Selinexor Combined with Ibrutinib Demonstrates Tolerability and Safety in Advanced B-Cell Malignancies: A Phase I Study von Stephens, Deborah M, Huang, Ying, Ruppert, Amy S, Walker, Janek S, Canfield, Daniel, Cempre, Casey B, Fu, Qiang, Baker, Sharyn, Hu, Boyu, Shah, Harsh, Vadeboncoeur, Renee, Rogers, Kerry A, Bhat, Seema, Jaglowski, Samantha M, Lockman, Hank, Lapalombella, Rosa, Byrd, John C, Woyach, Jennifer A

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Dysregulation of PRMT5 in chronic lymphocytic leukemia promotes progression with high risk of Richter’s transformation von Hing, Zachary A., Walker, Janek S., Whipp, Ethan C., Brinton, Lindsey, Cannon, Matthew, Zhang, Pu, Sher, Steven, Cempre, Casey B., Brown, Fiona, Smith, Porsha L., Agostinelli, Claudio, Pileri, Stefano A., Skinner, Jordan N., Williams, Katie, Phillips, Hannah, Shaffer, Jami, Beaver, Larry P., Pan, Alexander, Shin, Kyle, Gregory, Charles T., Ozer, Gulcin H., Yilmaz, Selen A., Harrington, Bonnie K., Lehman, Amy M., Yu, Lianbo, Coppola, Vincenzo, Yan, Pearlly, Scherle, Peggy, Wang, Min, Pitis, Philip, Xu, Chaoyi, Vaddi, Kris, Chen-Kiang, Selina, Woyach, Jennifer, Blachly, James S., Alinari, Lapo, Yang, Yiping, Byrd, John C., Baiocchi, Robert A., Blaser, Bradley W., Lapalombella, Rosa

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Recurrent XPO1 mutations alter pathogenesis of chronic lymphocytic leukemia von Walker, Janek S, Hing, Zachary A, Harrington, Bonnie, Baumhardt, Jordan, Ozer, Hatice Gulcin, Lehman, Amy, Giacopelli, Brian, Beaver, Larry, Williams, Katie, Skinner, Jordan N, Cempre, Casey B, Sun, Qingxiang, Shacham, Sharon, Stromberg, Benjamin R, Summers, Matthew K, Abruzzo, Lynne V, Rassenti, Laura, Kipps, Thomas J, Parikh, Sameer, Kay, Neil E, Rogers, Kerry A, Woyach, Jennifer A, Coppola, Vincenzo, Chook, Yuh Min, Oakes, Christopher, Byrd, John C, Lapalombella, Rosa

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Rare t(X;14)(q28;q32) translocation reveals link between MTCP1 and chronic lymphocytic leukemia von Walker, Janek S., Hing, Zachary A., Sher, Steven, Cronin, James, Williams, Katie, Harrington, Bonnie, Skinner, Jordan N., Cempre, Casey B., Gregory, Charles T., Pan, Alexander, Yano, Max, Beaver, Larry P., Walker, Brandi R., Labanowska, Jadwiga M., Heerema, Nyla A., Mrózek, Krzysztof, Woyach, Jennifer A., Ruppert, Amy S., Lehman, Amy, Ozer, Hatice Gulcin, Coppola, Vincenzo, Yan, Pearlly, Byrd, John C., Blachly, James S., Lapalombella, Rosa

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Targeting OXPHOS de novo purine synthesis as the nexus of FLT3 inhibitor-mediated synergistic antileukemic actions von Zhang, Pu, Brinton, Lindsey T, Gharghabi, Mehdi, Sher, Steven, Williams, Katie, Cannon, Matthew, Walker, Janek S, Canfield, Daniel, Beaver, Larry, Cempre, Casey B, Phillips, Hannah, Chen, Xuyong, Yan, Pearlly, Lehman, Amy, Scherle, Peggy, Wang, Min, Vaddi, Kris, Baiocchi, Robert, Wang, Ruoning, Sampath, Deepa, Alinari, Lapo, Blachly, James S, Lapalombella, Rosa

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Simultaneous Disruption of XPO1 and A20 in Murine B Cells Influences Both B and T Cell Repertoire von Walker, Janek S., Cempre, Casey B., Skinner, Jordan N., Walker, Brandi R., Byrd, John C., Lapalombella, Rosa

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LP-118, a Selective Bcl-2 Inhibitor with Tuned Bcl-Xl Activity, Causes Myeloid Differentiation and Cell Death in Acute Myeloid Leukemia (AML) von Koenig, Kristin L, Brame, Colin, Sher, Steven, Beaver, Larry, Cempre, Casey B., Williams, Katie, Purcell, Matthew, Harrington, Bonnie, Chen, Yi, Tan, Felai, Anthony, Stephen P., Chen, Yu, Shen, Yue, Byrd, John C., Lapalombella, Rosa

