Structure-Based Design, Synthesis and Validation of CD4-Mimetic Small Molecule Inhibitors of HIV‑1 Entry: Conversion of a Viral Entry Agonist to an Antagonist von Courter, Joel R, Madani, Navid, Sodroski, Joseph, Schön, Arne, Freire, Ernesto, Kwong, Peter D, Hendrickson, Wayne A, Chaiken, Irwin M, LaLonde, Judith M, Smith, Amos B

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Altered Env conformational dynamics as a mechanism of resistance to peptide-triazole HIV-1 inactivators von Zhang, Shiyu, Holmes, Andrew P, Dick, Alexej, Rashad, Adel A, Enríquez Rodríguez, Lucía, Canziani, Gabriela A, Root, Michael J, Chaiken, Irwin M

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A Model of Peptide Triazole Entry Inhibitor Binding to HIV‑1 gp120 and the Mechanism of Bridging Sheet Disruption von Emileh, Ali, Tuzer, Ferit, Yeh, Herman, Umashankara, Muddegowda, Moreira, Diogo R. M, LaLonde, Judith M, Bewley, Carole A, Abrams, Cameron F, Chaiken, Irwin M

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Peptide Triazole Thiol Irreversibly Inactivates Metastable HIV-1 Env by Accessing Conformational Triggers Intrinsic to Virus–Cell Entry von Ang, Charles Gotuaco, Carter, Erik, Haftl, Ann, Zhang, Shiyu, Rashad, Adel A., Kutzler, Michele, Abrams, Cameron F., Chaiken, Irwin M.

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Interleukin-5 Receptor Subunit Oligomerization and Rearrangement Revealed by Fluorescence Resonance Energy Transfer Imaging von Zaks-Zilberman, Meirav, Harrington, Adrian E., Ishino, Tetsuya, Chaiken, Irwin M.

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Broad-Spectrum Anti-Human Immunodeficiency Virus (HIV) Potential of a Peptide HIV Type 1 Entry Inhibitor von COCKLIN, Simon, GOPI, Hosahudya, CHAIKEN, Irwin M, QUERIDO, Bianca, NIMMAGADDA, Manideepthi, KURIAKOSE, Syna, CICALA, Claudia, AJITH, Sandya, BAXTER, Sabine, ARTHOS, James, MARTIN-GARCIA, Julio

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Lytic Inactivation of Human Immunodeficiency Virus by Dual Engagement of gp120 and gp41 Domains in the Virus Env Protein Trimer von Parajuli, Bibek, Acharya, Kriti, Yu, Reina, Ngo, Brendon, Rashad, Adel A, Abrams, Cameron F, Chaiken, Irwin M

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Improved Durability to SARS-CoV-2 Vaccine Immunity following Coimmunization with Molecular Adjuvant Adenosine Deaminase-1 von Cusimano, Gina M, Gary, Ebony N, Bell, Matthew R, Warner, Bryce M, Connors, Jennifer, Tursi, Nicholas J, Ali, Ali R, Zhang, Shiyu, Canziani, Gabriela, Taramangalam, Bhavani, Gordon, Emma A, Chaiken, Irwin M, Wootton, Sarah K, Smith, Trevor, Ramos, Stephanie, Kobasa, Darwyn, Weiner, David B, Kutzler, Michele A, Haddad, Elias K

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Click Chemistry on Azidoproline: High-Affinity Dual Antagonist for HIV-1 Envelope Glycoprotein gp120 von Gopi, Hosahudya N., Tirupula, Kalyan C., Baxter, Sabine, Ajith, Sandya, Chaiken, Irwin M.

