Positive Feedback Between PU.1 and the Cell Cycle Controls Myeloid Differentiation von Kueh, Hao Yuan, Champhekhar, Ameya, Nutt, Stephen L., Elowitz, Michael B., Rothenberg, Ellen V.

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Overcoming Genetically Based Resistance Mechanisms to PD-1 Blockade von Torrejon, Davis Y, Abril-Rodriguez, Gabriel, Champhekar, Ameya S, Tsoi, Jennifer, Campbell, Katie M, Kalbasi, Anusha, Parisi, Giulia, Zaretsky, Jesse M, Garcia-Diaz, Angel, Puig-Saus, Cristina, Cheung-Lau, Gardenia, Wohlwender, Thomas, Krystofinski, Paige, Vega-Crespo, Agustin, Lee, Christopher M, Mascaro, Pau, Grasso, Catherine S, Berent-Maoz, Beata, Comin-Anduix, Begoña, Hu-Lieskovan, Siwen, Ribas, Antoni

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Melanoma dedifferentiation induced by IFN-γ epigenetic remodeling in response to anti-PD-1 therapy von Kim, Yeon Joo, Sheu, Katherine M, Tsoi, Jennifer, Abril-Rodriguez, Gabriel, Medina, Egmidio, Grasso, Catherine S, Torrejon, Davis Y, Champhekar, Ameya S, Litchfield, Kevin, Swanton, Charles, Speiser, Daniel E, Scumpia, Philip O, Hoffmann, Alexander, Graeber, Thomas G, Puig-Saus, Cristina, Ribas, Antoni

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Opposing tumor-cell-intrinsic and -extrinsic roles of the IRF1 transcription factor in antitumor immunity von Purbey, Prabhat K., Seo, Joowon, Paul, Manash K., Iwamoto, Keisuke S., Daly, Allison E., Feng, An-Chieh, Champhekar, Ameya S., Langerman, Justin, Campbell, Katie M., Schaue, Dörthe, McBride, William H., Dubinett, Steven M., Ribas, Antoni, Smale, Stephen T., Scumpia, Philip O.

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ERK mediates interferon gamma-induced melanoma cell death von Champhekar, Ameya, Heymans, Rachel, Saco, Justin, Turon Font, Guillem, Gonzalez, Cynthia, Gao, Anne, Pham, John, Lee, June, Maryoung, Ryan, Medina, Egmidio, Campbell, Katie M, Karin, Daniel, Austin, David, Damioseaux, Robert, Ribas, Antoni

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Targeting the Cbl-b-Notch1 axis as a novel immunotherapeutic strategy to boost CD8+ T-cell responses von Monticone, Giulia, Huang, Zhi, Csibi, Fred, Leit, Silvana, Ciccone, David, Champhekar, Ameya S, Austin, Jermaine E, Ucar, Deniz A, Hossain, Fokhrul, Ibba, Salome V, Boulares, A Hamid, Carpino, Nicholas, Xu, Keli, Majumder, Samarpan, Osborne, Barbara A, Loh, Christine, Miele, Lucio

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Correction: ERK mediates interferon gamma-induced melanoma cell death von Champhekar, Ameya, Heymans, Rachel, Saco, Justin, Font, Guillem Turon, Gonzalez, Cynthia, Gao, Anne, Pham, John, Lee, June, Maryoung, Ryan, Medina, Egmidio, Campbell, Katie M, Karin, Daniel, Austin, David, Damioseaux, Robert, Ribas, Antoni

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Type I and Type II Interferon Coordinately Regulate Suppressive Dendritic Cell Fate and Function during Viral Persistence von Cunningham, Cameron R, Champhekar, Ameya, Tullius, Michael V, Dillon, Barbara Jane, Zhen, Anjie, de la Fuente, Justin Rafael, Herskovitz, Jonathan, Elsaesser, Heidi, Snell, Laura M, Wilson, Elizabeth B, de la Torre, Juan Carlos, Kitchen, Scott G, Horwitz, Marcus A, Bensinger, Steven J, Smale, Stephen T, Brooks, David G