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Genome-Wide CRISPR/Cas9 Knockout Screen Reveals Novel Gilteritinib Combinations Targeting Oxidative Phosphorylation and De-Novo Purine Biosynthesis Pathways for FLT3-ITD+ Acute Mye... von Sher, Steven, Zhang, Pu, Brinton, Lindsey, Gharghabi, Mehdi, Williams, Katie, Cannon, Matthew, Walker, Janek S., Canfield, Daniel, Beaver, Larry, Cempre, Casey B., Phillips, Hannah, Chen, Xuyong, Yan, Pearlly S., Lehman, Amy M., Scherle, Peggy, Wang, Min, Vaddi, Kris, Baiocchi, Robert A., Wang, Ruoning, Sampath, Deepa, Alinari, Lapo, Blachly, James S., Lapalombella, Rosa

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Dysregulation of PRMT5 in Chronic Lymphocytic Leukemia Supports Transformation to Diffuse Large B-Cell Lymphoma von Whipp, Ethan, Hing, Zachary A, Walker, Janek S., Sher, Steven, Cempre, Casey B., Brown, Fiona, Agostinelli, Claudio, Pileri, Stefano A, Williams, Katie, Beaver, Larry, Pan, Alexander, Gregory, Charles T., Yan, Pearlly S., Scherle, Peggy, Wang, Min, Vaddi, Kris, Chen-Kiang, Selina, Woyach, Jennifer A., Blachly, James S., Alinari, Lapo, Yang, Yiping, Baiocchi, Robert A., Blaser, Bradley W, Lapalombella, Rosa

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Abstract 2260: Evaluating a rare t(X;14)(q28;q32) translocation reveals MTCP1 as a driving factor in chronic lymphocytic leukemia von Walker, Janek S., Hing, Zachary A., Sher, Steven, Cronin, James, Williams, Katie, Harrington, Bonnie, Skinner, Jordan N., Cempre, Casey B., Gregory, Charles T., Yano, Max, Beaver, Larry P., Walker, Brandi R., Labanowska, Jadwiga M., Heerema, Nyla A., Mrozek, Krzysztof, Woyach, Jennifer A., Ruppert, Amy S., Lehman, Amy, Ozer, Hatice Gulcin, Coppola, Vincenzo, Byrd, John C., Blachly, James S., Lapalombella, Rosa

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PRMT5 Initiates an Epigenetic Program That Promotes Progression of Chronic Lymphocytic Leukemia von Hing, Zachary A, Skinner, Jordan N., Beaver, Larry P., Lai, Tzung-Huei, Cempre, Casey B., Harrington, Bonnie K., Sampath, Deepa, Lehman, Amy M., Yu, Lianbo, Alinari, Lapo, Byrd, John C., Baiocchi, Robert A, Lapalombella, Rosa

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Additional file 2 of Recurrent XPO1 mutations alter pathogenesis of chronic lymphocytic leukemia von Walker, Janek S., Hing, Zachary A., Harrington, Bonnie, Baumhardt, Jordan, Ozer, Hatice Gulcin, Lehman, Amy, Giacopelli, Brian, Beaver, Larry, Williams, Katie, Skinner, Jordan N., Cempre, Casey B., Qingxiang Sun, Shacham, Sharon, Stromberg, Benjamin R., Summers, Matthew K., Abruzzo, Lynne V., Rassenti, Laura, Kipps, Thomas J., Parikh, Sameer, Kay, Neil E., Rogers, Kerry A., Woyach, Jennifer A., Coppola, Vincenzo, Yuh Min Chook, Oakes, Christopher, Byrd, John C., Lapalombella, Rosa

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Additional file 1 of Recurrent XPO1 mutations alter pathogenesis of chronic lymphocytic leukemia von Walker, Janek S., Hing, Zachary A., Harrington, Bonnie, Baumhardt, Jordan, Ozer, Hatice Gulcin, Lehman, Amy, Giacopelli, Brian, Beaver, Larry, Williams, Katie, Skinner, Jordan N., Cempre, Casey B., Qingxiang Sun, Shacham, Sharon, Stromberg, Benjamin R., Summers, Matthew K., Abruzzo, Lynne V., Rassenti, Laura, Kipps, Thomas J., Parikh, Sameer, Kay, Neil E., Rogers, Kerry A., Woyach, Jennifer A., Coppola, Vincenzo, Yuh Min Chook, Oakes, Christopher, Byrd, John C., Lapalombella, Rosa

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Additional file 3 of Recurrent XPO1 mutations alter pathogenesis of chronic lymphocytic leukemia von Walker, Janek S., Hing, Zachary A., Harrington, Bonnie, Baumhardt, Jordan, Ozer, Hatice Gulcin, Lehman, Amy, Giacopelli, Brian, Beaver, Larry, Williams, Katie, Skinner, Jordan N., Cempre, Casey B., Qingxiang Sun, Shacham, Sharon, Stromberg, Benjamin R., Summers, Matthew K., Abruzzo, Lynne V., Rassenti, Laura, Kipps, Thomas J., Parikh, Sameer, Kay, Neil E., Rogers, Kerry A., Woyach, Jennifer A., Coppola, Vincenzo, Yuh Min Chook, Oakes, Christopher, Byrd, John C., Lapalombella, Rosa

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