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Mode of Action for Linear Peptide Inhibitors of HIV-1 gp120 Interactions von Biorn, Alyssa C, Cocklin, Simon, Madani, Navid, Si, Zhihai, Ivanovic, Tijana, Samanen, James, Van Ryk, Donald I, Pantophlet, Ralph, Burton, Dennis R, Freire, Ernesto, Sodroski, Joseph, Chaiken, Irwin M

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Covalent Conjugation of a Peptide Triazole to HIV‑1 gp120 Enables Intramolecular Binding Site Occupancy von Emileh, Ali, Duffy, Caitlin, Holmes, Andrew P, Rosemary Bastian, Arangassery, Aneja, Rachna, Tuzer, Ferit, Rajagopal, Srivats, Li, Huiyuan, Abrams, Cameron F, Chaiken, Irwin M

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Interaction with CD4 and Antibodies to CD4-Induced Epitopes of the Envelope gp120 from a Microglial Cell-Adapted Human Immunodeficiency Virus Type 1 Isolate von MARTIN-GARCIA, Julio, COCKLIN, Simon, CHAIKEN, Irwin M, GONZALEZ-SCARANO, Francisco

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Abasic phosphorothioate oligomers inhibit HIV-1 reverse transcription and block virus transmission across polarized ectocervical organ cultures von Fraietta, Joseph A, Mueller, Yvonne M, Lozenski, Karissa L, Ratner, Deena, Boesteanu, Alina C, Hancock, Aidan S, Lackman-Smith, Carol, Zentner, Isaac J, Chaiken, Irwin M, Chung, Suhman, LeGrice, Stuart F J, Snyder, Beth A, Mankowski, Marie K, Jones, Natalie M, Hope, Jennifer L, Gupta, Phalguni, Anderson, Sharon H, Wigdahl, Brian, Katsikis, Peter D

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Introducing metallocene into a triazole peptide conjugate reduces its off-rate and enhances its affinity and antiviral potency for HIV-1 gp120 von Gopi, Hosahudya, Cocklin, Simon, Pirrone, Vanessa, McFadden, Karyn, Tuzer, Ferit, Zentner, Isaac, Ajith, Sandya, Baxter, Sabine, Jawanda, Navneet, Krebs, Fred C., Chaiken, Irwin M.

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Use of the quartz crystal microbalance to monitor ligand-induced conformational rearrangements in HIV-1 envelope protein gp120 von Lee, Hyun-Su, Contarino, Mark, Umashankara, M, Schön, Arne, Freire, Ernesto, Smith, Amos B. III, Chaiken, Irwin M, Penn, Lynn S

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Non-natural Peptide Triazole Antagonists of HIV-1 Envelope gp120 von Kamanna, Kantharaju, Aneja, Rachna, Duffy, Caitlin, Kubinski, Pamela, Rodrigo Moreira, Diogo, Bailey, Lauren D., McFadden, Karyn, Schön, Arne, Holmes, Andrew, Tuzer, Ferit, Contarino, Mark, Freire, Ernesto, Chaiken, Irwin M.

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Monoclonal Antibody m18 Paratope Leading to Dual Receptor Antagonism of HIV-1 gp120 von Gift, Syna Kuriakose, McFadden, Karyn, Zentner, Isaac J, Rajagopal, Srivats, Zhang, Mei-Yun, Dimitrov, Dimiter S, Chaiken, Irwin M

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Kinetic and Structural Analysis of Mutant CD4 Receptors that are Defective in HIV gp120 Binding von Wu, Hao, Myszka, David G., Tendian, Susan W., Brouillette, Christie G., Sweet, Ray W., Chaiken, Irwin M., Hendrickson, Wayne A.

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Conformational and Structural Features of HIV-1 gp120 Underlying the Dual Receptor Antagonism by Cross-Reactive Neutralizing Antibody m18 von Gift, Syna Kuriakose, Zentner, Isaac J, Schön, Arne, McFadden, Karyn, Umashankara, M, Rajagopal, Srivats, Contarino, Mark, Duffy, Caitlin, Courter, Joel R, Zhang, Mei-Yun, Gershoni, Jonathan M, Cocklin, Simon, Dimitrov, Dimiter S, Smith, Amos B, Freire, Ernesto, Chaiken, Irwin M

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From receptor recognition mechanisms to bioinspired mimetic antagonists in HIV-1/cell docking von Dowd, Cynthia S., Zhang, Wentao, Li, Chuanzhao, Chaiken, Irwin M.

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