JNJ-28312141, a novel orally active colony-stimulating factor-1 receptor/FMS-related receptor tyrosine kinase-3 receptor tyrosine kinase inhibitor with potential utility in solid t... von Manthey, Carl L, Johnson, Dana L, Illig, Carl R, Tuman, Robert W, Zhou, Zhao, Baker, Judith F, Chaikin, Margery A, Donatelli, Robert R, Franks, Carol F, Zeng, Lee, Crysler, Carl, Chen, Yanmin, Yurkow, Edward J, Boczon, Lisa, Meegalla, Sanath K, Wilson, Kenneth J, Wall, Mark J, Chen, Jinsheng, Ballentine, Shelley K, Ott, Heidi, Baumann, Christian, Lawrence, Danielle, Tomczuk, Bruce E, Molloy, Christopher J

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Enhancement of kinase selectivity in a potent class of arylamide FMS inhibitors von Illig, Carl R., Manthey, Carl L., Meegalla, Sanath K., Wall, Mark J., Chen, Jinsheng, Wilson, Kenneth J., DesJarlais, Renee L., Ballentine, Shelley K., Schubert, Carsten, Crysler, Carl S., Chen, Yanmin, Molloy, Christopher J., Chaikin, Margery A., Donatelli, Robert R., Yurkow, Edward, Zhou, Zhao, Player, Mark R., Tomczuk, Bruce E.

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Optimization of a Potent Class of Arylamide Colony-Stimulating Factor-1 Receptor Inhibitors Leading to Anti-inflammatory Clinical Candidate 4-Cyano-N-[2-(1-cyclohexen-1-yl)-4-[1-[(... von Illig, Carl R, Manthey, Carl L, Wall, Mark J, Meegalla, Sanath K, Chen, Jinsheng, Wilson, Kenneth J, Ballentine, Shelley K, DesJarlais, Renee L, Schubert, Carsten, Crysler, Carl S, Chen, Yanmin, Molloy, Christopher J, Chaikin, Margery A, Donatelli, Robert R, Yurkow, Edward, Zhou, Zhao, Player, Mark R, Tomczuk, Bruce E

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Pyrido[2,3-d]pyrimidin-5-ones: A Novel Class of Antiinflammatory Macrophage Colony-Stimulating Factor-1 Receptor Inhibitors von Huang, Hui, Hutta, Daniel A, Rinker, James M, Hu, Huaping, Parsons, William H, Schubert, Carsten, DesJarlais, Renee L, Crysler, Carl S, Chaikin, Margery A, Donatelli, Robert R, Chen, Yanmin, Cheng, Deping, Zhou, Zhao, Yurkow, Edward, Manthey, Carl L, Player, Mark R

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Design and synthesis of a pyrido[2,3- d]pyrimidin-5-one class of anti-inflammatory FMS inhibitors von Huang, Hui, Hutta, Daniel A., Hu, Huaping, DesJarlais, Renee L., Schubert, Carsten, Petrounia, Ioanna P., Chaikin, Margery A., Manthey, Carl L., Player, Mark R.

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Synthesis and evaluation of novel 3,4,6-substituted 2-quinolones as FMS kinase inhibitors von Wall, Mark J., Chen, Jinsheng, Meegalla, Sanath, Ballentine, Shelley K., Wilson, Kenneth J., DesJarlais, Renee L., Schubert, Carsten, Chaikin, Margery A., Crysler, Carl, Petrounia, Ioanna P., Donatelli, Robert R., Yurkow, Edward J., Boczon, Lisa, Mazzulla, Marie, Player, Mark R., Patch, Raymond J., Manthey, Carl L., Molloy, Christopher, Tomczuk, Bruce, Illig, Carl R.

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Elimination of Fc Receptor-Dependent Effector Functions of a Modified IgG4 Monoclonal Antibody to Human CD4 von Reddy, Manjula P, Kinney, Cheryl Ann S, Chaikin, Margery A, Payne, Angela, Fishman-Lobell, Jacqueline, Tsui, Ping, Dal Monte, Paul R, Doyle, Michael L, Brigham-Burke, Michael R, Anderson, Darrell, Reff, Mitchell, Newman, Roland, Hanna, Nabil, Sweet, Raymond W, Truneh, Alemseged

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Discovery of novel FMS kinase inhibitors as anti-inflammatory agents von Illig, Carl R., Chen, Jinsheng, Wall, Mark J., Wilson, Kenneth J., Ballentine, Shelley K., Rudolph, M. Jonathan, DesJarlais, Renee L., Chen, Yanmin, Schubert, Carsten, Petrounia, Ioanna, Crysler, Carl S., Molloy, Christopher J., Chaikin, Margery A., Manthey, Carl L., Player, Mark R., Tomczuk, Bruce E., Meegalla, Sanath K.

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Structure-based optimization of a potent class of arylamide FMS inhibitors von Meegalla, Sanath K., Wall, Mark J., Chen, Jinsheng, Wilson, Kenneth J., Ballentine, Shelley K., DesJarlais, Renee L., Schubert, Carsten, Crysler, Carl S., Chen, Yanmin, Molloy, Christopher J., Chaikin, Margery A., Manthey, Carl L., Player, Mark R., Tomczuk, Bruce E., Illig, Carl R.

