The pro- and anti-inflammatory properties of the cytokine interleukin-6 von Scheller, Jürgen, Chalaris, Athena, Schmidt-Arras, Dirk, Rose-John, Stefan

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ADAM17: a molecular switch to control inflammation and tissue regeneration von Scheller, Jürgen, Chalaris, Athena, Garbers, Christoph, Rose-John, Stefan

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The soluble Interleukin 6 receptor: Generation and role in inflammation and cancer von Chalaris, Athena, Garbers, Christoph, Rabe, Björn, Rose-John, Stefan, Scheller, Jürgen

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Mechanistic insights into a TIMP3-sensitive pathway constitutively engaged in the regulation of cerebral hemodynamics von Capone, Carmen, Dabertrand, Fabrice, Baron-Menguy, Celine, Chalaris, Athena, Ghezali, Lamia, Domenga-Denier, Valérie, Schmidt, Stefanie, Huneau, Clément, Rose-John, Stefan, Nelson, Mark T, Joutel, Anne

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STAT3 regulated ARF expression suppresses prostate cancer metastasis von Pencik, Jan, Schlederer, Michaela, Gruber, Wolfgang, Unger, Christine, Walker, Steven M., Chalaris, Athena, Marié, Isabelle J., Hassler, Melanie R., Javaheri, Tahereh, Aksoy, Osman, Blayney, Jaine K., Prutsch, Nicole, Skucha, Anna, Herac, Merima, Krämer, Oliver H., Mazal, Peter, Grebien, Florian, Egger, Gerda, Poli, Valeria, Mikulits, Wolfgang, Eferl, Robert, Esterbauer, Harald, Kennedy, Richard, Fend, Falko, Scharpf, Marcus, Braun, Martin, Perner, Sven, Levy, David E., Malcolm, Tim, Turner, Suzanne D., Haitel, Andrea, Susani, Martin, Moazzami, Ali, Rose-John, Stefan, Aberger, Fritz, Merkel, Olaf, Moriggl, Richard, Culig, Zoran, Dolznig, Helmut, Kenner, Lukas

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Species Specificity of ADAM10 and ADAM17 Proteins in Interleukin-6 (IL-6) Trans-signaling and Novel Role of ADAM10 in Inducible IL-6 Receptor Shedding von Garbers, Christoph, Jänner, Nathalie, Chalaris, Athena, Moss, Marcia L., Floss, Doreen M., Meyer, Dörte, Koch-Nolte, Friedrich, Rose-John, Stefan, Scheller, Jürgen

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Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice von Chalaris, Athena, Adam, Nina, Sina, Christian, Rosenstiel, Philip, Lehmann-Koch, Judith, Schirmacher, Peter, Hartmann, Dieter, Cichy, Joanna, Gavrilova, Olga, Schreiber, Stefan, Jostock, Thomas, Matthews, Vance, Häsler, Robert, Becker, Christoph, Neurath, Markus F, Reiss, Karina, Saftig, Paul, Scheller, Jürgen, Rose-John, Stefan

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Epithelial RNase H2 Maintains Genome Integrity and Prevents Intestinal Tumorigenesis in Mice von Aden, Konrad, Bartsch, Kareen, Dahl, Joseph, Reijns, Martin A.M., Esser, Daniela, Sheibani-Tezerji, Raheleh, Sinha, Anupam, Wottawa, Felix, Ito, Go, Mishra, Neha, Knittler, Katharina, Burkholder, Adam, Welz, Lina, van Es, Johan, Tran, Florian, Lipinski, Simone, Kakavand, Nassim, Boeger, Christine, Lucius, Ralph, von Schoenfels, Witigo, Schafmayer, Clemens, Lenk, Lennart, Chalaris, Athena, Clevers, Hans, Röcken, Christoph, Kaleta, Christoph, Rose-John, Stefan, Schreiber, Stefan, Kunkel, Thomas, Rabe, Björn, Rosenstiel, Philip

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Apoptosis is a natural stimulus of IL6R shedding and contributes to the proinflammatory trans-signaling function of neutrophils von Chalaris, Athena, Rabe, Björn, Paliga, Krzysztof, Lange, Hans, Laskay, Tamas, Fielding, Ceri A., Jones, Simon A., Rose-John, Stefan, Scheller, Jürgen

