Multi-omic Characterization of the Mode of Action of a Potent New Antimalarial Compound, JPC-3210, Against Plasmodium falciparum von Birrell, Geoffrey W., Challis, Matthew P., De Paoli, Amanda, Anderson, Dovile, Devine, Shane M., Heffernan, Gavin D., Jacobus, David P., Edstein, Michael D., Siddiqui, Ghizal, Creek, Darren J.

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On-target, dual aminopeptidase inhibition provides cross-species antimalarial activity von Edgar, Rebecca C S, Malcolm, Tess R, Siddiqui, Ghizal, Giannangelo, Carlo, Counihan, Natalie A, Challis, Matthew, Duffy, Sandra, Chowdhury, Mrittika, Marfurt, Jutta, Dans, Madeline, Wirjanata, Grennady, Noviyanti, Rintis, Daware, Kajal, Suraweera, Chathura D, Price, Ric N, Wittlin, Sergio, Avery, Vicky M, Drinkwater, Nyssa, Charman, Susan A, Creek, Darren J, de Koning-Ward, Tania F, Scammells, Peter J, McGowan, Sheena

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Chemoproteomics validates selective targeting of Plasmodium M1 alanyl aminopeptidase as an antimalarial strategy von Giannangelo, Carlo, Challis, Matthew P, Siddiqui, Ghizal, Edgar, Rebecca, Malcolm, Tess R, Webb, Chaille T, Drinkwater, Nyssa, Vinh, Natalie, Macraild, Christopher, Counihan, Natalie, Duffy, Sandra, Wittlin, Sergio, Devine, Shane M, Avery, Vicky M, De Koning-Ward, Tania, Scammells, Peter, McGowan, Sheena, Creek, Darren J

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A gut bacterial amyloid promotes α-synuclein aggregation and motor impairment in mice von Sampson, Timothy R., Challis, Collin, Jain, Neha, Moiseyenko, Anastasiya, Ladinsky, Mark S., Shastri, Gauri G., Thron, Taren, Needham, Brittany D., Horvath, Istvan, Debelius, Justine W., Janssen, Stefan, Knight, Rob, Wittung-Stafshede, Pernilla, Gradinaru, Viviana, Chapman, Matthew, Mazmanian, Sarkis K.

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Discovery and Biosynthesis of Gladiolin: A Burkholderia gladioli Antibiotic with Promising Activity against Mycobacterium tuberculosis von Song, Lijiang, Jenner, Matthew, Masschelein, Joleen, Jones, Cerith, Bull, Matthew J, Harris, Simon R, Hartkoorn, Ruben C, Vocat, Anthony, Romero-Canelon, Isolda, Coupland, Paul, Webster, Gordon, Dunn, Matthew, Weiser, Rebecca, Paisey, Christopher, Cole, Stewart T, Parkhill, Julian, Mahenthiralingam, Eshwar, Challis, Gregory L

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Restrictive versus Liberal Fluid Therapy for Major Abdominal Surgery von Myles, Paul S, Bellomo, Rinaldo, Corcoran, Tomas, Forbes, Andrew, Peyton, Philip, Story, David, Christophi, Chris, Leslie, Kate, McGuinness, Shay, Parke, Rachael, Serpell, Jonathan, Chan, Matthew T.V, Painter, Thomas, McCluskey, Stuart, Minto, Gary, Wallace, Sophie

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Integrative Annotation of Variants from 1092 Humans: Application to Cancer Genomics von Khurana, Ekta, Fu, Yao, Colonna, Vincenza, Mu, Xinmeng Jasmine, Kang, Hyun Min, Lappalainen, Tuuli, Sboner, Andrea, Lochovsky, Lucas, Chen, Jieming, Harmanci, Arif, Das, Jishnu, Abyzov, Alexej, Balasubramanian, Suganthi, Beal, Kathryn, Chakravarty, Dimple, Challis, Daniel, Chen, Yuan, Clarke, Declan, Clarke, Laura, Cunningham, Fiona, Evani, Uday S., Flicek, Paul, Fragoza, Robert, Garrison, Erik, Gibbs, Richard, Gümüş, Zeynep H., Herrero, Javier, Kitabayashi, Naoki, Kong, Yong, Lage, Kasper, Liluashvili, Vaja, Lipkin, Steven M., MacArthur, Daniel G., Marth, Gabor, Muzny, Donna, Pers, Tune H., Ritchie, Graham R. S., Rosenfeld, Jeffrey A., Sisu, Cristina, Wei, Xiaomu, Wilson, Michael, Xue, Yali, Yu, Fuli, Dermitzakis, Emmanouil T., Yu, Haiyuan, Rubin, Mark A., Tyler-Smith, Chris, Gerstein, Mark

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The influence of soft tissue movement on ground reaction forces, joint torques and joint reaction forces in drop landings von Pain, Matthew T.G., Challis, John H.

