenous Biomarker in the First-in-Human, Dose Escalation Study von Cheung, Kit Wun Kathy, Yoshida, Kenta, Cheeti, Sravanthi, Chen, Buyun, Morley, Roland, Chan, Iris T., Sahasranaman, Srikumar, Liu, Lichuan

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The impact of cutting alcohol duties on drinking patterns in Hong Kong von CHUNG, Vincent C. H, YIP, Benjamin H. K, GRIFFITHS, Sian M, YU, Ellen L. M, KIM, Jean H, TAM, Wilson W. S, WONG, Alvin H. C, CHAN, Iris W. T, LAU, Joseph T. F

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Phase Ib study of the MEK inhibitor cobimetinib (GDC-0973) in combination with the PI3K inhibitor pictilisib (GDC-0941) in patients with advanced solid tumors von Shapiro, Geoffrey I., LoRusso, Patricia, Kwak, Eunice, Pandya, Susan, Rudin, Charles M., Kurkjian, Carla, Cleary, James M., Pilat, Mary Jo, Jones, Suzanne, de Crespigny, Alex, Fredrickson, Jill, Musib, Luna, Yan, Yibing, Wongchenko, Matthew, Hsieh, Hsin-Ju, Gates, Mary R., Chan, Iris T., Bendell, Johanna

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Specific oxylipins enhance vertebrate hematopoiesis via the receptor GPR132 von Lahvic, Jamie L., Ammerman, Michelle, Li, Pulin, Blair, Megan C., Stillman, Emma R., Fast, Eva M., Robertson, Anne L., Christodoulou, Constantina, Perlin, Julie R., Yang, Song, Chiang, Nan, Norris, Paul C., Daily, Madeleine L., Redfield, Shelby E., Chan, Iris T., Chatrizeh, Mona, Chase, Michael E., Weis, Olivia, Zhou, Yi, Serhan, Charles N., Zon, Leonard I.

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Discovery of a Potent Small-Molecule Antagonist of Inhibitor of Apoptosis (IAP) Proteins and Clinical Candidate for the Treatment of Cancer (GDC-0152) von Flygare, John A, Beresini, Maureen, Budha, Nageshwar, Chan, Helen, Chan, Iris T, Cheeti, Sravanthi, Cohen, Frederick, Deshayes, Kurt, Doerner, Karl, Eckhardt, S. Gail, Elliott, Linda O, Feng, Bainian, Franklin, Matthew C, Reisner, Stacy Frankovitz, Gazzard, Lewis, Halladay, Jason, Hymowitz, Sarah G, La, Hank, LoRusso, Patricia, Maurer, Brigitte, Murray, Lesley, Plise, Emile, Quan, Clifford, Stephan, Jean-Philippe, Young, Shin G, Tom, Jeffrey, Tsui, Vickie, Um, Joanne, Varfolomeev, Eugene, Vucic, Domagoj, Wagner, Andrew J, Wallweber, Heidi J. A, Wang, Lan, Ware, Joseph, Wen, Zhaoyang, Wong, Harvey, Wong, Jonathan M, Wong, Melisa, Wong, Susan, Yu, Ron, Zobel, Kerry, Fairbrother, Wayne J

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A first-in-human phase I study to evaluate the MEK1/2 inhibitor, cobimetinib, administered daily in patients with advanced solid tumors von Rosen, Lee S., LoRusso, Patricia, Ma, Wen Wee, Goldman, Jonathan W., Weise, Amy, Colevas, A. Dimitrios, Adjei, Alex, Yazji, Salim, Shen, Angela, Johnston, Stuart, Hsieh, Hsin-Ju, Chan, Iris T., Sikic, Branimir I.

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A phase Ib open-label dose escalation study of the safety, pharmacokinetics, and pharmacodynamics of cobimetinib (GDC-0973) and ipatasertib (GDC-0068) in patients with locally adva... von Shapiro, Geoffrey I., LoRusso, Patricia, Cho, Daniel C., Musib, Luna, Yan, Yibing, Wongchenko, Matthew, Chang, Ilsung, Patel, Premal, Chan, Iris T., Sanabria-Bohorquez, Sandra, Meng, Raymond D., Bendell, Johanna C.

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Absolute Bioavailability and Effect of Formulation Change, Food, or Elevated pH with Rabeprazole on Cobimetinib Absorption in Healthy Subjects von Musib, Luna, Choo, Edna, Deng, Yuzhong, Eppler, Steve, Rooney, Isabelle, Chan, Iris T, Dresser, Mark J

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Dogs are more sensitive to antagonists of inhibitor of apoptosis proteins than rats and humans: a translational toxicokinetic/toxicodynamic analysis von Wong, Harvey, Budha, Nageshwar R, West, Kristina, Blackwood, Elizabeth, Ware, Joseph A, Yu, Ron, Darbonne, Walter C, Gould, Stephen E, Steigerwalt, Ronald, Erickson, Rebecca, Hop, Cornelis E A C, LoRusso, Patricia, Eckhardt, S Gail, Wagner, Andrew, Chan, Iris T, Mamounas, Michael, Flygare, John A, Fairbrother, Wayne J

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Oncogenic K-ras cooperates with PML-RARα to induce an acute promyelocytic leukemia-like disease von Chan, Iris T., Kutok, Jeffery L., Williams, Ifor R., Cohen, Sarah, Moore, Sandra, Shigematsu, Hirokazu, Ley, Timothy J., Akashi, Koichi, Le Beau, Michelle M., Gilliland, D. Gary

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Oncogenic K-ras in mouse models of myeloproliferative disease and acute myeloid leukemia von Chan, Iris T, Gilliland, D Gary

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Oncogenic K-ras in Mouse Models of Myeloproliferative Disease and Acute Myeloid Leukemia von Chan, Iris T., Gilliland, D. Gary

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P227 - Pharmacokinetics of GDC-0810 and its interaction with coproporphyrin i in the first-in-human, ascending dose study in women with locally advanced or metastatic estrogen rece... von Kathy Cheung, Kit Wun, Yoshida, Kenta, Cheeti, Sravanthi, Chen, Buyun, Morley, Roland, Chan, Iris T., Sahasranaman, Srikumar, Liu, Lichuan

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COMBINATION THERAPIES FOR MELANOMA COMPRISING ADMINISTERING COBIMETINIB AND VEMURAFINIB von CHAN IRIS T, BRAY GORDON

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COMBINATION THERAPIES FOR MELANOMA COMPRISING ADMINISTERING COBIMETINIB AND VEMURAFINIB von CHAN IRIS T, BRAY GORDON

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A uniform format for manuscript submission von Zon, Leonard I., Boisvert, Jason D., Moreau, Hadley, Chan, Iris, Weiss, Jodi, Barbano, Julia, Smith, Mackenzie, Weber, Margaret, Prasad, Meera, Stanhope, Meredith, Freeman, Rebecca, Modhurima, Rodsy, Freyer, Shannon, McConnell, Alicia, Choudhuri, Avik, Bornhorst, Dorothee, Hagedorn, Elliott, Ablain, Julien, Rossmann, Marlies, Fazio, Maurizio, Fairchild, Michael, Sporrij, Audrey, Avagyan, Serine

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