Oxidative changes and signalling pathways are pivotal in initiating age-related changes in articular cartilage von Hui, Wang, Young, David A, Rowan, Andrew D, Xu, Xin, Cawston, Tim E, Proctor, Carole J

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Leptin produced by joint white adipose tissue induces cartilage degradation via upregulation and activation of matrix metalloproteinases von Hui, Wang, Litherland, Gary J, Elias, Martina S, Kitson, Gareth I, Cawston, Tim E, Rowan, Andrew D, Young, David A

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Proteinases involved in matrix turnover during cartilage and bone breakdown von Cawston, Tim E., Young, David A.

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Understanding the role of tissue degrading enzymes and their inhibitors in development and disease von Cawston, Tim E., Wilson, Amy J.

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Activity of matrix metalloproteinase‐9 against native collagen types I and III von Bigg, Heather F., Rowan, Andrew D., Barker, Michael D., Cawston, Tim E.

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The Mammalian Chitinase-like Lectin, YKL-40, Binds Specifically to Type I Collagen and Modulates the Rate of Type I Collagen Fibril Formation von Bigg, Heather F., Wait, Robin, Rowan, Andrew D., Cawston, Tim E.

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Lipophilic statins prevent matrix metalloproteinase-mediated cartilage collagen breakdown by inhibiting protein geranylgeranylation von Barter, Matt J, Hui, Wang, Lakey, Rachel L, Catterall, John B, Cawston, Tim E, Young, David A

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HDAC-mediated control of ERK- and PI3K-dependent TGF-β-induced extracellular matrix-regulating genes von Barter, Matt J., Pybus, Leon, Litherland, Gary J., Rowan, Andrew D., Clark, Ian M., Edwards, Dylan R., Cawston, Tim E., Young, David A.

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Synergistic Collagenase Expression and Cartilage Collagenolysis Are Phosphatidylinositol 3-Kinase/Akt Signaling-dependent von Litherland, Gary J., Dixon, Craig, Lakey, Rachel L., Robson, Timothy, Jones, Debra, Young, David A., Cawston, Tim E., Rowan, Andrew D.

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Measurement of activity of collagenolytic MMP and inhibitors of MMPs using radiolabeled collagen substrate von Cawston, Tim E

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Metalloproteinase and inhibitor expression profiling of resorbing cartilage reveals pro-collagenase activation as a critical step for collagenolysis von Milner, Jennifer M, Rowan, Andrew D, Cawston, Tim E, Young, David A

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Lithium protects cartilage from cytokine-mediated degradation by reducing collagen-degrading MMP production via inhibition of the P38 mitogen-activated protein kinase pathway von Hui, Wang, Litherland, Gary J., Jefferson, Matthew, Barter, Matt J., Elias, Martina S., Cawston, Tim E., Rowan, Andrew D., Young, David A.

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Sulfasalazine blocks the release of proteoglycan and collagen from cytokine stimulated cartilage and down-regulates metalloproteinases von Lakey, Rachel L., Cawston, Tim E.

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Research in hand osteoarthritis: time for reappraisal and demand for new strategies. An opinion paper von Kloppenburg, Margreet, Stamm, Tanja, Watt, Iain, Kainberger, Franz, Cawston, Tim E, Birrell, Fraser N, Petersson, Ingemar F, Saxne, Tore, Kvien, Tore K, Slatkowsky-Christensen, Barbara, Dougados, Maxime, Gossec, Laure, Breedveld, Ferdinand C, Smolen, Josef S

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In Vitro Model of Cartilage Degradation von Hui, Wang, Cawston, Tim E.

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Adenoviral Gene Transfer of Interleukin-1 in Combination with Oncostatin M Induces Significant Joint Damage in a Murine Model von Rowan, Andrew D., Hui, Wang, Cawston, Tim E., Richards, Carl D.

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A model of inflammatory arthritis highlights a role for oncostatin M in pro-inflammatory cytokine-induced bone destruction via RANK/RANKL von Hui, Wang, Cawston, Tim E, Richards, Carl D, Rowan, Andrew D

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Drugs in development: bisphosphonates and metalloproteinase inhibitors von Catterall, Jon B, Cawston, Tim E

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A novel paradigm for dendritic cells as effectors of cartilage destruction von Lakey, Rachel L., Morgan, Tanya G., Rowan, Andrew D., Isaacs, John D., Cawston, Tim E., Hilkens, Catharien M. U.

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Assay of Matrix Metalloproteinases Against Matrix Substrates von Cawston, Tim E., Lakey, Rachel L., Rowan, Andrew D.

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