Leptin produced by joint white adipose tissue induces cartilage degradation via upregulation and activation of matrix metalloproteinases von Hui, Wang, Litherland, Gary J, Elias, Martina S, Kitson, Gareth I, Cawston, Tim E, Rowan, Andrew D, Young, David A

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The Mammalian Chitinase-like Lectin, YKL-40, Binds Specifically to Type I Collagen and Modulates the Rate of Type I Collagen Fibril Formation von Bigg, Heather F., Wait, Robin, Rowan, Andrew D., Cawston, Tim E.

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Lipophilic statins prevent matrix metalloproteinase-mediated cartilage collagen breakdown by inhibiting protein geranylgeranylation von Barter, Matt J, Hui, Wang, Lakey, Rachel L, Catterall, John B, Cawston, Tim E, Young, David A

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Understanding the role of tissue degrading enzymes and their inhibitors in development and disease von Cawston, Tim E., Wilson, Amy J.

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Sulfasalazine blocks the release of proteoglycan and collagen from cytokine stimulated cartilage and down-regulates metalloproteinases von Lakey, Rachel L., Cawston, Tim E.

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Metalloproteinase and inhibitor expression profiling of resorbing cartilage reveals pro-collagenase activation as a critical step for collagenolysis von Milner, Jennifer M, Rowan, Andrew D, Cawston, Tim E, Young, David A

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Research in hand osteoarthritis: time for reappraisal and demand for new strategies. An opinion paper von Kloppenburg, Margreet, Stamm, Tanja, Watt, Iain, Kainberger, Franz, Cawston, Tim E, Birrell, Fraser N, Petersson, Ingemar F, Saxne, Tore, Kvien, Tore K, Slatkowsky-Christensen, Barbara, Dougados, Maxime, Gossec, Laure, Breedveld, Ferdinand C, Smolen, Josef S

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In Vitro Model of Cartilage Degradation von Hui, Wang, Cawston, Tim E.

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A novel paradigm for dendritic cells as effectors of cartilage destruction von Lakey, Rachel L., Morgan, Tanya G., Rowan, Andrew D., Isaacs, John D., Cawston, Tim E., Hilkens, Catharien M. U.

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A model of inflammatory arthritis highlights a role for oncostatin M in pro-inflammatory cytokine-induced bone destruction via RANK/RANKL von Hui, Wang, Cawston, Tim E, Richards, Carl D, Rowan, Andrew D

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Matriptase is a novel initiator of cartilage matrix degradation in osteoarthritis von Milner, Jennifer M., Patel, Amit, Davidson, Rose K., Swingler, Tracey E., Desilets, Antoine, Young, David A., Kelso, Elizabeth B., Donell, Simon T., Cawston, Tim E., Clark, Ian M., Ferrell, William R., Plevin, Robin, Lockhart, John C., Leduc, Richard, Rowan, Andrew D.

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The Phosphodiesterase Type IV Inhibitor Cilomilast Decreases Pro-inflammatory Cytokine Production From Primary Bronchial Epithelial Cells in Lung Transplantation Patients von Murphy, Des M., Ward, Chris, Forrest, Ian A., Pritchard, Gail, Jones, Debbie, Stovold, Rachel, Fisher, Andrew J., Cawston, Tim E., Lordan, Jim L., Corris, Paul A.

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Early joint erosions and serum levels of matrix metalloproteinase 1, matrix metalloproteinase 3, and tissue inhibitor of metalloproteinases 1 in rheumatoid arthritis von Cunnane, Gaye, FitzGerald, Oliver, Beeton, Charlotte, Cawston, Tim E., Bresnihan, Barry

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Actions of IL-1 are selectively controlled by p38 mitogen-activated protein kinase: regulation of prostaglandin H synthase-2, metalloproteinases, and IL-6 at different levels von Ridley, SH, Sarsfield, SJ, Lee, JC, Bigg, HF, Cawston, TE, Taylor, DJ, DeWitt, DL, Saklatvala, J

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A rapid and reproducible assay for collagenase using [1- 14C]acetylated collagen von Cawston, Tim E., Barrett, Alan J.

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Involvement of a region near valine-69 of tissue inhibitor of metalloproteinases (TIMP)-1 in the interaction with matrix metalloproteinase 3 (stromelysin 1) von Nagase, H, Suzuki, K, Cawston, T E, Brew, K

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An aggrecan-degrading activity associated with chondrocyte membranes von Billington, C J, Clark, I M, Cawston, T E

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Erythrocyte sedimentation rate and C reactive protein in the assessment of polymyalgia rheumatica/giant cell arteritis on presentation and during follow up von Kyle, V, Cawston, T E, Hazleman, B L

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Musculoskeletal pharmacology von Harris, John B., Cawston, Tim E.

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All-Trans-Retinoic Acid Interacts Synergistically with Basic Fibroblast Growth Factor and Epidermal Growth Factor to Stimulate the Production of Tissue Inhibitor of Metalloproteina... von Bigg, H.F., Cawston, T.E.

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