A case history in natural product-based drug discovery: discovery of vorapaxar (Zontivity™) von Chackalamannil, Samuel

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Thrombin Receptor (Protease Activated Receptor-1) Antagonists as Potent Antithrombotic Agents with Strong Antiplatelet Effects von Chackalamannil, Samuel

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Discovery of Potent Orally Active Thrombin Receptor (Protease Activated Receptor 1) Antagonists as Novel Antithrombotic Agents von Chackalamannil, Samuel, Xia, Yan, Greenlee, William J, Clasby, Martin, Doller, Darìo, Tsai, Hsingan, Asberom, Theodros, Czarniecki, Michael, Ahn, Ho-Sam, Boykow, George, Foster, Carolyn, Agans-Fantuzzi, Jacqueline, Bryant, Matthew, Lau, Janice, Chintala, Madhu

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Discovery of a nortropanol derivative as a potent and orally active GPR119 agonist for type 2 diabetes von Xia, Yan, Chackalamannil, Samuel, Greenlee, William J., Jayne, Charles, Neustadt, Bernard, Stamford, Andrew, Vaccaro, Henry, Xu, Xiaoying (Lucy), Baker, Hana, O’Neill, Kim, Woods, Morgan, Hawes, Brian, Kowalski, Tim

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Metabolism-Based Identification of a Potent Thrombin Receptor Antagonist von Clasby, Martin C, Chackalamannil, Samuel, Czarniecki, Michael, Doller, Dario, Eagen, Keith, Greenlee, William, Kao, Grace, Lin, Yan, Tsai, Hsingan, Xia, Yan, Ahn, Ho-Sam, Agans-Fantuzzi, Jacqueline, Boykow, George, Chintala, Madhu, Foster, Carolyn, Smith-Torhan, April, Alton, Kevin, Bryant, Matthew, Hsieh, Yunsheng, Lau, Janice, Palamanda, Jairam

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Himbacine derived thrombin receptor antagonists: Discovery of a new tricyclic core von Clasby, Martin C., Chackalamannil, Samuel, Czarniecki, Michael, Doller, Darío, Eagen, Keith, Greenlee, William J., Lin, Yan, Tagat, Jayaram R., Tsai, Hsingan, Xia, Yan, Ahn, Ho-Sam, Agans-Fantuzzi, Jacqueline, Boykow, George, Chintala, Madhu, Hsieh, Yunsheng, McPhail, Andrew T.

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Discovery of a Novel, Orally Active Himbacine-Based Thrombin Receptor Antagonist (SCH 530348) with Potent Antiplatelet Activity von Chackalamannil, Samuel, Wang, Yuguang, Greenlee, William J, Hu, Zhiyong, Xia, Yan, Ahn, Ho-Sam, Boykow, George, Hsieh, Yunsheng, Palamanda, Jairam, Agans-Fantuzzi, Jacqueline, Kurowski, Stan, Graziano, Michael, Chintala, Madhu

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Total Synthesis of (+)-Himbacine and (+)-Himbeline von Chackalamannil, Samuel, Davies, Robert J, Wang, Yuguang, Asberom, Theodros, Doller, Darío, Wong, Jesse, Leone, Daria, McPhail, Andrew T

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A Highly Efficient Total Synthesis of (+)-Himbacine von Chackalamannil, Samuel, Davies, Robert J, Asberom, Theodros, Doller, Darío, Leone, Daria

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Design, synthesis, and structure-activity relationship studies of himbacine derived muscarinic receptor antagonists von Doller, Darío, Chackalamannil, Samuel, Czarniecki, Michael, McQuade, Robert, Ruperto, Vilma

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Discovery of hydroxy pyrimidine Factor IXa inhibitors von Jayne, Charles L., Andreani, Teresa, Chan, Tin-Yau, Chelliah, Mariappan V., Clasby, Martin C., Dwyer, Michael, Eagen, Keith A., Fried, Steve, Greenlee, William J., Guo, Zhuyan, Hawes, Brian, Hruza, Alan, Ingram, Richard, Keertikar, Kartik M., Neelamkavil, Santhosh, Reichert, Paul, Xia, Yan, Chackalamannil, Samuel