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G Protein-Coupled Receptor 43 Is Essential for Neutrophil Recruitment during Intestinal Inflammation von Sina, Christian, Gavrilova, Olga, Forster, Matti, Till, Andreas, Derer, Stefanie, Hildebrand, Friederike, Raabe, Bjorn, Chalaris, Athena, Scheller, Jurgen, Rehmann, Ateequr, Franke, Andre, Ott, Stephan, Hasler, Robert, Nikolaus, Susanna, Folsch, Ulrich R, Rose-John, Stefan, Jiang, Hui-Ping, Li, Jun, Schreiber, Stefan, Rosenstiel, Philip

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A Disintegrin and Metalloprotease 17 Dynamic Interaction Sequence, the Sweet Tooth for the Human Interleukin 6 Receptor von Düsterhöft, Stefan, Höbel, Katharina, Oldefest, Mirja, Lokau, Juliane, Waetzig, Georg H., Chalaris, Athena, Garbers, Christoph, Scheller, Jürgen, Rose-John, Stefan, Lorenzen, Inken, Grötzinger, Joachim

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Selective blockade of interleukin-6 trans-signaling improves survival in a murine polymicrobial sepsis model von Barkhausen, Tanja, Tschernig, Thomas, Rosenstiel, Philip, van Griensven, Martijn, Vonberg, Ralf-Peter, Dorsch, Martina, Mueller-Heine, Annika, Chalaris, Athena, Scheller, Jürgen, Rose-John, Stefan, Seegert, Dirk, Krettek, Christian, Waetzig, Georg H

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Transgenic blockade of interleukin 6 transsignaling abrogates inflammation von Rabe, Björn, Chalaris, Athena, May, Ulrike, Waetzig, Georg H., Seegert, Dirk, Williams, Anwen S., Jones, Simon A., Rose-John, Stefan, Scheller, Jürgen

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Senescence‐associated release of transmembrane proteins involves proteolytic processing by ADAM17 and microvesicle shedding von Effenberger, Timo, Heyde, Jan, Bartsch, Kareen, Garbers, Christoph, Schulze‐Osthoff, Klaus, Chalaris, Athena, Murphy, Gillian, Rose‐John, Stefan, Rabe, Björn

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Differentially regulated GPVI ectodomain shedding by multiple platelet–expressed proteinases von Bender, Markus, Hofmann, Sebastian, Stegner, David, Chalaris, Athena, Bösl, Michael, Braun, Attila, Scheller, Jürgen, Rose-John, Stefan, Nieswandt, Bernhard

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Mouse neutrophils express the decoy type 2 interleukin-1 receptor (IL-1R2) constitutively and in acute inflammatory conditions von Martin, Praxedis, Palmer, Gaby, Vigne, Solenne, Lamacchia, Céline, Rodriguez, Emiliana, Talabot‐Ayer, Dominique, Rose‐John, Stefan, Chalaris, Athena, Gabay, Cem

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The role of metalloproteinase ADAM17 in regulating ICOS ligand-mediated humoral immune responses von Marczynska, Joanna, Ozga, Aleksandra, Wlodarczyk, Agnieszka, Majchrzak-Gorecka, Monika, Kulig, Paulina, Banas, Magdalena, Michalczyk-Wetula, Dominika, Majewski, Pawel, Hutloff, Andreas, Schwarz, Jeanette, Chalaris, Athena, Scheller, Jürgen, Rose-John, Stefan, Cichy, Joanna

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TP53 co-mutations in EGFR mutated patients in NSCLC stage IV: A strong predictive factor of ORR, PFS and OS in EGFR mt+ NSCLC von Roeper, Julia, Falk, Markus, Chalaris-Rißmann, Athena, Lueers, Anne C, Ramdani, Hayat, Wedeken, Katrin, Stropiep, Ursula, Diehl, Linda, Tiemann, Markus, Heukamp, Lukas C, Otto-Sobotka, Fabian, Griesinger, Frank

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Structure-guided Optimization of the Interleukin-6 Trans-signaling Antagonist sgp130 von Tenhumberg, Stephanie, Waetzig, Georg H., Chalaris, Athena, Rabe, Björn, Seegert, Dirk, Scheller, Jürgen, Rose-John, Stefan, Grötzinger, Joachim

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N-Linked Glycosylation Is Essential for the Stability but Not the Signaling Function of the Interleukin-6 Signal Transducer Glycoprotein 130 von Waetzig, Georg H., Chalaris, Athena, Rosenstiel, Philip, Suthaus, Jan, Holland, Christin, Karl, Nadja, Vallés Uriarte, Lorena, Till, Andreas, Scheller, Jürgen, Grötzinger, Joachim, Schreiber, Stefan, Rose-John, Stefan, Seegert, Dirk

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