Involvement of the low-density lipoprotein receptor-related protein in the transcytosis of the brain delivery vector Angiopep-2 von Demeule, Michel, Currie, Jean-Christophe, Bertrand, Yanick, Ché, Christian, Nguyen, Tran, Régina, Anthony, Gabathuler, Reinhard, Castaigne, Jean-Paul, Béliveau, Richard

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ANG4043, a novel brain-penetrant peptide-mAb conjugate, is efficacious against HER2-positive intracranial tumors in mice von Regina, Anthony, Demeule, Michel, Tripathy, Sasmita, Lord-Dufour, Simon, Currie, Jean-Christophe, Iddir, Mustapha, Annabi, Borhane, Castaigne, Jean-Paul, Lachowicz, Jean E

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Transport characteristics of a novel peptide platform for CNS therapeutics von Bertrand, Yanick, Currie, Jean‐Christophe, Demeule, Michel, Régina, Anthony, Ché, Christian, Abulrob, Abedelnasser, Fatehi, Dorothy, Sartelet, Hervé, Gabathuler, Reinhard, Castaigne, Jean‐Paul, Stanimirovic, Danica, Béliveau, Richard

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Development and characterization of a glucagon-like peptide 1-albumin conjugate: The ability to activate the glucagon-like peptide 1 receptor in vivo von KIM, Jung-Guk, BAGGIO, Laurie L, BRIDON, Dominique P, CASTAIGNE, Jean-Paul, ROBITAILLE, Martin F, JETTE, Lucie, BENQUET, Corinne, DRUCKER, Daniel J

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Conjugation of a brain-penetrant peptide with neurotensin provides antinociceptive properties von Demeule, Michel, Beaudet, Nicolas, Régina, Anthony, Besserer-Offroy, Élie, Murza, Alexandre, Tétreault, Pascal, Belleville, Karine, Ché, Christian, Larocque, Alain, Thiot, Carine, Béliveau, Richard, Longpré, Jean-Michel, Marsault, Éric, Leduc, Richard, Lachowicz, Jean E, Gonias, Steven L, Castaigne, Jean-Paul, Sarret, Philippe

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New Angiopep-Modified Doxorubicin (ANG1007) and Etoposide (ANG1009) Chemotherapeutics With Increased Brain Penetration von Ché, Christian, Yang, Gaoqiang, Thiot, Carine, Lacoste, Marie-Claude, Currie, Jean-Christophe, Demeule, Michel, Régina, Anthony, Béliveau, Richard, Castaigne, Jean-Paul

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Synthesis and in vitro analysis of atrial natriuretic peptide-albumin conjugates von LEGER, Roger, ROBITAILLE, Martin, BRIDON, Dominique, QURAISHI, Omar, DENHOLM, Elizabeth, BENQUET, Corinne, CARETTE, Julie, VAN WYK, Pieter, PELLERIN, Isabelle, BOUSQUET-GAGNON, Nathalie, CASTAIGNE, Jean-Paul

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Synthesis and Evaluation of Insulin−Human Serum Albumin Conjugates von Thibaudeau, Karen, Léger, Roger, Huang, Xicai, Robitaille, Martin, Quraishi, Omar, Soucy, Chantal, Bousquet-Gagnon, Nathalie, van Wyk, Pieter, Paradis, Véronique, Castaigne, Jean-Paul, Bridon, Dominique

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Identification of CJC-1131-albumin bioconjugate as a stable and bioactive GLP-1(7–36) analog von Léger, Roger, Thibaudeau, Karen, Robitaille, Martin, Quraishi, Omar, van Wyk, Pieter, Bousquet-Gagnon, Nathalie, Carette, Julie, Castaigne, Jean-Paul, Bridon, Dominique P.

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Prolonged Stimulation of Growth Hormone (GH) and Insulin-Like Growth Factor I Secretion by CJC-1295, a Long-Acting Analog of GH-Releasing Hormone, in Healthy Adults von Teichman, Sam L., Neale, Ann, Lawrence, Betty, Gagnon, Catherine, Castaigne, Jean-Paul, Frohman, Lawrence A.

