Making Better Drugs: Decision Gates in Non-Clinical Drug Development von Pritchard, J. Fred, Jurima-Romet, Malle, Reimer, Mark L. J, Mortimer, Elisabeth, Rolfe, Brenda, Cayen, Mitchell N

Volltext

Drug Metabolites in Safety Testing von Baillie, Thomas A., Cayen, Mitchell N., Fouda, Hassan, Gerson, Ronald J., Green, James D., Grossman, Scott J., Klunk, Lewis J., LeBlanc, Bernard, Perkins, Darcy G., Shipley, Lisa A.

Volltext

Early drug development: strategies and routes to first-in-human trials. von Cayen, Mitchell N, Cayen, Mitchell N

Volltext

Pharmacokinetics of SCH 56592, a New Azole Broad-Spectrum Antifungal Agent, in Mice, Rats, Rabbits, Dogs, and Cynomolgus Monkeys von NOMEIR, A. A, KUMARI, P, HILBERT, M. J, GUPTA, S, LOEBENBERG, D, CACCIAPUOTI, A, HARE, R, MILLER, G. H, LIN, C.-C, CAYEN, M. N

Volltext

Bioavailability and Metabolism of Mometasone Furoate following Administration by Metered-Dose and Dry-Powder Inhalers in Healthy Human Volunteers von Affrime, Melton B., Cuss, Francis, Padhi, Desmond, Wirth, Mark, Pai, Sudhakar, Clement, Robert P., Lim, Josephine, Kantesaria, Bhavna, Alton, Kevin, Cayen, Mitchell N.

Volltext

The Penetration of Ceftibuten Into the Respiratory Tract von Krumpe, Peter, Lin, Chin-Chung, Radwanski, Elaine, Cayen, Mitchell N., Affrime, Melton B.

Volltext

In Vitro Uptake of SCH 27899 (Evernimicin) by Rat Alveolar Macrophages von ZBAIDA, Shmuel, BRIELAND, Joan, PATRICK, James E, KRIETER, Philip, LOEBENBERG, David, KRISHNA, Gopal, HORNE, Debra, LU, Xiaowen, YUAN YUAN, HARE, Roberta, CAYEN, Mitchell N

Volltext

Considerations in the Design of Toxicokinetic Programs von Cayen, Mitchell N.

Volltext

Toxicokinetic Challenges in the Pharmaceutical Industry von Cayen, Mitchell N.

Volltext

Early drug development: strategies and routes to first-in-human trials von Cayen, Mitchell N

Volltext

Characterization of AUCs from sparsely sampled populations in toxicology studies von PAI, S. M, FETTNER, S. H, HAJIAN, G, CAYEN, M. N, BATRA, V. K

Volltext

Novel in vivo procedure for rapid pharmacokinetic screening of discovery compounds in rats von Cox, Kathleen A., Dunn-Meynell, Kimberly, Korfmacher, Walter A., Broske, Lisa, Nomeir, Amin A., Lin, Chin-Chung, Cayen, Mitchell N., Barr, William H.

Volltext

Drug Discovery and Early Drug Development von Cayen, Mitchell N

Volltext

Exploratory INDs/CTAs von Cayen, Mitchell N

Volltext

Identification of human liver cytochrome P450 enzymes that metabolize the nonsedating antihistamine loratadine: Formation of descarboethoxyloratadine by CYP3A4 and CYP2D6 von Yumibe, Nathan, Huie, Keith, Chen, Kwang-Jong, Snow, Mark, Clement, Robert P., Cayen, Mitchell N.

Volltext

Desloratadine demonstrates dose proportionality in healthy adults after single doses von Gupta, Samir, Banfield, Christopher, Affrime, Melton, Marco, Aliceann, Cayen, Mitchell, Herron, Jerry, Padhi, Desmond

Volltext

Effect of race and sex on single and multiple dose pharmacokinetics of desloratadine von Affrime, Melton, Banfield, Christopher, Gupta, Samir, Cohen, Albert, Boutros, Tanya, Thonoor, Mohan, Cayen, Mitchell

Volltext

Disposition, metabolism and pharmacokinetics of antihyperlipidemic agents in laboratory animals and man von Cayen, Mitchell N.

Volltext

Hypolipidemic 4,5-dihydro-4-oxo-5,5-disubstituted-2-furancarboxylic acids von Jirkovsky, Ivo, Cayen, Mitchell N

Volltext

Racemic mixtures and single stereoisomers: Industrial concerns and issues in drug development von Cayen, Mitchell N.

Volltext