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Protein-protein interactions in trans-AT polyketide synthases von Kosol, Simone, Jenner, Matthew, Lewandowski, Józef R, Challis, Gregory L

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Diene incorporation by a dehydratase domain variant in modular polyketide synthases von Hobson, Christian, Jenner, Matthew, Jian, Xinyun, Griffiths, Daniel, Roberts, Douglas M., Rey-Carrizo, Matias, Challis, Gregory L.

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iPTF15eqv: Multiwavelength Exposé of a Peculiar Calcium-rich Transient von Milisavljevic, Dan, Patnaude, Daniel J., Raymond, John C., Drout, Maria R., Margutti, Raffaella, Kamble, Atish, Chornock, Ryan, Guillochon, James, Sanders, Nathan E., Parrent, Jerod T., Lovisari, Lorenzo, Chilingarian, Igor V., Challis, Peter, Kirshner, Robert P., Penny, Matthew T., Itagaki, Koichi, Eldridge, J. J., Moriya, Takashi J.

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Molecular basis for control of antibiotic production by a bacterial hormone von Zhou, Shanshan, Bhukya, Hussain, Malet, Nicolas, Harrison, Peter J., Rea, Dean, Belousoff, Matthew J., Venugopal, Hariprasad, Sydor, Paulina K., Styles, Kathryn M., Song, Lijiang, Cryle, Max J., Alkhalaf, Lona M., Fülöp, Vilmos, Challis, Gregory L., Corre, Christophe

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Exposure to the Tire Rubber-Derived Contaminant 6PPD-Quinone Causes Mitochondrial Dysfunction In Vitro von Mahoney, Hannah, da Silva Junior, Francisco C., Roberts, Catherine, Schultz, Matthew, Ji, Xiaowen, Alcaraz, Alper James, Montgomery, David, Selinger, Summer, Challis, Jonathan K., Giesy, John P., Weber, Lynn, Janz, David, Wiseman, Steve, Hecker, Markus, Brinkmann, Markus

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Structural basis for chain release from the enacyloxin polyketide synthase von Kosol, Simone, Gallo, Angelo, Griffiths, Daniel, Valentic, Timothy R., Masschelein, Joleen, Jenner, Matthew, de los Santos, Emmanuel L. C., Manzi, Lucio, Sydor, Paulina K., Rea, Dean, Zhou, Shanshan, Fülöp, Vilmos, Oldham, Neil J., Tsai, Shiou-Chuan, Challis, Gregory L., Lewandowski, Józef R.

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CANDELS: THE COSMIC ASSEMBLY NEAR-INFRARED DEEP EXTRAGALACTIC LEGACY SURVEY von Grogin, Norman A

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Kill and cure: genomic phylogeny and bioactivity of Burkholderia gladioli bacteria capable of pathogenic and beneficial lifestyles von Jones, Cerith, Webster, Gordon, Mullins, Alex J., Jenner, Matthew, Bull, Matthew J., Dashti, Yousef, Spilker, Theodore, Parkhill, Julian, Connor, Thomas R., LiPuma, John J., Challis, Gregory L., Mahenthiralingam, Eshwar

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Docking domain-mediated subunit interactions in natural product megasynthases von Smith, Helen G, Beech, Matthew J, Lewandowski, Jozef R, Challis, Gregory L, Jenner, Matthew

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Photodegradation of bitumen-derived organics in oil sands process-affected water von Challis, Jonathan K, Parajas, Angelique, Anderson, Julie C, Asiedu, Evelyn, Martin, Jonathan W, Wong, Charles S, Ross, Matthew S

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Overview of systematic reviews: Effective home support in dementia care, components and impacts—Stage 1, psychosocial interventions for dementia von Clarkson, Paul, Hughes, Jane, Xie, Chengqiu, Larbey, Matthew, Roe, Brenda, Giebel, Clarissa M., Jolley, David, Challis, David

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A POMC variant implicates β-melanocyte-stimulating hormone in the control of human energy balance von Lee, Yung Seng, Challis, Ben G., Thompson, Darren A., Yeo, Giles S.H., Keogh, Julia M., Madonna, Michael E., Wraight, Vicki, Sims, Matthew, Vatin, Vincent, Meyre, David, Shield, Julian, Burren, Christine, Ibrahim, Zala, Cheetham, Tim, Swift, Peter, Blackwood, Anthea, Hung, Chiao-Chien Connie, Wareham, Nicholas J., Froguel, Philippe, Millhauser, Glenn L., O'Rahilly, Stephen, Farooqi, I. Sadaf

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