Inactivating NF1 Mutations Are Enriched in Advanced Breast Cancer and Contribute to Endocrine Therapy Resistance von Pearson, Alex, Proszek, Paula, Pascual, Javier, Fribbens, Charlotte, Shamsher, Monee K., Kingston, Belinda, O'Leary, Ben, Herrera-Abreu, Maria T., Cutts, Rosalind J., Garcia-Murillas, Isaac, Bye, Hannah, Walker, Brian A., De Castro, David Gonzalez, Yuan, Lina, Jamal, Sabri, Hubank, Mike, Lopez-Knowles, Elena, Schuster, Eugene F., Dowsett, Mitch, Osin, Peter, Nerurkar, Ashutosh, Parton, Marina, Okines, Alicia F. C., Johnston, Stephen R. D., Ring, Alistair, Turner, Nicholas C.

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Multicenter Randomized Phase II Clinical Trial Comparing Neoadjuvant Oxaliplatin, Capecitabine, and Preoperative Radiotherapy With or Without Cetuximab Followed by Total Mesorectal... von DEWDNEY, Alice, CUNNINGHAM, David, YU JO CHUA, WONG, Rachel, BARBACHANO, Yolanda, OATES, Jacqueline, CHAU, Ian, TABERNERO, Josep, CAPDEVILA, Jaume, GLIMELIUS, Bengt, CERVANTES, Andres, TAIT, Diana, BROWN, Gina, WOTHERSPOON, Andrew, DE CASTRO, David Gonzalez

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Specific JAK2 mutation (JAK2R683) and multiple gene deletions in Down syndrome acute lymphoblastic leukemia von Kearney, Lyndal, Gonzalez De Castro, David, Yeung, Jenny, Procter, Julia, Horsley, Sharon W., Eguchi-Ishimae, Minenori, Bateman, Caroline M., Anderson, Kristina, Chaplin, Tracy, Young, Bryan D., Harrison, Christine J., Kempski, Helena, Wai E. So, Chi, Ford, Anthony M., Greaves, Mel

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Genomic landscape of platinum resistant and sensitive testicular cancers von Loveday, Chey, Litchfield, Kevin, Proszek, Paula Z., Cornish, Alex J., Santo, Flavia, Levy, Max, Macintyre, Geoff, Holryod, Amy, Broderick, Peter, Dudakia, Darshna, Benton, Barbara, Bakir, Maise Al, Hiley, Crispin, Grist, Emily, Swanton, Charles, Huddart, Robert, Powles, Tom, Chowdhury, Simon, Shipley, Janet, O’Connor, Simon, Brenton, James D., Reid, Alison, de Castro, David Gonzalez, Houlston, Richard S., Turnbull, Clare

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Next-generation sequencing: a change of paradigm in molecular diagnostic validation von Salto-Tellez, Manuel, Gonzalez de Castro, David

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The impact of SAMHD1 expression and mutation status in mantle cell lymphoma: An analysis of the MCL Younger and Elderly trial von Roider, Tobias, Wang, Xi, Hüttl, Katrin, Müller‐Tidow, Carsten, Klapper, Wolfram, Rosenwald, Andreas, Stewart, James Peter, Castro, David Gonzalez, Dreger, Peter, Hermine, Olivier, Kluin‐Nelemans, Hanneke C., Grabe, Niels, Dreyling, Martin, Pott, Christiane, Ott, German, Hoster, Eva, Dietrich, Sascha

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The clinical significance of NOTCH1 and SF3B1 mutations in the UK LRF CLL4 trial von Oscier, David G., Rose-Zerilli, Matthew J.J., Winkelmann, Nils, Gonzalez de Castro, David, Gomez, Belen, Forster, Jade, Parker, Helen, Parker, Anton, Gardiner, Anne, Collins, Andrew, Else, Monica, Cross, Nicholas C.P., Catovsky, Daniel, Strefford, Jonathan C.

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EuroClonality-NGS recommendations for evaluation of B cell clonality analysis by next-generation sequencing - a structured approach with the DEPART algorithm von van den Brand, Michiel, Mobs, Markus, Otto, Franziska, Kroeze, Leonie I, Castro, David Gonzalez-de, Stamatopoulos, Kostas, Davi, Frederic, Bravetti, Clotilde, Kolijn, P Martijn, Vlachonika, Elisavet, Stewart, J Peter, Pott, Christiane, Hummel, Michael, Darzentas, Nikos, Langerak, Anton W, Fend, Falko, Groenen, Patricia Jta

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Genetics and Prognostication in Splenic Marginal Zone Lymphoma: Revelations from Deep Sequencing von Parry, Marina, Rose-Zerilli, Matthew Jj, Ljungström, Viktor, Gibson, Jane, Wang, Jun, Walewska, Renata, Parker, Helen, Parker, Anton, Davis, Zadie, Gardiner, Anne, McIver-Brown, Neil, Kalpadakis, Christina, Xochelli, Aliki, Anagnostopoulos, Achilles, Fazi, Claudia, de Castro, David Gonzalez, Dearden, Claire, Pratt, Guy, Rosenquist, Richard, Ashton-Key, Margaret, Forconi, Francesco, Collins, Andrew, Ghia, Paolo, Matutes, Estella, Pangalis, Gerassimos, Stamatopoulos, Kostas, Oscier, David, Strefford, Jonathan C