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Differential Control of Peripheral Circadian Rhythms by Suprachiasmatic-Dependent Neural Signals von Guo, Hongnian, Brewer, Judy McKinley, Champhekar, Ameya, Ruth B. S. Harris, Bittman, Eric L., Rosbash, Michael

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IND-Enabling Studies for a Clinical Trial to Genetically Program a Persistent Cancer-Targeted Immune System von Puig-Saus, Cristina, Parisi, Giulia, Garcia-Diaz, Angel, Krystofinski, Paige E, Sandoval, Salemiz, Zhang, Ruixue, Champhekar, Ameya S, McCabe, James, Cheung-Lau, Gardenia C, Truong, Nhat A, Vega-Crespo, Agustin, Komenan, Marie Desiles S, Pang, Jia, Macabali, Mignonette H, Saco, Justin D, Goodwin, Jeffrey L, Bolon, Brad, Seet, Christopher S, Montel-Hagen, Amelie, Crooks, Gay M, Hollis, Roger P, Campo-Fernandez, Beatriz, Bischof, Daniela, Cornetta, Kenneth, Gschweng, Eric H, Adelson, Celia, Nguyen, Alexander, Yang, Lili, Witte, Owen N, Baltimore, David, Comin-Anduix, Begonya, Kohn, Donald B, Wang, Xiaoyan, Cabrera, Paula, Kaplan-Lefko, Paula J, Berent-Maoz, Beata, Ribas, Antoni

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Remodeling of the tumor microenvironment through PAK4 inhibition sensitizes tumors to immune checkpoint blockade von Abril-Rodríguez, Gabriel, Torrejon, Davis Y, Karin, Daniel, Campbell, Katie M, Medina, Egmidio, Saco, Justin D, Galvez, Mildred, Champhekar, Ameya S, Perez-Garcilazo, Ivan, Baselga-Carretero, Ignacio, Singh, Jas, Comin-Anduix, Begoña, Puig-Saus, Cristina, Ribas, Antoni

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Conserved Interferon-γ Signaling Drives Clinical Response to Immune Checkpoint Blockade Therapy in Melanoma von Grasso, Catherine S., Tsoi, Jennifer, Onyshchenko, Mykola, Abril-Rodriguez, Gabriel, Ross-Macdonald, Petra, Wind-Rotolo, Megan, Champhekar, Ameya, Medina, Egmidio, Torrejon, Davis Y., Shin, Daniel Sanghoon, Tran, Phuong, Kim, Yeon Joo, Puig-Saus, Cristina, Campbell, Katie, Vega-Crespo, Agustin, Quist, Michael, Martignier, Christophe, Luke, Jason J., Wolchok, Jedd D., Johnson, Douglas B., Chmielowski, Bartosz, Hodi, F. Stephen, Bhatia, Shailender, Sharfman, William, Urba, Walter J., Slingluff, Craig L., Diab, Adi, Haanen, John B.A.G., Algarra, Salvador Martin, Pardoll, Drew M., Anagnostou, Valsamo, Topalian, Suzanne L., Velculescu, Victor E., Speiser, Daniel E., Kalbasi, Anusha, Ribas, Antoni

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Forging T-Lymphocyte Identity: Intersecting Networks of Transcriptional Control von Rothenberg, Ellen V., Ungerbäck, Jonas, Champhekar, Ameya

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Regulation of early T-lineage gene expression and developmental progression by the progenitor cell transcription factor PU.1 von Champhekar, Ameya, Damle, Sagar S, Freedman, George, Carotta, Sebastian, Nutt, Stephen L, Rothenberg, Ellen V

