Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine von Campesato, Luis Felipe, Budhu, Sadna, Tchaicha, Jeremy, Weng, Chien-Huan, Gigoux, Mathieu, Cohen, Ivan Jose, Redmond, David, Mangarin, Levi, Pourpe, Stephane, Liu, Cailian, Zappasodi, Roberta, Zamarin, Dmitriy, Cavanaugh, Jill, Castro, Alfredo C., Manfredi, Mark G., McGovern, Karen, Merghoub, Taha, Wolchok, Jedd D.

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Antibody receptors steal the sweet spotlight von Oliva, Kelsey D., Cavanaugh, Jill M., Cobb, Brian A.

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Intestinal Tr1 Cells Confer Protection against Colitis in the Absence of Foxp3+ Regulatory T Cell-Derived IL-10 von Zhou, Julie Y, Glendenning, Leandre M, Cavanaugh, Jill M, McNeer, Sarah K, Goodman, Wendy A, Cobb, Brian A

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Discovery and characterization of a novel aryl hydrocarbon receptor inhibitor, IK-175, and its inhibitory activity on tumor immune suppression von McGovern, Karen, Castro, Alfredo C, Cavanaugh, Jill, Coma, Silvia, Walsh, Meghan, Tchaicha, Jeremy, Syed, Sakeena, Natarajan, Prabitha, Manfredi, Mark, Zhang, Xiaoyan M, Ecsedy, Jeffrey

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Abstract P216: IK-930 mediated TEAD inhibition decreases and delays tumor growth and enhances targeted apoptosis in lung and colon cancer xenografts when combined with MEK or EGFR... von Amidon, Benjamin, Frosch, Hyejin, Syed, Sakeena, Cavanaugh, Jill, Turcotte, Chelsea, O'Callaghan, Katie, Natarajan, Prabitha, Ecsedy, Jeffrey, McGovern, Karen, Castro, Alfredo

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Abstract 2474: Potent small molecule TEAD inhibitors targeting the Hippo pathway exhibit antiproliferation in vitro and anti-tumor effect in vivo von Amidon, Ben, Syed, Sakeena, Cavanaugh, Jill, Frosch, Hyejin, Natarajan, Prabitha, Ecsedy, Jeffrey, McGovern, Karen, Castro, Alfredo C.

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Abstract 4131: Overcoming aryl hydrocarbon receptor mediated tumor immunosuppression von Tchaicha, Jeremy, Coma, Silvia, Walsh, Meghan, Cavanaugh, Jill, Sanchez-Martin, Marta, Zhang, X. Michelle, Castro, Alfredo, Ecsedy, Jeff, Manfredi, Mark, McGovern, Karen

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Abstract 4723: Targeting the IDO and TDO pathway through inhibition of the aryl hydrocarbon receptor von Tchaicha, Jeremy, McGovern, Karen, Campesato, Luis Felipe, Coma, Silvia, Zhang, Xiaoyan Michelle, Walsh, Meghan, Cavanaugh, Jill, Merghoub, Taha, Wolchok, Jedd, Manfredi, Mark

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Abstract 3757: Targeting the IDO/TDO pathway through degradation of the immunosuppressive metabolite kynurenine von Coma, Silvia, Cavanaugh, Jill, Nolan, James, Tchaicha, Jeremy, McGovern, Karen, Stone, Everett, Lamb, Candice, Karamitros, Christos, Blazek, John, Garrison, Kendra, Georgiou, George, Manfredi, Mark, Zhang, Xiaoyan Michelle

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Targeting Hypoxia-Inducible Factor 1α in a New Orthotopic Model of Glioblastoma Recapitulating the Hypoxic Tumor Microenvironment von Nigim, Fares, Cavanaugh, Jill, Patel, Anoop P., Curry, William T., Esaki, Shin-ichi, Kasper, Ekkehard M., Chi, Andrew S., Louis, David N., Martuza, Robert L., Rabkin, Samuel D., Wakimoto, Hiroaki

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Abstract 1646: IK-930, a paralog-selective TEAD inhibitor for treating YAP/TAZ-TEAD dependent cancers von Young, Nathan, Punkosdy, George, Cavanaugh, Jill, Bantle, Collin, Constan, Alex, Li, Bin, Conley, James, Sanchez-Martin, Marta, Xu, Lan, McGovern, Karen, Castro, Alfredo, Zhang, Michelle, Ecsedy, Jeffrey

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Abstract B155: IK-595, a best-in-class MEK-RAF complex inhibitor, drives broad and potent anti-tumor activity in RAS/RAF-driven tumors von Haines, Eric, Catterall, Rachel, De Jesus, Victor, Li, Bin, Wessel, Sarah R, Cavanaugh, Jill, Burke, Michael, Manna, Joseph D, Zavidij, Okzana, Yang, Ao, Xu, Lan, Santillana, Sergio, Ecsedy, Jeffrey, Zhang, X. Michelle, Ruppel, Sabine K

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Abstract PR10: IK-595, a MEK-RAF complex inhibitor, obviates CRAF mediated resistance resulting in superior RAS/MAPK pathway inhibition and anti-tumor activity in RAS/RAF altered c... von Haines, Eric, Burke, Michael, Catterall, Rachel, De Jesus, Victor, Li, Bin, Manna, Joseph D., Punkosdy, George, Zavidij, Oksana, Wessel, Sarah R., Werosta, Grace, Cavanaugh, Jill, Newhouse, Sheila, Basavapathruni, Aravind, Xu, Lan, Santillana, Sergio, Zhang, X. Michelle, Ruppel, Sabine K.