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Investigating the potential clinical benefit of Selumetinib in resensitising advanced iodine refractory differentiated thyroid cancer to radioiodine therapy (SEL-I-METRY): protocol... von Brown, Sarah R, Hall, Andrew, Buckley, Hannah L, Flanagan, Louise, Gonzalez de Castro, David, Farnell, Kate, Moss, Laura, Gregory, Rebecca, Newbold, Kate, Du, Yong, Flux, Glenn, Wadsley, Jonathan

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KRAS and BRAF mutations in circulating tumour DNA from locally advanced rectal cancer von Sclafani, Francesco, Chau, Ian, Cunningham, David, Hahne, Jens C., Vlachogiannis, George, Eltahir, Zakaria, Lampis, Andrea, Braconi, Chiara, Kalaitzaki, Eleftheria, De Castro, David Gonzalez, Wotherspoon, Andrew, Capdevila, Jaume, Glimelius, Bengt, Tarazona, Noelia, Begum, Ruwaida, Lote, Hazel, Hulkki Wilson, Sanna, Mentrasti, Giulia, Brown, Gina, Tait, Diana, Oates, Jacqueline, Valeri, Nicola

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Rare disruptive mutations in ciliary function genes contribute to testicular cancer susceptibility von Litchfield, Kevin, Levy, Max, Dudakia, Darshna, Proszek, Paula, Shipley, Claire, Basten, Sander, Rapley, Elizabeth, Bishop, D. Timothy, Reid, Alison, Huddart, Robert, Broderick, Peter, Castro, David Gonzalez de, O'Connor, Simon, Giles, Rachel H., Houlston, Richard S., Turnbull, Clare

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Treatment and Survival Outcome of BRAF-Mutated Metastatic Colorectal Cancer: A Retrospective Matched Case-Control Study von Kayhanian, Hamzeh, Goode, Emily, Sclafani, Francesco, Ang, Joo Ern, Gerlinger, Marco, Gonzalez de Castro, David, Shepherd, Scott, Peckitt, Clare, Rao, Sheela, Watkins, David, Chau, Ian, Cunningham, David, Starling, Naureen

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Multi-purpose utility of circulating plasma DNA testing in patients with advanced cancers von Perkins, Geraldine, Yap, Timothy A, Pope, Lorna, Cassidy, Amy M, Dukes, Juliet P, Riisnaes, Ruth, Massard, Christophe, Cassier, Philippe A, Miranda, Susana, Clark, Jeremy, Denholm, Katie A, Thway, Khin, Gonzalez De Castro, David, Attard, Gerhardt, Molife, L Rhoda, Kaye, Stan B, Banerji, Udai, de Bono, Johann S

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Efficient Genotyping of KRAS Mutant Non-Small Cell Lung Cancer Using a Multiplexed Droplet Digital PCR Approach von Pender, Alexandra, Garcia-Murillas, Isaac, Rana, Sareena, Cutts, Rosalind J, Kelly, Gavin, Fenwick, Kerry, Kozarewa, Iwanka, Gonzalez de Castro, David, Bhosle, Jaishree, O'Brien, Mary, Turner, Nicholas C, Popat, Sanjay, Downward, Julian

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A Validation Study for the Use of ROS1 Immunohistochemical Staining in Screening for ROS1 Translocations in Lung Cancer von Viola, Patrizia, Maurya, Manisha, Croud, James, Gazdova, Jana, Suleman, Nadia, Lim, Eric, Newsom-Davis, Tom, Plowman, Nick, Rice, Alexandra, Montero, M. Angeles, Gonzalez de Castro, David, Popat, Sanjay, Nicholson, Andrew G.

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XBP1s levels are implicated in the biology and outcome of myeloma mediating different clinical outcomes to thalidomide-based treatments von Bagratuni, Tina, Wu, Ping, Gonzalez de Castro, David, Davenport, Emma L., Dickens, Nicholas J., Walker, Brian A., Boyd, Kevin, Johnson, David C., Gregory, Walter, Morgan, Gareth J., Davies, Faith E.

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Challenges in molecular testing in non-small-cell lung cancer patients with advanced disease von Hiley, Crispin T, MD, Le Quesne, John, FRCPath, Santis, George, Prof, Sharpe, Rowena, PhD, de Castro, David Gonzalez, Prof, Middleton, Gary, Prof, Swanton, Charles, Prof

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FGF7–FGFR2 autocrine signaling increases growth and chemoresistance of fusion‐positive rhabdomyosarcomas von Milton, Christopher I., Selfe, Joanna, Aladowicz, Ewa, Man, Stella Y. K., Bernauer, Carolina, Missiaglia, Edoardo, Walters, Zoë S., Gatz, Susanne A., Kelsey, Anna, Generali, Melanie, Box, Gary, Valenti, Melanie, Haven‐Brandon, Alexis, Galiwango, David, Hayes, Angela, Clarke, Matthew, Izquierdo, Elisa, Gonzalez De Castro, David, Raynaud, Florence I., Kirkin, Vladimir, Shipley, Janet M.

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Comparison of testing methods for the detection of BRAF V600E mutations in malignant melanoma: pre-approval validation study of the companion diagnostic test for vemurafenib von Lopez-Rios, Fernando, Angulo, Barbara, Gomez, Belen, Mair, Debbie, Martinez, Rebeca, Conde, Esther, Shieh, Felice, Vaks, Jeffrey, Langland, Rachel, Lawrence, H Jeffrey, de Castro, David Gonzalez

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