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Synthesis of Mono- and Difluoronaphthoic Acids von Tagat, Jayaram R, McCombie, Stuart W, Nazareno, Dennis V, Boyle, Craig D, Kozlowski, Joseph A, Chackalamannil, Samuel, Josien, Hubert, Wang, Yuguang, Zhou, Guowei

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Design and Synthesis of P2–P4 Macrocycles Containing a Unique Spirocyclic Proline: A New Class of HCV NS3/4A Inhibitors von Velázquez, Francisco, Chelliah, Mariappan, Clasby, Martin, Guo, Zhuyan, Howe, John, Miller, Randy, Neelamkavil, Santhosh, Shah, Unmesh, Soriano, Aileen, Xia, Yan, Venkatraman, Srikanth, Chackalamannil, Samuel, Davies, Ian W

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Synthesis and Evaluation of Polycyclic Pyrazolo[3,4-d]pyrimidines as PDE1 and PDE5 cGMP Phosphodiesterase Inhibitors von Xia, Yan, Chackalamannil, Samuel, Czarniecki, Michael, Tsai, Hsingan, Vaccaro, Henry, Cleven, Renee, Cook, John, Fawzi, Ahmad, Watkins, Robert, Zhang, Hongtao

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Identification of Novel Cannabinoid CB1 Receptor Antagonists by Using Virtual Screening with a Pharmacophore Model von Wang, Hongwu, Duffy, Ruth A, Boykow, George C, Chackalamannil, Samuel, Madison, Vincent S

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Discovery of MK-8282 as a Potent G‑Protein-Coupled Receptor 119 Agonist for the Treatment of Type 2 Diabetes von Neelamkavil, Santhosh F, Stamford, Andrew W, Kowalski, Timothy, Biswas, Dipshikha, Boyle, Craig, Chackalamannil, Samuel, Xia, Yan, Jayne, Charles, Neustadt, Bernard, Hao, Jinsong, Liu, Hong, Dai, Xing, Baker, Hana, Hawes, Brian, O’Neill, Kim, Tang, Huadong, Greenlee, William J

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Discovery of MK-8831, A Novel Spiro-Proline Macrocycle as a Pan-Genotypic HCV-NS3/4a Protease Inhibitor von Neelamkavil, Santhosh F, Agrawal, Sony, Bara, Thomas, Bennett, Chad, Bhat, Sathesh, Biswas, Dipshikha, Brockunier, Linda, Buist, Nicole, Burnette, Duane, Cartwright, Mark, Chackalamannil, Samuel, Chase, Robert, Chelliah, Mariappan, Chen, Austin, Clasby, Martin, Colandrea, Vincent J, Davies, Ian W, Eagen, Keith, Guo, Zhuyan, Han, Yongxin, Howe, John, Jayne, Charles, Josien, Hubert, Kargman, Stacia, Marcantonio, Karen, Miao, Shouwu, Miller, Randy, Nolting, Andrew, Pinto, Patrick, Rajagopalan, Murali, Ruck, Rebecca T, Shah, Unmesh, Soriano, Aileen, Sperbeck, Donald, Velazquez, Francisco, Wu, Jin, Xia, Yan, Venkatraman, Srikanth

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Himbacine-Derived Thrombin Receptor Antagonists: C 7 -Spirocyclic Analogues of Vorapaxar von Chelliah, Mariappan V., Eagen, Keith, Guo, Zhuyan, Chackalamannil, Samuel, Xia, Yan, Tsai, Hsingan, Greenlee, William J., Ahn, Ho-Sam, Kurowski, Stan, Boykow, George, Hsieh, Yunsheng, Chintala, Madhu

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Total Synthesis of (−)-Himgaline von Shah, Unmesh, Chackalamannil, Samuel, Ganguly, Ashit K, Chelliah, Mariappan, Kolotuchin, Sergei, Buevich, Alexei, McPhail, Andrew

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Thrombin receptor (PAR-1) antagonists as novel antithrombotic agents von Chackalamannil, Samuel, Xia, Yan

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