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IRIS: Discovery of cancer immunotherapy targets arising from pre-mRNA alternative splicing von Pan, Yang, Phillips, John W, Zhang, Beatrice D, Noguchi, Miyako, Kutschera, Eric, McLaughlin, Jami, Nesterenko, Pavlo A, Mao, Zhiyuan, Bangayan, Nathanael J, Wang, Robert, Tran, Wendy, Yang, Harry T, Wang, Yuanyuan, Xu, Yang, Obusan, Matthew B, Cheng, Donghui, Lee, Alex H, Kadash-Edmondson, Kathryn E, Champhekar, Ameya, Puig-Saus, Cristina, Ribas, Antoni, Prins, Robert M, Seet, Christopher S, Crooks, Gay M, Witte, Owen N, Xing, Yi

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Conserved Interferon-γ Signaling Drives Clinical Response to Immune Checkpoint Blockade Therapy in Melanoma von Grasso, Catherine S., Tsoi, Jennifer, Onyshchenko, Mykola, Abril-Rodriguez, Gabriel, Ross-Macdonald, Petra, Wind-Rotolo, Megan, Champhekar, Ameya, Medina, Egmidio, Torrejon, Davis Y., Shin, Daniel Sanghoon, Tran, Phuong, Kim, Yeon Joo, Puig-Saus, Cristina, Campbell, Katie, Vega-Crespo, Agustin, Quist, Michael, Martignier, Christophe, Luke, Jason J., Wolchok, Jedd D., Johnson, Douglas B., Chmielowski, Bartosz, Hodi, F. Stephen, Bhatia, Shailender, Sharfman, William, Urba, Walter J., Slingluff, Craig L., Diab, Adi, Haanen, John B.A.G., Algarra, Salvador Martin, Pardoll, Drew M., Anagnostou, Valsamo, Topalian, Suzanne L., Velculescu, Victor E., Speiser, Daniel E., Kalbasi, Anusha, Ribas, Antoni

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GATA-3 dose-dependent checkpoints in early T cell commitment von Scripture-Adams, Deirdre D, Damle, Sagar S, Li, Long, Elihu, Koorosh J, Qin, Shuyang, Arias, Alexandra M, Butler, 3rd, Robert R, Champhekar, Ameya, Zhang, Jingli A, Rothenberg, Ellen V

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Abstract 3166: The degree of conserved interferon gamma signaling guides response to immune checkpoint blockade therapy von Grasso, Catherine, Tsoi, Jennifer, Onyshchenko, Mykola, Abril-Rodriguez, Gabriel, Champhekar, Ameya, Medina, Egmidio, Torrejon, Davis, Shin, Daniel, Quist, Michael, Ross-Mcdonald, Petra, Wind-Rotolo, Megan, Speiser, Daniel, Kalbasi, Anusha, Ribas, Anthony

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Abstract 436: Whole body imaging of genetically labeled hematopoietic stem cells in human subjects von Nowicki, Theodore S., Berent-Maoz, Beata, Puig-Saus, Cristina, Kaplan-Lefko, Paula, Carretero, Ignacio Baselga, Champhekar, Ameya, Carlucci, Giuseppe, Macabali, Mignonette, Garcilazo, Ivan Perez, Vega-Crespo, Agustin, Rodriguez, Jonathan, Chmielowski, Bartosz, Singh, Arun, Allen-Auerbach, Martin, Zhu, Shaojun, Slavik, Roger, Comin-Anduix, Begonya, Williams, John, Ribas, Antoni

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Melanoma dedifferentiation induced by IFN-[gamma] epigenetic remodeling in response to anti-PD-1 therapy von Kim, Yeon Joo, Sheu, Katherine M, Tsoi, Jennifer, Abril-Rodriguez, Gabriel, Medina, Egmidio, Grasso, Catherine S, Torrejon, Davis Y, Champhekar, Ameya S, Litchfield, Kevin, Swanton, Charles, Speiser, Daniel E, Scumpia, Philip O, Hoffmann, Alexander, Graeber, Thomas G, Puig-Saus, Cristina, Ribas, Antoni

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