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448 Discovery of clinical candidate IK-175, a selective orally active AHR antagonist von Mcgovern, Karen, Castro, Alfredo, Cavanaugh, Jill, Sanchez-Martin, Marta, Tchaicha, Jeremy, Sakeena Syed, Frosch, Hyejin, Natarajan, Prabitha, Katie O’Callaghan, Amidon, Ben, Zhang, X Michelle, Ecsedy, Jeff

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AI-21HIF-1A TARGETING IN AN ORTHOTOPIC XENOGRAFT MODEL THAT RECAPITULATES THE HYPOXIC MICROENVIRONMENT OF GLIOBLASTOMA von Nigim, Fares, Cavanaugh, Jill, Patel, Anoop P., Curry, William T., Kasper, Ekkehard M., Chi, Andrew S., Martuza, Robert L., Rabkin, Samuel D., Wakimoto, Hiroaki

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AI-21 HIF-1A TARGETING IN AN ORTHOTOPIC XENOGRAFT MODEL THAT RECAPITULATES THE HYPOXIC MICROENVIRONMENT OF GLIOBLASTOMA von Nigim, F., Cavanaugh, J., Patel, A. P., Curry, W. T., Kasper, E. M., Chi, A. S., Martuza, R. L., Rabkin, S. D., Wakimoto, H.

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Identification of a Circadian Output Circuit for Rest:Activity Rhythms in Drosophila von Cavanaugh, Daniel J., Geratowski, Jill D., Wooltorton, Julian R.A., Spaethling, Jennifer M., Hector, Clare E., Zheng, Xiangzhong, Johnson, Erik C., Eberwine, James H., Sehgal, Amita

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From consumption to context: assessing poverty and inequality across diverse socio-ecological systems in Ghana von Cavanaugh, Alicia C, Bixby, Honor R, Mangwani, Saeesh, Agyei-Mensah, Samuel, Awuni, Cynthia Azochiman, Baumgartner, Jill C, Owusu, George, Robinson, Brian E

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Tuberculosis screening among ambulatory people living with HIV: a systematic review and individual participant data meta-analysis von Dhana, Ashar, Hamada, Yohhei, Kengne, Andre P, Kerkhoff, Andrew D, Rangaka, Molebogeng X, Kredo, Tamara, Baddeley, Annabel, Miller, Cecily, Singh, Satvinder, Hanifa, Yasmeen, Grant, Alison D, Fielding, Katherine, Affolabi, Dissou, Merle, Corinne S, Wachinou, Ablo Prudence, Yoon, Christina, Cattamanchi, Adithya, Hoffmann, Christopher J, Martinson, Neil, Mbu, Eyongetah Tabenyang, Sander, Melissa S, Balcha, Taye T, Skogmar, Sten, Reeve, Byron W P, Theron, Grant, Ndlangalavu, Gcobisa, Modi, Surbhi, Cavanaugh, Joseph, Swindells, Susan, Chaisson, Richard E, Ahmad Khan, Faiz, Howard, Andrea A, Wood, Robin, Thit, Swe Swe, Kyi, Mar Mar, Hanson, Josh, Drain, Paul K, Shapiro, Adrienne E, Kufa, Tendesayi, Churchyard, Gavin, Nguyen, Duc T, Graviss, Edward A, Bjerrum, Stephanie, Johansen, Isik S, Gersh, Jill K, Horne, David J, LaCourse, Sylvia M, Al-Darraji, Haider Abdulrazzaq Abed, Kamarulzaman, Adeeba, Kempker, Russell R, Tukvadze, Nestani, Barr, David A, Meintjes, Graeme, Maartens, Gary

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TransitionRx: Impact of community pharmacy postdischarge medication therapy management on hospital readmission rate von Luder, Heidi R., PharmD, BCACP, Frede, Stacey M., PharmD, BCACP, CDE, Kirby, James A., PharmD, BCPS, CDE, Epplen, Kelly, PharmD, BCACP, Cavanaugh, Teresa, PharmD, Martin-Boone, Jill E., PharmD, FASHP, Conrad, Wayne F., PharmD, FASHP, Kuhlmann, Diane, RN, Heaton, Pamela C., PhD, BSPharm

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