5-Substituted Pyrimidines with a 1,5-Anhydro-2,3-dideoxy-d-arabino-hexitol Moiety at N-1:  Synthesis, Antiviral Activity, Conformational Analysis, and Interaction with Viral Thymid... von Ostrowski, Tomasz, Wroblowski, Berthold, Busson, Roger, Rozenski, Jozef, De Clercq, Erik, Bennett, Matthew S, Champness, John N, Summers, William C, Sanderson, Mark R, Herdewijn, Piet

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Crystal structure of the anti-bacterial sulfonamide drug target dihydropteroate synthase von Achari, Aniruddha, Somers, Donald 0, Champness, John N, Bryant, Patrick .K, Rosemond, Jane, Stammers, David K

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2.0 Å X-ray structure of the ternary complex of 7,8-dihydro-6-hydroxymethylpterinpyrophosphokinase from Escherichia coli with ATP and a substrate analogue von Stammers, David K, Achari, Aniruddha, Somers, Donald O’N, Bryant, Patrick K, Rosemond, Jane, Scott, David L, Champness, John N

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Pyrrolo[2,3- d]pyrimidines and pyrido[2,3- d]pyrimidines as conformationally restricted analogues of the antibacterial agent trimethoprim von Kuyper, Lee F, Garvey, Janice M, Baccanari, David P, Champness, John N, Stammers, David K, Beddell, Christopher R

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Exploring the active site of herpes simplex virus type-1 thymidine kinase by X-ray crystallography of complexes with aciclovir and other ligands von Champness, John N., Bennett, Matthew S., Wien, Frank, Visse, Rob, Summers, William C., Herdewijn, Piet, de Clercq, Erik, Ostrowski, Tomasz, Jarvest, Richard L., Sanderson, Mark R.

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Isosteres of the DNA polymerase inhibitor aphidicolin as potential antiviral agents against human herpes viruses von Selwood, David L, Challand, S. Richard, Champness, John N, Gillam, Janet, Hibberd, Deborah K, Jandu, K. Singh, Lowe, Denise, Pether, Michael, Selway, John, Trantor, George E

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Receptor-based design of dihydrofolate reductase inhibitors: comparison of crystallographically determined enzyme binding with enzyme affinity in a series of carboxy-substituted tr... von Kuyper, Lee F, Roth, Barbara, Baccanari, David P, Ferone, Robert, Beddell, Christopher R, Champness, John N, Stammers, David K, Dann, John G, Norrington, Frank E. A

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2,4-Diamino-5-benzylpyrimidines as antibacterial agents. 7. Analysis of the effect of 3,5-dialkyl substituent size and shape on binding to four different dihydrofolate reductase en... von Roth, Barbara, Rauckman, Barbara S, Ferone, Robert, Baccanari, David P, Champness, John N, Hyde, Richard M

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Receptor-based design of dihydrofolate reductase inhibitors: comparison of crystallographically determined enzyme binding with enzyme affinity in a series of carboxy-substituted tr... von Kuyper, Lee F, Roth, Barbara, Baccanari, David P, Ferone, Robert, Beddell, Christopher R, Champness, John N, Stammers, David K, Dann, John G, Norrington, Frank E. A

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Structure to 1.9 Å resolution of a complex with herpes simplex virus type-1 thymidine kinase of a novel, non-substrate inhibitor: X-ray crystallographic comparison with binding of... von Bennett, Matthew S, Wien, Frank, Champness, John N, Batuwangala, Thilina, Rutherford, Thomas, Summers, William C, Sun, Hongmao, Wright, George, Sanderson, Mark R

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Crystal structure of Escherichia coli UvrB C-terminal domain, and a model for UvrB-UvrC interaction von Sohi, Maninder, Alexandrovich, Alexander, Moolenaar, Geri, Visse, Rob, Goosen, Nora, Vernede, Xavier, Fontecilla-Camps, Juan C., Champness, John, Sanderson, Mark R.

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A Silver(I) Difluorophosphate(V)-tetramethylhexathiaadamantane Coordination Polymer with a 3-D Rutile (TiO2) Framework Construction von Brooks, Neil R, Blake, Alexander J, Champness, Neil R, Cunningham, John W, Hubberstey, Peter, Schröder, Martin

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Anion influence on co-ordination polymers of Ag(I) with 1,4-dithiacyclohexane von Brooks, Neil R., Blake, Alexander J., Champness, Neil R., Cunningham, John W., Hubberstey, Peter, Teat, Simon J., Wilson, Claire, Schröder, Martin

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Bridging mode flexibility of 1,3-dithiacyclohexane in silver(i) co-ordination polymers von Brammer, Lee, Rodger, Colin S., Blake, Alexander J., Brooks, Neil R., Champness, Neil R., Cunningham, John W., Hubberstey, Peter, Teat, Simon J., Wilson, Claire, Schröder, Martin

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Recent developments von Hawke, Neil, Dobson, Paul, Hawke, Neil, Tillotson, John, Champness, Christopher, Khan, A. N., Seabrooke, Stephen

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