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Potent 2′-aminoanilide inhibitors of cFMS as potential anti-inflammatory agents von Patch, Raymond J., Brandt, Benjamin M., Asgari, Davoud, Baindur, Nand, Chadha, Naresh K., Georgiadis, Taxiarchis, Cheung, Wing S., Petrounia, Ioanna P., Donatelli, Robert R., Chaikin, Margery A., Player, Mark R.

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Identification of a Potent, Selective Non-peptide CXCR2 Antagonist That Inhibits Interleukin-8-induced Neutrophil Migration von White, John R., Lee, Judithann M., Young, Peter R., Hertzberg, Robert P., Jurewicz, Anthony J., Chaikin, Margery A., Widdowson, Katherine, Foley, James J., Martin, Lenox D., Griswold, Don E., Sarau, Henry M.

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Biochemical and biological characterization of a dodecameric CD4-Ig fusion protein: implications for therapeutic and vaccine strategies von Arthos, James, Cicala, Claudia, Steenbeke, Tavis D, Chun, Tae-Wook, Dela Cruz, Charles, Hanback, Douglas B, Khazanie, Prateeti, Nam, Daniel, Schuck, Peter, Selig, Sara M, Van Ryk, Donald, Chaikin, Margery A, Fauci, Anthony S

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Reducing ion channel activity in a series of 4-heterocyclic arylamide FMS inhibitors von Wilson, Kenneth J., Illig, Carl R., Chen, Jinsheng, Wall, Mark J., Ballentine, Shelley K., DesJarlais, Renee L., Chen, Yanmin, Schubert, Carsten, Donatelli, Robert, Petrounia, Ioanna, Crysler, Carl S., Molloy, Christopher J., Chaikin, Margery A., Manthey, Carl L., Player, Mark R., Tomczuk, Bruce E., Meegalla, Sanath K.

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Targeted lysis of HIV-infected cells by natural killer cells armed and triggered by a recombinant immunoglobulin fusion protein: implications for immunotherapy von Gupta, Neil, Arthos, James, Khazanie, Prateeti, Steenbeke, Tavis D., Censoplano, Nina M., Chung, Eva A., Cruz, Catherine C., Chaikin, Margery A., Daucher, Marybeth, Kottilil, Shyam, Mavilio, Domenico, Schuck, Peter, Sun, Peter D., Rabin, Ronald L., Radaev, Sergei, Van Ryk, Donald, Cicala, Claudia, Fauci, Anthony S.

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Optimization of a Potent Class of Arylamide Colony-Stimulating Factor-1 Receptor Inhibitors Leading to Anti-inflammatory Clinical Candidate 4-Cyano- N -[2-(1-cyclohexen-1-yl)-4-[1-... von Illig, Carl R., Manthey, Carl L., Wall, Mark J., Meegalla, Sanath K., Chen, Jinsheng, Wilson, Kenneth J., Ballentine, Shelley K., DesJarlais, Renee L., Schubert, Carsten, Crysler, Carl S., Chen, Yanmin, Molloy, Christopher J., Chaikin, Margery A., Donatelli, Robert R., Yurkow, Edward, Zhou, Zhao, Player, Mark R., Tomczuk, Bruce E.

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Identification of the residues in human CD4 critical for the binding of HIV von Arthos, James, Deen, Keith C., Chaikin, Margery A., Fornwald, James A., Sathe, Ganesh, Sattentau, Quentin J., Clapham, Paul R., Weiss, Robin A., McDougal, J.Steven, Pietropaolo, Concetta, Axel, Richard, Truneh, Alemseged, Maddon, Paul Jay, Sweet, Raymond W.

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Biological characterization and oncogene expression in human colorectal carcinoma cell lines von Trainer, Deborah L., Kline, Thomas, McCabe, Francis L., Faucette, Leo F., Feild, John, Chaikin, Margery, Anzano, Mario, Reiman, David, Hoffstein, Sylvia, Li, Dian‐Jun, Gennaro, Doris, Buscarino, Charles, Lynch, Mark, Poste, George, Greig, Russell

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Biochemical and Biological Characterization of a Dodecameric CD4-Ig Fusion Protein von Arthos, James, Cicala, Claudia, Steenbeke, Tavis D., Chun, Tae-Wook, Cruz, Charles Dela, Hanback, Douglas B., Khazanie, Prateeti, Nam, Daniel, Schuck, Peter, Selig, Sara M., Van Ryk, Donald, Chaikin, Margery A., Fauci, Anthony S.

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Identification of novel short chain 4-substituted indoles as potent αvβ3 antagonist using structure-based drug design von RABOISSON, Pierre, DESJARLAIS, Renee L, REED, Rolanda, LATTANZE, Jennifer, CHAIKIN, Margery, MANTHEY, Carl L, TOMCZUK, Bruce E, MARUGAN, Juan José

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Identification of novel short chain 4-substituted indoles as potent alphavbeta3 antagonist using structure-based drug design von Raboisson, Pierre, Desjarlais, Renee L, Reed, Rolanda, Lattanze, Jennifer, Chaikin, Margery, Manthey, Carl L, Tomczuk, Bruce E, Marugán, Juan José

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