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Once-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse von Alba, Maria, Fintini, Danilo, Sagazio, Alessia, Lawrence, Betty, Castaigne, Jean-Paul, Frohman, Lawrence A, Salvatori, Roberto

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Phase I study of GRN1005 in recurrent malignant glioma von Drappatz, Jan, Brenner, Andrew, Wong, Eric T, Eichler, April, Schiff, David, Groves, Morris D, Mikkelsen, Tom, Rosenfeld, Steve, Sarantopoulos, John, Meyers, Christina A, Fielding, Robert M, Elian, Kelly, Wang, Xiaolin, Lawrence, Betty, Shing, Mona, Kelsey, Stephen, Castaigne, Jean Paul, Wen, Patrick Y

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Systemic administration of a brain-penetrant peptide–iduronidase conjugate results in brain IDUA activity in MPS I mice von Lachowicz, Jean E., Demeule, Michel, Regina, Anthony, Das, Sanjoy, Moktefi, Kamel, Larocque, Alain, Castaigne, Jean-Paul

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Abstract 2465: Targeting HER2-positive brain metastases by incorporating the brain-penetrant Angiopep-2 peptide to an anti-HER2 antibody and anti-HER2 antibody drug conjugate von Demeule, Michel, Das, Sanjoy, Che, Christian, Yang, Gaoqiang, Currie, Jean-Christophe, Lord-Dufour, Simon, Tripathy, Sasmita, Regina, Anthony, Castaigne, Jean-Paul, Lachowicz, Jean E.

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Development and Characterization of a Glucagon-Like Peptide 1-Albumin Conjugate von Jung-Guk Kim, Laurie L. Baggio, Dominique P. Bridon, Jean-Paul Castaigne, Martin F. Robitaille, Lucie Jetté, Corinne Benquet, Daniel J. Drucker

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Abstract 2657: Utilization of the Angiopep platform to enable brain penetration of therapeutic mAbs or Antibody-Drug Conjugates for treatment of brain tumors von Demeule, Michel, Lachowicz, Jean E., Tripathy, Sasmita, Yang, Giogang, Das, Sanjoy, Che, Christian, Currie, Jean-Christophe, Lord-Dufour, Simon, Regina, Anthony, Castaigne, Jean-Paul

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Using the peptide angiopep-2 to create a GFP fusion protein with the ability to cross the blood-brain barrier and enter cells in the mouse brain von Lachowicz, Jean E., Boivin, Dominique, Demeule, Michel, Regina, Anthony, Angiochem, Jean-Paul Castaigne

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Using ANG4043, a brain-penetrant anti-HER2 mab, to increase survival in a murine intracranial breast tumor model von Lachowicz, Jean E, Demeule, Michel, Regina, Anthony, Tripathy, Sasmita, Che, Christian, Currie, Jean-Christophe, Lord-Dufour, Simon, Houle, Emilie, Castaigne, Jean-Paul

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Evaluation of CNS and peripheral antitumor activity of ANG1005 in patients with brain metastases from breast tumors and other advanced solid tumors von Lin, Nancy U., Gabrail, Nashat Y., Sarantopoulos, John, Schwartzberg, Lee Steven, Kesari, Santosh, Bates, Susan Elaine, Anders, Carey K., Elias, Anthony D., Castaigne, Jean-Paul, Iordanova, Vihra, Lawrence, Betty, Kurzrock, Razelle

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Abstract 864: ANG4043: A new brain-penetrant peptide-antibody conjugate that reduces tumor growth in a HER2-positive orthotopic tumor model von Lachowicz, Jean E., Demeule, Michel, Che, Christian, Tripathy, Sasmita, Currie, Jean-Christophe, Regina, Anthony, Nguyen, Tran, Lord-Dufour, Simon, Castaigne, Jean-Paul

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